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Locomotion et franchissement d'obstacles après lésion cérébrale : étude cinématique chez le rat

Abstract : Although the rat has become the favourite animal model in preclinical researches on locomotion, studies designed to assess the strategy used by rats to avoid obstacle avoidance are lacking in rats. Using an optoelectronic 3D motion analysis system, we have, therefore, compared the step pattern, timing and length variables of locomotor cycles, trajectories and joint angles values of limbs when rats stepped between and overcame obstacles (3 cm-height) fixed on a treadmill belt (25 cm/s). Motion of all the four limbs was serially recorded for a 10 weeks long-period in adult animals with an initial age of 11 weeks. The results show that obstacle avoidance results in disruption of the basic step pattern thus resulting in increased stride length of all limbs, increased duration of the swing phase of forelimbs, only, and appearance of quadrupedal stance phases. They also reveal that elevation of limbs above the obstacle not only involved their flexion but also displacement of corresponding girdles. Remarkably, trajectory of the forelimb that was the second to overcome obstacle was the mirror image of that of the leading forelimb. Lastly, all measured parameters remain stable over the observation period during which body weight gain reaches 100 g (one third of the initial body weight). In conclusion, our study may represent a basic work for futures studies aimed at understanding the neural pathways involved in pathologies associated with deficit/recovery of challenged locomotion.
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Submitted on : Friday, May 27, 2011 - 6:03:21 PM
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Olivier Perrot. Locomotion et franchissement d'obstacles après lésion cérébrale : étude cinématique chez le rat. Médecine humaine et pathologie. Université de Bourgogne, 2010. Français. ⟨NNT : 2010DIJOS043⟩. ⟨tel-00596578⟩



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