A. Marqué-par-tp-2py-l-'objectif-de-cette-Étude and S. Est, Nous avons eectué des dépôts d'ADN marqué par la TP-2Py. A l'aide du STM, l'idée était de visualiser le uorophore qui a une densité électronique plus importante que les bases de l'ADN. De plus, l'objectif de ces études visait à caracteriser l'existence d'une éventuelle modication de la conformation du double brin d'ADN lorsque le uorophore est inséré. La concentration de la TP-2Py dans la solution d'ADN

S. Uhv, Vt=-2538 mV) de l'ADN de hareng, Figure 88 Images STM (100×110 nm

L. Gure, auto-organisation des thiols hypochlorure de 11-amino-1-undecanethiol sur une surface d'Au. Sur la première image de la gure 106, il y a diérents domaines. Lorsque l'on agrandit une zone de l'image, on observe une structure hexagonale compacte identique aux alcanethiols non fonctionalisés. A l'inverse des dérivés TP-2Py thiols, les thiols hypochlorure de 11-amino-1-undecanethiol forment une mono-couche dense et organisée sur la surface d

.. Mesures-de-durées-de-vie-de-uorescence, 153 B.2.2 TP-3Py, p.159

M. J. Hannon, Supramolecular dna recognition, Chem. Soc. Rev, 2007.
DOI : 10.1002/chin.200717269

A. M. Macmillan, Fifty years of "Watson-Crick", Pure and Applied Chemistry, vol.76, issue.7-8, 2004.
DOI : 10.1351/pac200476071521

A. M. Macmillan, Chemistry of nucleic acids part 3 -preface, Pure Appl. Chem, 2004.

J. D. Watson and F. H. Crick, Molecular structure of nucleic acids -a structure for deoxyribose nuclaic acid, Nature, 1953.

R. E. Dickerson, H. R. Drew, B. N. Conner, R. M. Wing, A. V. Fratini et al., The anatomy of a-dna, b-dna, and z-dna, Science, 1982.

H. R. Drew, S. Samson, and R. E. Dickerson, Structure of a B-DNA dodecamer at 16 K., Proc. Natl. Acad. Sci, 1982.
DOI : 10.1073/pnas.79.13.4040

R. E. Dickerson and H. R. Drew, Kinematic model for B-DNA., Proc. Natl. Acad. Sci, 1981.
DOI : 10.1073/pnas.78.12.7318

S. Neidle, Dna minor-groove recognition by small molecules, Nat. Prod. Rep, 2001.

P. Belmont, J. Constant, and M. Demeunynck, Nucleic acid conformation diversity: from structure to function and regulation, Chemical Society Reviews, vol.30, issue.1, 2001.
DOI : 10.1039/a904630e

P. Hazel, J. Huppert, S. Balasubramanian, and S. Neidle, Loop-lenght-dependent folding of g-quadruplexes, J. Am. Chem. Soc, 2004.

N. J. Wheate, C. R. Brodie, J. G. Collins, S. Kemps, and J. R. Aldrich-wright, Dna intercalators in cancer therapy : Organic and inorganic drugs and their spectroscopie tools of analysis, Med. Chem, 2007.

D. Onidas, . Markovitsi, . Marguet, T. Sharonov, and . Gustavsson, Fluorescence Properties of DNA Nucleosides and Nucleotides:?? A Refined Steady-State and Femtosecond Investigation, The Journal of Physical Chemistry B, vol.106, issue.43
DOI : 10.1021/jp026063g
URL : https://hal.archives-ouvertes.fr/hal-00144518

W. Denk, W. Strickler, and . Webb, Two-photon laser scaning uorescence microscopy

C. Allain, Sondes uorescentes pour l'ADN : Marquage covalent et non-covalents, 2006.

C. Allain, F. Schmidt, R. Lartia, G. Bordeau, C. Fiorini-debuisschert et al., Teulade-Fichoua. Vinyl-pyridinium triphenylamines : Novel far-red emitters with high photostability and two-photon absorption properties for staining DNA, Chembiochem, 2007.

