L. Mn7, # R>S;<81#8?#O>8:B#6735;81#18?1# ;0O>6?2#256?1;5021#6?L18?1

L. H>, L+M"!32BC5HC-33

A. Aizer, Y. Brody, L. Ler, N. Sonenberg, R. Singer et al., The Dynamics of Mammalian P Body Transport, Assembly, and Disassembly In Vivo, Molecular Biology of the Cell, vol.19, issue.10, pp.4154-4166, 2008.
DOI : 10.1091/mbc.E08-05-0513

Y. Altuvia, P. Landgraf, G. Lithwick, N. Elefant, S. Pfeffer et al., Clustering and conservation patterns of human microRNAs, Nucleic Acids Research, vol.33, issue.8, pp.2697-2706, 2005.
DOI : 10.1093/nar/gki567

M. Andrei, D. Ingelfinger, R. Heintzmann, T. Achsel, R. Rivera-pomar et al., A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies, RNA, vol.11, issue.5, pp.717-727, 2005.
DOI : 10.1261/rna.2340405

A. Audibert, D. Weil, and F. Dautry, In Vivo Kinetics of mRNA Splicing and Transport in Mammalian Cells, Molecular and Cellular Biology, vol.22, issue.19, pp.6706-6718, 2002.
DOI : 10.1128/MCB.22.19.6706-6718.2002

T. Lagrange and O. Voinnet, Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein, Genes Dev, vol.24, pp.904-915, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00788111

D. Baek, J. Villen, C. Shin, F. Camargo, S. Gygi et al., The impact of microRNAs on protein output, Nature, vol.35, issue.7209, pp.64-71, 2008.
DOI : 10.1038/nature07242

D. Banerjee and F. Slack, Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression, BioEssays, vol.286, issue.2, pp.119-129, 2002.
DOI : 10.1002/bies.10046

V. Barbu and F. Dautry, Northern blot normalization with a 28S rRNA olinucleotide probe, Nucleic Acids Research, vol.17, issue.17, p.7115, 1989.
DOI : 10.1093/nar/17.17.7115

D. Bartel, MicroRNAs: Target Recognition and Regulatory Functions, Cell, vol.136, issue.2, pp.215-233, 2009.
DOI : 10.1016/j.cell.2009.01.002

I. Behm-ansmant, J. Rehwinkel, T. Doerks, A. Stark, P. Bork et al., mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1, p.2, 2006.

E. Bernstein, A. Caudy, S. Hammond, and G. Hannon, Role for a bidentate ribonuclease in the initiation step of RNA interference, Nature, vol.409, issue.6818, pp.363-366, 2001.
DOI : 10.1038/35053110

K. Bohmert, I. Camus, C. Bellini, D. Bouchez, M. Caboche et al., AGO1 defines a novel locus of Arabidopsis controlling leaf development, The EMBO Journal, vol.17, issue.1, pp.170-180, 1998.
DOI : 10.1093/emboj/17.1.170

G. Borchert, W. Lanier, and B. Davidson, RNA polymerase III transcribes human microRNAs, Nature Structural & Molecular Biology, vol.13, issue.12, pp.1097-1101, 2006.
DOI : 10.1038/nsmb1167

J. Bosher, P. Dufourcq, S. Sookhareea, and M. Labouesse, RNA interference can target pre-mRNA: consequences for gene expression in a Caenorhabditis elegans operon, Genetics, vol.153, pp.1245-1256, 1999.

J. Brennecke, D. Hipfner, A. Stark, R. Russell, and S. Cohen, bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila, Cell, vol.113, issue.1, pp.25-36, 2003.
DOI : 10.1016/S0092-8674(03)00231-9

J. Broderick, W. Salomon, S. Ryder, N. Aronin, and P. Zamore, Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing, RNA, vol.17, issue.10, pp.1858-1869, 2011.
DOI : 10.1261/rna.2778911

P. Brodersen, L. Sakvarelidze-achard, M. Bruun-rasmussen, P. Dunoyer, Y. Yamamoto et al., Widespread Translational Inhibition by Plant miRNAs and siRNAs, Science, vol.320, issue.5880, pp.1185-1190, 2008.
DOI : 10.1126/science.1159151

P. Brodersen and O. Voinnet, Revisiting the principles of microRNA target recognition and mode of action, Nature Reviews Molecular Cell Biology, vol.125, issue.2, pp.141-148, 2009.
DOI : 10.1038/nrm2619

URL : https://hal.archives-ouvertes.fr/hal-00370008

M. Buhler, A. Verdel, and D. Moazed, Tethering RITS to a Nascent Transcript Initiates RNAi- and Heterochromatin-Dependent Gene Silencing, Cell, vol.125, issue.5, pp.873-886, 2006.
DOI : 10.1016/j.cell.2006.04.025

URL : https://hal.archives-ouvertes.fr/inserm-00332367

J. Camblong, N. Iglesias, C. Fickentscher, G. Dieppois, and F. Stutz, Antisense RNA Stabilization Induces Transcriptional Gene Silencing via Histone Deacetylation in S. cerevisiae, Cell, vol.131, issue.4, pp.706-717, 2007.
DOI : 10.1016/j.cell.2007.09.014

