Skip to Main content Skip to Navigation
Theses

Glucocorticoïdes et pratique sportive : effets sur la prise alimentaire, la composition corporelle et différentes sécrétions hormonales

Abstract : Glucocorticoids (GC) are substances widely used in therapy, but sometimes diverted from their primary use by athletes for their ergogenic effects. Whereas the side effects of chronic use of GC are well known, the impact of short treatment remains controversial. We first investigated the effects of 1 week treatment of GC (50-60 mg/day of prednisone/prednisolone) on food intake, body composition, blood glucose, insulinemia, and adipokine secretion in male and female recreationally-trained athletes. For ethical reasons, this study could not be conducted in elite athletes. The adipokines (ie, leptin and adiponectin) appear significantly increased in all subjects after the GC treatment, but the treatment does not induce any change in food intake, body composition or insulin concentrations. There is no gender effect with the exception of hyperglycemia demonstrated with GC only in males. It also appears that the short-term treatment of oral prednisone alters the hypothalamic-pituitary-adrenal axis only very transient, with a return to basal levels of cortisol and DHEA only 3 days after of treatment.
Keywords : Food intake
Document type :
Theses
Complete list of metadatas

Cited literature [236 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00684055
Contributor : Abes Star :  Contact
Submitted on : Friday, March 30, 2012 - 2:22:51 PM
Last modification on : Sunday, March 1, 2020 - 1:26:06 AM
Long-term archiving on: : Wednesday, December 14, 2016 - 7:32:26 PM

File

laetitia.jollin_2383.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00684055, version 1

Collections

Citation

Laetitia Jollin. Glucocorticoïdes et pratique sportive : effets sur la prise alimentaire, la composition corporelle et différentes sécrétions hormonales. Médecine humaine et pathologie. Université d'Orléans, 2011. Français. ⟨NNT : 2011ORLE2042⟩. ⟨tel-00684055⟩

Share

Metrics

Record views

665

Files downloads

3728