Skip to Main content Skip to Navigation
Theses

Régulation de la voie Hedgehog : étude structurale et fonctionnelle de protéines de signalisation

Abstract : The Hedgehog (Hh) signaling pathway is a highly conserved regulator of growth and differentiation that is essential for both vertebrate and invertebrate development. In Drosophila, the HH pathway is regulated by a high molecular weight intracellular protein complex called the Hedgehog Transducing Complex (HTC), whose composition is controlled by the activation of the pathway. My thesis project is to characterise the HTC complex that regulates the fate of the HH transcription factor, CI. I am using structural studies, biochemistry and enzymology to better understand the protein-protein interactions and function that govern the Hedgehog pathway. My work provide a high resolution view of the HTC and help to understand how those proteins work and interact with each other.
Document type :
Theses
Complete list of metadatas

https://tel.archives-ouvertes.fr/tel-00737495
Contributor : Abes Star :  Contact
Submitted on : Tuesday, October 2, 2012 - 1:04:13 AM
Last modification on : Friday, May 17, 2019 - 11:17:54 AM
Long-term archiving on: : Thursday, January 3, 2013 - 3:44:15 AM

File

VA2_JABRANI_Amira_11052012.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00737495, version 1

Collections

Citation

Amira Jabrani. Régulation de la voie Hedgehog : étude structurale et fonctionnelle de protéines de signalisation. Sciences agricoles. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA114813⟩. ⟨tel-00737495⟩

Share

Metrics

Record views

372

Files downloads

4546