Skip to Main content Skip to Navigation
Theses

Mécanotransduction osseuse : écoulement interstitiel, microstructure et couplages biochimiques

Abstract : Transport phenomena appearing within the cortical bone lacuno-canalicular network (LCN) and the osteon were the objective of this study. We developped a three-scale model to investigate the osteocyte mechanotranduction which is at the origin of the bone remodeling process. This model took into account three physical phenomena : the electrostatics (through the Poisson-Boltzman equation), the interstitial fluid flow (modeled by a modified Stokes equation) and the ionic transport (governed by a Nernst-Planck equation). Analysis of the electrical potential distribution highlighted the importance of the electrical double layers close to the pore charged surface. These electrical double layers, as well as the interstitial fluid chemical composition, induce osmotic and electroosmotic fluid flows and affect the ionic effective diffusion within the pores. Using a periodic asymptotic homogeneisation procedure, the model at the canalicular pore scale was upscaled at the canalicular scale and then at the osteonal scale. A parametric study pointed out the relevant parameters acting on the transport phenomena and possibly affecting osteocyte mecanosensitivity. Our results emphasized the importance of the electro-chemical effects. We thus focused on the chemistry and more especially on the effects of the physiological ionic fluxes on the osteocyte. In vitro experiments and numrical simulations were performed to elucidate these questions. Our results underlined the importance of the chemical exchanges between the osteocyte and the surrounding fluid. Finally, we showed that fluid flow and chemical transport occuring within the LCN and the osteon interact with each other, thus achieving a three-scale description of the transport phenomena in the osteon
Complete list of metadata

Cited literature [255 references]  Display  Hide  Download

https://tel.archives-ouvertes.fr/tel-00673263
Contributor : Abes Star :  Contact
Submitted on : Thursday, February 23, 2012 - 11:04:16 AM
Last modification on : Thursday, March 19, 2020 - 11:52:03 AM
Long-term archiving on: : Thursday, May 24, 2012 - 2:52:38 AM

File

TH2011PEST1089_complete.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00673263, version 1

Collections

Citation

Joanna Kaiser. Mécanotransduction osseuse : écoulement interstitiel, microstructure et couplages biochimiques. Médecine humaine et pathologie. Université Paris-Est, 2011. Français. ⟨NNT : 2011PEST1089⟩. ⟨tel-00673263⟩

Share

Metrics

Record views

1190

Files downloads

1653