L. Starza, R. Trubia, M. Crescenzi, B. Matteucci, C. Negrini et al., Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t

H. Shimada, Y. Arai, S. Sekiguchi, T. Ishii, S. Tanitsu et al., Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia, British Journal of Haematology, vol.70, issue.1, pp.210-213, 2000.
DOI : 10.1002/(SICI)1098-2264(199911)26:3<215::AID-GCC5>3.0.CO;2-1

R. Jaju, O. Haas, M. Neat, J. Harbott, V. Saha et al., A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG), Blood, vol.94, pp.773-780, 1999.

N. Cerveira, C. Correia, S. Doria, S. Bizarro, P. Rocha et al., Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia, Leukemia, vol.17, issue.11, 2003.
DOI : 10.1038/sj.leu.2403104

G. Cimino, T. Sprovieri, M. Rapanotti, R. Foa, C. Mecucci et al., Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia, Haematologica, vol.86, pp.436-437, 2001.

S. Romana, I. Radford-weiss, B. Abdelali, R. Schluth, C. Petit et al., NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytog??n??tique H??matologique, Leukemia, vol.86, issue.4, pp.696-706, 2006.
DOI : 10.1038/sj.leu.2404130

M. Moore, K. Chung, M. Plasilova, J. Schuringa, J. Shieh et al., NUP98 Dysregulation in Myeloid Leukemogenesis, Annals of the New York Academy of Sciences, vol.108, issue.1, pp.114-142, 2007.
DOI : 10.1111/j.1745-7254.2005.00192.x

L. Kasper, P. Brindle, C. Schnabel, C. Pritchard, M. Cleary et al., CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity, Molecular and Cellular Biology, vol.19, issue.1, pp.764-776, 1999.
DOI : 10.1128/MCB.19.1.764

G. Wang, L. Cai, M. Pasillas, and M. Kamps, NUP98???NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis, Nature Cell Biology, vol.442, issue.7, pp.804-812, 2007.
DOI : 10.1038/nature05140

G. Wang, J. Song, Z. Wang, H. Dormann, F. Casadio et al., Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger, Nature, vol.9, issue.7248, pp.847-851, 2009.
DOI : 10.1038/nature08036

A. Travers, Priming the nucleosome: a role for HMGB proteins?, EMBO reports, vol.20, issue.2, pp.131-136, 2003.
DOI : 10.1038/sj.embor.embor741

M. Nemeth, D. Curtis, M. Kirby, L. Garrett-beal, N. Seidel et al., Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation, Blood, vol.102, issue.4, pp.1298-1306, 2003.
DOI : 10.1182/blood-2002-11-3541

M. Nemeth, M. Kirby, and D. Bodine, Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation, Proceedings of the National Academy of Sciences, vol.103, issue.37, pp.13783-13788, 2006.
DOI : 10.1073/pnas.0604006103

T. Somervaille, C. Matheny, G. Spencer, M. Iwasaki, J. Rinn et al., Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells, Cell Stem Cell, vol.4, issue.2, pp.129-140, 2009.
DOI : 10.1016/j.stem.2008.11.015

X. Su, H. Drabkin, E. Clappier, E. Morgado, M. Busson et al., Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genesHOXA13,TLX1, andTLX3, Genes, Chromosomes and Cancer, vol.306, issue.9, pp.846-855, 2006.
DOI : 10.1002/gcc.20348

E. Kroon, U. Thorsteinsdottir, N. Mayotte, T. Nakamura, and G. Sauvageau, NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice, The EMBO Journal, vol.20, issue.3, pp.350-361, 2001.
DOI : 10.1093/emboj/20.3.350

S. Kogan, J. Ward, M. Anver, J. Berman, C. Brayton et al., Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice, Blood, vol.100, issue.1, pp.238-245, 2002.
DOI : 10.1182/blood.V100.1.238

K. Akashi, D. Traver, T. Miyamoto, and I. Weissman, A clonogenic common myeloid progenitor that gives rise to all myeloid lineages, Nature, vol.362, issue.6774, pp.193-197, 2000.
DOI : 10.1038/35004599

A. Cozzio, E. Passegue, P. Ayton, H. Karsunky, M. Cleary et al., Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors, Genes & Development, vol.17, issue.24, pp.3029-3035, 2003.
DOI : 10.1101/gad.1143403

A. Krivtsov and S. Armstrong, MLL translocations, histone modifications and leukaemia stem-cell development, Nature Reviews Cancer, vol.21, issue.11, pp.823-833, 2007.
DOI : 10.1038/nrc2253

L. Palmqvist, N. Pineault, C. Wasslavik, and R. Humphries, Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes, PLoS ONE, vol.66, issue.8, p.768, 2007.
DOI : 10.1371/journal.pone.0000768.t003

K. Hirose, C. Abramovich, B. Argiropoulos, and R. Humphries, Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor, Oncogene, vol.178, issue.46, pp.6056-6067, 2008.
DOI : 10.1038/onc.2008.210

D. Jankovic, P. Gorello, T. Liu, S. Ehret, L. Starza et al., Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia, Blood, vol.111, issue.12, pp.5672-5682, 2008.
DOI : 10.1182/blood-2007-09-108175

C. Abramovich and R. K. Humphries, Hox regulation of normal and leukemic hematopoietic stem cells, Current Opinion in Hematology, vol.12, issue.3, pp.210-216, 2005.
DOI : 10.1097/01.moh.0000160737.52349.aa

M. Ageberg, K. Drott, T. Olofsson, U. Gullberg, and A. Lindmark, Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis, Genes, Chromosomes and Cancer, vol.101, issue.4, pp.276-287, 2008.
DOI : 10.1002/gcc.20531

H. G. Ahuja, C. A. Felix, and P. D. Aplan, The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion, Blood, vol.94, pp.3258-3261, 1999.

H. G. Ahuja, C. A. Felix, and P. D. Aplan, Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations, Genes, Chromosomes and Cancer, vol.57, issue.2, pp.96-105, 2000.
DOI : 10.1002/1098-2264(2000)9999:9999<::AID-GCC1013>3.0.CO;2-T

H. G. Ahuja, J. Hong, P. D. Aplan, L. Tcheurekdjian, S. J. Forman et al., t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF), Cancer Res, vol.60, pp.6227-6229, 2000.

K. Akashi, D. Traver, T. Miyamoto, and I. L. Weissman, A clonogenic common myeloid progenitor that gives rise to all myeloid lineages, Nature, vol.362, issue.6774, pp.193-197, 2000.
DOI : 10.1038/35004599

Y. Arai, F. Hosoda, H. Kobayashi, K. Arai, Y. Hayashi et al., The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, pp.3936-3944, 1997.

Y. Arai, T. Kyo, H. Miwa, K. Arai, N. Kamada et al., Heterogeneous fusion transcripts involving the NUP98 gene and HOXD13 gene activation in a case of acute myeloid leukemia with the t(2;11)(q31;p15) translocation, Leukemia, vol.14, issue.9, pp.1621-1629, 2000.
DOI : 10.1038/sj.leu.2401881

B. Argiropoulos and R. K. Humphries, Hox genes in hematopoiesis and leukemogenesis, Oncogene, vol.63, issue.47, pp.6766-6776, 2007.
DOI : 10.1371/journal.pmed.0030173

S. A. Armstrong, J. E. Staunton, L. B. Silverman, R. Pieters, M. L. Den-boer et al., MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia, Nature Genetics, vol.30, issue.1, pp.41-47, 2002.
DOI : 10.1038/ng765

P. M. Ayton and M. L. Cleary, Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9, Genes & Development, vol.17, issue.18, pp.2298-2307, 2003.
DOI : 10.1101/gad.1111603

U. Bacher, T. Haferlach, C. Schoch, W. Kern, and S. Schnittger, Implications of NRAS mutations in AML: a study of 2502 patients, Blood, vol.107, issue.10, pp.3847-3853, 2006.
DOI : 10.1182/blood-2005-08-3522

J. L. Badano, C. C. Leitch, S. J. Ansley, H. May-simera, S. Lawson et al., Dissection of epistasis in oligogenic Bardet???Biedl syndrome, Nature, vol.97, issue.7074, pp.326-330, 2006.
DOI : 10.1038/nature04370

P. Badenhorst, M. Voas, I. Rebay, and C. Wu, Biological functions of the ISWI chromatin remodeling complex NURF, Genes & Development, vol.16, issue.24, pp.3186-3198, 2002.
DOI : 10.1101/gad.1032202

D. J. Baker, M. M. Dawlaty, P. Galardy, and J. M. Van-deursen, Mitotic regulation of the anaphase-promoting complex, Cellular and Molecular Life Sciences, vol.64, issue.5, pp.589-600, 2007.
DOI : 10.1007/s00018-007-6443-1

O. Barak, M. A. Lazzaro, W. S. Lane, D. W. Speicher, D. J. Picketts et al., Isolation of human NURF: a regulator of Engrailed gene expression, The EMBO Journal, vol.271, issue.22, pp.6089-6100, 2003.
DOI : 10.1093/emboj/cdg582

P. A. Beachy, S. S. Karhadkar, and D. M. Berman, Tissue repair and stem cell renewal in carcinogenesis, Nature, vol.24, issue.7015, pp.324-331, 2004.
DOI : 10.1038/nature03100

M. C. Bene, M. Bernier, R. O. Casasnovas, G. Castoldi, W. Knapp et al., The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias. The European Group for the Immunological Classification of Leukemias (EGIL), Blood, vol.92, pp.596-599, 1998.