D. Castanotto, S. Tommasi, M. Li, H. Li, S. Yanow et al., Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells, Molecular Therapy, vol.12, issue.1, pp.179-183, 2005.
DOI : 10.1016/j.ymthe.2005.03.003

A. Caudy, R. Ketting, S. Hammond, A. Denli, A. Bathoorn et al., A micrococcal nuclease homologue in RNAi effector complexes, Nature, vol.425, issue.6956, pp.411-414, 2003.
DOI : 10.1038/nature01956

M. Chekulaeva and W. Filipowicz, Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells, Current Opinion in Cell Biology, vol.21, issue.3, pp.452-460, 2009.
DOI : 10.1016/j.ceb.2009.04.009

C. Chen, D. Zheng, Z. Xia, and A. Shyu, Ago???TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps, Nature Structural & Molecular Biology, vol.59, issue.11, pp.1160-1166, 2009.
DOI : 10.1093/emboj/17.12.3461

T. Chendrimada, K. Finn, J. X. Baillat, D. Gregory, R. Liebhaber et al., MicroRNA silencing through RISC recruitment of eIF6, Nature, vol.23, issue.7146, pp.823-828, 2007.
DOI : 10.1038/nature05841

Y. Chu, X. Yue, S. Younger, B. Janowski, and D. Corey, Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter, Nucleic Acids Research, vol.38, issue.21, pp.7736-7748, 2010.
DOI : 10.1093/nar/gkq648

M. Clark, P. Amaral, F. Schlesinger, M. Dinger, R. Taft et al., The Reality of Pervasive Transcription, PLoS Biology, vol.25, issue.7, p.1000625, 2011.
DOI : 10.1371/journal.pbio.1000625.s008

N. Cougot, S. Babajko, and B. Seraphin, Cytoplasmic foci are sites of mRNA decay in human cells, The Journal of Cell Biology, vol.115, issue.1, pp.31-40, 2004.
DOI : 10.1016/S0962-8924(01)01982-1

A. Denli, B. Tops, R. Plasterk, R. Ketting, and G. Hannon, Processing of primary microRNAs by the Microprocessor complex, Nature, vol.432, issue.7014, pp.231-235, 2004.
DOI : 10.1016/0014-4827(86)90560-4

L. Ding, A. Spencer, K. Morita, and M. Han, The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans, Molecular Cell, vol.19, issue.4, pp.437-447, 2005.
DOI : 10.1016/j.molcel.2005.07.013

S. Ding and O. Voinnet, Antiviral Immunity Directed by Small RNAs, Cell, vol.130, issue.3, pp.413-426, 2007.
DOI : 10.1016/j.cell.2007.07.039

URL : https://hal.archives-ouvertes.fr/hal-00176625

I. Djupedal, M. Portoso, H. Spahr, C. Bonilla, C. Gustafsson et al., RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing, Genes & Development, vol.19, issue.19, pp.2301-2306, 2005.
DOI : 10.1101/gad.344205

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240039

S. Djuranovic, A. Nahvi, and R. Green, A Parsimonious Model for Gene Regulation by miRNAs, Science, vol.331, issue.6017, 2011.
DOI : 10.1126/science.1191138

J. Doench and P. Sharp, Specificity of microRNA target selection in translational repression, Genes & Development, vol.18, issue.5, 2004.
DOI : 10.1101/gad.1184404

T. Lagrange, Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components, Genes Dev, vol.21, pp.2539-2544, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00198842

S. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber et al., Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells, Nature, vol.411, issue.6836, pp.494-498, 2001.
DOI : 10.1038/35078107

A. Eulalio, I. Behm-ansmant, D. Schweizer, and E. Izaurralde, P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing, Molecular and Cellular Biology, vol.27, issue.11, pp.3970-3981, 2007.
DOI : 10.1128/MCB.00128-07

A. Eulalio, E. Huntzinger, and E. Izaurralde, GW182 interaction with Argonaute is essential for Bibliographie 183, 2008.

A. Eulalio, J. Rehwinkel, M. Stricker, E. Huntzinger, S. Yang et al., Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing, Genes & Development, vol.21, issue.20, pp.2558-2570, 2007.
DOI : 10.1101/gad.443107

A. Eulalio, F. Tritschler, R. Buttner, O. Weichenrieder, E. Izaurralde et al., The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing, Nucleic Acids Research, vol.37, issue.9, pp.2974-2983, 2009.
DOI : 10.1093/nar/gkp173

A. Eulalio, F. Tritschler, and E. Izaurralde, The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing, RNA, vol.15, issue.8, pp.1433-1442, 2009.
DOI : 10.1261/rna.1703809

T. Eystathioy, E. Chan, S. Tenenbaum, J. Keene, K. Griffith et al., A Phosphorylated Cytoplasmic Autoantigen, GW182, Associates with a Unique Population of Human mRNAs within Novel Cytoplasmic Speckles, Molecular Biology of the Cell, vol.13, issue.4, pp.1338-1351, 2002.
DOI : 10.1091/mbc.01-11-0544

T. Eystathioy, A. Jakymiw, E. Chan, B. Seraphin, N. Cougot et al., The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and, 2003.

