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Etude de la vascularisation utéro-placentaire par angiographie Doppler énergie tridimensionnelle : évaluations fondamentales de la technique sur modèles expérimentaux de brebis et lapines gestantes, et évaluations cliniques préliminaires chez la femme enceinte

Abstract : Intra-uterine growth retardation (IUGR) and preeclampsia (PE) are major complications of human pregnancy & are most often due to an insufficient utero-placental vascularization. Our aim was to evaluate the three-dimensional power Doppler angiography (PDA) as a new tool for the screening IUGR & PE & for the study placental function and IUGR in animal models. The correlation between 3D Doppler indices and the real blood flow within the utero-placental unit was first evaluated in the pregnant sheep model, as well as the impact of machine settings. A higher correlation degree was observed for VI and VFI (r = 0.86 and 0.82 respectively p<0.0001) than for FI (r = 0.64; p<0.0001).The interest of the technique was secondly demonstrated in a rabbit IUGR model (females treated with L-NAME).Thirdly, the predictive value of PDA as a screening test for IUGR & PE was demonstrated by conducting a prospective multicentric study in 70 low risk pregnant women (AUC 0.95, 100% NPV with a specificity of 85% for a 36.784 placental FI threshold).
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  • HAL Id : tel-00713921, version 1
  • PRODINRA : 317130

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Olivier Morel. Etude de la vascularisation utéro-placentaire par angiographie Doppler énergie tridimensionnelle : évaluations fondamentales de la technique sur modèles expérimentaux de brebis et lapines gestantes, et évaluations cliniques préliminaires chez la femme enceinte. Biologie du développement. Université Paris Sud - Paris XI, 2012. Français. ⟨NNT : 2012PA11T004⟩. ⟨tel-00713921⟩

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