M. C. Bene, M. Bernier, G. Castoldi, G. C. Faure, W. Knapp et al., Impact of immunophenotyping on management of acute leukemias, Haematologica, vol.84, pp.1024-1034, 1999.

M. C. Bene, G. Castoldi, W. Knapp, W. D. Ludwig, E. Matutes et al., Proposals for the immunological classification of acute leukemias, European Group for the Immunological Characterization of Leukemias (EGIL), 1995.

J. M. Bennett, D. Catovsky, M. T. Daniel, G. Flandrin, D. A. Galton et al., Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative Group, British Journal of Haematology, vol.1, issue.4, pp.451-458, 1976.
DOI : 10.1111/j.1365-2141.1976.tb03563.x

I. Ben-porath, M. W. Thomson, V. J. Carey, R. Ge, G. W. Bell et al., An embryonic stem cell???like gene expression signature in poorly differentiated aggressive human tumors, Nature Genetics, vol.22, issue.5, pp.499-507, 2008.
DOI : 10.1038/ng.127

J. Bijl, A. Thompson, R. Ramirez-solis, J. Krosl, D. G. Grier et al., Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells, Blood, vol.108, issue.1, pp.116-122, 2006.
DOI : 10.1182/blood-2005-06-2245

A. Blair, D. E. Hogge, and H. J. Sutherland, Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34, pp.71-4325, 1998.

S. K. Bohlander, ETV6: A versatile player in leukemogenesis, Seminars in Cancer Biology, vol.15, issue.3, pp.162-174, 2005.
DOI : 10.1016/j.semcancer.2005.01.008

D. Bonnet and J. E. Dick, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nature Medicine, vol.6, issue.7, pp.730-737, 1997.
DOI : 10.1038/367645a0

J. Borrow, A. M. Shearman, V. P. Stanton, . Jr, R. Becher et al., The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9, Nature Genetics, vol.19, issue.2, pp.159-167, 1996.
DOI : 10.1016/0165-4608(93)90012-B

D. T. Bowen, M. E. Frew, R. Hills, R. E. Gale, K. Wheatley et al., RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years, Blood, vol.106, issue.6, pp.2113-2119, 2005.
DOI : 10.1182/blood-2005-03-0867

C. R. Brown and P. A. Silver, Transcriptional regulation at the nuclear pore complex, Current Opinion in Genetics & Development, vol.17, issue.2, pp.100-106, 2007.
DOI : 10.1016/j.gde.2007.02.005

J. Brown, M. Jawad, S. R. Twigg, K. Saracoglu, A. Sauerbrey et al., A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay, Blood, vol.99, issue.7, pp.2526-2531, 2002.
DOI : 10.1182/blood.V99.7.2526

K. R. Calvo, D. B. Sykes, M. P. Pasillas, and M. P. Kamps, Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1, Oncogene, vol.21, issue.27, pp.4247-4256, 2002.
DOI : 10.1038/sj.onc.1205516

J. M. Casolari, C. R. Brown, S. Komili, J. West, H. Hieronymus et al., Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization, Cell, vol.117, issue.4, pp.427-439, 2004.
DOI : 10.1016/S0092-8674(04)00448-9

S. Cellot, J. Krosl, J. Chagraoui, S. Meloche, R. K. Humphries et al., Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells, Exp Hematol, vol.35, pp.802-816, 2007.

N. Cerveira, C. Correia, S. Doria, S. Bizarro, P. Rocha et al., Frequency of NUP98-NSD1 fusion transcript in childhood acute myeloid leukaemia, Leukemia, vol.17, issue.11, pp.2244-2247, 2003.
DOI : 10.1038/sj.leu.2403104

Y. Chalandon and J. Schwaller, Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies, Haematologica, vol.90, pp.949-968, 2005.

R. Chaligne, C. James, C. Tonetti, R. Besancenot, L. Couedic et al., Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis, Blood, vol.110, issue.10, pp.3735-3743, 2007.
DOI : 10.1182/blood-2007-05-089003

M. P. Chao, J. Seita, and I. L. Weissman, Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy, Cold Spring Harbor Symposia on Quantitative Biology, vol.73, issue.0, pp.439-449, 2008.
DOI : 10.1101/sqb.2008.73.031

T. Chaplin, P. Ayton, O. A. Bernard, V. Saha, D. Valle et al., A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia, Blood, vol.85, pp.1435-1441, 1995.

C. C. Chen, C. F. Yang, K. D. Lee, J. Y. You, Y. B. Yu et al., Complex karyotypes confer a poor survival in adult acute myeloid leukemia with unfavorable cytogenetic abnormalities, Cancer Genetics and Cytogenetics, vol.174, issue.2, pp.138-146, 2007.
DOI : 10.1016/j.cancergencyto.2006.12.002

S. Chen, Y. Xue, Z. Chen, Y. Guo, Y. Wu et al., Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia, Cancer Genetics and Cytogenetics, vol.140, issue.2, pp.153-156, 2003.
DOI : 10.1016/S0165-4608(02)00642-8

W. Chen, Q. Li, W. A. Hudson, A. Kumar, N. Kirchhof et al., A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy, Blood, vol.108, issue.2, pp.669-677, 2006.
DOI : 10.1182/blood-2005-08-3498

N. Cheung, L. C. Chan, A. Thompson, M. L. Cleary, and C. W. So, Protein arginine-methyltransferase-dependent oncogenesis, Nature Cell Biology, vol.13, issue.10, pp.1208-1215, 2007.
DOI : 10.1042/BJ20031794

W. C. Chou, C. Y. Chen, H. A. Hou, L. I. Lin, J. L. Tang et al., Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients, Leukemia, vol.91, issue.7, 2009.
DOI : 10.1038/nature04431

J. Christensen, K. Agger, P. A. Cloos, D. Pasini, S. Rose et al., RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3, Cell, vol.128, issue.6, pp.1063-1076, 2007.
DOI : 10.1016/j.cell.2007.02.003

G. Cimino, T. Sprovieri, M. C. Rapanotti, R. Foa, C. Mecucci et al., Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with Tacute lymphoblastic leukemia, Haematologica, vol.86, pp.436-437, 2001.

