Influence d'un phosphate de calcium substitué en strontium sur la physiologie de l'ostéoblaste humain en culture et évaluation de son potentiel de réparation osseusse chez la souris

Abstract : Calcium phosphate are widely used in medicine. Their upgrade tend to enhance their biocompatibility and their bioactivity. Strontium has interesting capability to modify the bone physiologie. Its incorporation in calcium phosphates could lead to modify the bone balance toward osteogenesis.The present work reveal the capacities of such biomaterials to enhance the replication of osteoblasts ant to modify the expression and the synthesis of proteins implicated in the bone balance (type I collagen, serpinH1, Matrix metalloproteinases 1 and 2, tissular inhibitors of MMPs). Moreover, non substituted calcium phosphate powders enhance the expression and synthesis of inflammatory cytokines (MCP-1 and Gro-a). This fact was not observed with the non substituted powder. In-vivo studies on a mouse model permit us to demonstrate the higher resorbability and the higher bone healing capability of the substituted powder.
Document type :
Theses
Médecine humaine et pathologie. Université de Reims - Champagne Ardenne, 2011. Français. <NNT : 2011REIM0201>


https://tel.archives-ouvertes.fr/tel-00591069
Contributor : Abes Star <>
Submitted on : Friday, May 6, 2011 - 1:39:07 PM
Last modification on : Friday, November 27, 2015 - 1:00:43 AM
Document(s) archivé(s) le : Sunday, August 7, 2011 - 2:43:25 AM

File

Braux2011REIM0201.pdf
Version validated by the jury (STAR)

Identifiers

  • HAL Id : tel-00591069, version 1

Collections

Citation

Julien Braux. Influence d'un phosphate de calcium substitué en strontium sur la physiologie de l'ostéoblaste humain en culture et évaluation de son potentiel de réparation osseusse chez la souris. Médecine humaine et pathologie. Université de Reims - Champagne Ardenne, 2011. Français. <NNT : 2011REIM0201>. <tel-00591069>

Export

Share

Metrics

Record views

397

Document downloads

839