, EEIE:LMB<BMRL>>>MA> K>OB>PPH??.:FIHGG.:FIHGG << III.2.b Neurogenesis 0A>> BG<K>, ??>QIHLNK>>MH >GKB<AF>GMEnrichment protocol starting at weaning.MMIHLMG:M:EE=:RR ( FB<>> P>K>>AHNL>==BGGGNF;>KKH??BGG:GG>GKB<A>==<:@>>=NKBG@@=:RL0A>>=>M><MBHGGH??K=11
, @>> =NKBG@@ HGERR P>>DLL 5HNG@@ Enrichment protocol starting at 6 weeks or more
, 0ABLLLI:MB:EEE>:KGBG@@M>LMMBLL :: IHP>K?, III.2.c Learning and memoryMorris water Maze (MWM):MM A:O>> IKBF:KBERR NL>= MABLL M>LMM MHH :LL>LLL PA>MA>KK !!! >QIHLNK>> <HNE==:EM>KKMA>><H@GBMBO>>?NG<MBHG A:LLLAHPGG<HG?EB<MBG@@K>LNEMLLL>>>?B@@
, ;E>> III.2.d Anxiety-like behavior Elevated Plus Maze (EPM), p.5
, GABA and its synthesis enzyme glutamate decarboxylase (GAD) 0A> :<MBOBMRR H??, E>>FB==E>:@>==FFFFB<>>?HEEHPBG@@>QIHLNK>>MHH>GKB<A>==>GOBKHGF>GMM <HFI:K>==MHH<HGMKHELL"KB<DD') $HP>O>K MA>>>QMK:<>EENE:KK<HG<>GMK:MBHGGH
, @N> :PE>RRK:MLL== ;:L:EE>QMK:<>EENE:KK <HG<>GMK:MBHGG H?? @ENM:F:M>> K>F:BGLL NG<A:G@>= Acetylcholine ACh and its synthesis enzyme " choline acetyltransferase " (ChAT)0ABLLG>NKHMK:GLFBMM>KKP:LLHGERRBGO>LMB@, MM>GMBHG%MMIE:RLL::F:CHKKKHE>>BGGF>=B:MBG@@FNEMBIE>>:LI><MLL H??<H@GBMBHGG:G==BLLBFIEB<:M>== BGG:PB=>>O:KB>MRRH??G>NKHEH@B<:EE:G== ILR<AB:MKB<<=BLHK=>KLL &:;>KK ) %GG :==BMBHG 00 BLL IKBF:KRR BG =>M>KFBGBG@@ MA>> >QMK:G>NKHG:EE <HG<>GMK:MBHGG H?? =HI:FBG>> :G== :GG BFIHKM:GMM MA>K:I>NMB<< M:K@>MM ?HKK G>NKHLMBFNE:GML 0ANL L>O>K:EE K>L>:K<A>KLL >QIEHK>== MA>> FH=B?B<:MBHGG H?? MABLL LRLM>FF MHH >GKB<A>== >GOBKHGF>GMLL HPGEBG@@ /( *:D:: " >S:K== ! *>N@>;:N>KK *)
, <>> >QIK>LLBHGG 6ANN & 6ANN & Noradrenaline (NA) and serotonin (5-HT). 3ABE>>, 00 =><K>:L>== BGG MA>> O>GMK:EE ABIIH<:FINL :L:EE<HG<>GMK:MBHGGH??;HMAA*:G==$00K>F:BG>==LM:;E>>BGGMA>>?KHGMHI:KB>M:EE<HKM>QQH
, 3A, Ionic glutamate receptors (AMPA)
URL : https://hal.archives-ouvertes.fr/in2p3-01314821