M. F. Clarke and M. Fuller, Stem Cells and Cancer: Two Faces of Eve, Cell, vol.124, issue.6, pp.1111-1115, 2006.
DOI : 10.1016/j.cell.2006.03.011

B. Clarkson, A. Strife, D. Wisniewski, C. L. Lambek, and C. Liu, Chronic myelogenous leukemia as a paradigm of early cancer and possible curative strategies, Leukemia, vol.17, issue.7, pp.1211-1262, 2003.
DOI : 10.1038/sj.leu.2402912

J. Clavel, A. Goubin, M. F. Auclerc, A. Auvrignon, C. Waterkeyn et al., Incidence of childhood leukaemia and, 2004.
URL : https://hal.archives-ouvertes.fr/inserm-00086407

. Hodgkin-'s-lymphoma-in-france, National Registry of Childhood Leukaemia and Lymphoma, 1990-1999, Eur J Cancer Prev, vol.13, pp.97-103

A. Cozzio, E. Passegue, P. M. Ayton, H. Karsunky, M. L. Cleary et al., Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors, Genes & Development, vol.17, issue.24, pp.3029-3035, 2003.
DOI : 10.1101/gad.1143403

A. B. Dash, I. R. Williams, J. L. Kutok, M. H. Tomasson, E. Anastasiadou et al., A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9, Proceedings of the National Academy of Sciences, vol.99, issue.11, pp.7622-7627, 2002.
DOI : 10.1073/pnas.102583199

F. Delhommeau, S. Dupont, D. Valle, V. James, C. Trannoy et al., in Myeloid Cancers, New England Journal of Medicine, vol.360, issue.22, pp.2289-2301, 2009.
DOI : 10.1056/NEJMoa0810069

W. Den-besten, M. L. Kuo, R. T. Williams, and C. J. Sherr, Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein, Cell Cycle, vol.4, issue.11, pp.1593-1598, 2005.
DOI : 10.4161/cc.4.11.2174

J. F. Dimartino, L. Selleri, D. Traver, M. T. Firpo, J. Rhee et al., The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver, Blood, vol.98, issue.3, pp.618-626, 2001.
DOI : 10.1182/blood.V98.3.618

C. L. Dobson, A. J. Warren, R. Pannell, A. Forster, and T. H. Rabbitts, Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene, The EMBO Journal, vol.88, issue.5, pp.843-851, 2000.
DOI : 10.1093/emboj/19.5.843

S. Dokudovskaya, L. M. Veenhoff, and M. P. Rout, Cleave to Leave, Molecular Cell, vol.10, issue.2, pp.221-223, 2002.
DOI : 10.1016/S1097-2765(02)00606-8
URL : http://doi.org/10.1016/s1097-2765(02)00606-8

A. M. Dorrance, S. Liu, W. Yuan, B. Becknell, K. J. Arnoczky et al., Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations, Journal of Clinical Investigation, vol.116, issue.10, pp.2707-2716, 2006.
DOI : 10.1172/JCI25546DS1

K. M. Eisenmann, K. J. Dykema, S. F. Matheson, N. F. Kent, A. D. Deward et al., 5q??? myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing actin dynamics, Oncogene, vol.14, issue.39, p.5, 2009.
DOI : 10.1038/onc.2009.207

L. W. Ellisen, J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds et al., TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms, Cell, vol.66, issue.4, pp.649-661, 1991.
DOI : 10.1016/0092-8674(91)90111-B

L. W. Ellisen, N. Carlesso, T. Cheng, D. T. Scadden, and D. A. Haber, The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells, The EMBO Journal, vol.20, issue.8, pp.1897-1909, 2001.
DOI : 10.1093/emboj/20.8.1897

S. Faderl, M. Talpaz, Z. Estrov, S. O-'brien, R. Kurzrock et al., The biology of chronic myeloid leukemia, N Engl J Med, vol.341, pp.164-172, 1999.

B. Falini, C. Mecucci, E. Tiacci, M. Alcalay, R. Rosati et al., Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype, New England Journal of Medicine, vol.352, issue.3, pp.254-266, 2005.
DOI : 10.1056/NEJMoa041974

J. Ferlay, F. Bray, P. Pisani, and D. M. Parkin, GLOBOCAN 2002: Cancer Incidence, Mortality and Prevalence Worldwide, 2004.

A. A. Ferrando, S. A. Armstrong, D. S. Neuberg, S. E. Sallan, L. B. Silverman et al., Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation, Blood, vol.102, issue.1, pp.262-268, 2003.
DOI : 10.1182/blood-2002-10-3221

B. M. Fontoura, S. Dales, G. Blobel, and H. Zhong, The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.3208-3213, 2001.
DOI : 10.1073/pnas.061014698

S. Frohling, C. Scholl, R. L. Levine, M. Loriaux, T. J. Boggon et al., Identification of Driver and Passenger Mutations of FLT3 by High-Throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles, Cancer Cell, vol.12, issue.6, pp.501-513, 2007.
DOI : 10.1016/j.ccr.2007.11.005

T. Fujino, A. Suzuki, Y. Ito, K. Ohyashiki, Y. Hatano et al., Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15), Blood, vol.99, issue.4, pp.1428-1433, 2002.
DOI : 10.1182/blood.V99.4.1428

Y. Fujiwara, C. P. Browne, K. Cunniff, S. C. Goff, and S. H. Orkin, Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1., Proceedings of the National Academy of Sciences, vol.93, issue.22, pp.12355-12358, 1996.
DOI : 10.1073/pnas.93.22.12355

H. Gal, N. Amariglio, L. Trakhtenbrot, J. Jacob-hirsh, O. Margalit et al., Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells, Leukemia, vol.130, issue.12, pp.2147-2154, 2006.
DOI : 10.1038/sj.leu.2404401

A. A. George, J. Franklin, K. Kerkof, A. J. Shah, M. Price et al., Detection of leukemic cells in the CD34+CD38- bone marrow progenitor population in children with acute lymphoblastic leukemia, Blood, vol.97, issue.12, pp.3925-3930, 2001.
DOI : 10.1182/blood.V97.12.3925

C. Gervais, L. Mauvieux, N. Perrusson, C. Helias, S. Struski et al., A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia, Leukemia, vol.19, pp.145-148, 2005.
DOI : 10.1038/sj.leu.2403565

G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale et al., The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells, Journal of Biological Chemistry, vol.279, issue.2, pp.866-875, 2004.
DOI : 10.1074/jbc.M307280200

A. Goubin, M. F. Auclerc, A. Auvrignon, C. Patte, C. Bergeron et al., Survival in France after childhood acute leukaemia and non-Hodgkin???s lymphoma (1990???2000), European Journal of Cancer, vol.42, issue.4, pp.534-541, 1990.
DOI : 10.1016/j.ejca.2005.08.041

C. Grabher, H. Von-boehmer, and A. T. Look, Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia, Nature Reviews Cancer, vol.8, issue.5, pp.347-359, 2006.
DOI : 10.1038/nrc1880

C. Graux, J. Cools, C. Melotte, H. Quentmeier, A. Ferrando et al., Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia, Nature Genetics, vol.9, issue.10, pp.1084-1089, 2004.
DOI : 10.1136/jmg.2003.016865

E. R. Griffis, N. Altan, J. Lippincott-schwartz, and M. A. Powers, Nup98 Is a Mobile Nucleoporin with Transcription-dependent Dynamics, Molecular Biology of the Cell, vol.13, issue.4, pp.1282-1297, 2002.
DOI : 10.1091/mbc.01-11-0538

E. R. Griffis, S. Xu, and M. A. Powers, Nup98 Localizes to Both Nuclear and Cytoplasmic Sides of the Nuclear Pore and Binds to Two Distinct Nucleoporin Subcomplexes, Molecular Biology of the Cell, vol.14, issue.2, pp.600-610, 2003.
DOI : 10.1091/mbc.E02-09-0582

S. Grisendi, C. Mecucci, B. Falini, and P. P. Pandolfi, Nucleophosmin and cancer, Nature Reviews Cancer, vol.106, issue.7, pp.493-505, 2006.
DOI : 10.1038/nrc1885

J. L. Grisolano, J. O-'neal, J. Cain, and M. H. Tomasson, An activated receptor tyrosine kinase, TEL/PDGF??R, cooperates with AML1/ETO to induce acute myeloid leukemia in mice, Proceedings of the National Academy of Sciences, vol.100, issue.16, pp.9506-9511, 2003.
DOI : 10.1073/pnas.1531730100

B. W. Gu, Q. Wang, J. M. Wang, Y. Q. Xue, J. Fang et al., Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity, Leukemia, vol.17, issue.9, pp.1858-1864, 2003.
DOI : 10.1038/sj.leu.2403036

M. G. Guenther, R. G. Jenner, B. Chevalier, T. Nakamura, C. M. Croce et al., Global and Hox-specific roles for the MLL1 methyltransferase, Proceedings of the National Academy of Sciences, vol.102, issue.24, pp.8603-8608, 2005.
DOI : 10.1073/pnas.0503072102

T. Haferlach, Molecular Genetic Pathways as Therapeutic Targets in Acute Myeloid Leukemia, Hematology, vol.2008, issue.1, pp.400-411, 2008.
DOI : 10.1182/asheducation-2008.1.400

Y. Harada and H. Harada, Molecular pathways mediating MDS/AML with focus on AML1/RUNX1 point mutations, Journal of Cellular Physiology, vol.49, issue.1, pp.16-20, 2009.
DOI : 10.1002/jcp.21769

D. P. Harper and P. D. Aplan, Chromosomal Rearrangements Leading to MLL Gene Fusions: Clinical and Biological Aspects, Cancer Research, vol.68, issue.24, pp.10024-10027, 2008.
DOI : 10.1158/0008-5472.CAN-08-2208

H. Hasle, T. A. Alonzo, A. Auvrignon, C. Behar, M. Chang et al., Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study, Blood, vol.109, issue.11, pp.4641-4647, 2007.
DOI : 10.1182/blood-2006-10-051342

J. L. Hess, MLL: a histone methyltransferase disrupted in leukemia, Trends in Molecular Medicine, vol.10, issue.10, pp.500-507, 2004.
DOI : 10.1016/j.molmed.2004.08.005

J. L. Hess, B. D. Yu, B. Li, R. Hanson, and S. J. Korsmeyer, Defects in yolk sac hematopoiesis in Mll-null embryos, Blood, vol.90, pp.1799-1806, 1997.

