S. E. Allan, S. Q. Crome, N. K. Crellin, L. Passerini, T. S. Steiner et al., Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production, International Immunology, vol.19, issue.4, pp.345-354, 2007.
DOI : 10.1093/intimm/dxm014

K. Amin, D. Ludviksdottir, C. Janson, O. Nettelbladt, E. Bjornsson et al., Inflammation and Structural Changes in the Airways of Patients with Atopic and Nonatopic Asthma, American Journal of Respiratory and Critical Care Medicine, vol.162, issue.6, pp.2295-2301, 2000.
DOI : 10.1164/ajrccm.162.6.9912001

M. Anthoni, N. Fyhrquist-vanni, H. Wolff, H. Alenius, and A. Lauerma, Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity, 2008.

I. Apostolou, V. Boehmer, and H. , In Vivo Instruction of Suppressor Commitment in Naive T Cells, The Journal of Experimental Medicine, vol.155, issue.10, pp.1401-1408, 2004.
DOI : 10.1126/science.1078231

R. Bacchetta, E. Gambineri, and M. G. Roncarolo, Role of regulatory T cells and FOXP3 in human diseases, Journal of Allergy and Clinical Immunology, vol.120, issue.2, pp.227-235, 2007.
DOI : 10.1016/j.jaci.2007.06.023

H. Bagavant and K. S. Tung, Failure of CD25+ T Cells from Lupus-Prone Mice to Suppress Lupus Glomerulonephritis and Sialoadenitis, The Journal of Immunology, vol.175, issue.2, pp.944-950, 2005.
DOI : 10.4049/jimmunol.175.2.944

A. Barczyk, W. Pierzchala, and E. Sozanska, Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine, Respiratory Medicine, vol.97, issue.6, pp.726-733, 2003.
DOI : 10.1053/rmed.2003.1507

C. Boxall, S. T. Holgate, and D. E. Davies, The contribution of transforming growth factor-?? and epidermal growth factor signalling to airway remodelling in chronic asthma, European Respiratory Journal, vol.27, issue.1, pp.208-229, 2006.
DOI : 10.1183/09031936.06.00130004

D. D. Brand, K. A. Latham, R. , and E. F. , Collagen-induced arthritis, Nature Protocols, vol.118, issue.5, pp.1269-1275, 2007.
DOI : 10.1038/nprot.2007.173

J. H. Buckner, Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases, Nature Reviews Immunology, vol.3, issue.12, pp.849-859, 2010.
DOI : 10.1038/nri2889

M. A. Burchill, J. Yang, C. Vogtenhuber, B. R. Blazar, and M. A. Farrar, IL-2 Receptor ??-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells, The Journal of Immunology, vol.178, issue.1, pp.280-290, 2007.
DOI : 10.4049/jimmunol.178.1.280

J. G. Chai, J. Y. Tsang, R. Lechler, E. Simpson, J. Dyson et al., CD4+CD25+ T cells as immunoregulatory T cells in vitro, European Journal of Immunology, vol.32, issue.8, pp.2365-2375, 2002.
DOI : 10.1002/1521-4141(200208)32:8<2365::AID-IMMU2365>3.0.CO;2-2

A. Chaudhry, R. M. Samstein, P. Treuting, Y. Liang, M. C. Pils et al., Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation, Immunity, vol.34, issue.4, pp.566-578, 2011.
DOI : 10.1016/j.immuni.2011.03.018

Q. Chen, Y. C. Kim, A. Laurence, G. A. Punkosdy, and E. M. Shevach, IL-2 Controls the Stability of Foxp3 Expression in TGF-??-Induced Foxp3+ T Cells In Vivo, The Journal of Immunology, vol.186, issue.11, pp.6329-6337, 2011.
DOI : 10.4049/jimmunol.1100061

M. Colonna, G. Trinchieri, and Y. J. Liu, Plasmacytoid dendritic cells in immunity, Nature Immunology, vol.165, issue.12, pp.1219-1226, 2004.
DOI : 10.1038/32588

J. L. Coombes, K. R. Siddiqui, C. V. Arancibia-carcamo, J. Hall, C. M. Sun et al., regulatory T cells via a TGF-????? and retinoic acid???dependent mechanism, The Journal of Experimental Medicine, vol.204, issue.8, pp.1757-1764, 2007.
DOI : 10.1093/nar/29.9.e45

M. B. Datto, J. P. Frederick, L. Pan, A. J. Borton, Y. Zhuang et al., Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor ??-Mediated Signal Transduction, Molecular and Cellular Biology, vol.19, issue.4, pp.2495-2504, 1999.
DOI : 10.1128/MCB.19.4.2495

