Common nonsynonymous variants in PCSK1 confer risk of obesity, Nature Genetics, vol.269, issue.8, pp.943-948, 2008. ,
DOI : 10.1093/hmg/ddl111
REFERENCES BIBLIOGRAPHIQUES 1 The epidemiology of obesity: the size of the problem, James, W.P. J Intern Med, vol.2, issue.263, pp.36-336, 2008. ,
Establishing a standard definition for child overweight and obesity worldwide: international survey, BMJ, vol.320, issue.7244, pp.1240-1243, 2000. ,
DOI : 10.1136/bmj.320.7244.1240
Definitions of childhood obesity: current practice, European Journal of Clinical Nutrition, vol.105, issue.10, pp.1189-94, 2006. ,
DOI : 10.1038/sj.ejcn.1602436
Defining childhood obesity: the relative body mass index (BMI), Acta Paediatrica, vol.39, issue.8, 1995. ,
DOI : 10.1016/0026-0495(77)90082-8
Extreme Obesity: A New Medical Crisis in the United States, Mayo Clinic Proceedings, vol.81, issue.10, pp.5-10, 2006. ,
DOI : 10.1016/S0025-6196(11)61175-0
Obesity in children Part 1: Epidemiology, measurement, risk factors, and screening Imaging techniques for measuring adipose-tissue distribution--a comparison between computed tomography and 1.5- T magnetic resonance, Bmj Am J Clin Nutr, vol.337, issue.51, pp.953-960, 1824. ,
Update on Obesity, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.6, pp.2027-2061, 2008. ,
DOI : 10.1210/jc.2008-0520
Trends in overweight and obesity in Swedish schoolchildren 1999-2005: has the epidemic reached a plateau Trends in the prevalence of childhood overweight and obesity in Australia between Obesity prevalence from a European perspective: a systematic review American Heart Association Childhood Obesity Research Summit: executive summary, Obes Rev Int J Obes (Lond) BMC Public Health Circulation, vol.11, issue.119, pp.553-562, 1985. ,
Predicting Obesity in Young Adulthood from Childhood and Parental Obesity, New England Journal of Medicine, vol.337, issue.13, pp.869-73, 1997. ,
DOI : 10.1056/NEJM199709253371301
A potential decline in life expectancy in the United States in the 21st century Diabetes mellitus and its chronic complications Obesity and dyslipidemia The disease burden associated with overweight and obesity Obesity: prevalence, theories, medical consequences, management, and research directions Extreme childhood obesity is associated with increased risk for gastroesophageal reflux disease in a large population-based study Obesity and urinary incontinence: epidemiology and clinical research update The prevalence and etiology of nongenetic obesity and associated disorders Psychiatric symptoms among prospective bariatric surgery patients: rates of prevalence and their relation to social desirability, pursuit of surgery, and follow-up attendance Social and economic consequences of overweight in adolescence and young adulthood Position of the American Dietetic Association: weight management How effective are traditional dietary and exercise interventions for weight loss? Management of obesity as a chronic disease: nonpharmacologic, pharmacologic, and surgical options Long term pharmacotherapy for obesity and overweight: updated meta-analysis Long-term persistence with orlistat and sibutramine in a population-based cohort, viii. 18. Must, pp.763-78, 1993. ,
The obesity epidemic: pharmacological challenges Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery Effects of bariatric surgery on mortality in Swedish obese subjects A decade of change in obesity surgery Bariatric surgery trends: an 18-year report from the International Bariatric Surgery Registry Trends in bariatric surgical procedures Long-term mortality after gastric bypass surgery Obesity and its surgical management Medical and surgical options in the treatment of severe obesity Clinical update: bariatric surgery, Mol Interv N Engl J Med N Engl J Med National Bariatric Surgery Registry (NBSR) Contributors. Obes Surg Am J Surg Jama N Engl J Med Am J Surg Am J Surg Lancet, vol.8, issue.370, pp.82-98, 1997. ,
Treatment of Mild to Moderate Obesity with Laparoscopic Adjustable Gastric Banding or an Intensive Medical Program, Annals of Internal Medicine, vol.144, issue.9, pp.625-658, 2006. ,
DOI : 10.7326/0003-4819-144-9-200605020-00005
Bariatric surgery for pediatric extreme obesity: now or later?, International Journal of Obesity, vol.38, issue.1, pp.1-14, 2007. ,
DOI : 10.1038/sj.ijo.0803525
