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Évaluation de la microarchitecture trabéculaire et des propriétés mécaniques osseuses in vivo chez l’humain par scanner périphérique a haute résolution : application clinique à l’ostéoporose

Abstract : Bone microarchitecture is one of the determinants of bone quality that can now be evaluated in vivo at the distal radius and tibia with an isotropic resolution of 82μm with a new high-resolution peripheral scanner (XtremeCT, SCANCO Medical AG). Moreover, the use of finite element analysis on the 3D bone volume acquired allows the assessment of bone biomechanical properties such as bone strength. Our studies show that this technique is promising to assess bone density, microarchitecture and strength at peripheral skeletal sites. Indeed those measures were associated with osteoporotic fractures of all kinds in women. We also demonstrated that those same measures were associated with osteoporotic fractures of all kinds, including vertebral fractures, in men, who are less prone to be affected by osteoporosis. Finite element analysis allows in vivo measurement of bone strength, which might provide additional information about bone fragility and fracture risk that are not assessed by measures of density or microarchitecture.
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Nicolas Vilayphiou. Évaluation de la microarchitecture trabéculaire et des propriétés mécaniques osseuses in vivo chez l’humain par scanner périphérique a haute résolution : application clinique à l’ostéoporose. Médecine humaine et pathologie. Université Claude Bernard - Lyon I, 2010. Français. ⟨NNT : 2010LYO10317⟩. ⟨tel-00730979⟩

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