Morphological and ultrastructural effects of microcystin-LR from Microcystis aeruginosa extract on a kidney cell line, Toxicon, vol.54, issue.3, pp.283-294, 2009. ,
DOI : 10.1016/j.toxicon.2009.04.014
Oxidative stress generation by microcystins in aquatic animals: Why and how, Environment International, vol.36, issue.2, pp.226-235, 2010. ,
DOI : 10.1016/j.envint.2009.10.010
Effects of microcystin???LR on the expression of P-glycoprotein in Jenynsia multidentata, Chemosphere, vol.74, issue.9, pp.1179-1186, 2009. ,
DOI : 10.1016/j.chemosphere.2008.11.068
Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells, Biochemical and Biophysical Research Communications, vol.175, issue.3, pp.880-885, 1991. ,
DOI : 10.1016/0006-291X(91)91647-U
Human intoxication by microcystins during renal dialysis treatment in Caruaru???Brazil, Toxicology, vol.181, issue.182, pp.181-182, 2002. ,
DOI : 10.1016/S0300-483X(02)00491-2
Microcystin-LR causes the collapse of actin filaments in primary human hepatocytes, Aquatic Toxicology, vol.65, issue.1, pp.85-91, 2003. ,
DOI : 10.1016/S0166-445X(03)00108-5
The role of microcystin-LR in the induction of apoptosis and oxidative stress in CaCo2 cells, Toxicon, vol.43, issue.1, pp.85-92, 2004. ,
DOI : 10.1016/j.toxicon.2003.10.025
The Cyanotoxins, Adv. Bot. Res, vol.27, pp.211-256, 1997. ,
DOI : 10.1016/S0065-2296(08)60282-7
Uptake, tissue distribution and accumulation of microcystin-RR in Corydoras paleatus, Jenynsia multidentata and Odontesthes bonariensis, Aquatic Toxicology, vol.75, issue.2, pp.178-190, 2005. ,
DOI : 10.1016/j.aquatox.2005.08.002
Study on the cytotoxicity of microcystin-LR on cultured cells, Chemosphere, vol.41, issue.1-2, pp.143-147, 2000. ,
DOI : 10.1016/S0045-6535(99)00402-6
Toxic Cyanobacteria in Water: A Guide to their Public Health Consequences, Monitoring and Management, 1999. ,
DOI : 10.4324/9780203478073
Multi-xenobiotic-resistance a possible explanation for the insensitivity of bivalves towards cyanobacterial toxins, Toxicon, vol.52, issue.8, pp.936-943, 2008. ,
DOI : 10.1016/j.toxicon.2008.09.005
Comparative study of the cytotoxic effect of microcistin-LR and purified extracts from Microcystis aeruginosa on a kidney cell line, Toxicon, vol.53, issue.5, pp.487-495, 2009. ,
DOI : 10.1016/j.toxicon.2009.01.029
Hepatotoxicity and formation of reactive oxygen species induced by microcystis aeruginosa toxin, Zhonghua yu fang yi xue za zhi, vol.32, pp.278-280, 1998. ,
Microcystic Cyanobacteria Extract Induces Cytoskeletal Disruption and Intracellular Glutathione Alteration in Hepatocytes, Environmental Health Perspectives, vol.108, issue.7, pp.605-609, 2000. ,
DOI : 10.1289/ehp.00108605
Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin, Experimental Cell Research, vol.185, issue.1, pp.86-100, 1989. ,
DOI : 10.1016/0014-4827(89)90039-6
Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin, Biochimica et Biophysica Acta (BBA) - Biomembranes, vol.1025, issue.1, pp.60-66, 1990. ,
DOI : 10.1016/0005-2736(90)90190-Y
Hepatocyte deformation induced by cyanobacterial toxins reflects inhibition of protein phosphatases, Biochemical and Biophysical Research Communications, vol.173, issue.3, pp.1347-1353, 1990. ,
DOI : 10.1016/S0006-291X(05)80936-2
Effect of the cyanobacterial (blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from the chicken small intestine, Toxicon, vol.30, issue.7, pp.790-793, 1992. ,
DOI : 10.1016/0041-0101(92)90016-X
Tumour promotion by cyanobacterial toxins, Phycologia, vol.35, issue.6S, pp.74-79, 1996. ,
DOI : 10.2216/i0031-8884-35-6S-74.1
Determination of Oligopeptide Diversity within a Natural Population of Microcystis spp. (Cyanobacteria) by Typing Single Colonies by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, Applied and Environmental Microbiology, vol.67, issue.11, pp.5069-5076, 2001. ,
DOI : 10.1128/AEM.67.11.5069-5076.2001
The toxicity of cyanobacterial toxins in the mouse: I Microcystin-LR, Human & Experimental Toxicology, vol.26, issue.3, pp.162-167, 1999. ,
DOI : 10.1177/096032719901800305
Oatp-associated uptake and toxicity of microcystins in primary murine whole brain cells, Toxicology and Applied Pharmacology, vol.234, issue.2, pp.247-255, 2009. ,
DOI : 10.1016/j.taap.2008.10.011
The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells, Toxicology and Applied Pharmacology, vol.245, issue.1, pp.9-20, 2010. ,
DOI : 10.1016/j.taap.2010.02.006
Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin, Toxicology and Applied Pharmacology, vol.203, issue.3, pp.257-263, 2005. ,
DOI : 10.1016/j.taap.2004.08.012
Evaluation of the Effect of Ethanol???s Toxic Metabolite Acetaldehyde on the Gastrointestinal Oligopeptide Transporter, PEPT1: In Vitro and in Vivo Studies, Alcoholism: Clinical and Experimental Research, vol.1, issue.1, pp.162-170, 2008. ,
DOI : 10.1111/j.1530-0277.2007.00551.x
Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice, Toxicology, vol.188, issue.2-3, pp.285-296, 2003. ,
DOI : 10.1016/S0300-483X(03)00112-4
Inhibition of nuclear protein phosphatase activity in mouse hepatocytes by the cyanobacterial toxin microcystin-LR, Toxicon, vol.41, issue.7, pp.773-781, 2003. ,
DOI : 10.1016/S0041-0101(03)00030-8
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties, Pfl???gers Archiv European Journal of Physiology, vol.447, issue.5, pp.653-665, 2004. ,
DOI : 10.1007/s00424-003-1168-y
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories, European Journal of Pharmaceutical Sciences, vol.35, issue.5, pp.383-396, 2008. ,
DOI : 10.1016/j.ejps.2008.08.004
Evaluation of potential chemoprotectants against microcystin-LR hepatotoxicity in mice, Journal of Applied Toxicology, vol.2, issue.1, 1991. ,
DOI : 10.1002/jat.2550110112
