S. L. Pimlott and A. Sutherland, Molecular tracers for the PET and SPECT imaging of disease, Chem. Soc. Rev., vol.50, issue.1, pp.40-149, 2011.
DOI : 10.1039/B922628C

F. Van-der-have, B. Vastenhouw, R. M. Ramakers, W. Branderhorst, J. O. Krah et al., U-SPECT-II: An Ultra-High-Resolution Device for Molecular Small-Animal Imaging, Journal of Nuclear Medicine, vol.50, issue.4, pp.50-599, 2009.
DOI : 10.2967/jnumed.108.056606

A. Viale and S. Aime, Current concepts on hyperpolarized molecules in MRI, Current Opinion in Chemical Biology, vol.14, issue.1, pp.90-129, 2010.
DOI : 10.1016/j.cbpa.2009.10.021

P. C. Van-zijl and N. N. Yadav, Chemical exchange saturation transfer (CEST): What is in a name and what isn't?, Magnetic Resonance in Medicine, vol.130, issue.4, pp.65-927, 2011.
DOI : 10.1002/mrm.22761

P. C. Van-zijl, C. K. Jones, J. Ren, C. R. Malloy, and A. D. Sherry, MR1 detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST), Proceedings of the National Academy of Sciences of the United States of America, pp.4359-4364, 2007.

K. M. Ward, A. H. Aletras, and R. S. Balaban, A New Class of Contrast Agents for MRI Based on Proton Chemical Exchange Dependent Saturation Transfer (CEST), Journal of Magnetic Resonance, vol.143, issue.1, pp.143-79, 2000.
DOI : 10.1006/jmre.1999.1956

D. Woessner, Nuclear Transfer Effects in Nuclear Magnetic Resonance Pulse Experiments, The Journal of Chemical Physics, vol.35, issue.1, pp.41-48, 1961.
DOI : 10.1063/1.1731931

D. E. Woessner, S. R. Zhang, M. E. Merritt, and A. D. Sherry, Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI, Magnetic Resonance in Medicine, vol.41, issue.4, pp.53-790, 2005.
DOI : 10.1002/mrm.20408

S. Wolff and R. Balaban, NMR imaging of labile proton exchange, Journal of Magnetic Resonance (1969), vol.86, issue.1, pp.164-169, 1990.
DOI : 10.1016/0022-2364(90)90220-4

S. D. Wolff and R. S. Balaban, Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo, Magn Reson Med, issue.10, pp.135-179, 1989.

S. D. Wolff and R. S. Balaban, Magnetization transfer imaging: practical aspects and clinical applications.: Radiology, v. 192, pp.593-602, 1994.

S. Zhang, C. Malloy, and A. Sherry, MRI Thermometry Based on PARACEST Agents, Journal of the American Chemical Society, vol.127, issue.50, pp.17572-17573, 2005.
DOI : 10.1021/ja053799t

S. Zhang, M. Merritt, D. Woessner, R. Lenkinski, and A. Sherry, PARACEST agents: modulating MRI contrast via water proton exchange, Acc Chem Res, pp.36-783, 2003.

S. R. Zhang, P. Winter, K. C. Wu, and A. D. Sherry, A Novel Europium(III)-Based MRI Contrast Agent, Journal of the American Chemical Society, vol.123, issue.7, pp.1517-1518, 2001.
DOI : 10.1021/ja005820q

J. M. Zhao, Y. E. Har-el, M. T. Mcmahon, J. Zhou, A. D. Sherry et al., Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes, Journal of the American Chemical Society, vol.130, issue.15, pp.130-5178, 2008.
DOI : 10.1021/ja710159q

J. Zhou and P. C. Van-zijl, Chemical exchange saturation transfer imaging and spectroscopy, Progress in Nuclear Magnetic Resonance Spectroscopy, vol.48, issue.2-3, pp.38-974, 2006.
DOI : 10.1016/j.pnmrs.2006.01.001

V. R. Sheth, Y. Li, L. Q. Chen, C. M. Howison, C. A. Flask et al., Measuring in vivo tumor pHe with CEST-FISP MRI, Magnetic Resonance in Medicine, vol.65, issue.3, 2011.
DOI : 10.1002/mrm.23038

J. Stancanello, E. Terreno, D. D. Castelli, C. Cabella, F. Uggeri et al., Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images, Contrast Media & Molecular Imaging, vol.26, issue.2, pp.136-149, 2008.
DOI : 10.1002/cmmi.240

