A. , N. Rupert, K. Bryant, E. Torok-storb, and B. , Failure of Adult Marrow-Derived Stem Cells to Generate Marrow Stroma after Successful Hematopoietic Stem Cell Transplantation, Experimental Hematology, vol.30, pp.937-942, 2002.

B. G. Hunter, G. K. Goldberg, and H. A. , Bone Sialoprotein-Collagen Interaction Promotes Hydroxyapatite Nucleation, Matrix Biology, vol.27, pp.600-608, 2008.

B. , A. Cojazzi, G. Panzavolta, S. Rubini, K. Roveri et al., Mechanical and Thermal Properties of Gelatin Films at Different Degrees of Glutaraldehyde Crosslinking, Biomateriais, vol.22, pp.763-768, 2001.

B. , L. Bunger, C. E. , K. , M. Mygind et al., Flow Perfusion Culture of Human Mesenchymal Stem Cells on Silicate-Substituted Tricalcium Phosphate Scaffolds, Biomaterials, vol.29, pp.2616-2627, 2008.

M. Bohner, Calcium orthophosphates in medicine: from ceramics to calcium phosphate cements, Injury, vol.31, pp.37-47, 2000.
DOI : 10.1016/S0020-1383(00)80022-4

B. , G. N. Sikavitsas, V. I. Mikos, and A. G. , Design of a Flow Perfusion Bioreactor System for Bone Tissue-Engineering Applications, Tissue Engineering, vol.9, issue.3, pp.549-554, 2003.

C. , D. M. Sena, L. A. Soares, and G. A. , Effect of Sterilization Method on Physico-Chemical Properties of Collagen-Hydroxyapatite Composite, XXI Congresso da Sociedade Brasileira de Microscopia e Microanálise. CARTA CAPITAL, 2007.

C. M. Ko-c-c and D. W. , Preparation of Hydroxyapatitegelatin Nanocomposite, Biomaterials, vol.24, pp.2853-2862, 2003.

C. , M. C. Tanaka, and J. , FT-IR Study for Hydroxyapatite/collagen Nanocomposite Cross-linked by Glutaraldehyde, Biomaterials, vol.23, pp.4811-4818, 2002.

C. , M. C. Tanaka, and J. , XPS Study for the microstructure Development of Hydroxyapatite-collagen Nanocomposites Cross-linked Using Glutaraldehyde, Biomaterials, vol.23, pp.3879-3885, 2002.

C. , D. T. Perelman, N. Ko, E. C. Nimni, and M. E. , Mechanism of Crosslinking of Proteins by Glutaraldehyde III. Reaction with Collagen en Tissues, Connective Tissue Research, vol.13, pp.109-115, 1985.

C. , F. Li, Y. Ge, and J. , Self-assembly of Mineralized Collagen Composites, Materials Science and Engineering, vol.57, pp.1-27, 2007.

C. , W. Li, X. Xie, C. Zhuang, H. Zhou et al., hydroxyapatite Nucleation and Growth Mechanism on Electrospun Fibers Functionalized with Different Chemical Groups and Their Combinations, Biomaterials, vol.31, pp.4620-4629, 2010.

D. , B. Bonnefont-rousselot, D. Oudina, K. Degat, M. C. Deschepper et al., A Perfusion Bioreactor for Engineering Bone Constructs: an In-Vitro and In- Vivo Study, Tissue Engineering: Part C, vol.17, issue.5, pp.505-516, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00692843

J. T. Oreffo and E. O. , Development of Specific Collagen Scaffolds to Support the Osteogenic and Chondrogenic Differentation of Human Bone Marrow Stromal Cells, Biomaterials, vol.29, pp.3105-3116, 2008.

D. , H. A. Verbeeck, R. M. De-ridder, L. I. Schacht, E. H. Cornelissen et al., Calcification as an Indicator of Osteoinductive Capacity of Biomaterials in Osteoblastic Cell Cultures, Biomaterials, vol.26, pp.4964-4974, 2005.

D. , A. Jensen, T. H. Kolind, K. Bünger, C. Kassem et al., Cell shape and spreading of stromal (mesenchymal) stem cells cultured on fibronectin coated gold and hydroxyapatite surfaces, Colloids and Surfaces B: Biointerfaces, vol.84, issue.1, pp.18-25, 2011.

D. , J. Uemura, T. Kojima, H. Kikuchi, M. Tanaka et al., Application of Low-pressure System to Sustain In-Vivo Bone Formation, 2001.

