Abstract : The aim of this research is to question the clinical field of lethal disease. This research deals with the subjective effect of the confrontation with lethal disease and the word of the subject. If the disease is first of all a rupture of "life in the silence of the organs", the corporal alteration is doubled by the risk of death. The registers of the body and of death are the basis of this clinical approach. The meta psychological coordinates of those registers will be given first by locating them in a splitting. Indeed, if for Freud, nconsciousness ignores death, isn't it to be considered as a necessary element of the symbolic language rule ? In the same way, the organic reality which mainly remains inaccessible for the subject, has to be considered as a necessary element to the construction of otherness ? It will be demonstrated that both body and death define the structural functions for the subject in a background of determining ignorance. The sudden appearance of the lethal disease will modify and disarticulate those functions. How will the subject possibly respond to it ? The presentation of a series of seven clinical fragments, stemming from our institutional practice, will enable the exploration of the response of the subject to the corporal breaking in of the lethal disease. It is the movement and the transfer that occurs from the rupture to the response, from the suspension to the word, from the event to the putting it into words that follows the transfer relationship, that are studied. With the proximity of a death threat and a corporal attack, it is the emergence and the persistence of the talking subject that is to be heard.