R. Stollberger and P. Wach, Imaging of the active B-1 field in vivo: Magnetic Resonance in Medicine, pp.35-246, 1996.

P. Sun, C. Farrar, and A. Sorensen, Correction for artifacts induced byB0 andB1 field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging, Magnetic Resonance in Medicine, vol.15, issue.6, pp.58-1207, 2007.
DOI : 10.1002/mrm.21398

P. Sun, P. Van-zijl, and J. Zhou, Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments, Journal of Magnetic Resonance, vol.175, issue.2, pp.175-193, 2005.
DOI : 10.1016/j.jmr.2005.04.005

E. Terreno, D. D. Castelli, E. Violante, H. Sanders, N. Sommerdijk et al., Osmotically Shrunken LIPOCEST Agents: An Innovative Class of Magnetic Resonance Imaging Contrast Media Based on Chemical Exchange Saturation Transfer, Chemistry - A European Journal, vol.12, issue.6, pp.15-1440, 2009.
DOI : 10.1002/chem.200801766

E. Terreno, J. Stancanello, D. Longo, D. Castelli, L. Milone et al., Methods for an improved detection of the MRI-CEST effect, Contrast Media & Molecular Imaging, vol.3, issue.5, pp.237-284, 2009.
DOI : 10.1002/cmmi.290

J. Tropp, K. Derby, C. Hawryszko, S. Sugiura, and H. Yamagata, Automated shimming of B0 for spectroscopic imaging, Journal of Magnetic Resonance (1969), vol.85, issue.2, pp.85-244, 1989.
DOI : 10.1016/0022-2364(89)90140-6

P. C. Van-zijl, C. K. Jones, J. Ren, C. R. Malloy, and A. D. Sherry, MR1 detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST), Proceedings of the National Academy of Sciences of the United States of America, pp.4359-4364, 2007.

J. Y. Zhou, B. Lal, D. A. Wilson, J. Laterra, and P. C. Van-zijl, Amide proton transfer (APT) contrast for imaging of brain tumors, Magnetic Resonance in Medicine, vol.15, issue.6, pp.50-1120, 2003.
DOI : 10.1002/mrm.10651

S. Aime, D. D. Castelli, and E. Terreno, Highly sensitive MRI chemical exchange saturation transfer agents using liposomes, Angewandte Chemie-International Edition, pp.44-5513, 2005.
DOI : 10.1002/anie.200501473

W. Akers, Z. Zhang, M. Berezin, Y. Ye, A. Agee et al., Targeting of alpha(v)beta(3)-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles: Nanomedicine, pp.715-726, 2010.

M. M. Ali, G. Liu, T. Shah, C. A. Flask, and M. D. , Using two chemical exchange saturation transfer magnetic resonance imaging contrast agents for molecular imaging studies, Acc Chem Res, pp.42-915, 2009.

D. F. Baban and L. W. Seymour, Control of tumour vascular permeability, Advanced Drug Delivery Reviews, vol.34, issue.1, pp.34-109, 1998.
DOI : 10.1016/S0169-409X(98)00003-9

. Velten, Cancer incidence and mortality in France over the period 1980-2005.: Rev Epidemiol Sante Publique, pp.159-75, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00428273

S. Benedetto, R. Pulito, S. G. Crich, G. Tarone, S. Aime et al., Quantification of the expression level of integrin receptor alpha(v)beta3 in cell lines and MR imaging with antibody-coated iron oxide particles, Magn Reson Med, pp.56-711, 2006.

P. C. Brooks, R. A. Clark, and D. A. Cheresh, Requirement of vascular integrin alpha v beta 3 for angiogenesis, Science, vol.264, issue.5158, pp.264-569, 1994.
DOI : 10.1126/science.7512751

K. Cai, G. E. Kiefer, S. D. Caruthers, S. A. Wickline, G. M. Lanza et al., Quantification of water exchange kinetics for targeted PARACEST perfluorocarbon nanoparticles, NMR in Biomedicine, vol.58, issue.6, 2011.
DOI : 10.1002/nbm.1746

M. C. Chamberlain, T. Cloughsey, D. A. Reardon, and P. Y. Wen, A novel treatment for glioblastoma: integrin inhibition, Expert Review of Neurotherapeutics, vol.12, issue.4, pp.12-421, 2012.
DOI : 10.1586/ern.11.188

C. Vi-, Imagerie CEST de l'angiogenèse tumorale dans un modèle rongeur de tumeur cérébrale U87 à l'aide de lipoCEST fonctionnalisés, p.127

B. Eliceiri and D. Cheresh, Role of alpha nu integrins during angiogenesis: Cancer Journal, pp.245-249, 2000.

J. Folkman, Tumor angiogenesis: therapeutic implications, N Engl J Med, issue.285, pp.1182-1188, 1971.

E. Haacke, R. Brown, M. Thompson, and R. Venkateson, Magnetic resonance imaging: physical principles and sequence design, p.349, 1999.

