D. Discussion and .. , 59 1) Influence de l'hypothermie sur le pronostic en fonction du rythme cardiaque initial 59 a. Rythme initial choquable, p.63

B. Les-défis-À-venir and .. , 79 1) Evaluation de l'état neurologique et qualité de vie sur le long terme : projet de création d'une cohorte prospective régionale Ile de, p.79

A. Annexe-des-données and .. , Error! Bookmark not defined. 1) données du patient : Error! Bookmark not defined. 2) événements pré?hospitaliers : Error! Bookmark not defined. 3) hospitalisation en réanimation, ., vol.1

L. , D. Adams, R. Brown, T. Carnethon, M. Dai et al., Heart disease and stroke statistics--2010 update: a report from the American Heart Association, Circulation, vol.121, issue.7, pp.46-215, 2010.

M. Eckstein, S. Stratton, and L. Chan, Cardiac Arrest Resuscitation Evaluation in Los Angeles: CARE-LA, Annals of Emergency Medicine, vol.45, issue.5, pp.504-513, 2005.
DOI : 10.1016/j.annemergmed.2004.11.024

G. Lombardi, J. Gallagher, and P. Gennis, Outcome of out-of-hospital cardiac arrest in New York City. The Pre-Hospital Arrest Survival Evaluation (PHASE) Study, JAMA: The Journal of the American Medical Association, vol.271, issue.9, pp.678-83, 1994.
DOI : 10.1001/jama.271.9.678

L. Becker, M. Ostrander, J. Barrett, and G. Kondos, Outcome of CPR in a large metropolitan area--where are the survivors? Annals of emergency medicine, pp.355-61, 1991.

A. Travers, T. Rea, B. Bobrow, D. Edelson, R. Berg et al., Part 4: CPR Overview: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Circulation, vol.122, issue.18_suppl_3, pp.676-84, 2010.
DOI : 10.1161/CIRCULATIONAHA.110.970913

K. Sunde, M. Pytte, D. Jacobsen, A. Mangschau, L. Jensen et al., Implementation of a standardised treatment protocol for post resuscitation care after out-of-hospital cardiac arrest, Resuscitation, vol.73, issue.1, pp.29-39, 2007.
DOI : 10.1016/j.resuscitation.2006.08.016

O. Tomte, I. Sjaastad, L. Wik, A. Kuzovlev, M. Eriksen et al., Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest, Resuscitation, vol.81, issue.4, pp.488-92, 2010.
DOI : 10.1016/j.resuscitation.2009.12.028

C. Sasson, M. Rogers, J. Dahl, and A. Kellermann, Predictors of Survival From Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis, Circulation: Cardiovascular Quality and Outcomes, vol.3, issue.1, pp.63-81, 2010.
DOI : 10.1161/CIRCOUTCOMES.109.889576

J. Nolan, R. Neumar, C. Adrie, M. Aibiki, R. Berg et al., Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication, Resuscitation, vol.79, issue.3, pp.350-79, 2008.
DOI : 10.1016/j.resuscitation.2008.09.017

P. Safar, W. Behringer, B. Bottiger, and F. Sterz, Cerebral resuscitation potentials for cardiac arrest, Critical Care Medicine, vol.30, issue.Supplement, pp.140-144, 2002.
DOI : 10.1097/00003246-200204001-00004

P. Grace, Ischaemia-reperfusion injury, British Journal of Surgery, vol.29, issue.5, pp.637-684, 1994.
DOI : 10.1002/bjs.1800810504

A. Geppert, G. Zorn, G. Delle-karth, M. Koreny, P. Siostrzonek et al., Plasma concentrations of von Willebrand factor and intracellular adhesion molecule-1 for prediction of outcome after successful cardiopulmonary resuscitation, Critical Care Medicine, vol.31, issue.3, pp.805-816, 2003.
DOI : 10.1097/01.CCM.0000054861.69462.B5

C. Adrie, M. Adib-conquy, I. Laurent, M. Monchi, C. Vinsonneau et al., Successful Cardiopulmonary Resuscitation After Cardiac Arrest as a "Sepsis-Like" Syndrome, Circulation, vol.106, issue.5, pp.562-570, 2002.
DOI : 10.1161/01.CIR.0000023891.80661.AD

S. Gando and I. Tedo, Increased neutrophil elastase release in patients with cardiopulmonary arrest: Role of elastase inhibitor, Intensive Care Medicine, vol.6, issue.8, pp.636-676, 1995.
DOI : 10.1007/BF01711540

S. Gando, T. Kameue, S. Nanzaki, M. Igarashi, and Y. Nakanishi, Platelet activation with massive formation of thromboxane A 2 during and after cardiopulmonary resuscitation, Intensive Care Medicine, vol.23, issue.1, pp.71-77, 1997.
DOI : 10.1007/s001340050293

S. Gando, S. Nanzaki, Y. Morimoto, S. Kobayashi, and O. Kemmotsu, Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury, Intensive Care Medicine, vol.26, issue.1, pp.38-44, 2000.
DOI : 10.1007/s001340050009

S. Gando, T. Kameue, S. Nanzaki, and Y. Nakanishi, Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest, Thrombosis and haemostasis, vol.77, issue.2, pp.278-82, 1997.

