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Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence

Abstract : Magnetic resonance imaging is a commonly used diagnostic method in medicinal practice as well as in biological and preclinical research. However, the relaxivity of commercial contrast agents is only a few percent of the theoretically predicted relaxivity. An optimisation of the different parameters who have an impact on the relaxivity (number of gadolinium bound water molecules, water exchange rate, rotation dynamic of the complex, electronic relaxation, Gd(III)-proton distance) is needed to obtain higher relaxivities. In this work, we present the synthesis, the stability and the relaxivity of the Gd(III) complexes of two series of 8-hydroxyquinolinate-based ligands, one using a 1,4,7 triazacyclononane platform, the other one using a central nitrogen architecture. Theses complexes show stabilities comparable to commercial agents, and high relaxivities in both water and serum. The 8-hydroxyquinolinate moiety allows these ligands to sensitize Nd(III) and Yb(III) for Near Infra Red (NIR) luminescence, leading to a new class of potential bimodal systems.
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Submitted on : Wednesday, November 2, 2011 - 2:07:33 PM
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Gaylord Tallec. Nouveaux complexes de lanthanides pour le développement d'agents de contraste bimodaux IRM/luminescence. Autre [q-bio.OT]. Université Grenoble Alpes, 2011. Français. ⟨NNT : 2011GRENV051⟩. ⟨tel-00637586⟩

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