Hepatic ultrastructural changes induced by the toxin microcystin-LR (MCLR) in mice, J. Environ. Pathol. Toxicol. Oncol, vol.12, pp.101-106, 1993. ,
Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines, Drug Metabolism and Disposition, vol.35, issue.8, pp.1333-1340, 2007. ,
DOI : 10.1124/dmd.107.014902
Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases, J. Biol. Chem, vol.265, 1990. ,
The apoptotic effect of oral administration of microcystin-RR on mice liver, Environmental Toxicology, vol.12, issue.5, 2010. ,
DOI : 10.1002/tox.20570
Hepatic necrosis in aged mice by oral administration of microcystin-LR, Toxicon, vol.35, issue.2, pp.231-239, 1997. ,
DOI : 10.1016/S0041-0101(96)00129-8
Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice, Toxicology, vol.220, issue.2-3, pp.136-146, 2006. ,
DOI : 10.1016/j.tox.2005.12.007
Effect of Alcohol on Drug Efflux Protein and Drug Metabolic Enzymes in U937 Macrophages, Alcoholism: Clinical and Experimental Research, vol.392, issue.1, pp.132-139, 2011. ,
DOI : 10.1111/j.1530-0277.2010.01330.x
Pharmacogenomics of human OATP transporters, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.36, issue.6, pp.432-443, 2006. ,
DOI : 10.1007/s00210-006-0040-y
Similar uptake profiles of microcystin-LR and -RR in an in vitro human intestinal model, Toxicology, vol.290, issue.1, 2011. ,
DOI : 10.1016/j.tox.2011.08.005
Analysis of drug transporter expression in human intestinal Caco-2 cells by real-time PCR, Fundamental & Clinical Pharmacology, vol.21, issue.6, pp.659-663, 2007. ,
DOI : 10.1124/dmd.106.009530
URL : https://hal.archives-ouvertes.fr/hal-00690294
Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog, Toxicon, vol.28, issue.12, pp.1439-1446, 1990. ,
DOI : 10.1016/0041-0101(90)90157-3
Identification of ATP-synthase as a novel intracellular target for microcystin-LR, Chemico-Biological Interactions, vol.142, issue.3, 2003. ,
DOI : 10.1016/S0009-2797(02)00075-3
Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells, Molecular Cancer Therapeutics, vol.6, issue.2, pp.587-598, 2007. ,
DOI : 10.1158/1535-7163.MCT-06-0500
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR, Journal of Cancer Research and Clinical Oncology, vol.116, issue.6, pp.420-424, 1992. ,
DOI : 10.1007/BF01629424
The biological and clinical role of drug transporters at the intestinal barrier, Cancer Treatment Reviews, vol.35, issue.2, pp.137-147, 2009. ,
DOI : 10.1016/j.ctrv.2008.09.004
Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil, The Lancet, vol.352, issue.9121, pp.21-26, 1998. ,
DOI : 10.1016/S0140-6736(97)12285-1
Comparison of the toxicity induced by microcystin-RR and microcystin-YR in differentiated and undifferentiated Caco-2 cells, Toxicon, vol.54, issue.2, pp.161-169, 2009. ,
DOI : 10.1016/j.toxicon.2009.03.030
Microcystin-LR induces toxic effects in differentiated and undifferentiated Caco-2 cells, Archives of Toxicology, vol.261, issue.5, 2010. ,
DOI : 10.1007/s00204-010-0513-0
Microcystin Uptake and Inhibition of Protein Phosphatases: Effects of Chemoprotectants and Self-Inhibition in Relation to Known Hepatic Transporters, Toxicology and Applied Pharmacology, vol.134, issue.2, pp.264-272, 1995. ,
DOI : 10.1006/taap.1995.1192
In Vivo and in Vitro Binding of Microcystin to Protein Phosphatase 1 and 2A, Biochemical and Biophysical Research Communications, vol.216, issue.1, pp.162-169, 1995. ,
DOI : 10.1006/bbrc.1995.2605
PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS, Drug Metabolism and Disposition, vol.34, issue.8, pp.1423-1431, 2006. ,
DOI : 10.1124/dmd.106.009530
Molecular Aspects of Microcystin-induced Hepatotoxicity and Hepatocarcinogenesis, Journal of Environmental Science and Health, Part C, vol.30, issue.1, 2010. ,
DOI : 10.1007/s10330-008-0137-5
Cytotoxicity effects of microcystins of different hydrophobicities, International Conference on Toxic Cyanobacteria, 2010. ,
Interaction between microcystins of different hydrophobicities and lipid monolayers, Toxicon, vol.41, issue.3, pp.349-355, 2003. ,
DOI : 10.1016/S0041-0101(02)00315-X
The role of reactive oxygen species in microcystin-LR-induced DNA damage, Toxicology, vol.200, pp.59-68, 2004. ,
Oxidative stress generation by microcystins in aquatic animals: Why and how, Environment International, vol.36, issue.2, pp.226-235, 2010. ,
DOI : 10.1016/j.envint.2009.10.010
Effects of microcystin???LR on the expression of P-glycoprotein in Jenynsia multidentata, Chemosphere, vol.74, issue.9, pp.1179-1186, 2009. ,
DOI : 10.1016/j.chemosphere.2008.11.068
Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67???84.1, Advanced Drug Delivery Reviews, vol.46, issue.1-3, pp.27-43, 2001. ,
DOI : 10.1016/S0169-409X(00)00128-9
The role of microcystin-LR in the induction of apoptosis and oxidative stress in CaCo2 cells, Toxicon, vol.43, issue.1, pp.85-92, 2004. ,
DOI : 10.1016/j.toxicon.2003.10.025
Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress, Journal of Biological Chemistry, vol.285, issue.24, pp.18452-18463, 2010. ,
DOI : 10.1074/jbc.M109.077925
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays, Hepatology, vol.33, issue.5, pp.1239-1258, 2001. ,
DOI : 10.1053/jhep.2001.23560
Differential detoxification and antioxidant response in diverse organs of Corydoras paleatus experimentally exposed to microcystin-RR, Aquatic Toxicology, vol.76, issue.1, pp.1-12, 2006. ,
DOI : 10.1016/j.aquatox.2005.08.011
Human antiquitin: Structural and functional studies, Chemico-Biological Interactions, vol.191, issue.1-3, 2010. ,
DOI : 10.1016/j.cbi.2010.12.019
Identification of human liver mitochondrial aldehyde dehydrogenase as a potential target for microcystin-LR, Toxicology, vol.220, issue.1 ,
DOI : 10.1016/j.tox.2005.12.001
