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Multifunctional nanoparticles for MR and fluorescence imaging

Abstract : This thesis describes a strategy of synthesis of new generations of nanoparticles (NPs) for biomedical applications, aiming at an improvement of their performances for the imaging, and the therapeutic diagnosis. These NPs present several functionalities enabling them to carry out multiple tasks. Two types of bimodal probes were developed and studied so as to evaluate their potential as contrast agents (1) in MRI and (2) and luminescence. These objects combine the properties of the lanthanide complexes (Ln3+) and those of NPs of silica or core/shell Fe2O3SiO2 for a bimodal imaging. These NPs tested on living cells were able to illustrate the proof of the concept not only in MRI with an increase of intensity of the images and a significant impact on the relaxivities r1, r 2 and r2* but also in photoluminescence. The study of the core/shell system showed that the influence of the fine control of the shell around the iron oxide core could be modeled.
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Submitted on : Wednesday, January 18, 2012 - 5:33:14 PM
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Sonia Luzia Claro Pinho. Multifunctional nanoparticles for MR and fluorescence imaging. Material chemistry. Université Sciences et Technologies - Bordeaux I, 2011. English. ⟨NNT : 2011BOR14399⟩. ⟨tel-00661206⟩

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