M. Fabian, G. Mathonnet, T. Sundermeier, H. Mathys, J. Zipprich et al., Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation, Molecular Cell, vol.35, issue.6, pp.868-880, 2009.
DOI : 10.1016/j.molcel.2009.08.004

A. Fire, S. Xu, M. Montgomery, S. Kostas, S. Driver et al., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, vol.391, issue.6669, pp.806-811, 1998.
DOI : 10.1038/35888

N. Gehring, M. Hentze, and A. Kulozik, Chapter 23 Tethering Assays to Investigate Nonsense???Mediated mRNA Decay Activating Proteins, Methods Enzymol, vol.448, pp.467-482, 2008.
DOI : 10.1016/S0076-6879(08)02623-2

D. Gibbings, C. Ciaudo, M. Erhardt, and O. Voinnet, Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity, Nature Cell Biology, vol.110, issue.9, pp.1143-1149, 2009.
DOI : 10.1016/S0168-9525(03)00140-9

URL : https://hal.archives-ouvertes.fr/hal-00423288

A. Giner, L. Lakatos, M. Garcia-chapa, J. Lopez-moya, and J. Burgyan, Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW Motifs, PLoS Pathogens, vol.142, issue.7, p.1000996, 2010.
DOI : 10.1371/journal.ppat.1000996.s003

P. Gondran, F. Amiot, D. Weil, and F. Dautry, Accumulation of mature mRNA in the nuclear fraction of mammalian cells, FEBS Letters, vol.110, issue.3, pp.324-328, 1999.
DOI : 10.1016/S0014-5793(99)01175-8

R. Gregory, K. Yan, G. Amuthan, T. Chendrimada, B. Doratotaj et al., The Microprocessor complex mediates the genesis of microRNAs, Nature, vol.12, issue.7014, pp.235-240, 2004.
DOI : 10.1038/nature03120

S. Grewal and S. Elgin, Transcription and RNA interference in the formation of heterochromatin, Nature, vol.282, issue.7143, pp.399-406, 2007.
DOI : 10.1038/nature05914

D. Grimm, K. Streetz, C. Jopling, T. Storm, K. Pandey et al., Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways, Nature, vol.78, issue.7092, pp.537-541, 2006.
DOI : 10.1038/nature04791

A. Grishok, J. Sinskey, and P. Sharp, Transcriptional silencing of a transgene by RNAi in the soma of C. elegans, Genes & Development, vol.19, issue.6, pp.683-696, 2005.
DOI : 10.1101/gad.1247705

H. Guo, N. Ingolia, J. Weissman, and D. Bartel, Mammalian microRNAs predominantly act to decrease target mRNA levels, Nature, vol.5, issue.7308, pp.835-840, 2010.
DOI : 10.1038/nature09267

A. Haase, L. Jaskiewicz, H. Zhang, S. Laine, R. Sack et al., TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing, EMBO reports, vol.3, issue.10, 2005.
DOI : 10.1038/9684

A. Hamilton and D. Baulcombe, A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants, Science, vol.286, issue.5441, pp.950-952, 1999.
DOI : 10.1126/science.286.5441.950

S. Hammond, E. Bernstein, D. Beach, and G. Hannon, An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells, Nature, vol.404, pp.293-296, 2000.

S. Hammond, S. Boettcher, A. Caudy, R. Kobayashi, and G. Hannon, Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi, Science, vol.293, issue.5532, pp.1146-1150, 2001.
DOI : 10.1126/science.1064023

J. Han, D. Kim, and K. Morris, Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells, Proceedings of the National Academy of Sciences, vol.104, issue.30, pp.12422-12427, 2007.
DOI : 10.1073/pnas.0701635104

B. Hassel, A. Zhou, C. Sotomayor, A. Maran, and R. Silverman, A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon, EMBO J, vol.12, pp.3297-3304, 1993.

P. Hawkins, S. Santoso, C. Adams, V. Anest, and K. Morris, Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells, Nucleic Acids Research, vol.37, issue.9, pp.2984-2995, 2009.
DOI : 10.1093/nar/gkp127

L. He and G. Hannon, MicroRNAs: small RNAs with a big role in gene regulation, Nature Reviews Genetics, vol.1, issue.7, pp.522-531, 2004.
DOI : 10.1038/nature02363

S. Lowe, G. Hannon, and S. Hammond, A microRNA polycistron as a potential human oncogene, Nature, vol.435, pp.828-833, 2005.