A. Jablonski, Uber den mechanisms des photolumineszenz von farbstophosphores, Z phys, 1935.

M. Kasha, Characterization of electronic transitions in complex molecules, Discussions of the Faraday Society, vol.9, issue.9, p.1419, 1950.
DOI : 10.1039/df9500900014

J. Enderlein and R. Erdmann, Fast tting of multi-exponential decay curves, Optics Communications, vol.134, issue.16, p.371378, 1997.

D. F. Eaton, Recommended methods for uorescence decay analysis, Pure and Appl. Chem, 1990.

V. V. Apanasovich and E. G. Novikov, Methods of analysis of uorescence decay curves in pulsed uorometry (review) [22] TN Solie, EW Small, and I Isenberg. Analysis of non-exponential uorescence decay data by a method of moments, Journal of Applied Spectroscopy Biophysical Journal, vol.56, issue.43, pp.31727-29367378, 1980.

M. Goeppert-mayer, Elementary processes with two quantum transitions, Annalen der Physik, vol.18, issue.7-8, p.466479, 2009.
DOI : 10.1002/andp.200910358

M. Oheim, Principles of two-photon excitation uorescence microscopy and other nonlinear imaging approaches. Advanced Drug delivery review, 2006.

O. Nakamura, Fundamental of two-photon microscopy, Microscopy Research and Technique, vol.6, issue.3, 1999.
DOI : 10.1002/(SICI)1097-0029(19991101)47:3<165::AID-JEMT2>3.0.CO;2-D

C. Xu and W. W. Webb, Measurement of two-photon excitation cross sections of molecular uorophores with data from 690 to 1050 nm, Journal of the Optical Society of America B-Optical Physics, 1996.

M. A. Albota, C. Xu, and W. W. Webb, Two-photon uorescence excitation cross sections of biomolecular probes from 690 to 960 nm, Applied Optics, 1998.

A. Hopt and E. Neher, Highly nonlinear photodamage in two-photon uorescence microscopy, Biophysical Journal, 2001.

P. Metezeau, . Tachdjian, . Kiefer, M. Cacheux, and . Bensaada, Analysis of laser eects on chromosomal structure by uorescence in situ hybridization and image cytometry : Methodological approach for precise microdissection, Lasers in Medical Science, vol.10, issue.4, p.261266, 1995.

T. Förster, Zwischenmolekulare energiewanderung und uoreszenz, 1948.

S. Hell and M. Kroug, Ground-state depletion uorescence microscopy, a concept for breaking the diraction resolution limit, Appl. Phys. B, 1997.

D. Axelrod, T. P. Burghardt, and N. L. Thompson, Total internal reection uorescence

K. Konig, Multiphoton microscopy in life sciences, Journal of Microscopy, vol.200, issue.2, 2000.
DOI : 10.1046/j.1365-2818.2000.00738.x

M. Gu and C. J. Sheppard, Comparison of three-dimensional imaging properties between two-photon and single-photon uorescence microscopy, J. Microsc, 1995.

W. R. Zipfel, R. M. Williams, and W. W. Webb, Nonlinear magic: multiphoton microscopy in the biosciences, Nature Biotechnology, vol.21, issue.11, 2003.
DOI : 10.1038/nbt899

B. Richards and E. Wolf, Electromagnetic diraction in optical systems .2. structure of the image eld in an aplanatic system, Proceedings of the Royal Society of London series A-Mathematical and Physical Sciences

R. M. Williams, D. W. Piston, and W. W. Webb, 2-Photon Molecular-Excitation Provides Intrinsic 3-Dimensional Resolution for Laser-Based Microscopy and Microphotochemistry, Faseb Journal, 1994.

S. Hell and E. H. Stelzer, Fundamental improvement resolution with 4-pi-confocal uorescence microscope using two photon excitation, Opt. Commun, 1992.

A. David, A. Gustafsson, M. G. , and J. W. Sedat, Sevenfold improvement of resolution with a 4pi-confocal uorescence microscope using two-photon excitation, Proc. SPIE, 1995.

M. Wahl, R. Erdmann, K. Lauritsen, and H. J. Rahn, Hadware solution for continuous times resolved burst detection of single molecules in ow, Proc. SPIE, 1998.