T. S. Davidson, R. J. Dipaolo, J. Andersson, and E. M. Shevach, Cutting Edge: IL-2 Is Essential for TGF-??-Mediated Induction of Foxp3+ T Regulatory Cells, The Journal of Immunology, vol.178, issue.7, pp.4022-4026, 2007.
DOI : 10.4049/jimmunol.178.7.4022

G. Discombe, CRITERIA OF EOSINOPHILIA, The Lancet, vol.247, issue.6389, 0195.
DOI : 10.1016/S0140-6736(46)91306-2

T. Doherty and D. Broide, Cytokines and growth factors in airway remodeling in asthma, Current Opinion in Immunology, vol.19, issue.6, pp.676-680, 2007.
DOI : 10.1016/j.coi.2007.07.017

D. Clos, T. W. Rubin, R. L. Tan, and E. M. , Monoclonal antibody for DNA measurement in biological fluids, Journal of Immunological Methods, vol.88, issue.2, pp.185-192, 1986.
DOI : 10.1016/0022-1759(86)90005-0

L. Fahlen, S. Read, L. Gorelik, S. D. Hurst, R. L. Coffman et al., regulatory T cells, The Journal of Experimental Medicine, vol.142, issue.5, pp.737-746, 2005.
DOI : 10.1074/jbc.M104521200

C. H. Fanta, Asthma, New England Journal of Medicine, vol.360, issue.10, pp.1002-1014, 2009.
DOI : 10.1056/NEJMra0804579

M. C. Fantini, C. Becker, G. Monteleone, F. Pallone, P. R. Galle et al., Cutting Edge: TGF-?? Induces a Regulatory Phenotype in CD4+CD25- T Cells through Foxp3 Induction and Down-Regulation of Smad7, The Journal of Immunology, vol.172, issue.9, pp.5149-5153, 2004.
DOI : 10.4049/jimmunol.172.9.5149

D. Favre, J. Mold, P. W. Hunt, B. Kanwar, P. Loke et al., Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease, Science Translational Medicine, vol.2, issue.32, pp.32-36, 2010.
DOI : 10.1126/scitranslmed.3000632

S. Floess, J. Freyer, C. Siewert, U. Baron, S. Olek et al., Epigenetic Control of the foxp3 Locus in Regulatory T Cells, PLoS Biology, vol.31, issue.2, p.38, 2007.
DOI : 10.1371/journal.pbio.0050038.st001

F. Flores-borja, E. C. Jury, C. Mauri, and M. R. Ehrenstein, Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis, Proceedings of the National Academy of Sciences, vol.105, issue.49, pp.19396-19401, 2008.
DOI : 10.1073/pnas.0806855105

J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nature Immunology, vol.4, issue.4, pp.330-336, 2003.
DOI : 10.1038/ni904

R. K. Gershon and K. Kondo, Cell interactions in the induction of tolerance: the role of thymic lymphocytes, Immunology, vol.18, pp.723-737, 1970.

E. Godebu, D. Summers-torres, M. M. Lin, B. J. Baaten, and L. M. Bradley, Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells, The Journal of Immunology, vol.181, issue.3, 2008.
DOI : 10.4049/jimmunol.181.3.1798
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025323

J. Haas, A. Hug, A. Viehover, B. Fritzsching, C. S. Falk et al., Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis, European Journal of Immunology, vol.169, issue.11, pp.3343-3352, 2005.
DOI : 10.1002/eji.200526065

D. Hartl, B. Koller, A. T. Mehlhorn, D. Reinhardt, T. Nicolai et al., Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in??pediatric asthma, Journal of Allergy and Clinical Immunology, vol.119, issue.5, pp.1258-1266, 2007.
DOI : 10.1016/j.jaci.2007.02.023

S. Haxhinasto, D. Mathis, and C. Benoist, cells, The Journal of Experimental Medicine, vol.70, issue.3, pp.565-574, 2008.
DOI : 10.1073/pnas.0409832102

M. H. Heemskerk, R. S. Hagedoorn, M. A. Van-der-hoorn, L. T. Van-der-veken, M. Hoogeboom et al., Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex, Blood, vol.109, issue.1, pp.235-243, 2007.
DOI : 10.1182/blood-2006-03-013318

T. Hellmark, J. L. Niles, A. B. Collins, R. T. Mccluskey, and C. Brunmark, Comparison of anti- GBM antibodies in sera with or without ANCA, J Am Soc Nephrol, vol.8, pp.376-385, 1997.