J. Hock, L. Weinmann, C. Ender, S. Rudel, E. Kremmer et al., Proteomic and functional analysis of Argonaute-containing mRNA???protein complexes in human cells, EMBO reports, vol.4, issue.11, pp.1052-1060, 2007.
DOI : 10.1126/science.1111444

L. Huang, S. Mollet, S. Souquere, L. Roy, F. Ernoult-lange et al., Mitochondria Associate with P-bodies and Modulate MicroRNA-mediated RNA Interference, Journal of Biological Chemistry, vol.286, issue.27, pp.24219-24230, 2011.
DOI : 10.1074/jbc.M111.240259

E. Huntzinger, J. Braun, S. Heimstadt, L. Zekri, and E. Izaurralde, Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing, The EMBO Journal, vol.11, issue.24, pp.4146-4160, 2010.
DOI : 10.1261/rna.1448009

T. Iida, J. Nakayama, and D. Moazed, siRNA-Mediated Heterochromatin Establishment Requires HP1 and Is Associated with Antisense Transcription, Molecular Cell, vol.31, issue.2, pp.178-189, 2008.
DOI : 10.1016/j.molcel.2008.07.003

D. Irvine, M. Zaratiegui, N. Tolia, D. Goto, D. Chitwood et al., Argonaute Slicing Is Required for Heterochromatic Silencing and Spreading, Science, vol.313, issue.5790, pp.1134-1137, 2006.
DOI : 10.1126/science.1128813

B. Janowski, K. Huffman, J. Schwartz, R. Ram, R. Nordsell et al., Involvement of AGO1 and AGO2 in mammalian transcriptional silencing, Nature Structural & Molecular Biology, vol.1, issue.9, pp.787-792, 2006.
DOI : 10.1038/nature02519

B. Janowski, S. Younger, D. Hardy, R. R. Huffman, K. Corey et al., Activating gene expression in mammalian cells with promoter-targeted duplex RNAs, Nature Chemical Biology, vol.60, issue.3, pp.166-173, 2007.
DOI : 10.1073/pnas.0607015103

S. Johnson, H. Grosshans, J. Shingara, M. Byrom, R. Jarvis et al., RAS Is Regulated by the let-7 MicroRNA Family, Cell, vol.120, issue.5, pp.635-647, 2005.
DOI : 10.1016/j.cell.2005.01.014

M. Jones-rhoades, D. Bartel, B. Bartel, A. Micrornas, . Their et al., MicroRNAs AND THEIR REGULATORY ROLES IN PLANTS, Annual Review of Plant Biology, vol.57, issue.1, pp.19-53, 2006.
DOI : 10.1146/annurev.arplant.57.032905.105218

H. Kawasaki and K. Taira, Induction of DNA methylation and gene silencing by short interfering RNAs in human cells, Nature, vol.6, issue.7005, pp.211-217, 2004.
DOI : 10.1016/S0960-9822(02)00792-3

N. Kedersha, G. Stoecklin, M. Ayodele, P. Yacono, J. Lykke-andersen et al., Stress granules and processing bodies are dynamically linked sites of mRNP remodeling, The Journal of Cell Biology, vol.20, issue.6, pp.871-884, 2005.
DOI : 10.1242/jcs.01477

J. Kennerdell and R. Carthew, Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway, Cell, vol.95, issue.7, pp.1017-1026, 1998.
DOI : 10.1016/S0092-8674(00)81725-0

A. Khvorova, A. Reynolds, and S. Jayasena, Functional siRNAs and miRNAs Exhibit Strand Bias, Cell, vol.115, issue.2, pp.209-216, 2003.
DOI : 10.1016/S0092-8674(03)00801-8

D. Kim, P. Saetrom, O. Snove, J. Rossi, and J. , MicroRNA-directed transcriptional gene silencing in mammalian cells, Proceedings of the National Academy of Sciences, vol.105, issue.42, pp.16230-16235, 2008.
DOI : 10.1073/pnas.0808830105

D. Kim, L. Villeneuve, K. Morris, and J. Rossi, Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells, Nature Structural & Molecular Biology, vol.251, issue.9, pp.793-797, 2006.
DOI : 10.1016/j.cell.2006.01.036

V. Kim, Small RNAs: classification, biogenesis, and function, Mol Cells, vol.19, pp.1-15, 2005.

M. Kiriakidou, G. Tan, S. Lamprinaki, D. Planell-saguer, M. Nelson et al., An mRNA m7G Cap Binding-like Motif within Human Ago2 Represses Translation, Cell, vol.129, issue.6, pp.1141-1151, 2007.
DOI : 10.1016/j.cell.2007.05.016

J. Kooter, M. Matzke, and P. Meyer, Listening to the silent genes: transgene silencing, gene regulation and pathogen control, Trends in Plant Science, vol.4, issue.9, pp.340-347, 1999.
DOI : 10.1016/S1360-1385(99)01467-3

D. Lazzaretti, I. Tournier, and E. Izaurralde, The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins, RNA, vol.15, issue.6, pp.1059-1066, 2009.
DOI : 10.1261/rna.1606309

R. Lee, R. Feinbaum, and A. V. , The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, vol.75, issue.5, pp.843-854, 1993.
DOI : 10.1016/0092-8674(93)90529-Y

URL : https://hal.archives-ouvertes.fr/in2p3-00597159

A. Leung, J. Calabrese, and P. Sharp, Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules, Proceedings of the National Academy of Sciences, vol.103, issue.48, pp.18125-18130, 2006.
DOI : 10.1073/pnas.0608845103

D. Levin and I. London, Regulation of protein synthesis: Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2, Proceedings of the National Academy of Sciences, vol.75, issue.3, pp.1121-1125, 1978.
DOI : 10.1073/pnas.75.3.1121

L. Li, S. Okino, H. Zhao, D. Pookot, R. Place et al., Small dsRNAs induce transcriptional activation in human cells, Proceedings of the National Academy of Sciences, vol.103, issue.46, pp.17337-17342, 2006.
DOI : 10.1073/pnas.0607015103

