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Feature selection based segmentation of multi-source images : application to brain tumor segmentation in multi-sequence MRI

Nan Zhang 1
1 MOTIVATE - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé : 139739
Abstract : Multi-spectral images have the advantage of providing complementary information to resolve some ambiguities. But, the challenge is how to make use of the multi-spectral images effectively. In this thesis, our study focuses on the fusion of multi-spectral images by extracting the most useful features to obtain the best segmentation with the least cost in time. The Support Vector Machine (SVM) classification integrated with a selection of the features in a kernel space is proposed. The selection criterion is defined by the kernel class separability. Based on this SVM classification, a framework to follow up brain tumor evolution is proposed, which consists of the following steps: to learn the brain tumors and select the features from the first magnetic resonance imaging (MRI) examination of the patients; to automatically segment the tumor in new data using a multi-kernel SVM based classification; to refine the tumor contour by a region growing technique; and to possibly carry out an adaptive training. The proposed system was tested on 13 patients with 24 examinations, including 72 MRI sequences and 1728 images. Compared with the manual traces of the doctors as the ground truth, the average classification accuracy reaches 98.9%. The system utilizes several novel feature selection methods to test the integration of feature selection and SVM classifiers. Also compared with the traditional SVM, Fuzzy C-means, the neural network and an improved level set method, the segmentation results and quantitative data analysis demonstrate the effectiveness of our proposed system.
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Nan Zhang. Feature selection based segmentation of multi-source images : application to brain tumor segmentation in multi-sequence MRI. Other. INSA de Lyon, 2011. English. ⟨NNT : 2011ISAL0079⟩. ⟨tel-00701545⟩

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