K. L. Hippen, S. C. Merkel, D. K. Schirm, C. Nelson, N. C. Tennis et al., Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease, American Journal of Transplantation, vol.11, issue.6, pp.1148-1157, 2011.
DOI : 10.1111/j.1600-6143.2011.03558.x

P. Hoffmann, T. J. Boeld, R. Eder, J. Huehn, S. Floess et al., stimulation, European Journal of Immunology, vol.159, issue.4, pp.1088-1097, 2009.
DOI : 10.1002/eji.200838904
URL : https://hal.archives-ouvertes.fr/inserm-00592522

D. A. Horwitz, S. G. Zheng, and J. D. Gray, Natural and TGF-?????induced Foxp3+CD4+ CD25+ regulatory T cells are not mirror images of each other, Trends in Immunology, vol.29, issue.9, pp.429-435, 2008.
DOI : 10.1016/j.it.2008.06.005

D. A. Horwitz, S. G. Zheng, J. D. Gray, J. H. Wang, K. Ohtsuka et al., Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease, Seminars in Immunology, vol.16, issue.2, pp.135-143, 2004.
DOI : 10.1016/j.smim.2003.12.009

W. J. Housley, C. O. Adams, F. C. Nichols, L. Puddington, E. G. Lingenheld et al., Natural but Not Inducible Regulatory T Cells Require TNF-?? Signaling for In Vivo Function, The Journal of Immunology, vol.186, issue.12, pp.6779-87, 2011.
DOI : 10.4049/jimmunol.1003868

E. N. Huter, G. H. Stummvoll, R. J. Dipaolo, D. D. Glass, and E. M. Shevach, Cutting Edge: Antigen-Specific TGF??-Induced Regulatory T Cells Suppress Th17-Mediated Autoimmune Disease, The Journal of Immunology, vol.181, issue.12, pp.8209-8213, 2008.
DOI : 10.4049/jimmunol.181.12.8209
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788513

C. Infante-duarte, H. F. Horton, M. C. Byrne, and T. Kamradt, Microbial Lipopeptides Induce the Production of IL-17 in Th Cells, The Journal of Immunology, vol.165, issue.11, pp.6107-6115, 2000.
DOI : 10.4049/jimmunol.165.11.6107

S. Jana, P. Jailwala, D. Haribhai, J. Waukau, S. Glisic et al., The role of NF-??B and Smad3 in TGF-??-mediated Foxp3 expression, European Journal of Immunology, vol.2, issue.9, pp.2571-2583, 2009.
DOI : 10.1002/eji.200939201

K. Kautz-neu, M. Noordegraaf, S. Dinges, C. L. Bennett, D. John et al., response, The Journal of Experimental Medicine, vol.163, issue.5, pp.885-891, 2011.
DOI : 10.1084/jem.20060956

J. M. Kel, M. J. Girard-madoux, B. Reizis, and B. E. Clausen, TGF-?? Is Required To Maintain the Pool of Immature Langerhans Cells in the Epidermis, The Journal of Immunology, vol.185, issue.6, pp.3248-3255, 2010.
DOI : 10.4049/jimmunol.1000981

H. P. Kim, L. , and W. J. , 73 CREB/ATF-Dependent T-cell Receptor-Induced FoxP3 Gene Expression: A Role for DNA Methylation, Cytokine, vol.39, issue.1, pp.1543-1551, 2007.
DOI : 10.1016/j.cyto.2007.07.078

C. Koenecke, N. Czeloth, A. Bubke, S. Schmitz, A. Kissenpfennig et al., and do not protect from experimental GVHD, European Journal of Immunology, vol.180, issue.11, pp.3091-3096, 2009.
DOI : 10.1002/eji.200939432
URL : https://hal.archives-ouvertes.fr/hal-00431886

M. Kumar, N. Putzki, V. Limmroth, R. Remus, M. Lindemann et al., CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis, Journal of Neuroimmunology, vol.180, issue.1-2, pp.178-184, 2006.
DOI : 10.1016/j.jneuroim.2006.08.003

M. Laan, L. Palmberg, K. Larsson, and A. Linden, Free, soluble interleukin-17 protein during severe inflammation in human airways, European Respiratory Journal, vol.19, issue.3, pp.534-537, 2002.
DOI : 10.1183/09031936.02.00280902

G. Lagna, A. Hata, A. Hemmati-brivanlou, and J. Massague, Partnership between DPC4 and SMAD proteins in TGF-?? signalling pathways, Nature, vol.383, issue.6603, pp.832-836, 1996.
DOI : 10.1038/383832a0