D. P. Hutcheson, D. H. Gray, B. Venugopal, and T. D. Luckey, Studies of nutritional safety of some heavy metals in mice, J Nutr, pp.105-670, 1975.

C. Jones, A. Li, M. Suchy, R. Hudson, R. Menon et al., In vivo detection of PARACEST agents with relaxation correction, Magnetic Resonance in Medicine, vol.61, issue.5, pp.63-1184, 2010.
DOI : 10.1002/mrm.22340

. Gao, In vivo Off-Resonance Saturation Magnetic Resonance Imaging of alpha(v)beta(3)-Targeted Superparamagnetic Nanoparticles: Cancer Research, pp.69-1651, 2009.

F. Kiessling, J. Huppert, C. Zhang, J. Jayapaul, S. Zwick et al., RGD-labeled USPIO Inhibits Adhesion and Endocytotic Activity of alpha(v)beta(3)-Integrin-expressing Glioma Cells and Only Accumulates in the Vascular Tumor Compartment: Radiology, pp.253-462, 2009.

H. Kobayashi and P. C. Lin, Nanotechnology for antiangiogenic cancer therapy, Nanomedicine, vol.1, issue.1, pp.17-22, 2006.
DOI : 10.2217/17435889.1.1.17

G. Liu, M. M. Ali, B. Yoo, M. A. Griswold, J. A. Tkach et al., PARACEST MRI with improved temporal resolution, Magnetic Resonance in Medicine, vol.58, issue.2, pp.61-399, 2009.
DOI : 10.1002/mrm.21863

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877027

C. Vi-, Imagerie CEST de l'angiogenèse tumorale dans un modèle rongeur de tumeur cérébrale U87 à l'aide de lipoCEST fonctionnalisés -128

D. M. Mcdonald and P. L. Choyke, Imaging of angiogenesis: from microscope to clinic, Nature Medicine, vol.9, issue.6, pp.713-738, 2003.
DOI : 10.1038/nm0603-713

A. Meyer, J. Auernheimer, A. Modlinger, and H. Kessler, Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting, Current Pharmaceutical Design, vol.12, issue.22, pp.12-2723, 2006.
DOI : 10.2174/138161206777947740

A. Morawski, P. Winter, X. Yu, R. Fuhrhop, M. Scott et al., Quantitative "magnetic resonance immunohistochemistry" with ligand-targeted F-19 nanoparticles: Magnetic Resonance in Medicine, pp.52-1255, 2004.

K. H. Plate, G. Breier, H. A. Weich, and W. Risau, Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo, Nature, vol.359, issue.6398, pp.359-845, 1992.
DOI : 10.1038/359845a0

A. Schmieder, S. Caruthers, H. Zhang, T. Williams, J. Robertson et al., Three-dimensional MR mapping of angiogenesis with alpha(5)beta(1)(alpha(v)beta(3))-targeted theranostic nanoparticles in the MDA-MB- 435 xenograft mouse model, Faseb Journal, pp.22-4179, 2008.

G. Scott, J. Hu, S. Robertson, G. Wickline, and . Lanza, Molecular MR imaging of melanoma angiogenesis with alpha(nu)beta(3)-targeted paramagnetic nanoparticles, Magnetic Resonance in Medicine, pp.53-621, 2005.

L. W. Seymour, Passive tumor targeting of soluble macromolecules and drug conjugates, Crit Rev Ther Drug Carrier Syst, issue.9, pp.135-87, 1992.

J. W. Smith and D. A. Cheresh, Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor, J Biol Chem, pp.265-2168, 1990.

E. Terreno, D. D. Castelli, L. Milone, S. Rollet, J. Stancanello et al., First ex-vivo MRI co-localization of two LIPOCEST agents: Contrast Media and amp, Molecular Imaging, issue.3, pp.38-43, 2008.