E. Hidaka, M. Tanaka, K. Matsuda, M. Ishikawa-matsumura, K. Yamauchi et al., A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia, Cancer Genetics and Cytogenetics, vol.176, issue.2, pp.137-143, 2007.
DOI : 10.1016/j.cancergencyto.2007.04.005

K. Hirose, C. Abramovich, B. Argiropoulos, and R. K. Humphries, Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor, Oncogene, vol.178, issue.46, pp.6056-6067, 2008.
DOI : 10.1038/onc.2008.210

P. A. Ho, T. A. Alonzo, R. B. Gerbing, J. Pollard, D. L. Stirewalt et al., Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group, Blood, vol.113, issue.26, pp.6558-6566, 2009.
DOI : 10.1182/blood-2008-10-184747

A. E. Hodel, M. R. Hodel, E. R. Griffis, K. A. Hennig, G. A. Ratner et al., The Three-Dimensional Structure of the Autoproteolytic, Nuclear Pore-Targeting Domain of the Human Nucleoporin Nup98, Molecular Cell, vol.10, issue.2, pp.347-358, 2002.
DOI : 10.1016/S1097-2765(02)00589-0

A. Hoischen, B. W. Van-bon, C. Gilissen, P. Arts, B. Van-lier et al., De novo mutations of SETBP1 cause Schinzel-Giedion syndrome, Nature Genetics, vol.271, issue.6, pp.483-485, 2010.
DOI : 10.1002/ajmg.10348

D. Hong, R. Gupta, P. Ancliff, A. Atzberger, J. Brown et al., Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia, Science, vol.319, issue.5861, pp.336-339, 2008.
DOI : 10.1126/science.1150648

K. J. Hope, L. Jin, and J. E. Dick, Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity, Nature Immunology, vol.93, issue.7, pp.738-743, 2004.
DOI : 10.1038/76095

B. J. Huntly, H. Shigematsu, K. Deguchi, B. H. Lee, S. Mizuno et al., MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors, Cancer Cell, vol.6, issue.6, pp.587-596, 2004.
DOI : 10.1016/j.ccr.2004.10.015

D. J. Hussey, S. Moore, M. Nicola, and A. Dobrovic, Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation, BMC Genetics, vol.2, issue.1, p.20, 2001.
DOI : 10.1186/1471-2156-2-20

D. J. Hussey, M. Nicola, S. Moore, G. B. Peters, and A. Dobrovic, The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia, Blood, vol.94, pp.2072-2079, 1999.

K. Ikegami and J. D. Lieb, Nucleoporins and Transcription: New Connections, New Questions, PLoS Genetics, vol.276, issue.2, p.1000861, 2010.
DOI : 10.1371/journal.pgen.1000861.g001

M. Ishikawa, F. Yagasaki, D. Okamura, T. Maeda, Y. Sugahara et al., A novel gene, ANKRD28 on 3p25, is fused with NUP98 on 11p15 in a cryptic 3-way translocation of t(3;5;11)(p25;q35;p15) in an adult patient with myelodysplastic syndrome/acute myelogenous leukemia, International Journal of Hematology, vol.19, issue.3, pp.238-245, 2007.
DOI : 10.1007/BF03006927

Y. Ishikawa, H. Kiyoi, A. Tsujimura, S. Miyawaki, Y. Miyazaki et al., Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia, Eur J Haematol, 2009.

S. Iwase, N. Akiyama, T. Sekikawa, S. Saito, Y. Arakawa et al., BothNUP98/TOP1 andTOP1/NUP98 transcripts are detected in a de novo AML with t(11;20)(p15;q11), Genes, Chromosomes and Cancer, vol.100, issue.1, pp.102-105, 2003.
DOI : 10.1002/gcc.10239

R. J. Jaju, C. Fidler, O. A. Haas, A. J. Strickson, F. Watkins et al., A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia, Blood, vol.98, issue.4, pp.1264-1267, 2001.
DOI : 10.1182/blood.V98.4.1264

C. H. Jamieson, L. E. Ailles, S. J. Dylla, M. Muijtjens, C. Jones et al., Granulocyte???Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML, New England Journal of Medicine, vol.351, issue.7, pp.657-667, 2004.
DOI : 10.1056/NEJMoa040258

C. H. Jamieson, I. L. Weissman, and E. Passegue, Chronic versus acute myelogenous leukemia, Cancer Cell, vol.6, issue.6, pp.531-533, 2004.
DOI : 10.1016/j.ccr.2004.12.005
URL : http://doi.org/10.1016/j.ccr.2004.12.005

I. Janoueix-lerosey, G. Schleiermacher, E. Michels, V. Mosseri, A. Ribeiro et al., Overall Genomic Pattern Is a Predictor of Outcome in Neuroblastoma, Journal of Clinical Oncology, vol.27, issue.7, pp.1026-1033, 2009.
DOI : 10.1200/JCO.2008.16.0630
URL : https://hal.archives-ouvertes.fr/inserm-00369944

M. W. Jansen, L. Corral, V. H. Van-der-velden, R. Panzer-grumayer, M. Schrappe et al., Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement, Leukemia, vol.19, pp.633-641, 2007.
DOI : 10.1038/sj.leu.2404578

K. B. Jeganathan, D. J. Baker, and J. M. Van-deursen, Securin Associates with APCCdh1 in Prometaphase but its Destruction is Delayed by Rae1 and Nup98 until the Metaphase/Anaphase Transition, Cell Cycle, vol.5, issue.4, pp.366-370, 2006.
DOI : 10.4161/cc.5.4.2483

K. B. Jeganathan, L. Malureanu, and J. M. Van-deursen, The Rae1???Nup98 complex prevents aneuploidy by inhibiting securin degradation, Nature, vol.144, issue.7070, pp.1036-1039, 2005.
DOI : 10.1038/nature04221

T. Jenuwein, G. Laible, R. Dorn, and G. Reuter, SET domain proteins modulate chromatin domains in eu- and heterochromatin, Cellular and Molecular Life Sciences (CMLS), vol.54, issue.1, pp.80-93, 1998.
DOI : 10.1007/s000180050127

L. H. Kasper, P. K. Brindle, C. A. Schnabel, C. E. Pritchard, M. L. Cleary et al., CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity, Molecular and Cellular Biology, vol.19, issue.1, pp.764-776, 1999.
DOI : 10.1128/MCB.19.1.764

L. M. Kelly, J. L. Kutok, I. R. Williams, C. L. Boulton, S. M. Amaral et al., PML/RAR?? and FLT3-ITD induce an APL-like disease in a mouse model, Proceedings of the National Academy of Sciences, vol.99, issue.12, pp.8283-8288, 2002.
DOI : 10.1073/pnas.122233699

L. King-underwood and K. Pritchard-jones, Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance, Blood, vol.91, pp.2961-2968, 1998.

