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Spécialisation hémisphérique et cartographie du langage chez le sujet sain et les patients épileptiques : effet des variables inter- et intra-individuelles. Evaluation comportementale, neuropsychologique et neurophysiologique (IRM fonctionnelle)

Abstract : The purpose of this PhD research was to identify the effect of several individual and experimental variables on hemispheric specialization and cortical mapping of language in healthy subjects and epileptic patients. The question was addressed by means of a multidisciplinary approach including behavioral, neuropsychological and neurophysiological (fMRI) testing. The main goal of this work was to corroborate data provided from all these methods and to build a model of the representation and reorganization (plasticity) of language according to the considered factors. Moreover, we aimed to provide several practical tools to clinicians for presurgical evaluation of hemispheric specialization in patients with drug-resistant epilepsy. Overall, our results reflect the necessity to use a multidimensional approach composed of complementary techniques and methods, in order to assess cerebral representations in normal and pathological conditions. Key words: language, specialization, hemisphere, divided visual field, fMRI, phonology, semantics, prosody, gender, healthy, epilepsy, plasticity, reorganization.
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https://tel.archives-ouvertes.fr/tel-00716387
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Submitted on : Tuesday, July 10, 2012 - 2:30:31 PM
Last modification on : Thursday, January 21, 2021 - 9:28:01 AM
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Marcela Perrone-Bertolotti. Spécialisation hémisphérique et cartographie du langage chez le sujet sain et les patients épileptiques : effet des variables inter- et intra-individuelles. Evaluation comportementale, neuropsychologique et neurophysiologique (IRM fonctionnelle). Médecine humaine et pathologie. Université de Grenoble, 2011. Français. ⟨NNT : 2011GRENS035⟩. ⟨tel-00716387⟩

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