, BG:N== . 3:EE:<>> / +ELLHGG 0 A, HKK 6!*'' 'KHQ:ELHHDGHPGG:LL>@K *#"%:ELHHDGHPGG:LL*NKK * 0%/ HKK0.:G=
, <MHKLLLN<A:LL *BL:LB@G:MNK>H??, III.2.i Neurotrophic and growth factors BDNF in the hippocampusERR BGG MA> ABIIH<:FINLL 5HNG@@ ):GRR LMN=B>LL A:O>> MKB>= MHH <HKK>E:M>> MA>> BG=N<MBHGG H? *""BGGMA>ABIIH<:FINLLPBMAAHMA>KKIE:LMB<BMRRF:KD>KLL:LLG>NKH@>G>LBLL.HLLBB
, A:LL;>>GGH, >EBG@ !EBL:: :G== 3>LM>KGG ;EHMM BG=NN .HLLBB 6ANN /3 #H;;HH +( %<D>LL 5HNG@@ GGBG<K>
, BFFNGHK>:<MBOBMRR5HNG@@ "BGE>O>EEBGGMA>>O>GMK:EEABIIH<:FINLL%<D>LL BDNF in other brain regions, LM:GMB:: GB@K:: I:KLL <HFI:<M::":A>KMRR & ,KHM>BGG E>O>EE A:LL ;>>GG K>IHKM>== MHH BG<K>:L>> BGG MA>> <HKM>Q ;:L:EE ?HK>
, A:FF 0) ; %<D>LL A:LL, HEEHPBG@@>QIHLNK>>MHH>GKB<A>==>GOBKHGF>GM Other factors. 0A>> @>G>> >QIK>LLBHGG H?? NGF 0HK:L=HMM>KK ) /<AG>B=>KK &/ :G== BMLL IKHM>BGG E>O>ELL 0HK:L=HMM>KK ) :G== MA>> >GMHKABG:EE <HKM>QQ ,A:FF 0)
, 3 ?480 =,?> ;:>4?4:90
, 74<@:?> 22 :1 ?30 >, pp.30-30
, @> 7 >:7@?4:99 &30
, 0/ 42!.3#2)04 ,%6%, -%!352%$ ). 4(% 6%, p.43
, 3(%%.1)#(%$'1/403
, 7@C::7 67/@=BB7 <B=<3::7 :=3 ::3D, pp.33-5323
, 9 12;A.A2 4F?B@ 1B?6;4 =<@A;.A.9 12C29<=:2;AA 2G.?1 <C2?< && 296; B0<;42? && .08@<;; 2D6@ )) $?G21/<?@86 && $6
, A86;@<; &A2C2;<; !! )2;2?
, 9A2? ;2B?<A?<=56
, 9 :2:<?F ?.;8 !&A.;92F?<D
, =884-5-6<)4 1/ )447?, 7+1)4 16<-:)+<176; :)<
, 7+)4 51+:7;+78A ;A;<-5 -1+), )<176 )*7=< )6<1*7
, 32737-*6&1**;7*27, &2) $! &2), p.678
, 20
, 65)+22;2'88)54)+4:8':/54" +22%65&
, 65)+22;2'88)54)+4:8':/54" +22%65&
, 3783*964)*,*3*6&8144# .3 8-* &3) 8-* 6-54 -&), &1 )*8*(8.434+ *9 7.< )&=7 &+8*6 !, pp.22934-78464957
, >3-=><+>/13/= 91?-23$=+@+<3>35<+3 $/81, pp.3-93
, A4A4 =D?3=:;:40?49 =0.0;?:= >;74, pp.49-749
, 3=:;:40?49 ,9/ 0=D?3=:;:40?49 =0
, 3=:;:40?49 ,9/ 0=D?3=:;:40?49 =0.0;?:= 0C, p.409
, (:(3 *65+0, 0776*(47<:+<905.7036*(9705, pp.69065-69071
, 7+)4 51+:7;+78A ;A;<-5 -1+))
, 755)<=:-0=5)687?)