Q. Lan, H. Fan, V. Quesniaux, B. Ryffel, Z. Liu et al., Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?, Journal of Molecular Cell Biology, vol.4, issue.1, 2011.
DOI : 10.1093/jmcb/mjr039

M. Larche, Regulatory T Cells in Allergy and Asthma, Chest, vol.132, issue.3, pp.1007-1014, 2007.
DOI : 10.1378/chest.06-2434

A. Laurence, C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen et al., Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation, Immunity, vol.26, issue.3, pp.371-381, 2007.
DOI : 10.1016/j.immuni.2007.02.009
URL : http://doi.org/10.1016/j.immuni.2007.02.009

J. J. Letterio, A. G. Geiser, A. B. Kulkarni, H. Dang, L. Kong et al., Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression., Journal of Clinical Investigation, vol.98, issue.9, pp.2109-2119, 1996.
DOI : 10.1172/JCI119017

C. R. Li, M. F. Deiro, E. Godebu, and L. M. Bradley, IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-beta7-dependent localization, J Autoimmun, 2011.

S. Liang, P. Alard, Y. Zhao, S. Parnell, S. L. Clark et al., regulatory T cells in vivo requires B7 costimulation, but not the thymus, The Journal of Experimental Medicine, vol.162, issue.1, pp.127-137, 2005.
DOI : 10.1084/jem.20040249

E. M. Ling, T. Smith, X. D. Nguyen, C. Pridgeon, M. Dallman et al., Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease, The Lancet, vol.363, issue.9409, pp.608-615, 2004.
DOI : 10.1016/S0140-6736(04)15592-X

L. Lu, J. Ma, Z. Li, Q. Lan, M. Chen et al., All-Trans Retinoic Acid Promotes TGF-beta-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus, PLoS One, vol.6, 24590.

L. Lu, J. Ma, Z. Li, Q. Lan, M. Chen et al., All-Trans Retinoic Acid Promotes TGF-beta-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus, PLoS One, vol.6, 2011.

L. Lu, J. Ma, X. Wang, J. Wang, F. Zhang et al., Synergistic effect of TGF-?? superfamily members on the induction of Foxp3+ Treg, European Journal of Immunology, vol.261, issue.1, pp.142-152, 2010.
DOI : 10.1002/eji.200939618

T. R. Malek and A. L. Bayer, Tolerance, not immunity, crucially depends on IL-2, Nature Reviews Immunology, vol.9, issue.9, pp.665-674, 2004.
DOI : 10.1056/NEJM200007273430401

K. J. Maloy, L. Salaun, R. Cahill, G. Dougan, N. J. Saunders et al., Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms, The Journal of Experimental Medicine, vol.161, issue.1, pp.111-119, 2003.
DOI : 10.1034/j.1600-065X.2001.1820101.x
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193798

P. Y. Mantel, N. Ouaked, B. Ruckert, C. Karagiannidis, R. Welz et al., Molecular Mechanisms Underlying FOXP3 Induction in Human T Cells, The Journal of Immunology, vol.176, issue.6, pp.3593-3602, 2006.
DOI : 10.4049/jimmunol.176.6.3593

J. C. Marie, J. J. Letterio, M. Gavin, and A. Y. Rudensky, regulatory T cells, The Journal of Experimental Medicine, vol.145, issue.7, pp.1061-1067, 2005.
DOI : 10.1073/pnas.90.2.770

V. S. Marsden and A. Strasser, : Bcl-2, BH3-Only Proteins and More, Annual Review of Immunology, vol.21, issue.1, pp.71-105, 2003.
DOI : 10.1146/annurev.immunol.21.120601.141029

S. C. Mckarns, R. H. Schwartz, and N. E. Kaminski, Smad3 Is Essential for TGF-??1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation, The Journal of Immunology, vol.172, issue.7, pp.4275-4284, 2004.
DOI : 10.4049/jimmunol.172.7.4275

M. Miyara, Z. Amoura, C. Parizot, C. Badoual, K. Dorgham et al., Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus, The Journal of Immunology, vol.175, issue.12, pp.8392-8400, 2005.
DOI : 10.4049/jimmunol.175.12.8392

M. Miyara, Y. Yoshioka, A. Kitoh, T. Shima, K. Wing et al., Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor, Immunity, vol.30, issue.6, pp.899-911, 2009.
DOI : 10.1016/j.immuni.2009.03.019

S. Molet, Q. Hamid, F. Davoine, E. Nutku, R. Taha et al., IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines, Journal of Allergy and Clinical Immunology, vol.108, issue.3, pp.430-438, 2001.
DOI : 10.1067/mai.2001.117929

S. Monrad and M. J. Kaplan, Dendritic cells and the immunopathogenesis of systemic lupus erythematosus, Immunologic Research, vol.113, issue.2, pp.135-145, 2007.
DOI : 10.1007/BF02685895

J. E. Moorman, R. A. Rudd, C. A. Johnson, M. King, P. Minor et al., National surveillance for asthma--United States, MMWR Surveill Summ, vol.56, pp.1-54, 1980.