S. Li, S. Lian, J. Moser, M. Fritzler, M. Fritzler et al., Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing, Journal of Cell Science, vol.121, issue.24, pp.4134-4144, 2008.
DOI : 10.1242/jcs.036905

S. Lian, S. Li, G. Abadal, B. Pauley, M. Fritzler et al., The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing, RNA, vol.15, issue.5, pp.804-813, 2009.
DOI : 10.1261/rna.1229409

J. Liao, L. Ma, Y. Guo, Y. Zhang, H. Zhou et al., Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3??? Trailers, PLoS ONE, vol.13, issue.5, p.10563, 2010.
DOI : 10.1371/journal.pone.0010563.s012

L. Lim, N. Lau, P. Garrett-engele, A. Grimson, J. Schelter et al., Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, vol.22, issue.7027, pp.769-773, 2005.
DOI : 10.1016/S0092-8674(00)00015-5

Z. Lippman and R. Martienssen, The role of RNA interference in heterochromatic silencing, Nature, vol.161, issue.7006, pp.364-370, 2004.
DOI : 10.1016/0092-8674(94)90119-8

J. Liu, M. Carmell, F. Rivas, C. Marsden, J. Thomson et al., Argonaute2 Is the Catalytic Engine of Mammalian RNAi, Science, vol.305, issue.5689, pp.1437-1441, 2004.
DOI : 10.1126/science.1102513

J. Liu, M. Valencia-sanchez, G. Hannon, and R. Parker, MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies, Nature Cell Biology, vol.7, issue.7, pp.719-723, 2005.
DOI : 10.1261/rna.2340405

E. Lund, S. Guttinger, A. Calado, J. Dahlberg, and U. Kutay, Nuclear Export of MicroRNA Precursors, Science, vol.303, issue.5654, pp.95-98, 2004.
DOI : 10.1126/science.1090599

E. Darzynkiewicz, R. Pillai, W. Filipowicz, T. Duchaine, and N. Sonenberg, MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F, Science, vol.317, pp.1764-1767, 2007.

C. Matranga, Y. Tomari, C. Shin, D. Bartel, and P. Zamore, Passenger-Strand Cleavage Facilitates Assembly of siRNA into Ago2-Containing RNAi Enzyme Complexes, Cell, vol.123, issue.4, pp.607-620, 2005.
DOI : 10.1016/j.cell.2005.08.044

M. Matzke and J. Birchler, RNAi-mediated pathways in the nucleus, Nature Reviews Genetics, vol.269, issue.1, pp.24-35, 2005.
DOI : 10.1006/excr.1996.0186

C. Mayr, M. Hemann, and D. Bartel, Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation, Science, vol.315, issue.5818, pp.1576-1579, 2007.
DOI : 10.1126/science.1137999

G. Meister, M. Landthaler, A. Patkaniowska, Y. Dorsett, G. Teng et al., Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs, Molecular Cell, vol.15, issue.2, pp.185-197, 2004.
DOI : 10.1016/j.molcel.2004.07.007

URL : http://doi.org/10.1016/j.molcel.2004.07.007

M. Mette, W. Aufsatz, J. Van-der-winden, M. Matzke, and A. Matzke, Transcriptional silencing and promoter methylation triggered by double-stranded RNA, The EMBO Journal, vol.101, issue.19, pp.5194-5201, 2000.
DOI : 10.1093/emboj/19.19.5194

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC302106

T. Miyoshi, A. Takeuchi, H. Siomi, and M. Siomi, A direct role for Hsp90 in pre-RISC formation in Drosophila, Nature Structural & Molecular Biology, vol.15, issue.8, pp.1024-1026, 2010.
DOI : 10.1021/jm980403y

D. Moazed, Small RNAs in transcriptional gene silencing and genome defence, Nature, vol.21, issue.7228, pp.413-420, 2009.
DOI : 10.1038/nature07756

A. Monteys, R. Spengler, J. Wan, L. Tecedor, K. Lennox et al., Structure and activity of putative intronic miRNA promoters, RNA, vol.16, issue.3, pp.495-505, 2010.
DOI : 10.1261/rna.1731910

M. Montgomery, S. Xu, and A. Fire, RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans, Proceedings of the National Academy of Sciences, vol.95, issue.26, pp.15502-15507, 1998.
DOI : 10.1073/pnas.95.26.15502

K. Morris, S. Chan, S. Jacobsen, and D. Looney, Small Interfering RNA-Induced Transcriptional Gene Silencing in Human Cells, Science, vol.305, issue.5688, pp.1289-1292, 2004.
DOI : 10.1126/science.1101372

K. Morris, S. Santoso, A. Turner, C. Pastori, and P. Hawkins, Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells, PLoS Genetics, vol.102, issue.11, p.1000258, 2008.
DOI : 10.1371/journal.pgen.1000258.s006

M. Motamedi, A. Verdel, S. Colmenares, S. Gerber, S. Gygi et al., Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs, Cell, vol.119, issue.6, pp.789-802, 2004.
DOI : 10.1016/j.cell.2004.11.034

