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Évènements de vie : rôle dans la survenue d’un infarctus cérébral et d’une dépression post-AVC

Abstract : Methods and main results. In our systematic review of potential triggers of ischemic stroke, the only study that examined stressful life events didn’t show any association with stroke onset. In a prospective study of 247 consecutive patients admitted for ischemic stroke, exposure to at least one stressful life event was significantly more common during the first month preceding stroke onset than during the five control periods (OR=2.96 ; 95% CI 2.19-4.00). Stressful life events exposure also predicted depression occurring within six months after ischemic stroke onset. The other predictors of post-stroke depression were a modified Rankin score > 2, a prior history of depression, a left caudate and/or lenticular lesion, the female sex and pathologic crying.Conclusion and perspectives. Our results support the role of stressful life events as triggers of ischemic stroke and predictors of post-stroke depression. Our research also highlights the difficulty of studying stressful life events, due to potential influence of memory biases and lack of precise definitions of stressful life events, severe vs. minor events and hazard period durations. These preliminary results should be confirmed in order to assess benefits of preventive strategies.
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Vincent Guiraud. Évènements de vie : rôle dans la survenue d’un infarctus cérébral et d’une dépression post-AVC. Médecine humaine et pathologie. Université René Descartes - Paris V, 2012. Français. ⟨NNT : 2012PA05S007⟩. ⟨tel-00715171⟩

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