D. Santos, E. A. Farina, M. Soares, G. A. Anselme, and K. , Chemical and topographical influence of hydroxyapatite and ??-tricalcium phosphate surfaces on human osteoblastic cell behavior, 20th European Conference on Biomaterials.European Conference on Biomaterials, 2006.
DOI : 10.1002/jbm.a.31991

F. , B. Weng, J. , Y. , B. C. Qu et al., Characterization of titanium surfaces with calcium and phosphate and osteoblast adhesion, Biomaterials, vol.25, pp.17-3421, 2004.

F. W. Lee and G. , Basic thermoanalytical studies of insoluble collagen matrices, Biomaterials, vol.17, pp.2289-2294, 1996.

F. , O. Marie, P. J. Lomri, and A. , Differential Effects of Transforming Growth Factor ?2, Dexamethasone and 1,25-Dihydroxyvitamin D on Human Bone Marrow Stromal Cells, Cytokine, vol.9, issue.8, pp.613-623, 1997.

G. M. Welzel-p, S. P. Bernhardt-a, and . Konig-u, Porous Three-Dimensional Scaffolds Made af Mineralised Collagen: Preparation and Proporties af a Biomimetic Nanocomposite Material For Tissue Engineering af Bone, Chemical Engineering Journal, vol.137, pp.84-96, 2008.

G. , S. Zannettino, A. C. Hay, S. J. Shi, S. Graves et al., Molecular and Cellular Characterisation of Highly Purified Stromal Stem Cells Derived from Human Bone Marrow, Journal of Cell Science, vol.116, pp.1827-1835, 2003.

H. , P. Anselme, K. Flautre, B. Bianchi, F. Bascoulergue et al., Ingénierie tissulaire et maladies du squelette, Rev Rhum, vol.67, pp.498-504, 2000.

J. , M. J. Plunkett, N. A. O-'brien, and F. J. , Design and Validation of a Dynamic Flow Perfusion Bioreactor for use with Compliant Tissue Engineering Scaffolds, Journal of Biotechnology, vol.133, pp.490-496, 2008.

J. , B. Wu, Z. Zhao, H. Tang, F. Lu et al., Electron Beam Irradiation Modification of Collagen Membrane, Biomaterials, vol.22, issue.1, pp.15-23, 2006.

K. , S. J. Bhardwaj, A. Bhatt, and H. A. , Nanocrystalline Calcium Phosphate Ceramics in Biomedical Engineering, Materials Science and Engineering C, vol.27, issue.3, pp.441-449, 2006.

K. , S. Balamurugan, A. Rajeswari, and S. , Bio-composites: A Review of Literature, Trends in Biomaterials & Artificial Organs, vol.14, issue.2, pp.30-36, 2001.

K. , V. Ng, and K. W. , Cell Lines and Primary Cell Cultures in the Study of, Bone Cell Biology Molecular and Cellular Endocrinology, vol.288, pp.79-102, 2004.

K. , M. Abdallah, B. M. Saeed, and H. , Osteoblastic Cells: Differentiation and trans-differentiation, Archives of Biochemistry and Biophysics, vol.473, pp.183-187, 2008.

K. , M. Suetsugu, Y. Tanaka, J. Itoh, S. Ichinose et al., The biomimetc synthesis and biocompatibility of self-organized hydroxyaoatite/collagen composites, Bioceramics, vol.12, pp.393-396, 1999.

K. , M. Ikoma, T. Itoh, S. Matsumoto, H. N. Koyama et al., Biomimetic Synthesis of Bone-Like Nanocomposites Using the Self-Organization Mechanism of Hydroxyapatite and Collagen, Composites Science and Technology, vol.64, pp.819-825, 2004.

K. , M. Matsumoto, H. N. Yamada, T. Koyama, Y. Tkakuda et al., Glutaraldehyde cross-linked hydroxyapatite/collagen selforganized nanocomposites, Biomaterials, vol.25, pp.63-69, 2004.

K. , M. A. Carolyn, B. S. Sargent, Y. Mcdevitt, and T. C. , The Multiparametric Effects of Hydrodynamic Environments on Stem Cell Culture, Tissue Engineering: Part B, vol.17, issue.4, pp.249-262, 2011.

L. , W. J. Silver, and F. , The structure and Function of Normally, 2002.

L. , C. Han, Z. Czernuska, and J. T. , Gradiente Collagen/hydroxyapatite Composite Scaffold: Development and Characterization, Acta Biomaterialia, vol.5, pp.661-669, 2009.

M. Da, S. , H. Mateescu, M. Damia-c, E. Champion et al., Importance of dynamic culture for evaluating osteoblast activity on dense silicon-substituted hydroxyapatite, Colloids and Surfaces B: Biointerfaces, vol.80, issue.2, pp.138-144, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00562587

M. , I. Wendt, D. Heberer, and M. , The Role of Bioreactors in Tissue Engineering, TRENDS in Biotechnology, vol.22, issue.2, pp.80-86, 2004.