Induction of Apoptosis in Mouse Liver by Microcystin-LR: A Combined Transcriptomic, Proteomic, And Simulation Strategy, Molecular & Cellular Proteomics, vol.4, issue.7, pp.958-974, 2005. ,
DOI : 10.1074/mcp.M400185-MCP200
Toxic cyanobacteria in water : a guide to their public health consequences, monitoring and management. WHO, 1999. 13 Chronic microcystin exposure induces hepatocyte proliferation with increased expression of mitotic and cyclinassociated genes in p53-deficient mice Hepatotoxicity and formation of reactive oxygen species induced by microcystis aeruginosa toxin, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine, pp.190-203, 1998. ,
DOI : 10.4324/9780203478073
Role of oxidative stress and mitochondrial changes in cyanobacteria-induced apoptosis and hepatotoxicity, FEMS Microbiology Letters, vol.220, issue.1, pp.1-7, 2003. ,
DOI : 10.1016/S0378-1097(03)00100-9
Localization of microcystin-LR in medaka fish tissues after cyanotoxin gavage Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin, Toxicon Biochimica et Biophysica Acta - Biomembranes, vol.55, issue.1025, pp.531-535, 1990. ,
Effect of the cyanobacterial (blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from the chicken small intestine, Toxicon, vol.30, issue.7, pp.790-793, 1992. ,
DOI : 10.1016/0041-0101(92)90016-X
Cytoskeletal changes in hepatocytes induced by ,
The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells, Microcystis toxins and their relation to hyperphosphorylation of cell proteins, pp.181-196, 1992. ,
DOI : 10.1016/j.taap.2010.02.006
Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions, Toxicol Appl Pharmacol Cellular and Molecular Life Sciences: CMLS, vol.203, issue.63, pp.257-263, 2005. ,
Activation of Nrf2 by Microcystin-LR Provides Advantages for Liver Cancer Cell Growth, Chemical Research in Toxicology, vol.23, issue.9, pp.1477-1484, 2010. ,
DOI : 10.1021/tx1001628
Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice Hepatic oxidative stress following prolonged sublethal microcystin LR exposure Analytical and functional characterization of microcystins [Asp3]MC-RR and [Asp3,Dhb7]MC-RR: consequences for risk assessment?, Toxicology Toxicologic pathology Environmental Science & Technology, vol.188, issue.41, pp.285-296, 1999. ,
Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation, J Biol Chem Toxicology and Applied Pharmacology, vol.265, issue.220, pp.357-364, 1990. ,
First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method, Toxicon, vol.38, issue.1, pp.37-48, 2000. ,
DOI : 10.1016/S0041-0101(99)00084-7
Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds, Toxicon, vol.40, issue.7 ,
DOI : 10.1016/S0041-0101(02)00099-5
Activity and gene expression profile of certain antioxidant enzymes to microcystin-LR induced oxidative stress in mice Mitochondria a key role in microcystin-LR kidney intoxication, Toxicology J Appl Toxicol, vol.220, issue.28, pp.136-146, 2006. ,
The first study on the effects of microcystin-RR on gene expression profiles of antioxidant enzymes and heat shock protein-70 in Synechocystis sp. PCC6803, Toxicon, vol.53, issue.6 ,
DOI : 10.1016/j.toxicon.2008.11.005
Detection by 32P-postlabelling of 8-oxo-7,8-dihydro-2???-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol.564, issue.1, pp.9-20, 2004. ,
DOI : 10.1016/j.mrgentox.2004.06.010
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily, Expert Opinion on Drug Metabolism & Toxicology, vol.182, issue.6, pp.697-720, 2008. ,
DOI : 10.1016/j.brainres.2006.09.081
Threonine Phosphatases for Drug Development Proteomic and phosphoproteomic analysis of cellular responses in medaka fish (Oryzias latipes) following oral gavage with microcystin-LR, Molecular Pharmacology Toxicon: Official Journal of the International Society on Toxinology, vol.75, issue.51, pp.1249-1261, 2008. ,
Microcystin-LR promote intestinal secretion of water and electrolytes in rats Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture, 43. Pouria S, De Andrade A GH, and Codd GA. Fatal microcystin intoxication in haemodialysis unit in Caruaru, pp.555-559, 1983. ,
Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp.) Aquatic Toxicology, FrÃ-as JE, and Cameán AM. Differential oxidative stress responses to pure Microcystin-LR and Microcystin-containing and noncontaining cyanobacterial crude extracts on Caco-2 cells, pp.314-321, 2006. ,
Issues arising when interpreting the results of the protein phosphatase 2A inhibition assay for the monitoring of microcystins Microcystin uptake and inhibition of protein phosphatases: Effects of chemoprotectants and self-inhibition in relation to known hepatic transporters In vivo and in vitro binding of microcystin to protein phosphatases 1 and 2A The Caco-2 cell monolayer: Usefulness and limitations, 50. Tusher VG, Tibshirani R, and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences of the United States of America, pp.339-346, 1995. ,
Protein profiles in zebrafish (Danio rerio) brains exposed to chronic microcystin-LR, Chemosphere, vol.81, issue.6, pp.716-724, 2010. ,
DOI : 10.1016/j.chemosphere.2010.07.061
Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection, Toxicon, vol.52, issue.6 ,
DOI : 10.1016/j.toxicon.2008.08.004
Effects of cyanobacterial toxin microcystin-LR on the transcription levels of immune-related genes in grass carp Ctenopharyngodon idella, Environmental Biology of Fishes, vol.174, issue.3, pp.231-238, 1998. ,
DOI : 10.1007/s10641-009-9488-1
Alteration of intracellular GSH levels and its role in microcystin-LR-induced DNA damage in human hepatoma HepG2 cells Mutation Research - Genetic Toxicology and Environmental Mutagenesis Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage 58. Zegura B, Zajc I, Lah TT, and Filipic M. Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis, MT, and Lan Q. Systems biology of human benzene exposure, pp.74-81, 2006. ,
Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles, The International Journal of Biochemistry & Cell Biology, vol.41, issue.10, pp.1805-1821, 2009. ,
DOI : 10.1016/j.biocel.2009.02.017
Overexpression of OATP1B3 Confers Apoptotic Resistance in Colon Cancer, Cancer Research, vol.68, issue.24, pp.10315-10338, 2008. ,
DOI : 10.1158/0008-5472.CAN-08-1984
Human Intestinal Permeability, Journal of Pharmaceutical Sciences, vol.87, issue.4, pp.403-413, 1998. ,
DOI : 10.1021/js970332a
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense, Toxicology and Applied Pharmacology, vol.204, issue.3, pp.216-253, 2005. ,
DOI : 10.1016/j.taap.2004.10.012
Risques sanitaires liés à la présence de cyanobactéries dans l " eau : évaluation des risques liés à la présence de cyanobactéries et de leurs toxines dans les eaux destinées à l " alimentation, 2006. ,
Screening for human ADME/Tox drug properties in drug discovery, Drug Discovery Today, vol.6, issue.7, pp.357-66, 2001. ,
DOI : 10.1016/S1359-6446(01)01712-3
Microcystin-induced variations in transcription of GSTs in an omnivorous freshwater fish, goldfish, Aquatic Toxicology, vol.88, issue.1, pp.75-80, 2008. ,
DOI : 10.1016/j.aquatox.2008.03.007
Microcystin -LR (MCLR) Induces a Compensation of PP2A Actvity Mediated by alpha4 Protein in HEK293 Cells, Int J Biol Sci, pp.740-52, 2011. ,
Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR, Environmental Toxicology, vol.116, issue.6, pp.517-539, 2001. ,
DOI : 10.1002/tox.10012
Responses of antioxidant systems in the hepatocytes of common carp (Cyprinus carpio L.) to the toxicity of microcystin-LR, Toxicon, vol.42, issue.1, pp.85-94, 2003. ,
DOI : 10.1016/S0041-0101(03)00104-1
The toxic effects of microcystin-LR on the reproductive system of male rats in vivo and in vitro, Reproductive Toxicology, vol.26, issue.3-4, pp.239-284, 2008. ,
DOI : 10.1016/j.reprotox.2008.09.004
of Microcystin-RR and -LR Using LC-MS, The Scientific World JOURNAL, vol.11, pp.20-26, 2011. ,
DOI : 10.1100/tsw.2011.17
Paracellular Porosity and Pore Size of the Human Intestinal Epithelium in Tissue and Cell Culture Models, Journal of Pharmaceutical Sciences, vol.99, issue.4, pp.2166-75, 2010. ,
DOI : 10.1002/jps.21961
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines, Proceedings of the National Academy of Sciences, vol.103, issue.4, pp.976-81, 2006. ,
DOI : 10.1073/pnas.0510146103
Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR, Toxicological Sciences, vol.103, issue.1, pp.35-45, 2008. ,
DOI : 10.1093/toxsci/kfn038
Simultaneous changes in cell quotas of microcystin, chlorophyll a, protein and carbohydrate during different growth phases of a batch culture experiment with Microcystis aeruginosa, Journal of Plankton Research, vol.26, issue.7, pp.727-763, 2004. ,
DOI : 10.1093/plankt/fbh071
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants, FEBS Letters, vol.159, issue.2, pp.187-92, 1990. ,
DOI : 10.1016/0014-5793(90)80245-E
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1, FEBS Letters, vol.371, pp.236-276, 1995. ,
Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ), Toxicon, vol.42, issue.3, pp.289-95, 2003. ,
DOI : 10.1016/S0041-0101(03)00144-2
Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats, Chemico-Biological Interactions, vol.159, issue.3, pp.223-257, 2006. ,
DOI : 10.1016/j.cbi.2005.12.001
Proteomic study of the effects of microcystin-LR on organelle and membrane proteins in medaka fish liver, Aquatic Toxicology, vol.94, issue.2, pp.153-61, 2009. ,
DOI : 10.1016/j.aquatox.2009.06.012
Simulated lake phytoplankton composition shifts toward cyanobacteria dominance in a future warmer climate, Ecological Applications, vol.30, issue.3, pp.752-67, 2010. ,
DOI : 10.1029/2004GL019530
Microcystin Dynamics in Aquatic Organisms, Journal of Toxicology and Environmental Health, Part B, vol.135, issue.1, pp.65-82, 2009. ,
DOI : 10.1046/j.1365-2427.1999.00499.x
Analysis of drug transporter expression in human intestinal Caco-2 cells by real-time PCR, Fundamental & Clinical Pharmacology, vol.21, issue.6, pp.659-63, 2007. ,
DOI : 10.1124/dmd.106.009530
URL : https://hal.archives-ouvertes.fr/hal-00690294
Targeting Protein Serine/Threonine Phosphatases for Drug Development, Molecular Pharmacology, vol.75, issue.6, pp.1249-61, 2009. ,
DOI : 10.1124/mol.108.053140
Organic Anion Transporting Polypeptides of the OATP/SLCO Superfamily: Identification of New Members in Nonmammalian Species, Comparative Modeling and a Potential Transport Mode, Journal of Membrane Biology, vol.437, issue.(Suppl. 6), pp.213-240, 2006. ,
DOI : 10.1007/s00232-005-7004-x
Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract, Drug Metabolism and Disposition, vol.35, issue.4, pp.590-594, 2007. ,
DOI : 10.1124/dmd.106.013342
Endoplasmic reticulum stress compromises the ubiquitin-proteasome system, Human Molecular Genetics, vol.14, issue.19, pp.2787-99, 2005. ,
DOI : 10.1093/hmg/ddi312
Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog, Toxicon, vol.28, issue.12, pp.1439-1485, 1990. ,
DOI : 10.1016/0041-0101(90)90157-3
Immuno-crossreactivity and toxicity assessment of conjugation products of the cyanobacterial toxin, microcystin-LR, FEMS Microbiology Letters, vol.189, issue.2, pp.155-163, 2000. ,
DOI : 10.1111/j.1574-6968.2000.tb09222.x
Identification of ATP-synthase as a novel intracellular target for microcystin-LR, Chemico-Biological Interactions, vol.142, issue.3, pp.223-260, 2003. ,
DOI : 10.1016/S0009-2797(02)00075-3
Evidence for a Novel Marine Harmful Algal Bloom: Cyanotoxin (Microcystin) Transfer from Land to Sea Otters, PLoS ONE, vol.74, issue.9, pp.1-11, 2010. ,