D. Magde, P. Wong, and . Seybold, Fluorescence quantum yields and their relation to lifetimes of rhodamine 6G and uorescein in nine solvents : Improved absolute standards for quantum yields, Photochemistry and Photobiology, vol.75, issue.4, p.327334, 2002.

M. Albota, D. Beljonne, J. L. Bredas, J. E. Ehrlich, J. Y. Fu et al., Design of Organic Molecules with Large Two-Photon Absorption Cross Sections, Science, vol.281, issue.5383, 1998.
DOI : 10.1126/science.281.5383.1653

M. Albota, D. Beljonne, J. L. Bredas, J. E. Ehrlich, J. Y. Fu et al., Design of Organic Molecules with Large Two-Photon Absorption Cross Sections, Science, vol.281, issue.5383, 1998.
DOI : 10.1126/science.281.5383.1653

S. J. Chung, M. Rumi, V. Alain, S. Barlow, J. W. Perry et al., Strong, Low-Energy Two-Photon Absorption in Extended Amine-Terminated Cyano-Substituted Phenylenevinylene Oligomers, Journal of the American Chemical Society, vol.127, issue.31, 2005.
DOI : 10.1021/ja052926i

W. H. Lee, M. H. Cho, S. J. Jeon, and B. R. Cho, Two-Photon Absorption and Second Hyperpolarizability of the Linear Quadrupolar Molecule, The Journal of Physical Chemistry A, vol.104, issue.47, 2000.
DOI : 10.1021/jp001363o

L. Ventelon, L. Moreaux, J. Mertz, and M. Blanchard-desce, New quadrupolar uorophores with high two-photon excited uorescence, Chem. Comm, 1999.

M. Blanchard-desce, Molecular engineering of NLO-phores for new NLO microscopies, Comptes Rendus Physique, vol.3, issue.4, 2002.
DOI : 10.1016/S1631-0705(02)01329-4

O. Mongin, L. Porres, L. Moreaux, J. Mertz, and M. Blanchard-desce, Synthesis and photophysical properties of new conjugated uorophores designed for two-photon-excited uorescence, Org. Lett, 2002.

O. Mongin, L. Porres, M. Charlot, C. Katan, M. Blanchard-desce et al., Synthesis, uorescence , and two-photon absorption of a series of elongated rodlike and banana-shaped quadrupolar uorophores : A comprehensive study of structure-property relationships, pdihexylaminostyryl )styryl]anthracene derivatives with large two-photon cross sections, pp.6-10, 2005.

S. Ohira, I. Rudra, K. Schmidt, S. Barlow, S. Chung et al., Electronic and vibronic contributions to two-photon absorption in donoracceptor-donor squaraine chromophores, Chem. Eur. J, 2008.

S. A. Odom, S. Webster, L. A. Padilha, D. Peceli, H. Hu et al., Synthesis and Two-Photon Spectrum of a Bis(Porphyrin)-Substituted Squaraine, Journal of the American Chemical Society, vol.131, issue.22, 2009.
DOI : 10.1021/ja901244e

K. D. Beleld, M. V. Bondar, F. E. Hernandez, and O. V. Przhonska, Photophysical characterization , two-photon absorption and optical power limiting of two uorenylperylene diimides

Z. Liu, T. Chen, B. Liu, T. Huang, S. Li et al., Two-photon absorption of a series of V-shape molecules: the influence of acceptor's strength on two-photon absorption in a noncentrosymmetric D????????A????????D system, Journal of Materials Chemistry, vol.16, issue.44, 2007.
DOI : 10.1039/b707909e

H. M. Kim, Y. O. Lee, C. S. Lim, J. S. Kim, and B. R. Cho, Two-Photon Absorption Properties of Alkynyl-Conjugated Pyrene Derivatives, The Journal of Organic Chemistry, vol.73, issue.13, 2008.
DOI : 10.1021/jo800363v

J. Zyss and I. Ledoux, Nonlinear optics in multipolar media: theory and experiments, Chemical Reviews, vol.94, issue.1, 1994.
DOI : 10.1021/cr00025a003