P. Winter, S. Caruthers, J. Allen, K. Cai, T. Williams et al., Molecular Imaging of Angiogenic Therapy in Peripheral Vascular Disease With alpha(v)beta(3)-Integrin-Targeted Nanoparticles: Magnetic Resonance in Medicine, pp.64-369, 2010.

C. Vi-, Imagerie CEST de l'angiogenèse tumorale dans un modèle rongeur de tumeur cérébrale U87 à l'aide de lipoCEST fonctionnalisés, p.129

Y. Ye, S. Bloch, B. Xu, and S. Achilefu, Design, Synthesis, and Evaluation of Near Infrared Fluorescent Multimeric RGD Peptides for Targeting Tumors, Journal of Medicinal Chemistry, vol.49, issue.7, pp.49-2268, 2006.
DOI : 10.1021/jm050947h

S. Aime, D. D. Castelli, and E. Terreno, Highly sensitive MRI chemical exchange saturation transfer agents using liposomes, Angewandte Chemie-International Edition, pp.44-5513, 2005.
DOI : 10.1002/anie.200501473

T. Ceckler, J. Maneval, and B. Melkowits, Modeling Magnetization Transfer Using a Three-Pool Model and Physically Meaningful Constraints on the Fitting Parameters, Journal of Magnetic Resonance, vol.151, issue.1, pp.151-160, 2001.
DOI : 10.1006/jmre.2001.2326

R. Deichmann and A. Haase, Quantification of T1 values by SNAPSHOT-FLASH NMR imaging, Journal of Magnetic Resonance (1969), vol.96, issue.3, pp.608-612, 1992.
DOI : 10.1016/0022-2364(92)90347-A

H. T. Edzes and E. T. Samulski, Cross relaxation and spin diffusion in the proton NMR of hydrated collagen, Nature, vol.61, issue.5594, pp.265-521, 1977.
DOI : 10.1038/265521a0

M. Culp and G. S. Karczmar, New model for analysis of dynamic contrastenhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors, Magn Reson Med, pp.51-487, 2004.

N. Goffeney, J. W. Bulte, J. Duyn, L. H. Bryant, and P. C. Van-zijl, Sensitive NMR Detection of Cationic-Polymer-Based Gene Delivery Systems Using Saturation Transfer via Proton Exchange, Journal of the American Chemical Society, vol.123, issue.35, pp.8628-8629, 2001.
DOI : 10.1021/ja0158455

J. Grad, D. Mendelson, F. Hyder, and R. G. Bryant, Applications of nuclear magnetic cross-relaxation spectroscopy to tissues, Magnetic Resonance in Medicine, vol.11, issue.2, pp.17-452, 1991.
DOI : 10.1002/mrm.1910170216

R. Gregory, L. Crabo, A. Percy, and A. Rosenberg, Water catalysis of peptide hydrogen isotope exchange, Biochemistry, vol.22, issue.4, pp.910-917, 1983.
DOI : 10.1021/bi00273a031

R. M. Henkelman, X. Huang, Q. S. Xiang, G. J. Stanisz, S. D. Swanson et al., Quantitative interpretation of magnetization transfer, Magnetic Resonance in Medicine, vol.86, issue.6, pp.29-759, 1993.
DOI : 10.1002/mrm.1910290607

I. Kiricuta and V. Simplaceanu, Tissue Water Content and Nuclear Magnetic Resonance in Normal and Tumor Tissues: Cancer Research, pp.35-1164, 1975.

C. Lentner, Geigy scientific tables, 1981.

A. X. Li, R. H. Hudson, J. W. Barrett, C. K. Jones, S. H. Pasternak et al., Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents, Magnetic Resonance in Medicine, vol.49, issue.5, pp.60-1197, 2008.
DOI : 10.1002/mrm.21752

H. Mcconnell, Reaction Rates by Nuclear Magnetic Resonance, The Journal of Chemical Physics, vol.28, issue.3, pp.430-431, 1958.
DOI : 10.1063/1.1744152

M. T. Mcmahon, A. A. Gilad, J. Y. Zhou, P. Z. Sun, J. W. Bulte et al., Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer, Magnetic Resonance in Medicine, vol.17, issue.4, pp.55-836, 2006.
DOI : 10.1002/mrm.20818

C. Morrison and R. M. Henkelman, A Model for Magnetization Transfer in Tissues, Magnetic Resonance in Medicine, vol.106, issue.1, pp.33-475, 1995.
DOI : 10.1002/mrm.1910330404

O. Mougin, R. Coxon, A. Pitiot, and P. Gowland, Magnetization transfer phenomenon in the human brain at 7??T, NeuroImage, vol.49, issue.1, pp.49-272, 2010.
DOI : 10.1016/j.neuroimage.2009.08.022

G. Scott, J. Hu, S. Robertson, G. Wickline, and . Lanza, Molecular MR imaging of melanoma angiogenesis with alpha(nu)beta(3)-targeted paramagnetic nanoparticles, Magnetic Resonance in Medicine, pp.53-621, 2005.