C. Adrie, M. Monchi, I. Laurent, S. Um, S. Yan et al., Coagulopathy After Successful Cardiopulmonary Resuscitation Following Cardiac Arrest, Journal of the American College of Cardiology, vol.46, issue.1, pp.21-29, 2005.
DOI : 10.1016/j.jacc.2005.03.046

URL : http://doi.org/10.1016/j.jacc.2005.03.046

L. Cobb, C. Fahrenbruch, M. Olsufka, and M. Copass, Changing Incidence of Out-of-Hospital Ventricular Fibrillation, 1980-2000, JAMA, vol.288, issue.23, pp.3008-3021, 1980.
DOI : 10.1001/jama.288.23.3008

I. Laurent, M. Monchi, J. Chiche, L. Joly, C. Spaulding et al., Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest, Journal of the American College of Cardiology, vol.40, issue.12, pp.2110-2116, 2002.
DOI : 10.1016/S0735-1097(02)02594-9

V. Negovsky, Postresuscitation disease, Critical Care Medicine, vol.16, issue.10, pp.942-948, 1988.
DOI : 10.1097/00003246-198810000-00004

H. Deantonio, S. Kaul, and B. Lerman, Reversible Myocardial Depression in Survivors of Cardiac Arrest, Pacing and Clinical Electrophysiology, vol.66, issue.8, pp.982-987, 1990.
DOI : 10.1016/0002-8703(88)90607-2

W. Tang, M. Weil, S. Sun, R. Gazmuri, and J. Bisera, Progressive myocardial dysfunction after cardiac resuscitation, Critical Care Medicine, vol.21, issue.7, pp.1046-50, 1993.
DOI : 10.1097/00003246-199307000-00022

R. Gazmuri, M. Weil, J. Bisera, W. Tang, M. Fukui et al., Myocardial dysfunction after successful resuscitation from cardiac arrest, Critical Care Medicine, vol.24, issue.6, pp.992-1000, 1996.
DOI : 10.1097/00003246-199606000-00020

R. Gazmuri, M. Berkowitz, and H. Cajigas, Myocardial effects of ventricular fibrillation in the isolated rat heart, Critical Care Medicine, vol.27, issue.8, pp.1542-50, 1999.
DOI : 10.1097/00003246-199908000-00023

K. Kern, R. Hilwig, K. Rhee, and R. Berg, Myocardial dysfunction after resuscitation from cardiac arrest: An example of global myocardial stunning, Journal of the American College of Cardiology, vol.28, issue.1, pp.232-272, 1996.
DOI : 10.1016/0735-1097(96)00130-1

R. Meyer, K. Kern, R. Berg, R. Hilwig, and G. Ewy, Post-resuscitation right ventricular dysfunction: delineation and treatment with dobutamine, Resuscitation, vol.55, issue.2, pp.187-91, 2002.
DOI : 10.1016/S0300-9572(02)00204-6

E. Cerchiari, P. Safar, E. Klein, and W. Diven, Visceral, hematologic and bacteriologic changes and neurologic outcome after cardiac arrest in dogs. The visceral post-resuscitation syndrome, Resuscitation, vol.25, issue.2, pp.119-155, 1993.
DOI : 10.1016/0300-9572(93)90090-D

A. Vasquez, K. Kern, R. Hilwig, J. Heidenreich, R. Berg et al., Optimal dosing of dobutamine for treating post-resuscitation left ventricular dysfunction, Resuscitation, vol.61, issue.2, pp.199-207, 2004.
DOI : 10.1016/j.resuscitation.2004.01.002

W. Chang, M. Ma, K. Chien, C. Huang, M. Tsai et al., Postresuscitation myocardial dysfunction: correlated factors and prognostic implications, Intensive Care Medicine, vol.122, issue.1, pp.88-95, 2007.
DOI : 10.1007/s00134-006-0442-9

M. Ruiz-bailen, E. Aguayo-de-hoyos, S. Ruiz-navarro, M. Diaz-castellanos, L. Rucabado-aguilar et al., Reversible myocardial dysfunction after cardiopulmonary resuscitation, Resuscitation, vol.66, issue.2, pp.175-81, 2005.
DOI : 10.1016/j.resuscitation.2005.01.012

G. Hekimian, T. Baugnon, M. Thuong, M. Monchi, H. Dabbane et al., CORTISOL LEVELS AND ADRENAL RESERVE AFTER SUCCESSFUL CARDIAC ARREST RESUSCITATION, Shock, vol.22, issue.2, pp.116-125, 2004.
DOI : 10.1097/01.shk.0000132489.79498.c7

F. Pene, H. Hyvernat, V. Mallet, A. Cariou, P. Carli et al., Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest, Intensive Care Medicine, vol.345, issue.5, pp.627-660, 2005.
DOI : 10.1007/s00134-005-2603-7

S. Laver, C. Farrow, D. Turner, and J. Nolan, Mode of death after admission to an intensive care unit following cardiac arrest, Intensive Care Medicine, vol.30, issue.11, pp.2126-2134, 2004.
DOI : 10.1007/s00134-004-2425-z

J. Cruz, J. Jaggi, and O. Hoffstad, Cerebral blood flow, vascular resistance, and oxygen metabolism in acute brain trauma, Critical Care Medicine, vol.23, issue.8, pp.1412-1419, 1995.
DOI : 10.1097/00003246-199508000-00016

G. Bouma and J. Muizelaar, Cerebral blood flow in severe clinical head injury, New horizons, vol.3, issue.3, pp.384-94, 1995.