W. H. Lee, H. Lee, J. A. Kim, J. H. Choi, M. H. Cho et al., Two-Photon Absorption and Nonlinear Optical Properties of Octupolar Molecules, Journal of the American Chemical Society, vol.123, issue.43, 2001.
DOI : 10.1021/ja004226d

S. J. Chung, K. S. Kim, T. H. Lin, G. S. He, J. Swiatkiewicz et al., Cooperative Enhancement of Two-Photon Absorption in Multi-branched Structures, The Journal of Physical Chemistry B, vol.103, issue.49, 1999.
DOI : 10.1021/jp992846z

J. L. Marder and . Bredas, Role of dimensionality on the two-photon absorption response of conjugated molecules : The case of octupolar compounds, Advanced Functional Materials, 2002.

C. Katan, F. Terenziani, O. Mongin, M. H. Werts, L. Porres et al., Eects of (multi)branching of dipolar chromophores on photophysical properties and two-photon absorption, J. Phys. Chem. A, 2005.

R. Kannan, G. S. He, T. C. Lin, P. N. Prasad, R. A. Vaia et al., Toward Highly Active Two-Photon Absorbing Liquids. Synthesis and Characterization of 1,3,5-Triazine-Based Octupolar Molecules, Chemistry of Materials, vol.16, issue.1, 2004.
DOI : 10.1021/cm034358g

X. Jiang-feng, P. Lam-wu, F. Bolze, H. W. Leung, K. F. Li et al., Cyanines as New Fluorescent Probes for DNA Detection and Two-Photon Excited Bioimaging, Organic Letters, issue.10, p.1221942197, 2010.

J. T. Dy, K. Ogawa, A. Satake, A. Ishizumi, and Y. Kobuke, Water-Soluble Self-Assembled Butadiyne-Bridged Bisporphyrin: A Potential Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy, Chemistry - A European Journal, vol.102, issue.12, 2007.
DOI : 10.1002/chem.200601205

Y. Nakamura, S. Y. Yang, T. Tanaka, N. Aratani, J. M. Lim et al., Borametallocenophanes of group 4 metals : Synthesis and structure, Chem. Eur. J, 2008.

J. Arnbjerg, A. Jiménez-banzo, M. J. Paterson, S. Nonell, J. I. Borell et al., Two-Photon Absorption in Tetraphenylporphycenes:?? Are Porphycenes Better Candidates than Porphyrins for Providing Optimal Optical Properties for Two-Photon Photodynamic Therapy?, Journal of the American Chemical Society, vol.129, issue.16, 2007.
DOI : 10.1021/ja0688777

J. Seo, S. Y. Jang, D. Kim, and H. Kim, Octupolar trisporphyrin conjugates exhibiting strong two-photon absorpion, Tetrahedron, 2008.

M. Williamns-harry, A. Bhaskar, G. Ramakrishna, T. Goodson, I. et al., Giant thienylene-acetylene-ethylene macrocycles with large two-photon absorption cross section and semishape-persistence, J. Am. Chem. Soc, 2008.

G. P. Bartholomew, M. Rumi, S. J. Pond, J. W. Perry, S. Tretiak et al., Twophoton absorption in three-dimensional chromophores based on [2.2]-paracyclophane, J. Am. Chem. Soc, 2004.

G. P. Bartholomew, I. Ledoux, S. Mukamel, G. C. Bazan, and J. Zyss, Three-Dimensional Nonlinear Optical Chromophores Based on Through-Space Delocalization, Journal of the American Chemical Society, vol.124, issue.45, 2002.
DOI : 10.1021/ja0272179

R. Michael, O. Harpham, C. Suezer, P. Ma, T. Baeuerle et al., Thiophene dendrimers as entangled photon sensor materials, Journal of the American Chemical Society, vol.131, issue.3, p.973979, 2009.

A. D. 'aleo, G. Pompidor, J. Elena, P. L. Vicat, L. Baldeck et al., Two-photon microscopy and spectroscopy of lanthanide bioprobes, Chem. Phys. Chem, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01320785

A. Picot, O. Maury, F. Malvolti, B. Le-guennic, P. L. Baldeck et al., Two-photon antenna eect induced in octupolar europium complexes, Inorg. Chem, 2007.