, @>-8 :1>B;A? ?E?@19
, 10@4-@@41 93 73<58
, 85?410 @4-@ :1A>;0131:1>-@5B1 <>;/1??1?
, $-32" -/1$"$#$.-2$3, pp.3-5
, $05<BA2; ?B6AD.42, p.25
, # 5?<;60;2?C20<:=?2@@6<;6;7B?F6;1B02@.=52;<AF=60 @D6A05 <3 ;2B?<;@ D6A56; A52 1<?@.9 ?<<A 4.;496, 6B ) B B, vol.5264214, issue.2, p.60521
, G=:K=BS:MBHG I.1. Development of the Marlau? cage+G>H?MA>F:CHKK<HGMKB;NMBHGLLH?MABLLMA>LBLL A:LL, >>G MA> =>O>EHIF>GMM :G= O:EB=:MBHG H? MA> ):KE:N]] <:@> :LL : LBFIE> P:RR MH LM:G=:K=BS> >GKB<A>= AHNLBG@ >GOBKHGF>GM
, EE>= 3:M>KK !QIEHK:MBHG 0>LMM 3!00 P> ?
, Activation of EpoR gene expression in the VLR by repeated hypoxic exposures
, Activation of EPO and EpoR gene expression in the VLR by environmental enrichment, GHM, vol.0
, KE:N 0) <:@>L !IH, >QIK>LLBHGP:LL :ELH :<MBO:M>= 0A>L>K>LNEMLL :K> BG EBG>PBMAIKBHKKLMN=B>LLLAHPBG@MA:M!IH.>QIK>LLBHGBG<NEMNK>=G>NKHGLLBLL=>I>G=>GMM
, Ubiquitous upregultion of EpoR gene expression after repeated hypoxic exposures when housed in Marlau? cages, NIK>@NE:MBHGOB:#0LB@G:EBG@ II.3 HKK K>I>:M>= ARIHQB: >QIHLNK>LL BG=>I>G=>GMERR H? MA> AHNLBG@ <HG=BMBHG >E>O:M>= !IH. @>G> >QIK>LLBHG BG MA> $B2 MH MA> L:F> >QM>GM %G MA> 2(. PABE> K:MLL
, Neuroprotection by rhEpo in the VLR following elevated EpoR gene expression 3ABE> F:QBF, BG:MBHG`AHNLBG@BG MBHG`AHNLBG@BG):KE:N 0) <:@>LLIENLLK>I>:M>=ARIHQB<>QIHLNK>La P><HNE=GHMMM>LMMPA>MA>KK
, QBF:E G>NKHIKHM><MBO> >??><MM ?HEEHPBG@ status epilepticus
, Preserved spatial learning performances in epileptic rats housed in Marlau? cages: towards an adaptative process 3> A, O> GHMB<>= :G BFIHKM:GMM <H@GBMBO>=><EBG>BG`>IBE>IMB<aaK:MLLAHNL>=BGLM:G=:K=<:@>L :LL>O:EN:M>=BGMA>)HKKBLL
, Persistence of anxiety-trait in epileptic rats housed in Marlau? cages: can it be considered as an adaptive process? +NKKLMN=RRA:LLLAHPGMA:MMK:MLLLN, )HKKBLL 3:M>KK ):S>> %G :==BMBHG MA>L> K:MLL >QAB;BM>=L>O>K>:GQB>MREBD>=BLHK=>KL :LLF>:LNK>=BGMA>!E>O:M>=,ENLL):S>:G=BGMA>
, M> :G=MA:MM MA>RR :=:IMM MA>BKK ;>A:OBHKK<HGLM:GMERRMH:OHB=IHM>GMB:EERR=:G@>KHNLLLBMN:MBHGL III.3. rhEpo provided functional protection in epileptic rats reared in standard cages but not in Marlau? cages 0H, MLLLN;C><M>=MH,BEH/!>BMA>KK:MM:=NEMM:@>HKK:MMP>:GBG@
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