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Rôle du système plexus choroïde-liquide céphalorachidien dans la distribution des cellules immunes au sein du système nerveux central, exemple de l'encéphalomyélite auto-immune expérimentale

Abstract : The central nervous system is an immunologically specialized site, because of the blood-brain barrier and the blood-cerebrospinal fluid barrier. The choroid plexuses had been considered as a preferential site for the entry of lymphocytes into the CNS. And the cerebrospinal fluid has been considered as a preferential pathway of circulation for immune cells during physiological neuroimmune surveillance, in all cerebral compartments, as the cerebrospinal fluid circulates from the ventricles to the subarachnoid spaces as well as the velum and internal cisterns. We evaluate the involvement of the choroid plexus-cerebrospinal fluid system in the cerebral infiltration and distribution of immune cells in CNS inflammation. First we realized a time course analysis of the different type of immune cell association with the CSF-containing compartments in two experimental autoimmune encephalomyelitis, models of multiple sclerosis. Secondly, we analyzed the molecular partners that could be involved in CNS inflammation development, such as adhesion molecules expressed on the choroid plexus, and chemokines secreted into the cerebrospinal fluid. Results identified the choroid plexuses as a source of chemokines, released into the cerebrospinal fluid that orchestrates the immune cell invasion during CNS inflammation.
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https://tel.archives-ouvertes.fr/tel-00664941
Contributor : Charlotte Schmitt <>
Submitted on : Tuesday, January 31, 2012 - 5:14:35 PM
Last modification on : Wednesday, November 20, 2019 - 3:17:03 AM
Long-term archiving on: : Tuesday, May 1, 2012 - 2:50:11 AM

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  • HAL Id : tel-00664941, version 1

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Charlotte Schmitt. Rôle du système plexus choroïde-liquide céphalorachidien dans la distribution des cellules immunes au sein du système nerveux central, exemple de l'encéphalomyélite auto-immune expérimentale. Neurosciences. Université Claude Bernard - Lyon I, 2012. Français. ⟨tel-00664941⟩

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