M. , R. O-'brien, and F. J. , Influence of Shear Stress in Perfusion Bioreactor Cultures for the Development of Three-Dimensional Bone Tissue Constructs: A Review, Tissue Engineering: part B, vol.16, pp.587-601, 2010.

M. , C. Dalconi, M. C. Nuzzo, S. Mobilio, S. Wenk et al., Rietveld Refinement on X-Ray Diffraction Patterns of Bioapatite in Human Fetal Bones, Biophysical Journal, pp.84-2021, 2003.

A. and P. Tirage, Détermination Quantitative Du Rapport Ca/P de Phosphates de Calcium, pp.98-103

O. , B. O. Lomri, A. Hott, M. Marie, and P. J. , Isolation and Characterization of Human Clonogenic Osteoblast Progenitors Immunoselected from Fetal Bone Marrow Stroma using STRO-1 Monoclonal Antibody, Journal of Bone and Mineral Research, vol.14, issue.3, pp.351-361, 1999.

P. , S. Plunkett, N. A. Kelly, D. J. O-'brien, and F. J. , Stimulation of Osteoblasts using Rest Periods During Bioreactor Culture on, 2010.

P. , Y. S. Gao, S. , M. Arshad, M. S. Leck et al., Porous Collagen-apatite Nanocomposite Foams as Bone Regeneration Scaffolds, Biomaterials, vol.29, pp.4300-4305, 2008.

P. , P. P. Vanderby, and R. J. , Collagen Fibril Morphology and Organization: Implications for Force Transmission in Ligament and Tendon, Matrix Biology, vol.25, pp.71-84, 2006.

R. , J. Milan, F. Gunther, K. P. Stiehler, and M. , Bioreactor Systems for Bone Tissue Engineering, Tissue Engineering: Part B, vol.17, issue.4, pp.263-280, 2011.

R. , S. H. Suetsugu, Y. Tanaka, and J. , Biomimetic Configurational Arrays of Hydroxyapatite Nanocrystals on bio-organics, Biomaterials, vol.22, pp.2843-2847, 2001.

R. , F. T. Martins, V. C. Plepis, and A. M. , Comportamento Térmico de Matrizes de Colágeno tipo I Reticuladas com Glutaraldeído, 2006.

R. , P. Paschalis, E. P. Fratzl, P. Klaushofer, and K. , Bone mineralization density distribution in health and disease, Bone, vol.42, issue.3, pp.456-466, 2008.

R. , F. R. Oreffo, and R. O. , Bone Tissue Engineering: Hope vs Hype, Biochemical and Biophysical Research Communications, vol.292, pp.1-7, 2002.

R. , M. Champion, E. Hardouin, P. Anselme, and K. , Quantitative kinetic analysis of gene expression during human osteoblastic adhesion on orthopaedic materials, Biomaterials, vol.27, issue.14, pp.2829-2844, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00087534

R. , J. M. De-wijn, J. R. Boon, and M. E. , Glutaraldehyde crosslinking of collagen: Effects of time, temperature, concentration and presoaking as measured by shrinkage temperature, Clinical Materials, vol.17, issue.1, pp.23-27, 1994.

S. , M. H. Heneine, L. G. , M. , and H. S. , Synthesis and Characterization of Calcium Phosphate/Collagen Biocomposites doped with Zn 2+, Materials Science and Engineering C, vol.28, pp.563-571, 2008.

S. , L. A. Caraballo, M. M. Rossi, A. M. Soares, and G. A. , Synthesis and Characterization of Biocomposites with Different Hydroxyapatite-Collagen Ratios, J. Mater. Sci.: Mater. Med, vol.20, pp.2395-2400, 2009.

S. , D. Born, R. Flade, K. Roessler, S. Stoelzel et al., Mineralization Behaviour of Collagen Type I Immobilized on Different Substrates, Biomaterials, vol.25, pp.2371-2380, 2004.

S. , A. Paszkiewicz, Z. Paluszkiewicz, and C. , FTIR and XRD Evalution of Carbonated Hydroxyapatite Powders Synthesized by Wet Methods, Journal of Molecular Structure, pp.744-747, 2005.

S. , Y. Ito, A. Kamo, M. Sakurai, T. Onuma et al., Hydrolysis and cytocompatibility of zinccontaining ?-tricalcium phosphate powder, Materials Science and Engineering: C, vol.24, pp.6-8, 2004.