URL : https://hal.archives-ouvertes.fr/inserm-00332373

C. Napoli, C. Lemieux, and R. Jorgensen, Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans, THE PLANT CELL ONLINE, vol.2, issue.4, pp.279-289, 1990.
DOI : 10.1105/tpc.2.4.279

S. Napoli, C. Pastori, M. Magistri, G. Carbone, and C. Catapano, Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells, The EMBO Journal, vol.28, issue.12, pp.1708-1719, 2009.
DOI : 10.1073/pnas.0503853102

O. Farrell and M. , Synthesis and Modification of Nuclear Proteins in Serum-Stimulated 3T3 Cells, Biochemical Society Transactions, vol.5, issue.4, p.940, 1977.
DOI : 10.1042/bst0050940

C. Okada, E. Yamashita, S. Lee, S. Shibata, J. Katahira et al., A High-Resolution Structure of the Pre-microRNA Nuclear Export Machinery, Science, vol.326, issue.5957, pp.1275-1279, 2009.
DOI : 10.1126/science.1178705

V. Olive, M. Bennett, J. Walker, C. Ma, I. Jiang et al., miR-19 is a key oncogenic component of mir-17-92, Genes & Development, vol.23, issue.24, pp.2839-2849, 2009.
DOI : 10.1101/gad.1861409

P. Olsen and A. V. , The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation, Developmental Biology, vol.216, issue.2, pp.671-680, 1999.
DOI : 10.1006/dbio.1999.9523

U. Orom, F. Nielsen, and A. Lund, MicroRNA-10a Binds the 5???UTR of Ribosomal Protein mRNAs and Enhances Their Translation, Molecular Cell, vol.30, issue.4, pp.460-471, 2008.
DOI : 10.1016/j.molcel.2008.05.001

J. Pare, N. Tahbaz, J. Lopez-orozco, P. Lapointe, P. Lasko et al., Hsp90 Regulates the Function of Argonaute 2 and Its Recruitment to Stress Granules and P-Bodies, Molecular Biology of the Cell, vol.20, issue.14, pp.3273-3284, 2009.
DOI : 10.1091/mbc.E09-01-0082

J. Parker and D. Barford, Argonaute: a scaffold for the function of short regulatory RNAs, Trends in Biochemical Sciences, vol.31, issue.11, pp.622-630, 2006.
DOI : 10.1016/j.tibs.2006.09.010

A. Pasquinelli, B. Reinhart, F. Slack, M. Martindale, M. Kuroda et al., Conservation of the sequence and temporal expression of let-7, 2000.

X. Piao, X. Zhang, L. Wu, and J. Belasco, CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells, Molecular and Cellular Biology, vol.30, issue.6, pp.1486-1494, 2010.
DOI : 10.1128/MCB.01481-09

R. Pillai, C. Artus, and W. Filipowicz, Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis, RNA, vol.10, issue.10, pp.1518-1525, 2004.
DOI : 10.1261/rna.7131604

R. Place, L. Li, D. Pookot, E. Noonan, and R. Dahiya, MicroRNA-373 induces expression of genes with complementary promoter sequences, Proceedings of the National Academy of Sciences, vol.105, issue.5, pp.1608-1613, 2008.
DOI : 10.1073/pnas.0707594105

R. Place, E. Noonan, Z. Foldes-papp, and L. Li, Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity, Current Pharmaceutical Biotechnology, vol.11, issue.5, pp.518-526, 2010.
DOI : 10.2174/138920110791591463

S. Pulukuri and J. Rao, Small Interfering RNA Directed Reversal of Urokinase Plasminogen Activator Demethylation Inhibits Prostate Tumor Growth and Metastasis, Cancer Research, vol.67, issue.14, pp.6637-6646, 2007.
DOI : 10.1158/0008-5472.CAN-07-0751

T. Rand, K. Ginalski, N. Grishin, and X. Wang, Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity, Proceedings of the National Academy of Sciences, vol.101, issue.40, pp.14385-14389, 2004.
DOI : 10.1073/pnas.0405913101

F. Rivas, N. Tolia, J. Song, J. Aragon, J. Liu et al., Purified Argonaute2 and an siRNA form recombinant human RISC, Nature Structural & Molecular Biology, vol.17, issue.4, pp.340-349, 2005.
DOI : 10.1107/S0907444994006396

G. Robb, K. Brown, J. Khurana, and T. Rana, Specific and potent RNAi in the nucleus of human cells, Nature Structural & Molecular Biology, vol.9, issue.2, pp.133-137, 2005.
DOI : 10.1038/nbt936

H. Saini, S. Griffiths-jones, and A. Enright, Genomic analysis of human microRNA transcripts, Proceedings of the National Academy of Sciences, vol.104, issue.45, pp.17719-17724, 2007.
DOI : 10.1073/pnas.0703890104

R. Sanchez and W. Marzluff, The Oligo(A) Tail on Histone mRNA Plays an Active Role in Translational Silencing of Histone mRNA during Xenopus Oogenesis, Molecular and Cellular Biology, vol.24, issue.6, pp.2513-2525, 2004.
DOI : 10.1128/MCB.24.6.2513-2525.2004