R. J. Klose, Q. Yan, Z. Tothova, K. Yamane, H. Erdjument-bromage et al., The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase, Cell, vol.128, issue.5, pp.889-900, 2007.
DOI : 10.1016/j.cell.2007.02.013

S. C. Kogan, J. M. Ward, M. R. Anver, J. J. Berman, C. Brayton et al., Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice, Blood, vol.100, issue.1, pp.238-245, 2002.
DOI : 10.1182/blood.V100.1.238

A. V. Krivtsov and S. A. Armstrong, MLL translocations, histone modifications and leukaemia stem-cell development, Nature Reviews Cancer, vol.21, issue.11, pp.823-833, 2007.
DOI : 10.1038/nrc2253

A. V. Krivtsov, D. Twomey, Z. Feng, M. C. Stubbs, Y. Wang et al., Transformation from committed progenitor to leukaemia stem cell initiated by MLL???AF9, Nature, vol.442, issue.7104, pp.818-822, 2006.
DOI : 10.1016/j.cub.2004.11.012

E. Kroon, J. Krosl, U. Thorsteinsdottir, S. Baban, A. M. Buchberg et al., Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b, The EMBO Journal, vol.17, issue.13, pp.3714-3725, 1998.
DOI : 10.1093/emboj/17.13.3714

A. R. Kumar, Q. Li, W. A. Hudson, W. Chen, T. Sam et al., A role for MEIS1 in MLL-fusion gene leukemia, Blood, vol.113, issue.8, pp.1756-1758, 2009.
DOI : 10.1182/blood-2008-06-163287

Y. L. Kwong and A. Pang, Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia, Genes, Chromosomes and Cancer, vol.25, issue.1, pp.70-74, 1999.
DOI : 10.1002/(SICI)1098-2264(199905)25:1<70::AID-GCC11>3.3.CO;2-5

L. Starza, R. Brandimarte, L. Pierini, V. Nofrini, V. Gorello et al., A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement, Cancer Genetics and Cytogenetics, vol.193, issue.2, pp.109-111, 2009.
DOI : 10.1016/j.cancergencyto.2009.04.015

L. Starza, R. Trubia, M. Crescenzi, B. Matteucci, C. Negrini et al., Human homeobox geneHOXC13 is the partner ofNUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13), Genes, Chromosomes and Cancer, vol.100, issue.4, pp.420-423, 2003.
DOI : 10.1002/gcc.10182

I. Lahortiga, J. L. Vizmanos, X. Agirre, I. Vazquez, J. C. Cigudosa et al., NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15), Cancer Res, vol.63, pp.3079-3083, 2003.

D. H. Lam and P. D. Aplan, NUP98 gene fusions in hematologic malignancies, Leukemia, vol.15, issue.11, pp.1689-1695, 2001.
DOI : 10.1038/sj.leu.2402269

S. W. Lane, D. T. Scadden, and D. G. Gilliland, The leukemic stem cell niche: current concepts and therapeutic opportunities, Blood, vol.114, issue.6, pp.1150-1157, 2009.
DOI : 10.1182/blood-2009-01-202606

D. Lemons and W. Mcginnis, Genomic Evolution of Hox Gene Clusters, Science, vol.313, issue.5795, 1918.
DOI : 10.1126/science.1132040

J. Lessard and G. Sauvageau, Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells, Nature, vol.2, issue.6937, pp.255-260, 2003.
DOI : 10.1038/sj.onc.1201883

J. Lessard and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis, Experimental Hematology, vol.31, issue.7, pp.567-585, 2003.
DOI : 10.1016/S0301-472X(03)00081-X

R. L. Levine, M. Wadleigh, J. Cools, B. L. Ebert, G. Wernig et al., Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis, ) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis, pp.387-397, 2005.
DOI : 10.1016/j.ccr.2005.03.023

M. Levis and D. Small, FLT3: ITDoes matter in leukemia, Leukemia, vol.17, issue.9, pp.1738-1752, 2003.
DOI : 10.1038/sj.leu.2403099

T. J. Ley, E. R. Mardis, L. Ding, B. Fulton, M. D. Mclellan et al., DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome, Nature, vol.99, issue.7218, pp.66-72, 2008.
DOI : 10.1038/nature07485

H. Li, S. Ilin, W. Wang, E. M. Duncan, J. Wysocka et al., Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF, Nature, vol.31, pp.91-95, 2006.
DOI : 10.1038/nature04802

M. Liedtke and M. L. Cleary, Therapeutic targeting of MLL, Blood, vol.113, issue.24, pp.6061-6068, 2009.
DOI : 10.1182/blood-2008-12-197061

M. Little and C. Wells, A clinical overview of WT1 gene mutations, Human Mutation, vol.77, issue.3, pp.209-225, 1997.
DOI : 10.1002/(SICI)1098-1004(1997)9:3<209::AID-HUMU2>3.0.CO;2-2

H. Liu, E. H. Cheng, and J. J. Hsieh, Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions, Genes & Development, vol.21, issue.19, pp.2385-2398, 2007.
DOI : 10.1101/gad.1574507

H. Liu, E. H. Cheng, and J. J. Hsieh, MLL fusions: Pathways to leukemia, Cancer Biology & Therapy, vol.8, issue.13, 2009.
DOI : 10.4161/cbt.8.13.8924

S. Malinge, R. Ben-abdelali, C. Settegrana, I. Radford-weiss, M. Debre et al., Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia, Blood, vol.109, issue.5, pp.2202-2204, 2007.
DOI : 10.1182/blood-2006-09-045963

N. Mayotte, D. C. Roy, J. Yao, E. Kroon, and G. Sauvageau, Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system, Blood, vol.100, issue.12, pp.4177-4184, 2002.
DOI : 10.1182/blood-2002-04-1244

M. A. Mcdevitt, R. A. Shivdasani, Y. Fujiwara, H. Yang, and S. H. Orkin, A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1, Proceedings of the National Academy of Sciences, vol.94, issue.13, pp.6781-6785, 1997.
DOI : 10.1073/pnas.94.13.6781

C. Meyer, E. Kowarz, J. Hofmann, A. Renneville, J. Zuna et al., New insights to the MLL recombinome of acute leukemias, Leukemia, vol.56, issue.8, pp.1490-1499, 2009.
DOI : 10.1016/j.ccr.2008.10.001

T. A. Milne, C. M. Hughes, R. Lloyd, Z. Yang, O. Rozenblatt-rosen et al., Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors, Proceedings of the National Academy of Sciences, vol.102, issue.3, pp.749-754, 2005.
DOI : 10.1073/pnas.0408836102

T. A. Milne, M. E. Martin, H. W. Brock, R. K. Slany, and J. L. Hess, Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications, Cancer Research, vol.65, issue.24, pp.11367-11374, 2005.
DOI : 10.1158/0008-5472.CAN-05-1041

F. Mitelman, B. Johansson, and F. Mertens, The impact of translocations and gene fusions on cancer causation, Nature Reviews Cancer, vol.3, issue.4, pp.233-245, 2007.
DOI : 10.1038/nrc2091

C. B. Moens and L. Selleri, Hox cofactors in vertebrate development, Developmental Biology, vol.291, issue.2, pp.193-206, 2006.
DOI : 10.1016/j.ydbio.2005.10.032

A. V. Moorman, S. M. Richards, H. M. Robinson, J. C. Strefford, B. E. Gibson et al., Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21), Blood, vol.109, issue.6, pp.21-2327, 2007.
DOI : 10.1182/blood-2006-08-040436

C. Morerio, M. Acquila, A. Rapella, E. Tassano, C. Rosanda et al., Inversion (11)(p15q22) with NUP98???DDX10 fusion gene in pediatric acute myeloid leukemia, Cancer Genetics and Cytogenetics, vol.171, issue.2, pp.122-125, 2006.
DOI : 10.1016/j.cancergencyto.2006.07.002

C. Morerio, M. Acquila, C. Rosanda, A. Rapella, E. Tassano et al., t(9;11)(p22;p15) with NUP98-LEDGF fusion gene in pediatric acute myeloid leukemia, Leukemia Research, vol.29, issue.4, pp.467-470, 2005.
DOI : 10.1016/j.leukres.2004.09.002

K. Mrozek, Cytogenetic, Molecular Genetic, and Clinical Characteristics of Acute Myeloid Leukemia With a Complex Karyotype, Seminars in Oncology, vol.35, issue.4, pp.365-377, 2008.
DOI : 10.1053/j.seminoncol.2008.04.007

B. U. Mueller and T. Pabst, C/EBP?? and the pathophysiology of acute myeloid leukemia, Current Opinion in Hematology, vol.13, issue.1, pp.7-14, 2006.
DOI : 10.1097/01.moh.0000190110.08156.96

D. Mueller, C. Bach, D. Zeisig, M. P. Garcia-cuellar, S. Monroe et al., A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification, Blood, vol.110, issue.13, pp.4445-4454, 2007.
DOI : 10.1182/blood-2007-05-090514

C. G. Mullighan, S. Goorha, I. Radtke, C. B. Miller, E. Coustan-smith et al., Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia, Nature, vol.38, issue.7137, pp.758-764, 2007.
DOI : 10.1038/nature05690

C. G. Mullighan, C. B. Miller, I. Radtke, L. A. Phillips, J. Dalton et al., BCR???ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros, Nature, vol.102, issue.7191, pp.110-114, 2008.
DOI : 10.1038/nature06866

C. G. Mullighan, X. Su, J. Zhang, I. Radtke, L. A. Phillips et al., and Prognosis in Acute Lymphoblastic Leukemia, New England Journal of Medicine, vol.360, issue.5, pp.470-480, 2009.
DOI : 10.1056/NEJMoa0808253

T. Nakamura, D. A. Largaespada, M. P. Lee, L. A. Johnson, K. Ohyashiki et al., Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia, Nature Genetics, vol.12, issue.2, pp.154-158, 1996.
DOI : 10.1038/ng0393-266

T. Nakamura, Y. Yamazaki, Y. Hatano, and I. Miura, NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15), Blood, vol.94, pp.741-747, 1999.

