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Elaboration et caractérisations de nanocristaux organiques fluorescents insérés en coquille sol-gel : vers le développement d'un nouveau type d'agent imageant

Abstract : We demonstrated the feasibility and the reproducibility of our method of one-step elaboration of organic nanocrystals in sol-gel shell obtained by atomization, by using various sort of organic molecules, solvent and sol-gel matrices. The use of different techniques of characterization (scanning electronic microscopy, one and two photons luminescence spectroscopy) allowed to optimized the conditions of elaboration to obtain hybrid nanoparticles of small sizes, with a maximum of fluorophore, highly luminescent and biocompatible. The scanning electronic microscopy and the electronic diffraction allowed us to prove the presence of a single-crystal heart within nanoparticles and to define the crystalline structures. The properties of nanocrystals as labels for imaging the microvascularization of the small animal brain in two photons were then analyzed by two photons fluorescence spectroscopy as well as the non-toxicity of nanoparticles. Finally, the first invivo tests of nanoparticles as labels grew to us to functionalize to increase their stealth and add it a new function of targeting.
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https://tel.archives-ouvertes.fr/tel-00580367
Contributor : Cécile Philippot <>
Submitted on : Monday, March 28, 2011 - 9:39:39 AM
Last modification on : Thursday, November 19, 2020 - 1:01:02 PM
Long-term archiving on: : Wednesday, June 29, 2011 - 2:37:28 AM

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  • HAL Id : tel-00580367, version 1

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Cécile Philippot. Elaboration et caractérisations de nanocristaux organiques fluorescents insérés en coquille sol-gel : vers le développement d'un nouveau type d'agent imageant. Chimie. Université de Grenoble, 2010. Français. ⟨tel-00580367⟩

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