A. Abbotto, L. Beverina, S. Bradamante, A. Facchetti, and G. A. Pagani, Design and synthesis of heterocyclic multi-branched dyes for two-photon absorption, Synthetic Metals, vol.139, issue.3, 2003.
DOI : 10.1016/S0379-6779(03)00281-9

G. Bordeau, R. Lartia, G. Metgé, C. Fiorini-debuisschert, F. Charra et al., Trinaphthylamines as Robust Organic Materials for Two-Photon-Induced Fluorescence, Journal of the American Chemical Society, vol.130, issue.50
DOI : 10.1021/ja8055112

G. Bordeau, Nouvelles triarylamines pour la microscopie biphotonique : application au marquage des acides nucléiques, 2009.

A. Hayek, . Bolze, . Nicoud, Y. Baldeck, and . Mely, Synthesis and characterization of water-soluble two-photon excited blue uorescent chromophores for bioimaging, Photochemical and Photobiological Sciences, vol.5, issue.1, p.102106, 2006.

. Desce, Water-soluble dendrimeric two-photon tracers for in vivo imaging, Angewandte Chemie-International Edition, vol.45, issue.28, p.46454648, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00322860

D. R. Boer, A. Canals, and M. Coll, DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes, Dalton Trans., vol.25, issue.3, 2009.
DOI : 10.1039/B809873P

L. S. Lerman, THE STRUCTURE OF THE DNA-ACRIDINE COMPLEX, Proc. Natl. Acad. USA, 1963.
DOI : 10.1073/pnas.49.1.94

P. Herzyk, S. Neidle, and J. M. Goodfellow, Conformation and dynamics of drug-dna intercalation [92] Nucleic acids in chemistry and biology Chaires. Sequence-specic dna minor groove binders : Design and synthesis of netropsin and distamyin analogues, J. Biomol. Struct. Dyn. A IRL Oxford Bioconjugate Chem, 1992.

Y. Pommier, G. Kohlhagen, C. Bailly, M. Waring, A. Mazumber et al., Dna sequence and structure-selective alkylation of guanine n2 in the dna minor groove by ecteinascidin 743, a potent entitumor compound from the caribean tunicate ecteinascidin turbinata, Biochemistry, 1996.

D. Tevis, A. Kumar, C. Stephens, D. Boykin, and W. Wilson, Large sequence-dependent eects on dna conformation by minor groove binding compounds, Nucleic Acids Research, 2009.

F. Wolter, K. Schneider, B. Davies, E. Socher, G. Nicholson et al., Total Synthesis of Proximicin A???C and Synthesis of New Furan-Based DNA Binding Agents, Organic Letters, vol.11, issue.13, 2009.
DOI : 10.1021/ol901003p

T. Beebe, . Wilson, . Df-ogletree, . Katz, . Balhorn et al., Direct observation of native DNA structures with the scanning tunneling microscope, Science, vol.243, issue.4889, p.243370372, 1989.
DOI : 10.1126/science.2911747

G. Lee, . Arscott, D. Va-bloomeld, and . Evans, Scanning tunneling microscopy of nucleicacids, Science, vol.244, issue.4903, p.475477, 1989.

P. Arscott, . Lee, D. Blommeld, and . Evans, Scanning tunnelling microscopy of Z-DNA, Nature, vol.339, issue.6224, p.484486, 1989.
DOI : 10.1038/339484a0

C. Clemmer and T. Beebe, Graphite: a mimic for DNA and other biomolecules in scanning tunneling microscope studies, Science, vol.251, issue.4994, p.640642, 1991.
DOI : 10.1126/science.1992517

W. Heckl and G. Binning, Domain walls on graphite mimic DNA, Ultramicroscopy, vol.42, issue.44, p.10731078, 1992.
DOI : 10.1016/0304-3991(92)90404-8

H. Tanaka and T. Kawai, Scanning tunneling microscopy imaging and manipulation of DNA oligomer adsorbed on Cu(111) surfaces by a pulse injection method, Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures, vol.15, issue.3, 1997.
DOI : 10.1116/1.589299

G. Binnig and H. Rohrer, Scanning tunneling microscopy, Helvetica Physica Acta, vol.55, issue.6, pp.726-735, 1982.

J. Terso and D. Hamann, Theory and Application for the Scanning Tunneling Microscope, Physical Review Letters, vol.50, issue.25, 1983.