G. Buunk, J. Van-der-hoeven, M. Frolich, and A. Meinders, Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest? Intensive care medicine, pp.1191-1197, 1996.

E. Edgren, P. Enblad, A. Grenvik, A. Lilja, S. Valind et al., Cerebral blood flow and metabolism after cardiopulmonary resuscitation. A pathophysiologic and prognostic positron emission tomography pilot study, Resuscitation, vol.57, issue.2, pp.161-70, 2003.
DOI : 10.1016/S0300-9572(03)00004-2

V. Lemiale, O. Huet, B. Vigue, A. Mathonnet, C. Spaulding et al., Changes in cerebral blood flow and oxygen extraction during post-resuscitation syndrome, Resuscitation, vol.76, issue.1, pp.17-24, 2008.
DOI : 10.1016/j.resuscitation.2007.06.028

E. Zandbergen, R. De-haan, J. Reitsma, and A. Hijdra, Survival and recovery of consciousness in anoxic-ischemic coma after cardiopulmonary resuscitation, Intensive Care Medicine, vol.29, issue.11, pp.1911-1916, 2003.
DOI : 10.1007/s00134-003-1951-4

C. Adrie, A. Cariou, B. Mourvillier, I. Laurent, H. Dabbane et al., Predicting survival with good neurological recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA score, European Heart Journal, vol.27, issue.23, pp.2840-2845, 2006.
DOI : 10.1093/eurheartj/ehl335

R. Neumar, J. Nolan, C. Adrie, M. Aibiki, R. Berg et al., Post-Cardiac Arrest Syndrome: Epidemiology, Pathophysiology, Treatment, and Prognostication A Consensus Statement From the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council, Circulation, vol.118, issue.23, pp.2452-83, 2008.
DOI : 10.1161/CIRCULATIONAHA.108.190652

M. Peberdy, C. Callaway, R. Neumar, R. Geocadin, J. Zimmerman et al., Part 9: Post-Cardiac Arrest Care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care, Circulation, vol.122, issue.18_suppl_3, pp.768-86, 2010.
DOI : 10.1161/CIRCULATIONAHA.110.971002

I. Jacobs, V. Nadkarni, J. Bahr, R. Berg, J. Billi et al., Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update and Simplification of the Utstein Templates for Resuscitation Registries: A Statement for Healthcare Professionals From a Task Force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa), Circulation, vol.110, issue.21, pp.3385-97, 2004.
DOI : 10.1161/01.CIR.0000147236.85306.15

K. Polderman, Induced hypothermia and fever control for prevention and treatment of neurological injuries, The Lancet, vol.371, issue.9628, pp.1955-69, 2008.
DOI : 10.1016/S0140-6736(08)60837-5

A. Farb, A. Tang, A. Burke, L. Sessums, Y. Liang et al., Sudden Coronary Death : Frequency of Active Coronary Lesions, Inactive Coronary Lesions, and Myocardial Infarction, Circulation, vol.92, issue.7, pp.1701-1710, 1995.
DOI : 10.1161/01.CIR.92.7.1701

C. Spaulding, L. Joly, A. Rosenberg, M. Monchi, S. Weber et al., Immediate Coronary Angiography in Survivors of Out-of-Hospital Cardiac Arrest, New England Journal of Medicine, vol.336, issue.23, pp.1629-1662, 1997.
DOI : 10.1056/NEJM199706053362302

P. Garot, T. Lefevre, H. Eltchaninoff, M. Morice, F. Tamion et al., Six-Month Outcome of Emergency Percutaneous Coronary Intervention in Resuscitated Patients After Cardiac Arrest Complicating ST-Elevation Myocardial Infarction, Circulation, vol.115, issue.11, pp.1354-62, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.657619

S. Wolfrum, C. Pierau, P. Radke, H. Schunkert, and V. Kurowski, Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest due to acute ST-segment elevation myocardial infarction undergoing immediate percutaneous coronary intervention*, Critical Care Medicine, vol.36, issue.6, pp.1780-1786, 2008.
DOI : 10.1097/CCM.0b013e31817437ca

C. Lettieri, S. Savonitto, D. Servi, S. Guagliumi, G. Belli et al., Emergency percutaneous coronary intervention in patients with ST-elevation myocardial infarction complicated by out-of-hospital cardiac arrest: Early and medium-term outcome, American Heart Journal, vol.157, issue.3, pp.569-575, 2009.
DOI : 10.1016/j.ahj.2008.10.018