K. Nebral, M. Konig, H. H. Schmidt, D. Lutz, W. R. Sperr et al., Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization, Haematologica, vol.90, pp.746-752, 2005.

M. J. Nemeth, A. P. Cline, S. M. Anderson, L. J. Garrett-beal, and D. M. Bodine, Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors, Blood, vol.105, issue.2, pp.627-634, 2005.
DOI : 10.1182/blood-2004-07-2551

M. J. Nemeth, D. J. Curtis, M. R. Kirby, L. J. Garrett-beal, N. E. Seidel et al., Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation, Blood, vol.102, issue.4, pp.1298-1306, 2003.
DOI : 10.1182/blood-2002-11-3541

M. J. Nemeth, M. R. Kirby, and D. M. Bodine, Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation, Proceedings of the National Academy of Sciences, vol.103, issue.37, pp.13783-13788, 2006.
DOI : 10.1073/pnas.0604006103

M. Nishiyama, Y. Arai, Y. Tsunematsu, H. Kobayashi, K. Asami et al., 11p15 translocations involving the NUP98 gene in childhood therapy???related acute myeloid leukemia/myelodysplastic syndrome, Genes, Chromosomes and Cancer, vol.26, issue.3, pp.215-220, 1999.
DOI : 10.1002/(SICI)1098-2264(199911)26:3<215::AID-GCC5>3.3.CO;2-T

R. Ono, H. Nakajima, K. Ozaki, H. Kumagai, T. Kawashima et al., Dimerization of MLL fusion proteins and FLT3 activation synergize to induce multiple-lineage leukemogenesis, Journal of Clinical Investigation, vol.115, issue.4, pp.919-929, 2005.
DOI : 10.1172/JCI200522725

B. M. Owens and R. G. Hawley, Homeobox Genes in Leukemic Hematopoiesis, Stem Cells, vol.339, issue.5, pp.364-379, 2002.
DOI : 10.1634/stemcells.20-5-364

L. Palmqvist, B. Argiropoulos, N. Pineault, C. Abramovich, L. M. Sly et al., The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia, Blood, vol.108, issue.3, pp.1030-1036, 2006.
DOI : 10.1182/blood-2005-12-007005

L. Palmqvist, N. Pineault, C. Wasslavik, and R. K. Humphries, Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes, PLoS ONE, vol.66, issue.8, p.768, 2007.
DOI : 10.1371/journal.pone.0000768.t003

Q. Pan, Y. J. Zhu, B. W. Gu, X. Cai, X. T. Bai et al., A new fusion gene NUP98-IQCG identified in an acute, pp.11-29, 2008.

I. Panagopoulos, T. Fioretos, M. Isaksson, G. Larsson, R. Billstrom et al., Expression of NUP98/TOP1, but not of TOP1/NUP98, in a treatment-related myelodysplastic syndrome with t(10, Genes Chromosomes Cancer, vol.20, issue.34, pp.11-24, 2002.

I. Panagopoulos, M. Isaksson, R. Billstrom, B. Strombeck, F. Mitelman et al., in acute myeloid leukemia with t(11;12)(p15;q13), Genes, Chromosomes and Cancer, vol.100, issue.1, pp.107-112, 2003.
DOI : 10.1002/gcc.10139

I. Panagopoulos, G. Kerndrup, N. Carlsen, B. Strombeck, M. Isaksson et al., Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12), British Journal of Haematology, vol.63, issue.2, pp.294-296, 2007.
DOI : 10.1080/10428190310001659325

C. Panarello, C. Rosanda, and C. Morerio, Cryptic translocation t(5;11)(q35;p15.5) with involvement of theNSD1 andNUP98 genes without 5q deletion in childhood acute myeloid leukemia, Genes, Chromosomes and Cancer, vol.94, issue.3, pp.277-281, 2002.
DOI : 10.1002/gcc.10119

E. Passegue, C. H. Jamieson, L. E. Ailles, and I. L. Weissman, Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?, Proceedings of the National Academy of Sciences, vol.100, issue.Supplement 1, pp.11842-11849, 2003.
DOI : 10.1073/pnas.2034201100

K. Paulsson and B. Johansson, High hyperdiploid childhood acute lymphoblastic leukemia, Genes, Chromosomes and Cancer, vol.20, issue.8, pp.637-660, 2009.
DOI : 10.1002/gcc.20671

M. Perez-caro, C. Cobaleda, I. Gonzalez-herrero, C. Vicente-duenas, C. Bermejo-rodriguez et al., Cancer induction by restriction of oncogene expression to the stem cell compartment, The EMBO Journal, vol.441, issue.1, pp.8-20, 2009.
DOI : 10.1038/emboj.2008.253

P. Perez-vera, O. Montero-ruiz, S. Frias, R. Rivera-luna, A. Valladares et al., Multiple copies of RUNX1: description of 14 new patients, follow-up, and a review of the literature, Cancer Genetics and Cytogenetics, vol.180, issue.2, pp.129-134, 2008.
DOI : 10.1016/j.cancergencyto.2007.10.004

A. Petit, I. Radford, M. C. Waill, S. Romana, and R. Berger, NUP98???NSD1 fusion by insertion in acute myeloblastic leukemia, Cancer Genetics and Cytogenetics, vol.180, issue.1, pp.43-46, 2008.
DOI : 10.1016/j.cancergencyto.2007.09.007

N. Pineault, C. Abramovich, and R. K. Humphries, Transplantable cell lines generated with NUP98???Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA, Leukemia, vol.126, 2005.
DOI : 10.1016/j.gde.2003.11.007

N. Pineault, C. Abramovich, H. Ohta, and R. K. Humphries, Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1, Molecular and Cellular Biology, vol.24, issue.5, pp.1907-1917, 2004.
DOI : 10.1128/MCB.24.5.1907-1917.2004

N. Pineault, C. Buske, M. Feuring-buske, C. Abramovich, P. Rosten et al., Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1, Blood, vol.101, issue.11, pp.4529-4538, 2003.
DOI : 10.1182/blood-2002-08-2484

D. K. Pokholok, C. T. Harbison, S. Levine, M. Cole, N. M. Hannett et al., Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast, Cell, vol.122, issue.4, pp.517-527, 2005.
DOI : 10.1016/j.cell.2005.06.026

L. Potenza, B. Sinigaglia, M. Luppi, M. Morselli, A. Saviola et al., A t(11;20)(p15;q11) may identify a subset of nontherapy-related acute myelocytic leukemia, Cancer Genetics and Cytogenetics, vol.149, issue.2, pp.164-168, 2004.
DOI : 10.1016/j.cancergencyto.2003.07.002

M. A. Powers, D. J. Forbes, J. E. Dahlberg, and E. Lund, The Vertebrate GLFG Nucleoporin, Nup98, Is an Essential Component of Multiple RNA Export Pathways, The Journal of Cell Biology, vol.11, issue.6, pp.241-250, 1997.
DOI : 10.1073/pnas.80.21.6436

C. E. Pritchard, M. Fornerod, L. H. Kasper, and J. M. Van-deursen, RAE1 Is a Shuttling mRNA Export Factor That Binds to a GLEBS-like NUP98 Motif at the Nuclear Pore Complex through Multiple Domains, The Journal of Cell Biology, vol.266, issue.2, pp.237-254, 1999.
DOI : 10.1002/(SICI)1097-0061(19970930)13:12<1167::AID-YEA154>3.0.CO;2-O

C. Ragu, Etude du rôle de SRF dans l'hématopoïèse normale et implication dans la transformation de la lignée mégacaryocytaire, p.213, 2009.

