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SYSTEMES ASSOCIATIFS A BASE D'ACIDE HYALURONIQUE MODIFIE : SYNTHESE ET ETUDE DES RELATIONS STRUCTURE/PROPRIETES RHEOLOGIQUES

Abstract : The work described in this memory is devoted to the development of new amphiphilic derivatives of hyaluronic acid (HA) obtained by grafting hydrophobic alkyl chains along the hydrophilic macromolecular backbone. The strategy of grafting presented was optimized in order to be able to transpose the synthesis on an industrial scale. The behavior in aqueous medium of the native polymers and the viscoelastic properties of the associative systems were studied by flow and dynamic rheological measurements. A modulation of the physicochemical properties is obtained by the variation of the HA molecular weight, the hydrophobicity of the grafts and/or the introduction into the associative system of host molecules (alpha and beta cyclodextrins) or of surfactants. Calorimetric titration coupled with two-dimensional NMR experiments (ROESY), viscosity measurements and molecular modeling, allowed us, after a detailed analysis, to elucidate the interactions between the alkylated HA derivatives and cyclodextrins. During this work, we presented various types of industrial products developed by European and American companies as viscosupplements, viscosupplementation being the application targeted for our derivatives developed within the framework of this thesis
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Shirin Kadi. SYSTEMES ASSOCIATIFS A BASE D'ACIDE HYALURONIQUE MODIFIE : SYNTHESE ET ETUDE DES RELATIONS STRUCTURE/PROPRIETES RHEOLOGIQUES. Polymères. Université de Grenoble, 2007. Français. ⟨tel-00734126⟩

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