Z. Anyfantakis, G. Baron, P. Aubry, D. Himbert, L. Feldman et al., Acute coronary angiographic findings in survivors of out-of-hospital cardiac arrest, American Heart Journal, vol.157, issue.2, pp.312-320, 2009.
DOI : 10.1016/j.ahj.2008.09.016

T. Rea, C. Fahrenbruch, L. Culley, R. Donohoe, C. Hambly et al., CPR with Chest Compression Alone or with Rescue Breathing, New England Journal of Medicine, vol.363, issue.5, pp.423-456, 2010.
DOI : 10.1056/NEJMoa0908993

F. Dumas, D. Grimaldi, B. Zuber, J. Fichet, J. Charpentier et al., Is Hypothermia After Cardiac Arrest Effective in Both Shockable and Nonshockable Patients?: Insights From a Large Registry, Circulation, vol.123, issue.8, pp.877-86, 2011.
DOI : 10.1161/CIRCULATIONAHA.110.987347

F. Dumas, A. Cariou, S. Manzo-silberman, D. Grimaldi, V. B. Rosencher et al., Immediate Percutaneous Coronary Intervention Is Associated With Better Survival After Out-of-Hospital Cardiac Arrest: Insights From the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) Registry, Circulation: Cardiovascular Interventions, vol.3, issue.3, pp.200-207, 2010.
DOI : 10.1161/CIRCINTERVENTIONS.109.913665

G. Sideris, S. Voicu, J. Dillinger, V. Stratiev, D. Logeart et al., Value of post-resuscitation electrocardiogram in the diagnosis of acute myocardial infarction in out-of-hospital cardiac arrest patients, Resuscitation, vol.82, issue.9, pp.1148-53, 2011.
DOI : 10.1016/j.resuscitation.2011.04.023

N. Grubb, K. Fox, and P. Cawood, Resuscitation from out-of-hospital cardiac arrest: implications for cardiac enzyme estimation, Resuscitation, vol.33, issue.1, pp.35-41, 1996.
DOI : 10.1016/S0300-9572(96)00971-9

M. Mullner, F. Sterz, M. Binder, M. Brunner, M. Hirschl et al., Creatine kinase and creatine kinase-MB release after nontraumatic cardiac arrest, The American Journal of Cardiology, vol.77, issue.8, pp.581-586, 1996.
DOI : 10.1016/S0002-9149(97)89310-1

S. Voicu, G. Sideris, N. Deye, J. Dillinger, D. Logeart et al., Role of cardiac troponin in the diagnosis of acute myocardial infarction in comatose patients resuscitated from out-of-hospital cardiac arrest, Resuscitation, vol.83, issue.4, 2011.
DOI : 10.1016/j.resuscitation.2011.10.008

C. Lin, T. Chiu, J. Fang, J. Kuan, and J. Chen, The influence of cardiopulmonary resuscitation without defibrillation on serum levels of cardiac enzymes: A time course study of out-of-hospital cardiac arrest survivors, Resuscitation, vol.68, issue.3, pp.343-352, 2006.
DOI : 10.1016/j.resuscitation.2005.07.018

C. Hamm, E. Giannitsis, and H. Katus, Cardiac Troponin Elevations in Patients Without Acute Coronary Syndrome, Circulation, vol.106, issue.23, pp.2871-2873, 2002.
DOI : 10.1161/01.CIR.0000044342.50593.63

R. Aviles, A. Askari, B. Lindahl, L. Wallentin, G. Jia et al., Troponin T Levels in Patients with Acute Coronary Syndromes, with or without Renal Dysfunction, New England Journal of Medicine, vol.346, issue.26, pp.2047-52, 2002.
DOI : 10.1056/NEJMoa013456

B. Freda, W. Tang, F. Van-lente, W. Peacock, and G. Francis, Cardiac troponins in renal insufficiency, Journal of the American College of Cardiology, vol.40, issue.12, pp.2065-71, 2002.
DOI : 10.1016/S0735-1097(02)02608-6

E. Antman, D. Anbe, P. Armstrong, E. Bates, L. Green et al., ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction), Circulation, vol.110, issue.5, pp.588-636, 2004.
DOI : 10.1161/01.CIR.0000134791.68010.FA

B. Bottiger, C. Bode, S. Kern, A. Gries, R. Gust et al., Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial, The Lancet, vol.357, issue.9268, pp.1583-1588, 2001.
DOI : 10.1016/S0140-6736(00)04726-7

B. Bottiger and E. Martin, Thrombolytic therapy during cardiopulmonary resuscitation and the role of coagulation activation after cardiac arrest, Current Opinion in Critical Care, vol.7, issue.3, pp.176-83, 2001.
DOI : 10.1097/00075198-200106000-00006