A. E. Morelli and A. W. Thomson, Tolerogenic dendritic cells and the quest for transplant tolerance, Nature Reviews Immunology, vol.5, issue.8, pp.610-621, 2007.
DOI : 10.1038/nri2132

M. E. Morgan, R. Flierman, L. M. Van-duivenvoorde, H. J. Witteveen, W. Van-ewijk et al., Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells, Arthritis & Rheumatism, vol.104, issue.7, pp.2212-2221, 2005.
DOI : 10.1002/art.21195

M. E. Morgan, R. P. Sutmuller, H. J. Witteveen, L. M. Van-duivenvoorde, E. Zanelli et al., CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis, Arthritis & Rheumatism, vol.39, issue.5, pp.1452-1460, 2003.
DOI : 10.1002/art.11063

S. Nakae, Y. Komiyama, A. Nambu, K. Sudo, M. Iwase et al., Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses, Immunity, vol.17, issue.3, pp.375-387, 2002.
DOI : 10.1016/S1074-7613(02)00391-6

K. D. Nguyen, C. Vanichsarn, A. Fohner, and K. C. Nadeau, Selective deregulation in chemokine signaling pathways of CD4+CD25hiCD127lo/??? regulatory T cells in human allergic asthma, Journal of Allergy and Clinical Immunology, vol.123, issue.4, pp.933-939, 2009.
DOI : 10.1016/j.jaci.2008.11.037

T. L. Nguyen, N. L. Sullivan, M. Ebel, R. M. Teague, and R. J. Dipaolo, Antigen-Specific TGF-??-Induced Regulatory T Cells Secrete Chemokines, Regulate T Cell Trafficking, and Suppress Ongoing Autoimmunity, The Journal of Immunology, vol.187, issue.4, pp.1745-1753, 2011.
DOI : 10.4049/jimmunol.1004112

O. Connor, R. A. Leech, M. D. Suffner, J. Hammerling, G. J. Anderton et al., Myelin-Reactive, TGF-??-Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo, The Journal of Immunology, vol.185, issue.12, pp.7235-7243, 2010.
DOI : 10.4049/jimmunol.1001551

M. T. Pallotta, C. Orabona, C. Volpi, C. Vacca, M. L. Belladonna et al., Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells, Nature Immunology, vol.171, issue.9, pp.870-878, 2011.
DOI : 10.1038/nm1196
URL : https://hal.archives-ouvertes.fr/hal-00664558

I. K. Park, J. J. Letterio, and J. D. Gorham, TGF-??1 inhibition of IFN-??-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent, Molecular Immunology, vol.44, issue.13, pp.3283-3290, 2007.
DOI : 10.1016/j.molimm.2007.02.024

C. Pasare and R. Medzhitov, Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells, Science, vol.299, issue.5609, pp.1033-1036, 2003.
DOI : 10.1126/science.1078231

C. Penaranda and J. A. Bluestone, Is antigen specificity of autoreactive T cells the key to islet entry? Immunity 31, pp.534-536, 2009.

C. A. Piccirillo, J. J. Letterio, A. M. Thornton, R. S. Mchugh, M. Mamura et al., Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor ??1 Production and Responsiveness, The Journal of Experimental Medicine, vol.163, issue.2, pp.237-246, 2002.
DOI : 10.1084/jem.20011629

C. Pot, L. Apetoh, and V. K. Kuchroo, Type 1 regulatory T cells (Tr1) in autoimmunity, Seminars in Immunology, vol.23, issue.3, 2011.
DOI : 10.1016/j.smim.2011.07.005

S. Read, R. Greenwald, A. Izcue, N. Robinson, D. Mandelbrot et al., Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo, The Journal of Immunology, vol.177, issue.7, pp.4376-4383, 2006.
DOI : 10.4049/jimmunol.177.7.4376

I. M. Richards, K. P. Kolbasa, G. E. Winterrowd, C. A. Hatfield, S. L. Vonderfecht et al., Role of intercellular adhesion molecule-1 in antigeninduced lung inflammation in brown Norway rats, Am J Physiol, vol.271, pp.267-276, 1996.