DOI : 10.1371/journal.pone.0012576.t003
Renal injuries induced by chronic intoxication with microcystins, Cellular and Molecular Biology Letters, vol.7, pp.139-180, 2002. ,
Nephrotoxic effects of chronic administration of microcystins -LR and -YR, Toxicon, vol.42, issue.3, pp.281-289, 2003. ,
DOI : 10.1016/S0041-0101(03)00143-0
Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats, Drug Metabolism and Disposition, vol.36, issue.6, pp.1039-1084, 2008. ,
DOI : 10.1124/dmd.107.019687
Comparison of in vivo and in vitro toxic effects of microcystin-LR in fasted rats, Toxicon, vol.27, issue.11, pp.1229-1269, 1989. ,
DOI : 10.1016/0041-0101(89)90031-7
Hepatotoxicity of microcystin-LR in fed and fasted rats, Toxicon, vol.29, issue.3, pp.337-383, 1991. ,
DOI : 10.1016/0041-0101(91)90287-2
Microcystins in groundwater wells and their accumulation in vegetable plants irrigated with contaminated waters in Saudi Arabia, Journal of Hazardous Materials, vol.172, issue.1, pp.310-315, 2009. ,
DOI : 10.1016/j.jhazmat.2009.07.010
Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells, Molecular Cancer Therapeutics, vol.6, issue.2, pp.587-98, 2007. ,
DOI : 10.1158/1535-7163.MCT-06-0500
Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally, Toxicon, vol.45, issue.4, pp.395-402, 2005. ,
DOI : 10.1016/j.toxicon.2004.11.001
Influencia de la Microcistina-LR sobre la actividad de enzimas de membrana en mucosa intestinal de rata, Journal of Physiology and Biochemistry, vol.36, issue.4, pp.293-300, 2003. ,
DOI : 10.1007/BF03179887
The adsorption of microcystin-LR by natural clay particles, Toxicon, vol.38, issue.2, pp.303-311, 2000. ,
DOI : 10.1016/S0041-0101(99)00149-X
Nonequivalent Nucleotide Trapping in the Two Nucleotide Binding Folds of the Human Multidrug Resistance Protein MRP1, Journal of Biological Chemistry, vol.275, issue.23, pp.17626-17656, 2000. ,
DOI : 10.1074/jbc.M000792200
Structure-Function Relationships of Microcystins, Liver Tumor Promoters, in Interaction with Protein Phosphatase, Japanese Journal of Cancer Research, vol.66, issue.B, pp.993-999, 1991. ,
DOI : 10.1111/j.1349-7006.1991.tb01933.x
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR, Journal of Cancer Research and Clinical Oncology, vol.116, issue.6, pp.420-424, 1992. ,
DOI : 10.1007/BF01629424
Two significant aspects of microcystin-LR: specific binding and liver specificity, Cancer Letters, vol.83, issue.1-2, pp.283-292, 1994. ,
DOI : 10.1016/0304-3835(94)90331-X
The role of phospholipase A2 and cyclooxygenase in renal toxicity induced by microcystin-LR, Toxicon, vol.39, issue.5, 2001. ,
DOI : 10.1016/S0041-0101(00)00193-8
Effects of microcystin-LR in isolated perfused rat kidney, Brazilian Journal of Medical and Biological Research, vol.32, issue.8, pp.985-993, 1999. ,
DOI : 10.1590/S0100-879X1999000800008
Involvement of reactive oxygen species in Microcystin-LR-induced cytogenotoxicity, Free Radical Research, vol.78, issue.12, pp.1326-1363, 2007. ,
DOI : 10.1016/S0891-5849(97)00463-2
Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes, Carcinogenesis, vol.13, issue.12, pp.2443-2450, 1992. ,
DOI : 10.1093/carcin/13.12.2443
Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver, Cancer Research, vol.54, pp.6402-6408, 1994. ,
Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers, Toxicology in Vitro, vol.14, issue.3, pp.219-245, 2000. ,
DOI : 10.1016/S0887-2333(00)00014-X
The biological and clinical role of drug transporters at the intestinal barrier, Cancer Treatment Reviews, vol.35, issue.2, pp.137-184, 2009. ,
DOI : 10.1016/j.ctrv.2008.09.004
Fast screening and quantitation of microcystins in microalgae dietary supplement products and water by liquid chromatography coupled to time of flight mass spectrometry, Analytica Chimica Acta, vol.617, issue.1-2, pp.230-237, 2008. ,
DOI : 10.1016/j.aca.2008.03.033
First evidence of estrogenic potential of the cyanobacterial heptotoxins the nodularin-R and the microcystin-LR in cultured mammalian cells, Journal of Hazardous Materials, vol.174, issue.1-3, pp.610-615, 2010. ,
DOI : 10.1016/j.jhazmat.2009.09.095
Toxicity and kinetics of [3H]microcystin-LR in isolated perfused rat livers, Toxicology and Applied Pharmacology, vol.107, issue.3, pp.391-401, 1991. ,
DOI : 10.1016/0041-008X(91)90303-V
Toxicity and kinetics of [3H]microcystin-LR in isolated perfused rat livers, Toxicology and Applied Pharmacology, vol.107, issue.3, pp.391-401, 1991. ,
DOI : 10.1016/0041-008X(91)90303-V
Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model, Pharmaceutical Research, vol.14, issue.9, pp.1210-1215, 1997. ,
DOI : 10.1023/A:1012111008617
CLIMATE: Blooms Like It Hot, Science, vol.320, issue.5872, pp.57-65, 2008. ,
DOI : 10.1126/science.1155398
Accumulation of microcystins in water and fish tissues: An estimation of risks associated with microcystins in most of the Greek Lakes, Environmental Toxicology, vol.257, issue.4, pp.418-445, 2010. ,
DOI : 10.1002/tox.20513
Dynamics of the microcystin in aquatic ecosystem, Bulletin of the Plankton Society of Japan, vol.55, pp.58-62, 2008. ,
Degradation of the cyanobacterial hepatotoxin microcystin by a new bacterium isolated from a hypertrophic lake, Environmental Toxicology, vol.22, issue.4, pp.337-380, 2001. ,
DOI : 10.1002/tox.1041
Global warming and cyanobacterial harmful algal blooms, Advances in Experimental Medicine and Biology, vol.619, pp.239-57, 2008. ,
DOI : 10.1007/978-0-387-75865-7_11
Tissue and Cell Distribution of the Multidrug Resistance-Associated Protein (MRP) in Mouse Intestine and Kidney, Journal of Histochemistry & Cytochemistry, vol.91, issue.6, pp.757-67, 1999. ,
DOI : 10.1177/42.7.8014473
