Etude d'une famille multigénique chez Encephalitozoon cuniculi, une microsporidie pathogène de l'homme

Abstract : Using the software to compare sequences Miropeat chromosomiquences Encephalitozoon cuniculi reveals the presence of sequences homologous to different ends. This mosaic structure of the ends was confirmed by a PCR approach. Most interesting is the presence of genes in these regions. Comparison of coding sequences revealed four gene families: Inter AE, InterB, interc, barring. We chose to invest the family interB, a homogeneous family with very few genes incomplete compared to the three other families. After validating the presence of genes interB among species of the genus Encephalitozoon, these genes were found in two other genera of microsporidia can parasitize humans (Brachiola algerae and Vittaforma corneae). By cons, these genes are absent in other genera of microsporidia 5, including 2 obligate parasites of insects and parasites strict three fish. The expression of these genes has been addressed in the species E. cuniculi. InterB genes are transcribed, and proteins interB also exist.
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Ndongo Dia. Etude d'une famille multigénique chez Encephalitozoon cuniculi, une microsporidie pathogène de l'homme. Biologie du développement. Université Blaise Pascal - Clermont-Ferrand II; Université d'Auvergne - Clermont-Ferrand I, 2006. Français. ⟨NNT : 2006CLF21724⟩. ⟨tel-00713572⟩

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