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Role de la protéine SOCS-1 dans la progression tumorale colique

Abstract : The SOCS-1 protein (Suppressor Of Cytokine Signalling 1) has historically been described as a negative regulator of the JAK/STAT signalling pathway. This pathway is activated by numerous cytokine, hormones and growth factors, and leads to activation of several target genes of which Socs-1. In a first study, we analysed the regulation of the Socs-1 gene in response to interferon-gamma. We have thus demonstrated the implication of the transcription factors IRF-1 and Sp2 in the Socs-1 gene expression. In many human tumours, expression of the Socs-1 gene is inhibited by aberrant DNA methylation. In the colon metastatic cell line SW620, re-expression of the SOCS-1 protein leads to an inhibition of the invasive phenotype. At the same time, we observed the re-expression of the adhesion molecule, E-cadherin at cell membrane.
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https://tel.archives-ouvertes.fr/tel-00598495
Contributor : Lyne Valentino <>
Submitted on : Monday, June 6, 2011 - 3:40:39 PM
Last modification on : Monday, October 19, 2020 - 11:01:05 AM
Long-term archiving on: : Sunday, December 4, 2016 - 10:01:00 AM

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  • HAL Id : tel-00598495, version 1

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Lyne Valentino. Role de la protéine SOCS-1 dans la progression tumorale colique. Sciences du Vivant [q-bio]. Université Paris Sud - Paris XI, 2009. Français. ⟨tel-00598495⟩

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