D. Sayed and M. Abdellatif, MicroRNAs in Development and Disease, Physiological Reviews, vol.91, issue.3, pp.827-887, 2011.
DOI : 10.1152/physrev.00006.2010

M. Schneider, N. Najand, S. Chaker, J. Pare, J. Haskins et al., development, The Journal of Cell Biology, vol.104, issue.3, pp.349-358, 2006.
DOI : 10.1242/jcs.01477

URL : https://hal.archives-ouvertes.fr/halshs-01073909

D. Schwarz, Y. Tomari, and P. Zamore, The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease, Current Biology, vol.14, issue.9, pp.787-791, 2004.
DOI : 10.1016/j.cub.2004.03.008

M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin et al., Widespread changes in protein synthesis induced by microRNAs, Nature, vol.4, issue.7209, pp.58-63, 2008.
DOI : 10.1038/nature07228

G. Sen and H. Blau, Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies, Nature Cell Biology, vol.7, issue.6, pp.633-636, 2005.
DOI : 10.1016/j.cell.2004.12.038

G. Sen, T. Wehrman, and H. Blau, mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage, Differentiation, vol.73, issue.6, pp.287-293, 2005.
DOI : 10.1111/j.1432-0436.2005.00029.x

A. Serman, L. Roy, F. Aigueperse, C. Kress, M. Dautry et al., GW body disassembly triggered by siRNAs independently of their silencing activity, Nucleic Acids Research, vol.35, issue.14, pp.4715-4727, 2007.
DOI : 10.1093/nar/gkm491

A. Seto, R. Kingston, and N. Lau, The Coming of Age for Piwi Proteins, Molecular Cell, vol.26, issue.5, pp.603-609, 2007.
DOI : 10.1016/j.molcel.2007.05.021

U. Sheth and R. Parker, Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies, Science, vol.300, issue.5620, pp.805-808, 2003.
DOI : 10.1126/science.1082320

J. Song, S. Smith, G. Hannon, and L. Joshua-tor, Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity, Science, vol.305, issue.5689, pp.1434-1437, 2004.
DOI : 10.1126/science.1102514

S. Souquere, S. Mollet, M. Kress, F. Dautry, G. Pierron et al., Unravelling the ultrastructure of Bibliographie 191, 2009.

H. Su, S. Meng, Y. Lu, M. Trombly, J. Chen et al., Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing, Molecular Cell, vol.43, issue.1, pp.97-109, 2011.
DOI : 10.1016/j.molcel.2011.06.013

URL : http://doi.org/10.1016/j.molcel.2011.06.013

N. Tahbaz, J. Carmichael, and T. Hobman, GERp95 Belongs to a Family of Signal-transducing Proteins and Requires Hsp90 Activity for Stability and Golgi Localization, Journal of Biological Chemistry, vol.276, issue.46, pp.43294-43299, 2001.
DOI : 10.1074/jbc.M107808200

N. Tahbaz, F. Kolb, H. Zhang, K. Jaronczyk, W. Filipowicz et al., Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer, EMBO reports, vol.5, issue.2, pp.189-194, 2004.
DOI : 10.1038/sj.embor.7400070

Y. Tay, J. Zhang, A. Thomson, B. Lim, and I. Rigoutsos, MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation, Nature, vol.280, issue.7216, pp.1124-1128, 2008.
DOI : 10.1038/nature07299

S. Till, E. Lejeune, R. Thermann, M. Bortfeld, M. Hothorn et al., A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain, Nature Structural & Molecular Biology, vol.74, issue.10, pp.897-903, 2007.
DOI : 10.1038/nsmb1302

A. Ting, K. Schuebel, J. Herman, and S. Baylin, Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation, Nature Genetics, vol.89, issue.8, pp.906-910, 2005.
DOI : 10.1038/ng1611

N. Vastenhouw, K. Brunschwig, K. Okihara, F. Muller, M. Tijsterman et al., Gene expression: Long-term gene silencing by RNAi, Nature, vol.441, issue.7105, p.882, 2006.
DOI : 10.1038/442882a

S. Vasudevan and J. Steitz, AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2, Cell, vol.128, issue.6, pp.1105-1118, 2007.
DOI : 10.1016/j.cell.2007.01.038

S. Vasudevan, Y. Tong, and J. Steitz, Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation, Science, vol.318, issue.5858, pp.1931-1934, 2007.
DOI : 10.1126/science.1149460

H. Vaucheret, C. Beclin, and M. Fagard, Post-transcriptional gene silencing in plants, J Cell Sci, vol.114, pp.3083-3091, 2001.
URL : https://hal.archives-ouvertes.fr/hal-01001529

H. Vaucheret and M. Fagard, Transcriptional gene silencing in plants: targets, inducers and regulators, Trends in Genetics, vol.17, issue.1, pp.29-35, 2001.
DOI : 10.1016/S0168-9525(00)02166-1

T. Volpe, C. Kidner, I. Hall, G. Teng, S. Grewal et al., Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi, Science, vol.297, issue.5588, pp.1833-1837, 2002.
DOI : 10.1126/science.1074973