J. Bardeen, Tunnelling from a Many-Particle Point of View, Physical Review Letters, vol.6, issue.2, p.57, 1961.
DOI : 10.1103/PhysRevLett.6.57

J. Terso and D. Hamann, Theory of the Scanning Tunneling Microscope, Physical Review B, vol.31, issue.2, p.805813, 1985.

A. Dazzi and D. Nutarelli, Travaux pratique d'initiation à la microscopie à eet tunnel (stm)

G. Schull, Dynamique d'auto-assemblages moléculaire bidimentionnels, 2006.

C. E. Chidsey, D. N. Loiacono, T. Sleator, and N. , STM study of the surface morphology of gold on mica, Surface Science, vol.200, issue.1, 1988.
DOI : 10.1016/0039-6028(88)90432-3

I. G. Higginbotham, R. H. Williams, and A. J. Mcevoy, Metal/non-metal interfaces: adhesion of gold on mica, Journal of Physics D: Applied Physics, vol.8, issue.9, 1975.
DOI : 10.1088/0022-3727/8/9/008

T. Fukuma, Y. Ueda, S. Yoshioka, and H. Asakawa, Atomic-scale distribution of water molecules at the mica-water interface visualized by three-dimensional scaning force microscopy

M. Levlin, A. Laakso, H. E. Niemi, and P. Hautojarvi, Evaporation of gold thin lms on mica : eect of evaporation parameters, Applied Surface Science, 1997.

D. W. Pashley, Nucleation growth structure and epitaxy of thin surface lms, Adv. Phy, 1965.

H. Poppa and E. H. Lee, Quantitative measurements of nuclation and growth kinetcs of gold on mica, Thin Solid Films, 1976.

M. H. Disner, M. M. Ivey, S. Gorer, and J. C. Hemminger, Preparation of gold thin lms by epitaxial growth on mica and the eect of ame annealing, J. Vac. Sci. Technol. A, 1998.

F. Yin, R. E. Palmer, and Q. Guo, Faceting of nanoscale ngers on the (111) surface of gold, Surface Science, 2006.

N. Toto, R. Ferrando, Q. M. Guo, and R. L. Johnston, Nanonger growth on au(111) arising from kinetic instability, Physical Review B, 2007.

S. Guo and A. Kandel, Scanning tunneling microscopy studies of pulse deposition of dinuclear organometallic molecules on Au(111), The Journal of Chemical Physics, vol.128, issue.1, 2008.
DOI : 10.1063/1.2819237

Y. Shirai, Y. Osgood, . Zhao, J. Kelly, and . Tour, Directional Control in Thermally Driven Single-Molecule Nanocars, Nano Letters, vol.5, issue.11, p.23302334, 2005.
DOI : 10.1021/nl051915k

Y. Shirai, Y. Osgood, Y. Zhao, . Yao, . Saudan et al., Surface-Rolling Molecules, Journal of the American Chemical Society, vol.128, issue.14, p.48544864, 2006.
DOI : 10.1021/ja058514r

Y. Terada, . Choi, . Heike, T. Fujimori, and . Hashizume, Injection of molecules onto hydrogen-terminated Si(100) surfaces via a pulse valve, Journal of Applied Physics, vol.93, issue.12, pp.10014-10017, 2003.
DOI : 10.1063/1.1572972

Y. Terada, . Choi, . Heike, T. Fujimori, and . Hashizume, Placing Conducting Polymers onto a H-Terminated Si(100) Surface via a Pulse Valve, Nano Letters, vol.3, issue.4, p.527531, 2003.
DOI : 10.1021/nl0259737

L. Grill, I. Stass, K. Rieder, and F. Moresco, Preparation of self-ordered molecular layers by pulse injection, Surface Science, vol.600, issue.11, 2006.
DOI : 10.1016/j.susc.2006.03.040

