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Sur un procédé hautes pressions de sécurisation du plasma sanguin humain

Abstract : High hydrostatic pressure (HHP) has shown its capacity to inactivate contaminating micro-organisms (yeasts, bacteria, spores, viruses...) present in various media. This technology has been first used and developed to an industrial scale for the food industry. Because of the low energy raised using high pressure, only weak interactions characterized by a negative ?V will be altered. This statement opens the way to numerous applications in the biology field. The objective of this PhD work was to inactivate all the pathogens that may contaminate blood products, and blood plasma in particular. The main challenge was to inactivate the contaminating micro-organisms while maintaining the activity of the plasma proteins (such as blood coagulation factors). To achieve this balance, several parameters were used: - the pressure value (from 100 to 300 MPa), - the treatment duration, - negative temperatures... Some original results will be presented, concerning differences in the high pressure sensitivity of proteins and the inactivation of pathogens.
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Contributor : Stéphane Toulin <>
Submitted on : Monday, July 11, 2011 - 1:09:54 PM
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  • HAL Id : tel-00607796, version 1



Nolwennig Rivalain. Sur un procédé hautes pressions de sécurisation du plasma sanguin humain. Matériaux. Université Sciences et Technologies - Bordeaux I, 2009. Français. ⟨NNT : 2009BOR13910⟩. ⟨tel-00607796⟩



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