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Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors

Abstract : In this thesis work, injectable formulations forming in-situ an implant that entraps superparamagnetic microparticles are developed in view of treating solid tumors by inducing magnetically a local moderate hyperthermia. We first review physical, biological and clinical aspects of induced hyperthermia for cancer treatment, emphasizing electro-magnetic modalities. The in vitro and in vivo investigations of materials and their formulation is then presented. In the next chapter, we characterize the physico-chemical, magnetic and heating properties under an alternating magnetic field (115 kHz, 9 - 12 mT) of silica microparticles embedding superparamagnetic iron oxide nanoparticles (SPIONs) and of selected formulations thereof: an alginate hydrogel and an organogel oof poly(ethylene-co-vinyl alcohol) in dimethysulfoxide). Finally, we demonstrate the therapeutic potential of the superparamagnetic injectable organogel to treat subcutaneous necrotizing solid tumors of human colocarcinoma in a murine model by 20-min magnetic induction of local hyperthemia.
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https://tel.archives-ouvertes.fr/tel-00709676
Contributor : Pol-Edern Le Renard <>
Submitted on : Tuesday, June 19, 2012 - 11:15:47 AM
Last modification on : Friday, October 23, 2020 - 4:33:42 PM
Long-term archiving on: : Thursday, September 20, 2012 - 2:25:50 AM

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  • HAL Id : tel-00709676, version 1

Citation

Pol-Edern Le Renard. Injectable formulations forming an implant in situ as vehicle of silica microparticles embedding superparamagnetic iron oxide nanoparticles for the local, magnetically mediated hyperthermia treatment of solid tumors. Pharmacie galénique. University of Geneva, 2011. Français. ⟨tel-00709676⟩

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