E. Wagner, S. Clement, and J. Lykke-andersen, An Unconventional Human Ccr4-Caf1 Deadenylase Complex in Nuclear Cajal Bodies, Molecular and Cellular Biology, vol.27, issue.5, pp.1686-1695, 2007.
DOI : 10.1128/MCB.01483-06

B. Wang, T. Love, M. Call, J. Doench, and C. Novina, Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro, Molecular Cell, vol.22, issue.4, pp.553-560, 2006.
DOI : 10.1016/j.molcel.2006.03.034

M. Wassenegger, S. Heimes, L. Riedel, and H. Sänger, RNA-directed de novo methylation of genomic sequences in plants, Cell, vol.76, issue.3, pp.567-576, 1994.
DOI : 10.1016/0092-8674(94)90119-8

M. Wassenegger and T. Pélissier, A model for RNA-mediated gene silencing in higher plants, Plant Molecular Biology, vol.37, issue.2, pp.349-362, 1998.
DOI : 10.1023/A:1005946720438

D. Weil, S. Boutain, A. Audibert, and F. Dautry, Mature mRNAs accumulated in the nucleus are neither the molecules in transit to the cytoplasm nor constitute a stockpile for gene expression, RNA, vol.6, issue.7, pp.962-975, 2000.
DOI : 10.1017/S1355838200000479

D. Weil, S. Brosset, and F. Dautry, RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2., Molecular and Cellular Biology, vol.10, issue.11, pp.5865-5875, 1990.
DOI : 10.1128/MCB.10.11.5865

M. Weinberg, S. Barichievy, L. Schaffer, J. Han, and K. Morris, An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation, Nucleic Acids Research, vol.35, issue.21, pp.7303-7312, 2007.
DOI : 10.1093/nar/gkm847

M. Weinberg, L. Villeneuve, A. Ehsani, M. Amarzguioui, L. Aagaard et al., The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells, RNA, vol.12, issue.2, pp.256-262, 2006.
DOI : 10.1261/rna.2235106

F. Wianny and M. Zernicka-goetz, Specific interference with gene function by double-stranded RNA in early mouse development, Nature Cell Biology, vol.126, issue.2, pp.70-75, 2000.
DOI : 10.1101/GAD.13.22.3015

B. Wightman, T. Burglin, J. Gatto, P. Arasu, and G. Ruvkun, Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development., Genes & Development, vol.5, issue.10, pp.1813-1824, 1991.
DOI : 10.1101/gad.5.10.1813

B. Wightman, I. Ha, and G. Ruvkun, Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans, Cell, vol.75, issue.5, pp.855-862, 1993.
DOI : 10.1016/0092-8674(93)90530-4

L. Wu, J. Fan, and J. Belasco, MicroRNAs direct rapid deadenylation of mRNA, Proceedings of the National Academy of Sciences, vol.103, issue.11, pp.4034-4039, 2006.
DOI : 10.1073/pnas.0510928103

S. Yang, S. Tutton, E. Pierce, and K. Yoon, Specific Double-Stranded RNA Interference in Undifferentiated Mouse Embryonic Stem Cells, Molecular and Cellular Biology, vol.21, issue.22, pp.7807-7816, 2001.
DOI : 10.1128/MCB.21.22.7807-7816.2001

B. Yao, S. Li, H. Jung, S. Lian, G. Abadal et al., Divergent GW182 functional domains in the regulation of translational silencing, Nucleic Acids Research, vol.39, issue.7, pp.2534-2547, 2011.
DOI : 10.1093/nar/gkq1099

S. Yekta, I. Shih, and D. Bartel, MicroRNA-Directed Cleavage of HOXB8 mRNA, Science, vol.304, issue.5670, pp.594-596, 2004.
DOI : 10.1126/science.1097434

S. Yekta, C. Tabin, and D. Bartel, MicroRNAs in the Hox network: an apparent link to posterior prevalence, Nature Reviews Genetics, vol.5, issue.10, pp.789-796, 2008.
DOI : 10.1038/nrg2400

R. Yi and E. Fuchs, MicroRNAs and their roles in mammalian stem cells, Journal of Cell Science, vol.124, issue.11, pp.1775-1783, 2011.
DOI : 10.1242/jcs.069104

R. Yi, Y. Qin, I. Macara, and B. Cullen, Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs, Genes & Development, vol.17, issue.24, pp.3011-3016, 2003.
DOI : 10.1101/gad.1158803

W. Yu, D. Gius, P. Onyango, K. Muldoon-jacobs, J. Karp et al., Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA, Nature, vol.290, issue.7175, pp.202-206, 2008.
DOI : 10.1038/nature06468

L. Zekri, E. Huntzinger, S. Heimstadt, and E. Izaurralde, The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release, Molecular and Cellular Biology, vol.29, issue.23, pp.6220-6231, 2009.
DOI : 10.1128/MCB.01081-09

Y. Zeng, H. Sankala, X. Zhang, and P. Graves, Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies, Biochemical Journal, vol.413, issue.3, pp.429-436, 2008.
DOI : 10.1042/BJ20080599

J. Zipprich, S. Bhattacharyya, H. Mathys, and W. Filipowicz, Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression, RNA, vol.15, issue.5, pp.781-793, 2009.
DOI : 10.1261/rna.1448009