caractérisation de la classe Kappa et rôle de ces enzymes dans l'hépatotoxicité des thiopurines. faculté de pharmacie -vie agro santé, Rennes Petitpas Mélanie HA Effets de cyanotoxines sur des cellules intestinales humaines en culture Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: The first step of detoxication, ANSES Biochimica et Biophysica Acta -General Subjects, vol.1425, pp.527-560, 1998. ,
Toxicity of a cyanobacterial extract containing microcystins to mouse lungs, Brazilian Journal of Medical and Biological Research, vol.37, issue.8, pp.1225-1234, 2004. ,
DOI : 10.1590/S0100-879X2004000800013
The use of the fish cell lines RTG-2 and PLHC-1 to compare the toxic effects produced by microcystins LR and RR, Toxicology in Vitro, vol.19, issue.7, pp.865-73, 2005. ,
DOI : 10.1016/j.tiv.2005.06.016
Health effects of exposure to cyanobacteria (blue-green algae) during recreational water-related activities, 1997. ,
Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture, Biology of the Cell, vol.47, pp.323-353, 1983. ,
Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil, The Lancet, vol.352, issue.9121, pp.21-27, 1998. ,
DOI : 10.1016/S0140-6736(97)12285-1
Differential oxidative stress responses to microcystins LR and RR in intraperitoneally exposed tilapia fish (Oreochromis sp.), Aquatic Toxicology, vol.77, issue.3, pp.314-335, 2006. ,
DOI : 10.1016/j.aquatox.2005.12.012
), Environmental Toxicology, vol.611, issue.6, pp.563-79, 2009. ,
DOI : 10.1002/tox.20458
Comparison of the toxicity induced by microcystin-RR and microcystin-YR in differentiated and undifferentiated Caco-2 cells, Toxicon, vol.54, issue.2, pp.161-170, 2009. ,
DOI : 10.1016/j.toxicon.2009.03.030
Microcystin-LR induces toxic effects in differentiated and undifferentiated Caco-2 cells, Archives of Toxicology, vol.261, issue.5, 2010. ,
DOI : 10.1007/s00204-010-0513-0
Microcystin-LR induces toxic effects in differentiated and undifferentiated Caco-2 cells, Archives of Toxicology, vol.261, issue.5, pp.405-415, 2010. ,
DOI : 10.1007/s00204-010-0513-0
Differential oxidative stress responses to pure Microcystin-LR and Microcystin-containing and non-containing cyanobacterial crude extracts on Caco-2 cells, Toxicon, vol.55, issue.2-3, pp.514-536, 2010. ,
DOI : 10.1016/j.toxicon.2009.10.003
Endoplasmic reticulum stress in murine liver and kidney exposed to microcystin-LR, Toxicon, vol.56, issue.8, pp.1334-1375, 2010. ,
DOI : 10.1016/j.toxicon.2010.07.017
The profound effects of microcystin on cardiac antioxidant enzymes, mitochondrial function and cardiac toxicity in rat, Toxicology, vol.257, issue.1-2, pp.86-94, 2009. ,
DOI : 10.1016/j.tox.2008.12.012
Toxins and bioactive compounds from cyanobacteria and their implications on human health, J Environ Biol, vol.23, pp.215-239, 2002. ,
Detection of microcystins with protein phosphatase inhibition assay, high-performance liquid chromatography???UV detection and enzyme-linked immunosorbent assay, Analytica Chimica Acta, vol.466, issue.2, pp.213-244, 2002. ,
DOI : 10.1016/S0003-2670(02)00588-3
Cellular responses to endoplasmic reticulum stress and apoptosis, Apoptosis, vol.11, issue.Pt 1, pp.996-1007, 2009. ,
DOI : 10.1007/s10495-009-0341-y
Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1, Apoptosis, vol.2, issue.1, pp.35-44, 2011. ,
DOI : 10.1007/s10495-010-0538-0
Summary of information on human CYP enzymes: human P450 metabolism data, Drug Metabolism Reviews, vol.131, issue.2, pp.83-448, 2002. ,
DOI : 10.1211/0022357011775479
Issues arising when interpreting the results of the protein phosphatase 2A inhibition assay for the monitoring of microcystins, Analytica Chimica Acta, vol.512, issue.2, pp.339-385, 2004. ,
DOI : 10.1016/j.aca.2004.03.004
Characterization of chemically tritiated microcystin-LR and its distribution in mice, Toxicon, vol.27, issue.9, pp.1035-1077, 1989. ,
DOI : 10.1016/0041-0101(89)90154-2
Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice, J Pharmacol Exp Ther, vol.256, pp.176-82, 1991. ,
Global Gene Expression Profiling in Larval Zebrafish Exposed to Microcystin-LR and Microcystis Reveals Endocrine Disrupting Effects of Cyanobacteria, Environmental Science & Technology, vol.45, issue.5, pp.1962-1971, 2011. ,
DOI : 10.1021/es103538b
The human colon carcinoma cell lines HT-29 and Caco-2: Two in vitro models for the study of intestinal differentiation, Biochimie, vol.68, issue.9, pp.1035-1075, 1986. ,
DOI : 10.1016/S0300-9084(86)80177-8
Microcystin Uptake and Inhibition of Protein Phosphatases: Effects of Chemoprotectants and Self-Inhibition in Relation to Known Hepatic Transporters, Toxicology and Applied Pharmacology, vol.134, issue.2, pp.264-72, 1995. ,
DOI : 10.1006/taap.1995.1192
In Vivo and in Vitro Binding of Microcystin to Protein Phosphatase 1 and 2A, Biochemical and Biophysical Research Communications, vol.216, issue.1, pp.162-171, 1995. ,
DOI : 10.1006/bbrc.1995.2605
Effect of toxin from the cyanobacterium Microcystis aeruginosa on ultrastructural morphology and actin polymerization in isolated hepatocytes, Toxicon, vol.24, issue.2, pp.109-124, 1986. ,
DOI : 10.1016/0041-0101(86)90112-1
Deformation of isolated rat hepatocytes by a peptide hepatotoxin from the blue-green alga <i>Microcystis aeruginosa<, 1981. ,
Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function, Biochemical Journal, vol.342, issue.1, pp.1-6, 1999. ,
DOI : 10.1042/bj3420001
The uptake of the cyanobacterial hepatotoxin microcystin by isolated rat hepatocytes, Toxicon, vol.29, issue.1, pp.43-51, 1991. ,
DOI : 10.1016/0041-0101(91)90038-S
Biliary excretion of biochemically active cyanobacteria (blue-green algae) hepatotoxins in fish, Toxicology, vol.106, issue.1-3, pp.123-153, 1996. ,
DOI : 10.1016/0300-483X(95)03173-D
PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS, Drug Metabolism and Disposition, vol.34, issue.8, pp.1423-1454, 2006. ,
DOI : 10.1124/dmd.106.009530
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics, Cell Biology and Toxicology, vol.21, issue.1, pp.1-26, 2005. ,
DOI : 10.1007/s10565-005-0085-6
Transcellular Transport of Organic Anions Across a Double-transfected Madin-Darby Canine Kidney II Cell Monolayer Expressing Both Human Organic Anion-transporting Polypeptide (OATP2/SLC21A6) and Multidrug Resistance-associated Protein 2 (MRP2/ABCC2), Journal of Biological Chemistry, vol.277, issue.8, pp.6497-503, 2002. ,
DOI : 10.1074/jbc.M109081200
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs, Cell, vol.77, issue.4, pp.491-502, 1994. ,
DOI : 10.1016/0092-8674(94)90212-7
Desmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa, G774-G83 xiv Schwarzenberger A, Courts C, 2009. ,
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells, European Journal of Pharmaceutical Sciences, vol.28, issue.4, pp.291-300, 2006. ,
DOI : 10.1016/j.ejps.2006.03.003
Enhancement of glutathione S-transferase placental-form positive liver cell foci development by microcystin-LR in aflatoxin B1-initiated rats, Carcinogenesis, vol.20, issue.1, pp.161-166, 1999. ,
DOI : 10.1093/carcin/20.1.161
Hepatic and branchial glutathione S-transferases of two fish species: Substrate specificity and biotransformation of microcystin-LR, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.149, issue.4, pp.515-538, 2009. ,
DOI : 10.1016/j.cbpc.2008.11.008
Protein Serine/Threonine Phosphatases???New Avenues for Cell Regulation, Annual Review of Cell Biology, vol.10, issue.1, pp.55-86, 1994. ,
DOI : 10.1146/annurev.cb.10.110194.000415
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians, 1994. ,
Cyanohepatotoxins influence on the neuroendocrine and immune systems in fish -A short review, Neuroendocrinology Letters, vol.30, pp.13-19, 2009. ,
The role of permability studies in preclinincal evaluation In Oral drug absorption : prediction and assessment, 2001. ,
Sublethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro, Brazil, Environmental Toxicology, vol.17, issue.2, pp.95-103, 2006. ,
DOI : 10.1002/tox.20160
The Caco-2 cell monolayer: usefulness and limitations, Expert Opinion on Drug Metabolism & Toxicology, vol.279, issue.4, pp.395-411, 2008. ,
DOI : 10.1023/A:1016140429238
A Catenary Model to Study Transport and Conjugation of Baicalein, a Bioactive Flavonoid, in the Caco-2 Cell Monolayer: Demonstration of Substrate Inhibition, Journal of Pharmacology and Experimental Therapeutics, vol.326, issue.1, pp.117-143, 2008. ,
DOI : 10.1124/jpet.108.137463
Organic Anion Transporting Polypeptides (OATPs): Regulation of Expression and Function, Current Drug Metabolism, vol.12, issue.2, pp.139-53, 2011. ,
DOI : 10.2174/138920011795016863
Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers, J Pharmacol Exp Ther, vol.299, pp.164-70, 2001. ,
Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases, Environmental Toxicology and Pharmacology, vol.9, issue.4, pp.135-144, 2001. ,
DOI : 10.1016/S1382-6689(00)00049-1
p53 Plays an Important Role in Cell Fate Determination after Exposure to Microcystin-LR, Environmental Health Perspectives, vol.118, issue.9, pp.1292-1300, 2010. ,
DOI : 10.1289/ehp.1001899
Gastroenteritis epidemic in the area of the Itaparica Dam, Bulletin of the Pan American Health Organization, vol.27, pp.244-53, 1993. ,
Blood pressure and hepatocellular effects of the cyclic heptapeptide toxin produced by the freshwater cyanobacterium (blue - green alga) Microcystis aeruginosa strain PCC-7820, Toxicon, vol.26, issue.7, pp.603-616, 1988. ,
DOI : 10.1016/0041-0101(88)90243-7
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways, Journal of Clinical Investigation, vol.119, issue.10, pp.2925-2966, 2009. ,
DOI : 10.1172/JCI38857
Identification of protein phosphatase 2A as the primary target for microcystin-LR in rat liver homogenates, FEBS Letters, vol.118, issue.2-3, pp.175-80, 1994. ,
DOI : 10.1016/0014-5793(94)00382-3
Protein phosphatases maintain the organization and structural interactions of hepatic keratin intermediate filaments, J Cell Sci, vol.110, pp.23-33, 1997. ,
MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions, Xenobiotica, vol.278, issue.3, pp.833-62, 2008. ,
DOI : 10.1016/S0006-291X(02)02658-X
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression, 1992. ,
Pneumonia associated with contact with cyanobacteria., BMJ, vol.300, issue.6737, pp.1440-1441, 1990. ,
DOI : 10.1136/bmj.300.6737.1440
Significance analysis of microarrays applied to the ionizing radiation response, Proceedings of the National Academy of Sciences, vol.98, issue.9, pp.5116-5137, 2001. ,
DOI : 10.1073/pnas.091062498
Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay, Carcinogenesis, vol.17, issue.6, pp.1317-1338, 1996. ,
DOI : 10.1093/carcin/17.6.1317
Toxins of cyanobacteria, Molecular Nutrition & Food Research, vol.36, issue.182, pp.7-60, 2007. ,
DOI : 10.1002/mnfr.200600185
Cytotoxicity effects of microcystins of different hydrophobicities, International Conference on Toxic Cyanobacteria, 2010. ,
Interaction between microcystins of different hydrophobicities and lipid monolayers, Toxicon, vol.41, issue.3, pp.349-55, 2003. ,
DOI : 10.1016/S0041-0101(02)00315-X
Variability in Caco-2 and MDCK Cell-Based Intestinal Permeability Assays, Journal of Pharmaceutical Sciences, vol.97, issue.2, pp.712-737, 2008. ,
DOI : 10.1002/jps.21010
Determination of in vivo absorption, metabolism, and transport of drugs by the human intestinal wall and liver with a novel perfusion technique, Clinical Pharmacology and Therapeutics, vol.70, pp.217-244, 2001. ,
