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Etudes épidémiologiques de la tremblante atypique ovine

Abstract : Atypical scrapie was discovered following the intensification of transmissible spongiform encephalopathy screening in small ruminants. The first evidences suggested that it could have a non infectious origin conversely to classical scrapie. This new type of scrapie raised questions on its dangerousness for men and animals and on its possible consequences on the efficacy of the scrapie control programs. The overall aim of the thesis was to describe the epidemiological situation of the disease in ovine and to describe the risk factors. We undertook a descriptive study based on surveillance data in France and in Europe, an exploratory study of the risk factors at the farm level and towards genetic risk and we studied the clustering of cases in space and in positive flocks. In most circumstances we compared our results with classical scrapie. The results of these studies were that atypical scrapie prevalence was quite similar between the different subpopulations compared, around six cases per ten thousands of animals tested, in contrast with classical scrapie which varied more. The genetic risk factors were strong and no risk factor associated with an infectious origin was identified. In addition the prevalence of atypical scrapie in positive flocks was not different from the prevalence in the general population and cases did not tend to cluster. These results supported the idea that atypical scrapie is not or hardly contagious which is compliant with a non infectious origin.
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https://tel.archives-ouvertes.fr/tel-00725320
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Submitted on : Monday, August 27, 2012 - 9:16:44 AM
Last modification on : Friday, October 23, 2020 - 4:49:20 PM
Long-term archiving on: : Friday, December 16, 2016 - 8:13:01 AM

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Alexandre Fediavsky. Etudes épidémiologiques de la tremblante atypique ovine. Santé publique et épidémiologie. Université Blaise Pascal - Clermont-Ferrand II, 2009. Français. ⟨NNT : 2009CLF21949⟩. ⟨tel-00725320⟩

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