R. Abu-laban, J. Christenson, G. Innes, C. Van-beek, K. Wanger et al., Tissue Plasminogen Activator in Cardiac Arrest with Pulseless Electrical Activity, New England Journal of Medicine, vol.346, issue.20, pp.1522-1530, 2002.
DOI : 10.1056/NEJMoa012885

B. Bottiger, H. Arntz, D. Chamberlain, E. Bluhmki, A. Belmans et al., Thrombolysis during Resuscitation for Out-of-Hospital Cardiac Arrest, New England Journal of Medicine, vol.359, issue.25, pp.2651-62, 2008.
DOI : 10.1056/NEJMoa070570

M. Castren, P. Nordberg, L. Svensson, F. Taccone, J. Vincent et al., Intra-Arrest Transnasal Evaporative Cooling: A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness), Circulation, vol.122, issue.7, pp.729-765, 2010.
DOI : 10.1161/CIRCULATIONAHA.109.931691

S. Bernard, K. Smith, P. Cameron, K. Masci, D. Taylor et al., Induction of Therapeutic Hypothermia by Paramedics After Resuscitation From Out-of-Hospital Ventricular Fibrillation Cardiac Arrest: A Randomized Controlled Trial, Circulation, vol.122, issue.7, pp.737-779, 2010.
DOI : 10.1161/CIRCULATIONAHA.109.906859

D. Stub, S. Bernard, S. Duffy, and D. Kaye, Post Cardiac Arrest Syndrome: A Review of Therapeutic Strategies, Circulation, vol.123, issue.13, pp.1428-1463, 2011.
DOI : 10.1161/CIRCULATIONAHA.110.988725

J. Hovdenes, J. Laake, L. Aaberge, H. Haugaa, and J. Bugge, Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock, Acta Anaesthesiologica Scandinavica, vol.282, issue.5, pp.137-179, 2007.
DOI : 10.1111/j.1399-6576.2005.00773.x

R. Knafelj, P. Radsel, T. Ploj, and M. Noc, Primary percutaneous coronary intervention and mild induced hypothermia in comatose survivors of ventricular fibrillation with ST-elevation acute myocardial infarction, Resuscitation, vol.74, issue.2, pp.227-261, 2007.
DOI : 10.1016/j.resuscitation.2007.01.016

K. Sunde, J. Kramer-johansen, M. Pytte, and P. Steen, Predicting survival with good neurologic recovery at hospital admission after successful resuscitation of out-of-hospital cardiac arrest: the OHCA score, European Heart Journal, vol.28, issue.6, pp.773-773, 2007.
DOI : 10.1093/eurheartj/ehl536

D. Gaieski, R. Band, B. Abella, R. Neumar, B. Fuchs et al., Early goal-directed hemodynamic optimization combined with therapeutic hypothermia in comatose survivors of out-of-hospital cardiac arrest, Resuscitation, vol.80, issue.4, pp.418-442, 2009.
DOI : 10.1016/j.resuscitation.2008.12.015

D. Stub, C. Hengel, W. Chan, D. Jackson, K. Sanders et al., Usefulness of Cooling and Coronary Catheterization to Improve Survival in Out-of-Hospital Cardiac Arrest, The American Journal of Cardiology, vol.107, issue.4, pp.522-529, 2011.
DOI : 10.1016/j.amjcard.2010.10.011

S. Bernard, T. Gray, M. Buist, B. Jones, W. Silvester et al., Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia, New England Journal of Medicine, vol.346, issue.8, pp.557-63, 2002.
DOI : 10.1056/NEJMoa003289

M. Holzer, S. Bernard, S. Hachimi-idrissi, R. Roine, F. Sterz et al., Hypothermia for neuroprotection after cardiac arrest: Systematic review and individual patient data meta-analysis, Critical Care Medicine, vol.33, issue.2, pp.414-422, 2005.
DOI : 10.1097/01.CCM.0000153410.87750.53

P. Vaagenes, P. Safar, J. Moossy, G. Rao, W. Diven et al., Asphyxiation versus ventricular fibrillation cardiac arrest in dogs., Resuscitation, vol.35, issue.1, pp.41-52, 1997.
DOI : 10.1016/S0300-9572(97)01108-8

P. Vaagenes, M. Ginsberg, U. Ebmeyer, L. Ernster, M. Fischer et al., Cerebral resuscitation from cardiac arrest, Critical Care Medicine, vol.24, issue.2, pp.57-68, 1996.
DOI : 10.1097/00003246-199602000-00048

J. Rittenberger and C. Callaway, Muddy waters: Hypothermia does not work?, Resuscitation, vol.82, issue.9, pp.1120-1121, 2011.
DOI : 10.1016/j.resuscitation.2011.07.003

S. Hachimi-idrissi, L. Corne, G. Ebinger, Y. Michotte, and L. Huyghens, Mild hypothermia induced by a helmet device: a clinical feasibility study, Resuscitation, vol.51, issue.3, pp.275-81, 2001.
DOI : 10.1016/S0300-9572(01)00412-9