C. V. Rao, H. Y. Yamada, Y. Yao, and W. Dai, Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice, Carcinogenesis, vol.30, issue.9, pp.1469-1474, 2009.
DOI : 10.1093/carcin/bgp081

G. V. Rayasam, O. Wendling, P. O. Angrand, M. Mark, K. Niederreither et al., NSD1 is essential for early post-implantation development and has a catalytically active SET domain, The EMBO Journal, vol.22, issue.12, pp.3153-3163, 2003.
DOI : 10.1093/emboj/cdg288

S. Z. Raza-egilmez, S. N. Jani-sait, M. Grossi, M. J. Higgins, T. B. Shows et al., NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia, Cancer Res, vol.58, pp.4269-4273, 1998.

J. C. Reader, J. S. Meekins, I. Gojo, and Y. Ning, A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia, Leukemia, vol.104, pp.842-844, 2007.
DOI : 10.1038/sj.leu.2404579

L. Remontet, A. Buemi, M. Velten, E. Jougla, and J. Estève, Evolution de l'incidence et de la mortalité par cancer en France de, 1978.

A. Renneville, N. Boissel, V. Zurawski, L. Llopis, V. Biggio et al., Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia, Cancer, vol.8, issue.16, pp.3719-3727, 2009.
DOI : 10.1002/cncr.24442

A. Renneville, C. Roumier, V. Biggio, O. Nibourel, N. Boissel et al., Cooperating gene mutations in acute myeloid leukemia: a review of the literature, Leukemia, vol.106, issue.5, pp.915-931, 2008.
DOI : 10.1038/leu.2008.19

S. P. Romana, L. Coniat, M. Berger, and R. , t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia, Genes, Chromosomes and Cancer, vol.5, issue.3, pp.186-191, 1994.
DOI : 10.1002/gcc.2870090307

S. P. Romana, I. Radford-weiss, B. Abdelali, R. Schluth, C. Petit et al., NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytog??n??tique H??matologique, NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique, pp.696-706, 2006.
DOI : 10.1038/sj.leu.2404130

R. Rosati, L. Starza, R. Veronese, A. Aventin, A. Schwienbacher et al., NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15), Blood, vol.99, issue.10, pp.3857-3860, 2002.
DOI : 10.1182/blood.V99.10.3857

F. Rosenbauer and D. G. Tenen, Transcription factors in myeloid development: balancing differentiation with transformation, Nature Reviews Immunology, vol.14, issue.2, pp.105-117, 2007.
DOI : 10.1038/nri2024

J. M. Rowe, Optimal management of adults with ALL, British Journal of Haematology, vol.110, issue.4, pp.468-483, 2009.
DOI : 10.1111/j.1365-2141.2008.07513.x

N. Rufer, T. H. Brummendorf, S. Kolvraa, C. Bischoff, K. Christensen et al., Telomere Fluorescence Measurements in Granulocytes and T Lymphocyte Subsets Point to a High Turnover of Hematopoietic Stem Cells and Memory T Cells in Early Childhood, The Journal of Experimental Medicine, vol.151, issue.2, pp.157-167, 1999.
DOI : 10.1084/jem.179.2.609

C. Satoh and K. Ogata, Hypothesis: Myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemia, Leukemia Research, vol.30, issue.4, pp.491-495, 2006.
DOI : 10.1016/j.leukres.2005.08.017

G. Sauvageau, P. M. Lansdorp, C. J. Eaves, D. E. Hogge, W. H. Dragowska et al., Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells., Proceedings of the National Academy of Sciences, vol.91, issue.25, pp.12223-12227, 1994.
DOI : 10.1073/pnas.91.25.12223

S. Schnittger, C. Schoch, W. Kern, C. Mecucci, C. Tschulik et al., Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype, Blood, vol.106, issue.12, pp.3733-3739, 2005.
DOI : 10.1182/blood-2005-06-2248

B. Schuettengruber, D. Chourrout, M. Vervoort, B. Leblanc, and G. Cavalli, Genome Regulation by Polycomb and Trithorax Proteins, Cell, vol.128, issue.4, pp.735-745, 2007.
DOI : 10.1016/j.cell.2007.02.009
URL : https://hal.archives-ouvertes.fr/hal-00133797

W. F. Shen, J. C. Montgomery, S. Rozenfeld, J. J. Moskow, H. J. Lawrence et al., AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins., Molecular and Cellular Biology, vol.17, issue.11, pp.6448-6458, 1997.
DOI : 10.1128/MCB.17.11.6448

A. Shilatifard, W. S. Lane, K. W. Jackson, R. C. Conaway, and J. W. Conaway, An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene, Science, vol.271, issue.5257, pp.1873-1876, 1996.
DOI : 10.1126/science.271.5257.1873

J. L. Shipley and J. N. Butera, Acute myelogenous leukemia, Experimental Hematology, vol.37, issue.6, pp.649-658, 2009.
DOI : 10.1016/j.exphem.2009.04.002

R. A. Shivdasani, Y. Fujiwara, M. A. Mcdevitt, and S. H. Orkin, A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development, The EMBO Journal, vol.16, issue.13, pp.3965-3973, 1997.
DOI : 10.1093/emboj/16.13.3965

C. W. So, H. Karsunky, E. Passegue, A. Cozzio, I. L. Weissman et al., MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice, Cancer Cell, vol.3, issue.2, pp.161-171, 2003.
DOI : 10.1016/S1535-6108(03)00019-9

C. W. So, H. Karsunky, P. Wong, I. L. Weissman, and M. L. Cleary, Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9, Blood, vol.103, issue.8, pp.3192-3199, 2004.
DOI : 10.1182/blood-2003-10-3722

C. W. So, M. Lin, P. M. Ayton, E. H. Chen, and M. L. Cleary, Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias, Cancer Cell, vol.4, issue.2, pp.99-110, 2003.
DOI : 10.1016/S1535-6108(03)00188-0

T. C. Somervaille and M. L. Cleary, Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia, Cancer Cell, vol.10, issue.4, pp.257-268, 2006.
DOI : 10.1016/j.ccr.2006.08.020

T. C. Somervaille, C. J. Matheny, G. J. Spencer, M. Iwasaki, J. L. Rinn et al., Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells, Cell Stem Cell, vol.4, issue.2, pp.129-140, 2009.
DOI : 10.1016/j.stem.2008.11.015

M. C. Stubbs, Y. M. Kim, A. V. Krivtsov, R. D. Wright, Z. Feng et al., MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment, Leukemia, vol.293, issue.1, pp.66-77, 2008.
DOI : 10.1038/sj.leu.2404951

H. G. Sutherland, K. Newton, D. G. Brownstein, M. C. Holmes, C. Kress et al., Disruption of Ledgf/Psip1 Results in Perinatal Mortality and Homeotic Skeletal Transformations, Molecular and Cellular Biology, vol.26, issue.19, pp.7201-7210, 2006.
DOI : 10.1128/MCB.00459-06

A. Takeda, N. J. Sarma, A. M. Abdul-nabi, and N. R. Yaseen, Inhibition of CRM1-mediated Nuclear Export of Transcription Factors by Leukemogenic NUP98 Fusion Proteins, Journal of Biological Chemistry, vol.285, issue.21, pp.16248-16257, 2010.
DOI : 10.1074/jbc.M109.048785

T. Taketani, T. Taki, H. Nakamura, M. Taniwaki, J. Masuda et al., NUP98???NSD3 fusion gene in radiation-associated myelodysplastic syndrome with t(8;11)(p11;p15) and expression pattern of NSD family genes, Cancer Genetics and Cytogenetics, vol.190, issue.2, pp.108-112, 2009.
DOI : 10.1016/j.cancergencyto.2008.12.008

T. Taketani, T. Taki, R. Ono, Y. Kobayashi, K. Ida et al., The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of theNUP98 gene with aHOXA cluster gene,HOXA13, but notHOXA9, Genes, Chromosomes and Cancer, vol.109, issue.4, pp.437-443, 2002.
DOI : 10.1002/gcc.10077

T. Taketani, T. Taki, N. Shibuya, E. Ito, J. Kitazawa et al., The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15), Cancer Res, vol.62, pp.33-37, 2002.

