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La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse

Abstract : Hsp27 belongs to the class of survival proteins like Bcl2 or survivin. This protein was well categorized as a major anti apoptotic protein as displaying a high level of expression in lot of tumor types. Moreover, Hsp27 is referenced as a major therapeutic target in cancer. During my PhD, I characterized stable peptides called aptamers, which functionally blocked Hsp27 antiapoptotic and tumorigenic properties. These aptamers disrupted biochemical and structural states of Hsp27 and promoted cell cycle arrest in xenografts. In the same time, I have characterized the effect of Hsp27 depletion in metastasis establishment and bone marrow tumor growth. I have shown that targeting level of Hsp27 induced degradation of several of its client proteins like caspase3, HDAC6 and STAT2
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Benjamin Gibert. La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse. Sciences agricoles. Université Claude Bernard - Lyon I, 2010. Français. ⟨NNT : 2010LYO10070⟩. ⟨tel-00733751⟩

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