S. , S. Uemura, T. Kikuchi, M. Chen, J. Itoh et al., Synthesis and In-vivo Evaluation of a Novel Hydroxyapatite/Collagen-Alginate as a Bone Filler and a Drug Delivery Carrier of Bone Morphogenetic Protein, Materials Science and Engineering C, vol.24, pp.341-347, 2004.

S. , M. Sahithi, K. Moorthi, A. Srinivasan, N. Ramasamy et al., Biocomposites Containing Natural Polymers and Hydroxyapatite for Bone Tissue Engineering, International Journal of Biological Macromolecules, vol.47, pp.1-4, 2010.

T. , W. Xu, and H. H. , Collagen-Calcium Phosphate Cement Scaffolds Seeded with Umbilical Cord Stem Cells for Bone Tissue Engineering, Tissue Engineering: Part A, vol.1724, issue.23, pp.2943-2953, 2011.

U. , L. Merkle, H. P. Meinel, and L. , Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells, Journal of Controlled Release, vol.127, issue.1, pp.12-21, 2008.

U. , R. Ramasami, and T. , Structure and conformation of intramolecularly Cross-linked Collagen, Colloids and Surfaces B: Biointerfaces, vol.41, pp.21-24, 2005.

M. Vallet-regí, Introduction to the World of Biomaterials, Anales de Química Int. Ed, vol.93, pp.6-14, 1997.

M. Vallet-regi and D. Arcos, Silicon substituted hydroxyapatites. A method to upgrade calcium phosphate based implants, J. Mater. Chem., vol.13, issue.220, pp.15-1509, 2005.
DOI : 10.1039/B414143A

V. , R. B. Gooden, M. D. Lara, S. L. Wight, and T. N. , Microgrooved Fibrillar Collagen Membranes as Scaffolds for Cell Support and Alignment, Biomaterials, vol.26, pp.3131-3140, 2005.

W. , D. A. Czernuszka, and J. T. , Collagen-Hydroxyapatite Composites for Hard Tissue Repair, European Cells and Materials, vol.11, pp.43-56, 2006.

W. , Y. Uemura, T. Dong, J. Kojima, and H. , Application of perfusion culture system improves in vitro and in vivo osteogenesis of bone marrowderived osteoblastic cells in porous ceramic materials, Tissue Eng, vol.9, issue.6, pp.1205-1214, 2003.

W. , H. Li, Y. Zuo, Y. Li, J. Ma et al., Biocompatibility and Osteogenesis of Biomimetic Nano-Hydroxyapatite/Polyamide Composite Scaffolds for Bone Tissue Engineering, Biomaterials, vol.28, pp.3338-3348, 2007.

W. , M. W. Gutwald, R. Lauer, G. Hubner, U. Schmelzeisen et al., How to Optimize Seeding and Culturing of Human Osteoblast-Like Cells on Various Biomaterials, Biomaterials, vol.23, pp.3319-3328, 2002.

W. , H. P. Meyer, U. Plate, U. Höhling, and H. J. , Aspects of, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00132533

W. , B. Pasteris, and J. D. , A Mineralogical Perspective on the Apatite in Bone, Materials Science and Engineering, vol.25, pp.131-143, 2005.

Y. , A. B. Fisher, and J. P. , Tubular Perfusion System for the Long-Term Dynamic Culture of Human Mesenchymal Stem Cells, Tissue Engineering: part C, vol.17, issue.3, pp.337-348, 2011.

Y. , A. B. Fisher, and J. P. , Bone Tissue Engineering Bioreactors: Dynamic Culture and the Influence of Shear Stress, Bone, vol.48, pp.171-181, 2011.

X. , Y. Mareddy, S. Crawford, and R. , Clonal Characterization of Bone Marrow Derived Stem Cells and their Application for Bone Regeneration, Int. J. Oral Sci, vol.2, issue.3, pp.127-135, 2010.

Z. , Y. Cui, F. Z. Wang, and Y. , Formation of Nano-Hydroxyapatite on Recombinant Human-Like Collagen Fibrils, Current Applied Physics, vol.5, pp.429-432, 2005.

Z. , L. Tang, P. Xu, M. Zhang, W. Chai et al., Effects of Crystalline Phase on the Biological Properties of Collagen-Hydroxyapatite Composites, Acta Biomaterialia, vol.6, pp.2189-2199, 2010.

Z. L. Webster and T. J. , Nanotechnology and Nanomaterials: Promises for Improved Tissue Regeneration, NanoToday, vol.4, pp.66-80, 2009.

Z. , F. Yin, Y. Lu, W. W. Leong, C. Zhang et al., Preparation and Histological Evaluation of Biomimetic Threedimensional Hydroxyapatite/Chitosan-Gelatin Network Composite Scaffolds, Biomaterials, vol.23, pp.3227-3234, 2002.