Structural and functional characterization of microcystin detoxification-related liver genes in a phytoplanktivorous fish, Nile tilapia (Oreochromis niloticus), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.144, issue.3, pp.216-243, 2006. ,
DOI : 10.1016/j.cbpc.2006.08.009
Protein profiles in zebrafish (Danio rerio) brains exposed to chronic microcystin-LR, Chemosphere, vol.81, issue.6, pp.716-740, 2010. ,
DOI : 10.1016/j.chemosphere.2010.07.061
Distribution of microcystins in various organs (heart, liver, intestine, gonad, brain, kidney and lung) of Wistar rat via intravenous injection, Toxicon, vol.52, issue.6, pp.721-728, 2008. ,
DOI : 10.1016/j.toxicon.2008.08.004
Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR, Apoptosis, vol.232, issue.8, pp.1031-1073, 2008. ,
DOI : 10.1007/s10495-008-0237-2
Cyanobacterial peptides ??? Nature's own combinatorial biosynthesis, FEMS Microbiology Reviews, vol.30, issue.4, pp.530-63, 2006. ,
DOI : 10.1111/j.1574-6976.2006.00022.x
The role of ROS in microcystin-LR-induced hepatocyte apoptosis and liver injury in mice, Toxicology, vol.232, issue.1-2, pp.15-23, 2007. ,
DOI : 10.1016/j.tox.2006.12.010
A review of cyanobacteria and cyanotoxins removal/inactivation in drinking water treatment, Analytical and Bioanalytical Chemistry, vol.40, issue.5, pp.1705-1719, 2010. ,
DOI : 10.1007/s00216-010-3709-5
The ecology of cyanobacteria: their diversity in time and space: Springer WHO Guidelines for Drinking Water Quality Addendum to Sequential ultrastructural and biochemical changes induced by microcystin-LR in isolated perfused rat livers, GUIDELINES FOR SAFE Nat Toxins, vol.1, issue.4, pp.195-205, 1996. ,
DOI : 10.1007/0-306-46855-7
Alterations in Microtubules, Intermediate Filaments, and Microfilaments Induced by Microcystin-LR in Cultured Cells, Toxicologic Pathology, vol.23, issue.3, pp.326-363, 1995. ,
DOI : 10.1177/019262339502300309
Microbial colonization of Ca-sulfate crusts in the hyperarid core of the Atacama Desert: implications for the search for life on Mars, Geobiology, vol.6, issue.39, pp.44-60, 2011. ,
DOI : 10.1111/j.1472-4669.2010.00254.x
Quantitative assessment of aerosolized cyanobacterial toxins at two New Zealand lakes, Journal of Environmental Monitoring, vol.23, issue.6, pp.1617-1641, 2011. ,
DOI : 10.1039/c1em10102a
Natural Photodegradation of the Cyanobacterial Toxins Microcystin and Cylindrospermopsin, Environmental Science & Technology, vol.44, issue.8, pp.3002-3009, 2010. ,
DOI : 10.1021/es9036012
Involvement of Fas/FasL system in apoptotic signaling in testicular germ cells of male Wistar rats injected i.v. with microcystins, Toxicon, vol.54, issue.1, pp.1-7, 2009. ,
DOI : 10.1016/j.toxicon.2009.01.035
Le modèle cellulaire Caco-2 pour prédire l'absorption intestinale des cyanotoxines : études préalables sur des marqueurs de différenciation et de perméabilité Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice, Natural Toxins, vol.5, pp.91-96, 1997. ,
Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicity, Journal of Cancer Research and Clinical Oncology, vol.26, issue.6, pp.609-623, 1990. ,
DOI : 10.1007/BF01637082
Cdc20: A WD40 Activator for a Cell Cycle Degradation Machine, Molecular Cell, vol.27, issue.1, pp.3-16, 2007. ,
DOI : 10.1016/j.molcel.2007.06.009
Primary prevention of hepatocellular carcinoma, Journal of Gastroenterology and Hepatology, vol.14, issue.6, pp.674-82, 1995. ,
DOI : 10.1016/0043-1354(89)90171-1
PRIMARY LIVER CANCER : NATURAL TOXINS AND PREVENTION IN CHINA, The Journal of Toxicological Sciences, vol.23, issue.SupplementII, pp.143-150, 1998. ,
DOI : 10.2131/jts.23.SupplementII_143
Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2, Toxicon, vol.41, issue.1, pp.41-49, 2003. ,
DOI : 10.1016/S0041-0101(02)00207-6
Different sensitivities of human colon adenocarcinoma (CaCo-2), astrocytoma (IPDDC-A2) and lymphoblastoid (NCNC) cell lines to microcystin-LR induced reactive oxygen species and DNA damage, Toxicon, vol.52, issue.3, pp.518-543, 2008. ,
DOI : 10.1016/j.toxicon.2008.06.026
Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis, Toxicon, vol.51, issue.4, pp.615-638, 2008. ,
DOI : 10.1016/j.toxicon.2007.11.009
Transfer, distribution and bioaccumulation of microcystins in the aquatic food web in Lake Taihu, China, with potential risks to human health, Science of The Total Environment, vol.407, issue.7, pp.2191-2200, 2009. ,
DOI : 10.1016/j.scitotenv.2008.12.039
Characterization of human small intestinal cytochromes P-450, Drug Metabolism and Disposition, vol.27, pp.804-813, 1999. ,
In vivo studies on the toxic effects of microcystins on mitochondrial electron transport chain and ion regulation in liver and heart of rabbit, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol.148, issue.3, pp.204-214, 2008. ,
DOI : 10.1016/j.cbpc.2008.05.008
Oxidative stress response after prolonged exposure of domestic rabbit to a lower dosage of extracted microcystins, Environmental Toxicology and Pharmacology, vol.27, issue.2, pp.195-204, 2009. ,
DOI : 10.1016/j.etap.2008.10.005
Relationship between microcystin in drinking water and colorectal cancer, Biomedical and environmental sciences : BES, vol.15, pp.166-71, 2002. ,
Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade, Carcinogenesis, vol.26, issue.7, pp.1207-1221, 2005. ,
DOI : 10.1093/carcin/bgi069
Hepatotoxic Cyanobacteria: A Review of the Biological Importance of Microcystins in Freshwater Environments, Journal of Toxicology and Environmental Health, Part B, vol.15, issue.1, pp.1-37, 2005. ,
DOI : 10.1093/plankt/11.1.25
Elimination of the cyanobacterial hepatotoxin microcystin from the freshwater pulmonate snail Lymnaea stagnalis jugularis (say), 2006. ,