S. Romagnani, Regulation of the T cell response, Clinical & Experimental Allergy, vol.71, issue.11, pp.1357-1366, 2006.
DOI : 10.1172/JCI28508

Y. P. Rubtsov and A. Y. Rudensky, TGF?? signalling in control of T-cell-mediated self-reactivity, Nature Reviews Immunology, vol.8, issue.6, pp.443-453, 2007.
DOI : 10.1038/nri2095

S. Sakaguchi, Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self, Nature Immunology, vol.168, issue.4, pp.345-352, 2005.
DOI : 10.1016/1074-7613(95)90125-6

S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J Immunol, vol.155, pp.1151-1164, 1995.

S. Sauer, L. Bruno, A. Hertweck, D. Finlay, M. Leleu et al., T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR, Proceedings of the National Academy of Sciences, vol.105, issue.22, pp.7797-7802, 2008.
DOI : 10.1073/pnas.0800928105

K. J. Scalapino, Q. Tang, J. A. Bluestone, M. L. Bonyhadi, and D. I. Daikh, Suppression of Disease in New Zealand Black/New Zealand White Lupus-Prone Mice by Adoptive Transfer of Ex Vivo Expanded Regulatory T Cells, The Journal of Immunology, vol.177, issue.3, pp.1451-1459, 2006.
DOI : 10.4049/jimmunol.177.3.1451

N. Seddiki, B. Santner-nanan, J. Martinson, J. Zaunders, S. Sasson et al., Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells, The Journal of Experimental Medicine, vol.66, issue.7, pp.1693-1700, 2006.
DOI : 10.1002/eji.200425763

R. K. Selvaraj and T. L. Geiger, Mitigation of Experimental Allergic Encephalomyelitis by TGF-?? Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance, The Journal of Immunology, vol.180, issue.5, pp.2830-2838, 2008.
DOI : 10.4049/jimmunol.180.5.2830

K. Serre, C. Benezech, G. Desanti, S. Bobat, K. M. Toellner et al., Helios Is Associated with CD4 T Cells Differentiating to T Helper 2 and Follicular Helper T Cells In Vivo Independently of Foxp3 Expression, PLoS ONE, vol.187, issue.6, 2011.
DOI : 10.1371/journal.pone.0020731.s002

A. Shustov, P. Nguyen, F. Finkelman, K. B. Elkon, and C. S. Via, Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease: up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production, J Immunol, vol.161, pp.2848-2855, 1998.

T. So and M. Croft, Cutting Edge: OX40 Inhibits TGF-??- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells, The Journal of Immunology, vol.179, issue.3, pp.1427-1430, 2007.
DOI : 10.4049/jimmunol.179.3.1427

C. L. Swanson, T. J. Wilson, P. Strauch, M. Colonna, R. Pelanda et al., Type I IFN enhances follicular B cell contribution to the T cell???independent antibody response, The Journal of Experimental Medicine, vol.14, issue.7, pp.1485-1500, 2010.
DOI : 10.1002/immu.200310003

T. Takimoto, Y. Wakabayashi, T. Sekiya, N. Inoue, R. Morita et al., Smad2 and Smad3 Are Redundantly Essential for the TGF-??-Mediated Regulation of Regulatory T Plasticity and Th1 Development, The Journal of Immunology, vol.185, issue.2, pp.842-855, 2010.
DOI : 10.4049/jimmunol.0904100

Q. Tang and J. A. Bluestone, The Foxp3+ regulatory T cell: a jack of all trades, master of regulation, Nature Immunology, vol.166, issue.3, pp.239-244, 2008.
DOI : 10.1038/ni1572

A. M. Thornton, P. E. Korty, D. Q. Tran, E. A. Wohlfert, P. E. Murray et al., Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells, The Journal of Immunology, vol.184, issue.7, pp.3433-3441, 2010.
DOI : 10.4049/jimmunol.0904028

A. M. Thornton and E. M. Shevach, Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific, The Journal of Immunology, vol.164, issue.1, pp.183-190, 2000.
DOI : 10.4049/jimmunol.164.1.183

Y. Tone, K. Furuuchi, Y. Kojima, M. L. Tykocinski, M. I. Greene et al., Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer, Nature Immunology, vol.85, issue.2, pp.194-202, 2008.
DOI : 10.1038/ni1549

H. Torres-aguilar, S. R. Aguilar-ruiz, G. Gonzalez-perez, R. Munguia, S. Bajana et al., T Cells, The Journal of Immunology, vol.184, issue.4, pp.1765-1775, 2010.
DOI : 10.4049/jimmunol.0902133