T. Taketani, T. Taki, N. Shibuya, A. Kikuchi, R. Hanada et al., Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13), Cancer Res, vol.62, pp.4571-4574, 2002.

R. Taub, I. Kirsch, C. Morton, G. Lenoir, D. Swan et al., Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells., Proceedings of the National Academy of Sciences, vol.79, issue.24, pp.7837-7841, 1982.
DOI : 10.1073/pnas.79.24.7837

C. Thiede, S. Koch, E. Creutzig, C. Steudel, T. Illmer et al., Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML), Blood, vol.107, issue.10, pp.4011-4020, 2006.
DOI : 10.1182/blood-2005-08-3167

S. Tosi, E. Ballabio, A. Teigler-schlegel, J. Boultwood, J. Bruch et al., Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in aNUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia, Genes, Chromosomes and Cancer, vol.78, issue.3, pp.225-232, 2005.
DOI : 10.1002/gcc.20233

N. Tosic, M. Stojiljkovic, N. Colovic, M. Colovic, and S. Pavlovic, Acute myeloid leukemia with NUP98???HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review, Cancer Genetics and Cytogenetics, vol.193, issue.2, pp.98-103, 2009.
DOI : 10.1016/j.cancergencyto.2009.03.007

A. A. Travers, Priming the nucleosome: a role for HMGB proteins?, EMBO reports, vol.20, issue.2, pp.131-136, 2003.
DOI : 10.1038/sj.embor.embor741

F. Y. Tsai, G. Keller, F. C. Kuo, M. Weiss, J. Chen et al., An early haematopoietic defect in mice lacking the transcription factor GATA-2, Nature, vol.371, issue.6494, pp.221-226, 1994.
DOI : 10.1038/371221a0

W. Vainchenker, A. Dusa, and S. N. Constantinescu, JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies, Seminars in Cell & Developmental Biology, vol.19, issue.4, pp.385-393, 2008.
DOI : 10.1016/j.semcdb.2008.07.002

L. J. Van-zutven, E. Onen, S. C. Velthuizen, E. Van-drunen, A. R. Von-bergh et al., Identification ofNUP98 abnormalities in acute leukemia:JARID1A (12p13) as a new partner gene, Genes, Chromosomes and Cancer, vol.39, issue.5, pp.437-446, 2006.
DOI : 10.1002/gcc.20308

J. M. Vaquerizas, R. Suyama, J. Kind, K. Miura, N. M. Luscombe et al., Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome, PLoS Genetics, vol.13, issue.2, p.1000846, 2010.
DOI : 10.1371/journal.pgen.1000846.s020

J. W. Vardiman, J. Thiele, D. A. Arber, R. D. Brunning, M. J. Borowitz et al., The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: rationale and important changes, Blood, 2009.

L. M. Vrooman and L. B. Silverman, Childhood acute lymphoblastic leukemia: update on prognostic factors, Current Opinion in Pediatrics, vol.21, issue.1, pp.1-8, 2009.
DOI : 10.1097/MOP.0b013e32831f1f24

C. R. Walkley, G. H. Olsen, S. Dworkin, S. A. Fabb, J. Swann et al., A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor ?? Deficiency, Cell, vol.129, issue.6, pp.1097-1110, 2007.
DOI : 10.1016/j.cell.2007.05.014
URL : https://hal.archives-ouvertes.fr/hal-00166246

C. R. Walkley, J. M. Shea, N. A. Sims, L. E. Purton, and S. H. Orkin, Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone??Marrow Microenvironment, Cell, vol.129, issue.6, pp.1081-1095, 2007.
DOI : 10.1016/j.cell.2007.03.055
URL : http://doi.org/10.1016/j.cell.2007.03.055

C. Q. Wang, B. Jacob, G. S. Nah, and M. Osato, Runx family genes, niche, and stem cell quiescence, Blood Cells, Molecules, and Diseases, vol.44, issue.4, 2010.
DOI : 10.1016/j.bcmd.2010.01.006

G. G. Wang, L. Cai, M. P. Pasillas, and M. P. Kamps, NUP98???NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis, Nature Cell Biology, vol.442, issue.7, pp.804-812, 2007.
DOI : 10.1038/nature05140

G. G. Wang, J. Song, Z. Wang, H. L. Dormann, F. Casadio et al., Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger, Nature, vol.9, issue.7248, pp.847-851, 2009.
DOI : 10.1038/nature08036

A. Waterstrat and G. Van-zant, Effects of aging on hematopoietic stem and progenitor cells, Current Opinion in Immunology, vol.21, issue.4, pp.408-413, 2009.
DOI : 10.1016/j.coi.2009.05.002

J. Wei, M. Wunderlich, C. Fox, S. Alvarez, J. C. Cigudosa et al., Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia, Cancer Cell, vol.13, issue.6, pp.483-495, 2008.
DOI : 10.1016/j.ccr.2008.04.020

A. P. Weng, A. A. Ferrando, W. Lee, J. P. Morris, L. B. Silverman et al., Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia, Science, vol.306, issue.5694, pp.269-271, 2004.
DOI : 10.1126/science.1102160

D. J. Wong, H. Liu, T. W. Ridky, D. Cassarino, E. Segal et al., Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells, Cell Stem Cell, vol.2, issue.4, pp.333-344, 2008.
DOI : 10.1016/j.stem.2008.02.009

X. Wu, L. H. Kasper, R. T. Mantcheva, G. T. Mantchev, M. J. Springett et al., Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function, Proceedings of the National Academy of Sciences, vol.98, issue.6, pp.3191-3196, 2001.
DOI : 10.1073/pnas.051631598

H. Xiao, R. Sandaltzopoulos, H. M. Wang, A. Hamiche, R. Ranallo et al., Dual Functions of Largest NURF Subunit NURF301 in Nucleosome Sliding and Transcription Factor Interactions, Molecular Cell, vol.8, issue.3, pp.531-543, 2001.
DOI : 10.1016/S1097-2765(01)00345-8

N. Xylourgidis and M. Fornerod, Acting Out of Character: Regulatory Roles of Nuclear Pore Complex Proteins, Developmental Cell, vol.17, issue.5, pp.617-625, 2009.
DOI : 10.1016/j.devcel.2009.10.015

L. Yang, D. Bryder, J. Adolfsson, J. Nygren, R. Mansson et al., Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients, Blood, vol.105, issue.7, pp.2717-2723, 2005.
DOI : 10.1182/blood-2004-06-2159

E. R. Yassin, A. M. Abdul-nabi, A. Takeda, and N. R. Yaseen, Effects of the NUP98???DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif, Leukemia, vol.13, issue.5, 2010.
DOI : 10.1093/emboj/20.6.1341

A. Yokoyama and M. L. Cleary, Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes, Cancer Cell, vol.14, issue.1, pp.36-46, 2008.
DOI : 10.1016/j.ccr.2008.05.003

A. Yokoyama, T. C. Somervaille, K. S. Smith, O. Rozenblatt-rosen, M. Meyerson et al., The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis, Cell, vol.123, issue.2, pp.207-218, 2005.
DOI : 10.1016/j.cell.2005.09.025

B. D. Yu, J. L. Hess, S. E. Horning, G. A. Brown, and S. J. Korsmeyer, Altered Hox expression and segmental identity in Mll-mutant mice, Nature, vol.225, issue.6556, pp.505-508, 1995.
DOI : 10.1038/378505a0

K. Yun, S. Garel, S. Fischman, and J. L. Rubenstein, Patterning of the lateral ganglionic eminence by theGsh1 andGsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia, The Journal of Comparative Neurology, vol.129, issue.2, pp.151-165, 2003.
DOI : 10.1002/cne.10685

L. Zhang, R. Alsabeh, C. Mecucci, L. Starza, R. Gorello et al., Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature, Cancer Genetics and Cytogenetics, vol.178, issue.1, pp.42-48, 2007.
DOI : 10.1016/j.cancergencyto.2007.06.012

X. Zhang, S. Chen, S. Yoo, S. Chakrabarti, T. Zhang et al., Mutation in Nuclear Pore Component NUP155 Leads to Atrial Fibrillation and Early Sudden Cardiac Death, Cell, vol.135, issue.6, pp.1017-1027, 2008.
DOI : 10.1016/j.cell.2008.10.022