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Génération de progéniteurs hépatiques dérivés de cellules souches : application à l’hypercholestérolémie familiale

Abstract : Hepatocyte transplantation represents an alternative to liver for the treatment of metabolic diseases including familial hypercholesterolaemia. Embryonic stem cells (ES) and induced pluripotent stem cells (iPS) represent new sources of hepatic cells. We have developed an approach to differentiate human stem cells into hepatic cells and thus we have generated hepatic cells derived from iPS of familial hypercholesterolaemia patients.
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https://tel.archives-ouvertes.fr/tel-00684386
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Submitted on : Monday, April 2, 2012 - 1:05:52 AM
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Sébastien Corbineau. Génération de progéniteurs hépatiques dérivés de cellules souches : application à l’hypercholestérolémie familiale. Sciences agricoles. Université Paris Sud - Paris XI, 2011. Français. ⟨NNT : 2011PA114821⟩. ⟨tel-00684386⟩

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