Abstract : Home health care structures (HHC) must face various operational problems. This PhD thesis proposes an investigation on decision support problems for managing human resources in HHC. Within the framework of a quality certification, we studied the HHC processes and we identify the logistic decisions. Two main problems were specified. The first one consists in calculating the nurses' timetables making a decision support tool. This tool was experimented and is dedicated for the HHC service: HAD EOVI Drôme nord. Several decision models were compared using two problem solving methods: the first one is based on integer linear programming and the second is based on constraint programming. The second studied problem is a drug delivery problem in a French HHC service: HAD Soins et Santé. We aim to help the HHC structure in managing their urgent deliveries. The HHC has in average forty urgent deliveries per day and these deliveries are very expensive regarding to the used external providers. A support decision tool in the framework of three different strategies of deliveries (starting deliveries when a specified delivery number is achieved, starting deliveries on a fixed delivery number per carrier and, starting deliveries on fixed hours) was developed. Regarding the best strategy, this tool was experimented using real data of the HHC service in order to compare the costs between using an external provider and permanent employee. We prove that the use of permanent employee is more profitable.