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Planification inverse de la dose en hadronthérapie : prise en compte de la qualité du rayonnement pour une optimisation de la dose biologique

François Smekens 1
1 Imagerie Tomographique et Radiothérapie
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Hadrontherapy is a recent and particularly attractive modality. Characterized by a specific dose deposition profile in matter and by a high biological effectiveness, ions are found to be very well-suited for cancer treatment. As an emergent modality, the research in hadrontherapy is extremely active and promises many improvements for the future. However, there is no tool to date to quantify the clinical benefit for the patient related to the proposed improvements, the use of a gantry for example. In this work, we propose to use the treatment planning system, usually dedicated to clinical practice, in a prospective purpose. Suppressing the classical constraints of precision and time, our optimization method is based on a genetic algorithm designed to approach a global solution including a high number of balistic parameters (free irradiation fields) for all regions of dosimetric interest. The optimization strategy is progressively complicated in order to efficientely take into account the main issues of the inverse planning problem. The robustness of plans towards the uncertainties related to the application of the treatment, essential in hadrontherapy, is evaluated. The results show that the inclusion, in the optimization, of parameters usually fixed by the human planner leads systematically to an improved treatment quality. The final product of this work is a prospective optimization tool characterized by an easy set-up system and the ability to perform comparative studies on the relevance of new irradiation modalities.
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François Smekens. Planification inverse de la dose en hadronthérapie : prise en compte de la qualité du rayonnement pour une optimisation de la dose biologique. Autre [cs.OH]. INSA de Lyon, 2011. Français. ⟨NNT : 2011ISAL0126⟩. ⟨tel-00716665⟩

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