L. W. Seymour, Passive tumor targeting of soluble macromolecules and drug conjugates, Crit Rev Ther Drug Carrier Syst, issue.9, pp.135-87, 1992.

J. G. Sled and G. B. Pike, Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI, Magnetic Resonance in Medicine, vol.31, issue.5, pp.46-923, 2001.
DOI : 10.1002/mrm.1278

J. W. Smith and D. A. Cheresh, Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor, J Biol Chem, pp.265-2168, 1990.

D. J. Tyler and P. A. Gowland, Rapid quantitation of magnetization transfer using pulsed off-resonance irradiation and echo planar imaging, Magnetic Resonance in Medicine, vol.12, issue.1, pp.53-103, 2005.
DOI : 10.1002/mrm.20323

H. R. Underhill, R. C. Rostomily, A. M. Mikheev, C. Yuan, and V. L. Yarnykh, Fast bound pool fraction imaging of the in vivo rat brain: Association with myelin content and validation in the C6 glioma model, NeuroImage, vol.54, issue.3, pp.54-2052, 2011.
DOI : 10.1016/j.neuroimage.2010.10.065

P. Winter, S. Caruthers, J. Allen, K. Cai, T. Williams et al., Molecular Imaging of Angiogenic Therapy in Peripheral Vascular Disease With alpha(v)beta(3)-Integrin-Targeted Nanoparticles: Magnetic Resonance in Medicine, pp.64-369, 2010.

D. Woessner, Nuclear Transfer Effects in Nuclear Magnetic Resonance Pulse Experiments, The Journal of Chemical Physics, vol.35, issue.1, pp.41-48, 1961.
DOI : 10.1063/1.1731931

D. E. Woessner, S. R. Zhang, M. E. Merritt, and A. D. Sherry, Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI, Magnetic Resonance in Medicine, vol.41, issue.4, pp.53-790, 2005.
DOI : 10.1002/mrm.20408

J. Y. Zhou, B. Lal, D. A. Wilson, J. Laterra, and P. C. Van-zijl, Amide proton transfer (APT) contrast for imaging of brain tumors, Magnetic Resonance in Medicine, vol.15, issue.6, pp.50-1120, 2003.
DOI : 10.1002/mrm.10651

J. Y. Zhou, J. F. Payen, D. A. Wilson, R. J. Traystman, and P. C. Van-zijl, Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI, Nature Medicine, vol.9, issue.8, pp.1085-1090, 2003.
DOI : 10.1038/nm907

J. Y. Zhou, D. A. Wilson, P. Z. Sun, J. A. Klaus, and P. C. Van-zijl, Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments, Magnetic Resonance in Medicine, vol.41, issue.5, pp.51-945, 2004.
DOI : 10.1002/mrm.20048

J. Flament, C. Marty, S. Giraudeau, S. Ahmed-ghaly, C. Mériaux et al., Optimized protocol for in vivo CEST-based MRI using zoom EPI adiabatic (zEPIa) sequence: ISMRM, 2010.

C. Giraudeau, J. Flament, B. Marty, F. Geffroy, C. Médina et al., Comparison of three MRI molecular imaging modalities: Application to angiogenesis imaging in a brain tumor mouse model, p.2012, 2012.

T. Shah, L. Lu, K. Dell, M. Pagel, M. Griswold et al., CEST-FISP: A Novel Technique for Rapid Chemical Exchange Saturation Transfer MRI at 7 T: Magnetic Resonance in Medicine, pp.65-432, 2011.

C. Giraudeau, J. Flament, M. B. Boumezbeur, F. Mériaux, S. Robic et al., F magnetic resonance imaging of perfluorooctylbromide, Magnetic Resonance in Medicine, vol.79, issue.4, pp.1119-1143, 2010.
DOI : 10.1002/mrm.22269

C. Quantitative and . Imaging, In vitro and in vivo validation with LipoCEST contrast agent, 2009.