M. Tritt, E. Sgouroudis, E. Hennezel, A. Albanese, and C. A. Piccirillo, Functional Waning of Naturally Occurring CD4+ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes, Diabetes, vol.57, issue.1, pp.113-123, 2008.
DOI : 10.2337/db06-1700

M. Tsuji, N. Komatsu, S. Kawamoto, K. Suzuki, O. Kanagawa et al., Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches, Science, vol.323, issue.5920, pp.1488-1492, 2009.
DOI : 10.1126/science.1169152

X. Valencia, G. Stephens, R. Goldbach-mansky, M. Wilson, E. M. Shevach et al., TNF downmodulates the function of human CD4+CD25hi T-regulatory cells, Blood, vol.108, issue.1, pp.253-261, 2006.
DOI : 10.1182/blood-2005-11-4567

J. M. Van-amelsfort, K. M. Jacobs, J. W. Bijlsma, F. P. Lafeber, and L. S. Taams, CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid, Arthritis & Rheumatism, vol.159, issue.9, pp.2775-2785, 2004.
DOI : 10.1002/art.20499

A. J. Van-oosterhout and N. Bloksma, Regulatory T-lymphocytes in asthma, European Respiratory Journal, vol.26, issue.5, pp.918-932, 2005.
DOI : 10.1183/09031936.05.00011205

V. Viglietta, C. Baecher-allan, H. L. Weiner, and D. A. Hafler, Regulatory T Cells in Patients with Multiple Sclerosis, The Journal of Experimental Medicine, vol.160, issue.7, pp.971-979, 2004.
DOI : 10.1016/S0896-8411(03)00117-3

A. Wakkach, N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez et al., Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo, Immunity, vol.18, issue.5, pp.605-617, 2003.
DOI : 10.1016/S1074-7613(03)00113-4

Y. Y. Wan and R. A. Flavell, Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression, Nature, vol.21, issue.7129, pp.766-770, 2007.
DOI : 10.1038/nature05479

S. E. Weber, J. Harbertson, E. Godebu, G. A. Mros, R. C. Padrick et al., Adaptive Islet-Specific Regulatory CD4 T Cells Control Autoimmune Diabetes and Mediate the Disappearance of Pathogenic Th1 Cells In Vivo, The Journal of Immunology, vol.176, issue.8, pp.4730-4739, 2006.
DOI : 10.4049/jimmunol.176.8.4730

R. S. Wildin, F. Ramsdell, J. Peake, F. Faravelli, J. L. Casanova et al., X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy, Nature Genetics, vol.27, issue.1, pp.18-20, 2001.
DOI : 10.1038/83707

C. K. Wong, C. Y. Ho, F. W. Ko, C. H. Chan, A. S. Ho et al., Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma, Clinical and Experimental Immunology, vol.14, issue.2, pp.177-183, 2001.
DOI : 10.1067/mai.2000.107038

J. L. Wrana, L. Attisano, J. Carcamo, A. Zentella, J. Doody et al., TGF?? signals through a heteromeric protein kinase receptor complex, Cell, vol.71, issue.6, pp.1003-1014, 1992.
DOI : 10.1016/0092-8674(92)90395-S

Y. Wu, M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan et al., FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT, Cell, vol.126, issue.2, pp.375-387, 2006.
DOI : 10.1016/j.cell.2006.05.042
URL : http://doi.org/10.1016/j.cell.2006.05.042

L. Xu, A. Kitani, I. Fuss, and W. Strober, Cutting Edge: Regulatory T Cells Induce CD4+CD25-Foxp3- T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-??, The Journal of Immunology, vol.178, issue.11, pp.6725-6729, 2007.
DOI : 10.4049/jimmunol.178.11.6725

L. Xu, A. Kitani, C. Stuelten, G. Mcgrady, I. Fuss et al., Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer I, Immunity, vol.33, issue.3, pp.313-325, 2010.
DOI : 10.1016/j.immuni.2010.09.001

K. Xue, Y. Zhou, S. Xiong, W. Xiong, and T. Tang, Analysis of CD4+CD25+ regulatory T cells and Foxp3 mRNA in the peripheral blood of patients with asthma, Journal of Huazhong University of Science and Technology, vol.106, issue.12, pp.31-33, 2007.
DOI : 10.1007/s11596-007-0109-y

S. Yamagiwa, J. D. Gray, S. Hashimoto, and D. A. Horwitz, A Role for TGF-?? in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood, The Journal of Immunology, vol.166, issue.12, pp.7282-7289, 2001.
DOI : 10.4049/jimmunol.166.12.7282