F. Kim, M. Olsufka, W. Longstreth, J. Maynard, C. Carlbom et al., Pilot Randomized Clinical Trial of Prehospital Induction of Mild Hypothermia in Out-of-Hospital Cardiac Arrest Patients With a Rapid Infusion of 4??C Normal Saline, Circulation, vol.115, issue.24, pp.3064-70, 2007.
DOI : 10.1161/CIRCULATIONAHA.106.655480

J. Arrich, Clinical application of mild therapeutic hypothermia after cardiac arrest*, Critical Care Medicine, vol.35, issue.4, pp.1041-1048, 2007.
DOI : 10.1097/01.CCM.0000259383.48324.35

M. Oddo, M. Schaller, F. Feihl, V. Ribordy, and L. Liaudet, From evidence to clinical practice: Effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest*, Critical Care Medicine, vol.34, issue.7, pp.1865-73, 2006.
DOI : 10.1097/01.CCM.0000221922.08878.49

M. Oddo, J. Schmidt, E. Carrera, N. Badjatia, E. Connolly et al., Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: A microdialysis study*, Critical Care Medicine, vol.36, issue.12, pp.3233-3241, 2008.
DOI : 10.1097/CCM.0b013e31818f4026

C. Storm, J. Schefold, L. Nibbe, F. Martens, A. Krueger et al., Therapeutic hypothermia after cardiac arrest - the implementation of the ILCOR guidelines in clinical routine is possible!, Critical Care, vol.10, issue.6, p.425, 2006.
DOI : 10.1186/cc5061

C. Don, W. Longstreth, J. Maynard, C. Olsufka, M. Nichol et al., Active surface cooling protocol to induce mild therapeutic hypothermia after out-of-hospital cardiac arrest: A retrospective before-and-after comparison in a single hospital*, Critical Care Medicine, vol.37, issue.12, pp.3062-3071, 2009.
DOI : 10.1097/CCM.0b013e3181b7f59c

T. Calandra and J. Cohen, The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit, Critical Care Medicine, vol.33, issue.7, pp.1538-1586, 2005.
DOI : 10.1097/01.CCM.0000168253.91200.83

P. Carli, Recommandations formalisées d'experts. Société française d'anesthésie et de réanimation, Société de réanimation de langue française. Prise en charge de l'arrêt cardiaque, Annales française anesthésie réanimation Ann Fr Anesth Reanim, vol.2627, pp.1008-19273, 2008.

K. Cheung, R. Green, and K. Magee, Conclusions:, CJEM, vol.24, issue.05, pp.329-366, 2006.
DOI : 10.1038/jcbfm.1989.21

J. Arrich, M. Holzer, H. Herkner, and M. Mullner, Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation. Cochrane database of systematic reviews, p.4128, 2009.

J. Walters, P. Morley, and J. Nolan, The role of hypothermia in post-cardiac arrest patients with return of spontaneous circulation: A systematic review, Resuscitation, vol.82, issue.5, pp.508-524, 2011.
DOI : 10.1016/j.resuscitation.2011.01.021

M. Hazinski, J. Nolan, J. Billi, B. Bottiger, L. Bossaert et al., Part 1: Executive Summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations, Circulation, vol.122, issue.16_suppl_2, pp.250-75, 2010.
DOI : 10.1161/CIRCULATIONAHA.110.970897

O. Tomte, G. Andersen, D. Jacobsen, T. Draegni, B. Auestad et al., Strong and weak aspects of an established post-resuscitation treatment protocol???A five-year observational study, Resuscitation, vol.82, issue.9, pp.1186-93, 2011.
DOI : 10.1016/j.resuscitation.2011.05.003

S. Hachimi-idrissi, L. Corne, and L. Huyghens, The effect of mild hypothermia and induced hypertension on long term survival rate and neurological outcome after asphyxial cardiac arrest in rats, Resuscitation, vol.49, issue.1, pp.73-82, 2001.
DOI : 10.1016/S0300-9572(00)00268-9

M. Oddo, V. Ribordy, F. Feihl, A. Rossetti, M. Schaller et al., Early predictors of outcome in comatose survivors of ventricular fibrillation and non-ventricular fibrillation cardiac arrest treated with hypothermia: A prospective study*, Critical Care Medicine, vol.36, issue.8, pp.2296-301, 2008.
DOI : 10.1097/CCM.0b013e3181802599

C. Storm, I. Steffen, J. Schefold, A. Krueger, M. Oppert et al., Mild therapeutic hypothermia shortens intensive care unit stay of survivors after out-of-hospital cardiac arrest compared to historical controls, Critical Care, vol.12, issue.3, p.78, 2008.
DOI : 10.1186/cc6925

Y. Kim, H. Yim, S. Jeong, M. Klem, and C. Callaway, Does therapeutic hypothermia benefit adult cardiac arrest patients presenting with non-shockable initial rhythms?: A systematic review and meta-analysis of randomized and non-randomized studies, Resuscitation, vol.83, issue.2, 2011.
DOI : 10.1016/j.resuscitation.2011.07.031

C. Storm, J. Nee, M. Roser, A. Jorres, and D. Hasper, Mild hypothermia treatment in patients resuscitated from non-shockable cardiac arrest. Emergency medicine journal : EMJ, 2011.

