Production de radioisotopes : de la mesure de la section efficace à la production

Abstract : New radioactive isotopes for nuclear medicine can be produced using particle accelerators. This is one goal of Arronax, a high energy - 70 MeV - high intensity - 2*350 µA - cyclotron set up in Nantes. A priority list was established containing beta- - 47Sc, 67Cu - beta+ - 44Sc, 64Cu, 82Sr/82Rb, 68Ge/68Ga - and alpha emitters - 211At. Among these radioisotopes, the Scandium 47 and the Copper 67 have a strong interest in targeted therapy. The optimization of their productions required a good knowledge of their cross-sections but also of all the contaminants created during irradiation. We launched on Arronax a program to measure these production cross-sections using the Stacked-Foils' technique. It consists in irradiating several groups of foils - target, monitor and degrader foils - and in measuring the produced isotopes by gamma-spectrometry. The monitor - Cu or Ni - is used to correct beam loss whereas degrader foils are used to lower beam energy. We chose to study the natTi(p,X)47Sc and 68Zn(p,2p)67Cu reactions. Targets are respectively natural Titanium foil - bought from Goodfellow - and enriched Zinc 68 deposited on Silver. In the latter case, Zn targets were prepared in-house - electroplating of 68Zn - and a chemical separation between Copper and Gallium isotopes has to be made before gamma counting. Cross-section values for more than 40 different reactions cross-sections have been obtained from 18 MeV to 68 MeV. A comparison with the Talys code is systematically done. Several parameters of theoretical models have been studied and we found that is not possible to reproduce faithfully all the cross-sections with a given set of parameters.
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Eric Garrido. Production de radioisotopes : de la mesure de la section efficace à la production. Physique Nucléaire Expérimentale [nucl-ex]. Université de Nantes, 2011. Français. ⟨tel-00662649v2⟩

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