B. Yan, S. Ye, G. Chen, M. Kuang, N. Shen et al., Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-?????producing antigen-presenting cells, Arthritis & Rheumatism, vol.115, issue.3, pp.801-812, 2008.
DOI : 10.1002/art.23268

Z. Yao, Y. Kanno, M. Kerenyi, G. Stephens, L. Durant et al., Nonredundant roles for Stat5a/b in directly regulating Foxp3, Blood, vol.109, issue.10, pp.4368-4375, 2007.
DOI : 10.1182/blood-2006-11-055756

S. L. Yu, C. K. Wong, P. T. Wong, D. P. Chen, C. C. Szeto et al., Down-Regulated NOD2 by Immunosuppressants in Peripheral Blood Cells in Patients with SLE Reduces the Muramyl Dipeptide-Induced IL-10 Production, PLoS ONE, vol.80, issue.8, 2011.
DOI : 10.1371/journal.pone.0023855.t006

Y. E. Zhang, Non-Smad pathways in TGF-?? signaling, Cell Research, vol.18, issue.1, pp.128-139, 2009.
DOI : 10.1042/0264-6021:3530417
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635127

S. G. Zheng, Emerging topics and new perspectives on regulatory and effector T cells, Journal of Molecular Cell Biology, vol.4, issue.1, 2011.
DOI : 10.1093/jmcb/mjr044

S. G. Zheng, J. D. Gray, K. Ohtsuka, S. Yamagiwa, and D. A. Horwitz, Generation Ex Vivo of TGF-??-Producing Regulatory T Cells from CD4+CD25- Precursors, The Journal of Immunology, vol.169, issue.8, pp.4183-4189, 2002.
DOI : 10.4049/jimmunol.169.8.4183

S. G. Zheng, L. Meng, J. H. Wang, M. Watanabe, M. L. Barr et al., Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient, International Immunology, vol.18, issue.2, pp.279-289, 2006.
DOI : 10.1093/intimm/dxh368

S. G. Zheng, J. Wang, and D. A. Horwitz, Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-?? Are Resistant to Th17 Conversion by IL-6, The Journal of Immunology, vol.180, issue.11, pp.7112-7116, 2008.
DOI : 10.4049/jimmunol.180.11.7112

S. G. Zheng, J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz, IL-2 Is Essential for TGF-?? to Convert Naive CD4+CD25- Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells, The Journal of Immunology, vol.178, issue.4, pp.2018-2027, 2007.
DOI : 10.4049/jimmunol.178.4.2018

S. G. Zheng, J. H. Wang, J. D. Gray, H. Soucier, and D. A. Horwitz, Natural and Induced CD4+CD25+ Cells Educate CD4+CD25- Cells to Develop Suppressive Activity: The Role of IL-2, TGF-??, and IL-10, The Journal of Immunology, vol.172, issue.9, pp.5213-5221, 2004.
DOI : 10.4049/jimmunol.172.9.5213

S. G. Zheng, J. H. Wang, M. N. Koss, F. Quismorio, . Jr et al., CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-?? Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome, The Journal of Immunology, vol.172, issue.3, pp.1531-1539, 2004.
DOI : 10.4049/jimmunol.172.3.1531

S. G. Zheng, J. H. Wang, W. Stohl, K. S. Kim, J. D. Gray et al., TGF-?? Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells, The Journal of Immunology, vol.176, issue.6, pp.3321-3329, 2006.
DOI : 10.4049/jimmunol.176.6.3321

Y. Zheng, S. Josefowicz, A. Chaudhry, X. P. Peng, K. Forbush et al., Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate, Nature, vol.204, issue.7282, pp.808-812, 2010.
DOI : 10.1038/nature08750

X. Zhou, N. Kong, H. Zou, D. Brand, X. Li et al., regulatory T cells in autoimmune diseases, Autoimmunity, vol.158, issue.1, pp.43-50, 2011.
DOI : 10.1016/j.immuni.2009.04.006

X. Zhou, J. Wang, W. Shi, D. D. Brand, Z. Liu et al., Isolation of Purified and Live Foxp3+ Regulatory T Cells using FACS Sorting on Scatter Plot, Journal of Molecular Cell Biology, vol.2, issue.3, pp.164-169, 2010.
DOI : 10.1093/jmcb/mjq007

E. Zorn, E. A. Nelson, M. Mohseni, F. Porcheray, H. Kim et al., IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo, Blood, vol.108, issue.5, pp.1571-1579, 2006.
DOI : 10.1182/blood-2006-02-004747