Tomographie optique diffuse et de fluorescence préclinique : instrumentation sans contact, modélisation et reconstruction 3D résolue en temps.

Farouk Nouizi 1
1 Imagerie in-vivo
LINC - Laboratoire d'Imagerie et de Neurosciences Cognitives
Abstract : Time-Resolved Diffuse Optical Tomography (TR-DOT) is a new non-invasive imaging technique increasingly used in the clinical and preclinical fields. It yields optical absorption and scattering maps of the explored organs, and related physiological parameters. Time-Resolved Fluorescence Diffuse Optical Tomography (TR-FDOT) is based on the detection of fluorescence photons. It provides spatio-temporal maps of fluorescent probe concentrations and life times, and allows access to metabolic and molecular imaging which is important for diagnosis and therapeutic monitoring, particularly in oncology. The main goal of this thesis was to reconstruct 3D TR-DOT/TR-FDOT images of small animals using time-resolved optical technology. Data were acquired using optical fibers fixed around the animal without contact with its surface. The work was achieved in four steps: 1- Setting up an imaging device to record the 3D coordinates of an animal's surface, 2- Modeling the no-contact approach to solve the forward problem, 3- Processing of the measured signals taking into account the impulse response of the device, 4- Implementation of a new image reconstruction method based on a selection of carefully chosen points. As a result, good-quality 3D optical images were obtained owing to reduced cross-talk between absorption and scattering. Moreover, the computation time was cut down, compared to full-time methods using whole temporal profiles.
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Theses
Medical Imaging. Université Louis Pasteur - Strasbourg I, 2011. French


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Submitted on : Tuesday, January 10, 2012 - 11:12:09 AM
Last modification on : Wednesday, October 29, 2014 - 1:23:26 PM

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Farouk Nouizi. Tomographie optique diffuse et de fluorescence préclinique : instrumentation sans contact, modélisation et reconstruction 3D résolue en temps.. Medical Imaging. Université Louis Pasteur - Strasbourg I, 2011. French. <tel-00658285>

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