Étude de l'interaction entre ions multichargés et systèmes complexes d'intérêt biologique : effets de l'environnement à l'échelle moléculaire

Abstract : This PhD thesis describes the experimental study of the interaction between slow multiply charged ions (tens of keV) and molecular systems of biological interest (amino acids and nucleobases). It is the aim to identify and to better understand the effect of a molecular environment on different collision induced phenomena. To do so, the time of flight spectra of cationic products emerging from collisions with isolated molecules as well as clusters are compared. It is shown that the molecular environment protects the molecule as it allows to distribute the transferred energies and charges over the whole system (global decrease of the fragmentation and quenching of some fragmentation channels). Furthermore, in the case of adenine clusters, the molecular environment weakens some intramolecular bonds. Moreover, products of chemical reactions are observed concerning proton transfer processes in hydrated cluster of adenine and the formation of peptides bonds between beta-alanine molecules in a cluster. The latter finding is studied as a function of the cluster size and type of the projectile. Some criteria for peptide bond formation, such as flexibility and geometry of the molecule, are investigated for different amino acids.
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  • HAL Id : tel-00741879, version 1

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Michael Capron. Étude de l'interaction entre ions multichargés et systèmes complexes d'intérêt biologique : effets de l'environnement à l'échelle moléculaire. Agrégats Moléculaires et Atomiques [physics.atm-clus]. Université de Caen, 2011. Français. ⟨tel-00741879⟩

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