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DC-SIGN, un récepteur détourné par des nombreux pathogènes: carcaterisation biochimique, structurale et développement d'inhibiteurs

Abstract : DC-SIGN is a C type lectin- receptor located on the surface of dendritic cells and implicated in the recognition of many pathogens. The fact that DC-SIGN plays a key role in the immune escape of a large number of pathogens (HIV, Ebola virus,Dengue virus...) makes it an interesting therapeutic target. In The beginning of this work, it was clear that the oligomeric form of this lectin is crucial in the pathogens recognition process.Therefore, we have developed ligands molecules, acting as potential inhibitors, which takes in consideration the oligomeric form of DC-SIGN. Even thought the structure of DC-SIGN's carbohydrate recognition domain (CRD) is known, few data are acquired about DC-SIGN oligomeric state.thus, we have characterized the terameric organisation of DC-SIGN by SAXS technique. When exposed to pathogens, DC-SIGN recognises and internalizes pathogens into lysosomial compartement with acidic pH. Analyses of the biochemical properties of this receptor in relation with its cellular function (interaction, internalization....)showed a pH-dependancy of DC-SIGN's oligomeric form stability.
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https://tel.archives-ouvertes.fr/tel-00741541
Contributor : Georges Tabarani Connect in order to contact the contributor
Submitted on : Saturday, October 13, 2012 - 4:21:54 PM
Last modification on : Saturday, March 26, 2022 - 3:17:28 AM
Long-term archiving on: : Saturday, December 17, 2016 - 12:46:24 AM

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Georges Tabarani. DC-SIGN, un récepteur détourné par des nombreux pathogènes: carcaterisation biochimique, structurale et développement d'inhibiteurs. Biochimie, Biologie Moléculaire. Université de Grenoble, 2008. Français. ⟨tel-00741541⟩

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