C. Testori, F. Sterz, W. Behringer, M. Haugk, T. Uray et al., Mild therapeutic hypothermia is associated with favourable outcome in patients after cardiac arrest with non-shockable rhythms, Resuscitation, vol.82, issue.9, pp.1162-1169, 2011.
DOI : 10.1016/j.resuscitation.2011.05.022

J. Lundbye, M. Rai, B. Ramu, A. Hosseini-khalili, D. Li et al., Therapeutic hypothermia is associated with improved neurologic outcome and survival in cardiac arrest survivors of non-shockable rhythms, Resuscitation, vol.83, issue.2, 2011.
DOI : 10.1016/j.resuscitation.2011.08.005

R. Pfeifer, C. Jung, S. Purle, A. Lauten, A. Yilmaz et al., Survival does not improve when therapeutic hypothermia is added to post-cardiac arrest care, Resuscitation, vol.82, issue.9, pp.1168-73, 2011.
DOI : 10.1016/j.resuscitation.2011.05.024

J. Rello, J. Valles, P. Jubert, A. Ferrer, C. Domingo et al., Lower respiratory tract infections following cardiac arrest and cardiopulmonary resuscitation Clinical infectious diseases : an official publication of the Infectious Diseases Society of, America, vol.21, issue.2, pp.310-314, 1995.

N. Nielsen, K. Sunde, J. Hovdenes, R. Riker, S. Rubertsson et al., Adverse events and their relation to mortality in out-of-hospital cardiac arrest patients treated with therapeutic hypothermia*, Critical Care Medicine, vol.39, issue.1, pp.57-64, 2011.
DOI : 10.1097/CCM.0b013e3181fa4301

T. Rea and F. Dumas, Resuscitation science: A role for observation?, Resuscitation, vol.83, issue.3, pp.281-283, 2012.
DOI : 10.1016/j.resuscitation.2011.12.025

S. Perbet, N. Mongardon, F. Dumas, C. Bruel, V. Lemiale et al., Early-Onset Pneumonia after Cardiac Arrest, American Journal of Respiratory and Critical Care Medicine, vol.184, issue.9, pp.1048-54, 2011.
DOI : 10.1164/rccm.201102-0331OC

F. Dumas, L. White, B. Stubbs, A. Cariou, and T. Rea, Long-Term Prognosis Following Resuscitation From Out of Hospital Cardiac Arrest, Journal of the American College of Cardiology, vol.60, issue.1, p.2012
DOI : 10.1016/j.jacc.2012.03.036

A. Wagner, S. Soumerai, F. Zhang, and D. Ross-degnan, Segmented regression analysis of interrupted time series studies in medication use research, Journal of Clinical Pharmacy and Therapeutics, vol.71, issue.4, pp.299-309, 2002.
DOI : 10.1001/jama.263.6.831

P. Kudenchuk, J. Redshaw, B. Stubbs, C. Fahrenbruch, F. Dumas et al., Impact of Changes in Resuscitation Practice on survival and Neurological Outcome after out-of-hospital Cardiac arrest resulting from non-shockable Arrythmias, Circulation, 2012.

W. Longstreth, J. Nelson, and L. , Smoking cessation and risk of stroke in women, JAMA : the journal of the American Medical Association, vol.269, issue.17, p.2214, 1993.

W. Longstreth and J. , Aspirin in Acute Ischemic Stroke, JAMA: The Journal of the American Medical Association, vol.284, issue.11, p.1379, 2000.
DOI : 10.1001/jama.284.11.1379

R. Roine, S. Kajaste, and M. Kaste, Neuropsychological Sequelae of Cardiac Arrest, JAMA: The Journal of the American Medical Association, vol.269, issue.2, pp.237-279, 1993.
DOI : 10.1001/jama.1993.03500020071034

T. Bunch, R. White, B. Gersh, R. Meverden, D. Hodge et al., Long-Term Outcomes of Out-of-Hospital Cardiac Arrest after Successful Early Defibrillation, New England Journal of Medicine, vol.348, issue.26, pp.2626-2659, 2003.
DOI : 10.1056/NEJMoa023053

T. Rea, M. Crouthamel, M. Eisenberg, L. Becker, and A. Lima, Temporal Patterns in Long-Term Survival After Resuscitation From Out-of-Hospital Cardiac Arrest, Circulation, vol.108, issue.10, pp.1196-201, 2003.
DOI : 10.1161/01.CIR.0000087403.24467.A4

T. Rea, M. Eisenberg, L. Becker, J. Murray, and T. Hearne, Temporal Trends in Sudden Cardiac Arrest: A 25-Year Emergency Medical Services Perspective, Circulation, vol.107, issue.22, pp.2780-2785, 2003.
DOI : 10.1161/01.CIR.0000070950.17208.2A