H. Tanaka and T. Kawai, Partial sequencing of a single DNA molecule with a scanning tunnelling microscope, Nature Nanotechnology, vol.123, issue.8, p.518522, 2009.
DOI : 10.1038/nnano.2009.155

M. Kind and C. Wöll, Organic surfaces exposed by self-assembled organothiol monolayers: Preparation, characterization, and application, Progress in Surface Science, vol.84, issue.7-8, pp.230-278, 2009.
DOI : 10.1016/j.progsurf.2009.06.001

E. Shapir, . Yi, . Cohen, . Kotlyar, D. Cuniberti et al., The Puzzle of Contrast Inversion in DNA STM Imaging, The Journal of Physical Chemistry B, vol.109, issue.30, p.1427014274, 2005.
DOI : 10.1021/jp052738e

E. Shapir, L. Sagiv, N. Borovok, T. Molotski, A. B. Kotlyar et al., High-resolution STM imaging of novel single G4-DNA molecules Structure and binding of alkanethiolates on gold and silver surfaces -implications for self-assembled monolayers, J. of Phys. Chem. B Journal of the American Chemical Society OCT, vol.112, issue.20, pp.92679269-11593899401, 1993.

J. Love, L. Estro, . Kriebel, G. Nuzzo, and . Whitesides, Self-assembled monolayers of thiolates on metals as a form of nanotechnology, Chemical Reviews, vol.105, issue.4, p.11031169, 2005.

L. Piot, Croissance et structure d'auto-assemblages supramoléulaires de molécules conjuguées sur surfaces atomiquement planes, 2006.

T. Anisotropie-en, Anisotropie en L

T. Exaltation-de-uorescence-de-la, A droite, Titration des TP-Py à une concentration de 1µM dans un tampon de cacodylate de sodium pH 7.2 10mM, 100mM NaCl par de l'ADN de testicule de hareng (l'exaltation de uorescence relative correspond au rapport entre l'intensité de uorescence du complexe marqueur/ADN à saturation et l'intensité de uorescence du marqueur à l'état libre dans la solution tampon)

T. Titrations-des-analogues-de, 1µm] (en rouge : la TP-2Py, en orange : la TP- 2PyO, en vert : la TP-2Bzim et en noir la TP-3Bzim) dans le DrewAT (tampon 10mM cacodylate de sodium, 100mM NaCl à pH 7

. Tp-2py,-en-orange....., TP-2PyO, en vert : TP-2Bzim) en fonction du nombre d'équivalents d'ADN de hareng ou de DrewAT. En pointillés, les durées de vie dans le DrewAT ; en traits continus

.. De-drewat, Variation du rapport sections ecace d'absorption à deux photons ( ? n ? 0 )des composés à deux branches [1µM ](en rouge : la TP-2Py, en orange : la TP-2PyO et en vert : la TP-2Bzim) en fonction du nombre d'équivalents, p.99

S. Image, Au en sortie du bâti (I t =10 nA et V t =-370 mV et 500

U. Stm, 118 87 A gauche, image STM (248×240 nm, I t =51 pA, V t =-2800 mV) de l'ADN de hareng [74 A droite, p.image STM

?. ?45-@bullet and S. , V t =-2538 mV) de l'ADN de hareng [87.1 nM] auquel on a ajouté le uorophore TP-2Py [0.2 mM] (12 pulses de 1.5 ms, ?, Images STM

?. @bullet and S. , ADN de hareng marqué par des TP-2Py thiolanes (solution d'ADN de hareng [87.1 nM] avec une concentration de TP-2Py thiolane qui est de 0.2 mM, Images STM, vol.10

. Images and .. Stm-d-'une-molécule-d-'adn-g4-sur-un-substrat-d-'au, [130] (V s =2.8 V et I t =20 pA), p.127

S. Image, une mono-couche auto-organisée de dodecanethiols (C 10 H 21 SH) et schéma représentant la structure de surface des dodecanethiols [128

]. Hamamatsu, Deux facteurs limitatifs de la résolution temporelle

C. Le, Spectres de transmission des diérents ltres sur la passage de la uorescence et le spectre de ltration vus par la uorescence avant