Hallucinations auditives verbales et langage intérieur dans la schizophrénie: traces physiologiques et bases cérébrales

Abstract : Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of pertinent external stimuli. They are one of the most disturbing symptoms of the schizophrenia pathology. Among the influential comprehensive models of AVHs, two are of interest: (1) models with a perceptual origin where the voices are due to increased vivid auditory mental imagery and (2) productive origin models where inner speech is disturbed in such a way that a patient's own verbal thoughts are attributed to an external agent. In order to examine the motor aspect of the productive models, an experiment focused on collecting oro-facial muscular traces during AVHs with surface electromyography was conducted on schizophrenia patients and control subjects. Findings have shown a trend towards an increase in muscular activity in the orbicularis muscles during AVHs for patients and during inner speech for controls compared to rest. In order to study the cerebral aspect of the productive models, an fMRI experiment was developed to investigate verbal thought generation and auditory perception in schizophrenia patients as well as in control subjects. Results suggest a hyper-activation of a network involving the temporal cortex and the anterior cingular cortex; however this still needs to be confirmed. The AVHs phenomenology study showed that AVHs differ from "typical" inner speech in several ways including that there can be numerous voices with defined acoustic features diverging from one's own inner speech. A multidimensional integrative model is proposed to satisfactorily understand the scope of AVHs complexity. In schizophrenia patients, there would be a predisposed perceptual hyper-activity associated with a deficient prediction system, modulated by top-down factors and by an externalization bias.
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Contributor : Lucile Rapin <>
Submitted on : Thursday, August 4, 2011 - 5:37:55 PM
Last modification on : Wednesday, August 14, 2019 - 2:34:04 PM
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Lucile Rapin. Hallucinations auditives verbales et langage intérieur dans la schizophrénie: traces physiologiques et bases cérébrales. Neurosciences [q-bio.NC]. Université de Grenoble, 2011. Français. ⟨tel-00613573⟩

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