M. Kuisma, J. Repo, and A. Alaspaa, The incidence of out-of-hospital ventricular fibrillation in Helsinki, Finland, from 1994 to 1999, The Lancet, vol.358, issue.9280, pp.473-477, 2001.
DOI : 10.1016/S0140-6736(01)05634-3

J. Herlitz, E. Andersson, A. Bang, J. Engdahl, M. Holmberg et al., Experiences from treatment of out-of-hospital cardiac arrest during 17 years in G??teborg, European Heart Journal, vol.21, issue.15, pp.1251-1259, 2000.
DOI : 10.1053/euhj.2000.2150

T. Iwami, T. Kawamura, A. Hiraide, R. Berg, Y. Hayashi et al., Effectiveness of Bystander-Initiated Cardiac-Only Resuscitation for Patients With Out-of-Hospital Cardiac Arrest, Circulation, vol.116, issue.25, pp.2900-2907, 2007.
DOI : 10.1161/CIRCULATIONAHA.107.723411

M. Kuisma and A. Alaspaa, Out-of-hospital cardiac arrests of non-cardiac origin: Epidemiology and outcome, European Heart Journal, vol.18, issue.7, pp.1122-1130, 1997.
DOI : 10.1093/oxfordjournals.eurheartj.a015407

J. Herlitz, J. Engdahl, L. Svensson, M. Young, K. Angquist et al., Decrease in the occurrence of ventricular fibrillation as the initially observed arrhythmia after out-of-hospital cardiac arrest during 11 years in Sweden, Resuscitation, vol.60, issue.3, pp.283-90, 2004.
DOI : 10.1016/j.resuscitation.2003.11.003

J. Pell, J. Sirel, A. Marsden, I. Ford, N. Walker et al., Presentation, management, and outcome of out of hospital cardiopulmonary arrest: comparison by underlying aetiology, Heart, vol.89, issue.8, pp.839-881, 2003.
DOI : 10.1136/heart.89.8.839

L. Svensson, K. Bohm, M. Castren, H. Pettersson, L. Engerstrom et al., Compression-Only CPR or Standard CPR in Out-of-Hospital Cardiac Arrest, New England Journal of Medicine, vol.363, issue.5, pp.434-476, 2010.
DOI : 10.1056/NEJMoa0908991

T. Rea, M. Helbock, S. Perry, M. Garcia, D. Cloyd et al., Increasing Use of Cardiopulmonary Resuscitation During Out-of-Hospital Ventricular Fibrillation Arrest: Survival Implications of Guideline Changes, Circulation, vol.114, issue.25, pp.2760-2765, 2006.
DOI : 10.1161/CIRCULATIONAHA.106.654715

B. Langholz and O. Borgan, Estimation of Absolute Risk from Nested Case-Control Data, Biometrics, vol.53, issue.2, pp.767-74, 1997.
DOI : 10.2307/2533977

A. Hartmann, T. Rundek, H. Mast, M. Paik, B. Boden-albala et al., Mortality and causes of death after first ischemic stroke: The Northern Manhattan Stroke Study, Neurology, vol.57, issue.11, pp.2000-2005, 2001.
DOI : 10.1212/WNL.57.11.2000

A. Barnato, S. Albert, D. Angus, J. Lave, and H. Degenholtz, Disability among elderly survivors of mechanical ventilation American journal of respiratory and critical care medicine, pp.1037-1079, 2011.

D. Luca, G. Suryapranata, H. Zijlstra, F. Van-'t-hof, A. Hoorntje et al., Symptom-onset-to-balloon time and mortality in patients with acute myocardial infarction treated by primary angioplasty, ACC Current Journal Review, vol.13, issue.1, pp.991-998, 2003.
DOI : 10.1016/j.accreview.2003.10.055

E. Boersma, N. Mercado, D. Poldermans, M. Gardien, J. Vos et al., Acute myocardial infarction, The Lancet, vol.361, issue.9360, pp.847-58, 2003.
DOI : 10.1016/S0140-6736(03)12712-2

K. Kern and O. Rahman, Emergent percutaneous coronary intervention for resuscitated victims of out-of-hospital cardiac arrest Catheterization and cardiovascular interventions : official journal of the Society for, Cardiac Angiography & Interventions, vol.75, issue.4, pp.616-640, 2010.

E. Wachelder, V. Moulaert, C. Van-heugten, J. Verbunt, S. Bekkers et al., Life after survival: Long-term daily functioning and quality of life after an out-of-hospital cardiac arrest, Resuscitation, vol.80, issue.5, pp.517-539, 2009.
DOI : 10.1016/j.resuscitation.2009.01.020

T. Horsted, L. Rasmussen, C. Meyhoff, and S. Nielsen, Long-term prognosis after out-of-hospital cardiac arrest, Resuscitation, vol.72, issue.2, pp.214-222, 2007.
DOI : 10.1016/j.resuscitation.2006.06.029

T. Rea and R. Page, Community Approaches to Improve Resuscitation After Out-of-Hospital Sudden Cardiac Arrest, Circulation, vol.121, issue.9, pp.1134-1174, 2010.
DOI : 10.1161/CIRCULATIONAHA.109.899799