Bariatric surgery in the management of childhood obesity: should there be an age limit? Obes Surg Lipectomy as a new approach to secondary procedure superficialization of direct autogenous forearm radial-cephalic arteriovenous accesses for hemodialysis Prevention of pediatric overweight and obesity An update in prevention and treatment of pediatric obesity Downward trends in the prevalence of childhood overweight in the setting of 12-year school-and community-based programmes Preventing childhood obesity: what works? Ten putative contributors to the obesity epidemic Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment, J Vasc Surg Pediatrics World J Pediatr Public Health Nutr Int J Obes (Lond) Crit Rev Food Sci Nutr Mol Psychiatry, vol.20, issue.12, pp.114-121, 2003. ,
Atypical Antipsychotic Drugs Directly Impair Insulin Action in Adipocytes: Effects on Glucose Transport, Lipogenesis, and Antilipolysis, Neuropsychopharmacology, vol.184, issue.4, pp.765-72, 2007. ,
DOI : 10.1038/sj.npp.1301142
Antipsychotic-induced weight gain: a comprehensive research synthesis Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males Infectobesity: obesity of infectious origin, Am J Psychiatry Environ Health Perspect, vol.156, issue.115, pp.1686-96, 1999. ,
Chronic systemic inflammation in overweight and obese adults NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia The gut microbiota as an environmental factor that regulates fat storage An obesity-associated gut microbiome with increased capacity for energy harvest Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children, Adv Food Nutr Res Proc Natl Acad Sci U S A Nature Br J Nutr, vol.52, issue.103, pp.61-102, 1997. ,
Microbial ecology: human gut microbes associated with obesity A human gut microbial gene catalogue established by metagenomic sequencing Obesity in childhood: A community study in Newcastle upon Tyne Risk factors for obesity in 7- year-old European children: the Auckland Birthweight Collaborative Study Timing of nutrient restriction and programming of fetal adipose tissue development Sleep deprivation in the rat: X. Integration and discussion of the findings Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin, Am J Clin Nutr Nature Nature Lancet Arch Dis Child Proc Nutr Soc Sleep Endocr Rev J Clin Endocrinol Metab, vol.87, issue.89, pp.534-542, 1977. ,
Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index Energy Balance and Obesity in Man Effect of ambience on food intake and food choice (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis, e62. 70. Garrow, pp.821-859, 1978. ,
Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice, Diabetes, vol.58, issue.2, pp.460-468, 2009. ,
DOI : 10.2337/db08-0490
Epigenetic differences arise during the lifetime of monozygotic twins The epigenetic basis of twin discordance in age-related diseases Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome, Proc Natl Acad Sci U S A Pediatr Res J Physiol, vol.102, issue.587, pp.10604-10613, 2005. ,
High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats Metabolic plasticity during mammalian development is directionally dependent on early nutritional status Gene-nutrient interactions and DNA methylation, 81. Friso, S. and Choi, S.W. (2005) Gene-nutrient interactions in one-carbon metabolism, pp.1-9, 2002. ,
Metabolic imprinting in obesity Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction Heritability in the genomics era-concepts and misconceptions Genetics of body-weight regulation, Curr Drug Metab Forum Nutr Am J Clin Nutr Nat Rev Genet Nature, vol.6, issue.404, pp.37-46, 2000. ,
Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment, Am J Clin Nutr, vol.87, pp.398-404, 2008. ,
Mutations in ligands and receptors of the leptin???melanocortin pathway that lead to obesity, Nature Clinical Practice Endocrinology & Metabolism, vol.7, issue.10, pp.569-77, 2003. ,
DOI : 10.1038/ncpendmet0966
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3 Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity, ) Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brainderived neurotrophic factor (BDNF) gene. Diabetes, pp.3369-73, 2000. ,
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency, Journal of Clinical Investigation, vol.112, issue.10, pp.1550-60, 1997. ,
DOI : 10.1172/JCI200318784
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans, Nature Genetics, vol.19, issue.2, pp.155-162, 1998. ,
DOI : 10.1038/509
Congenital leptin deficiency is associated with severe early-onset obesity in humans (1998) A leptin missense mutation associated with hypogonadism and morbid obesity A frameshift mutation in human MC4R is associated with a dominant form of obesity, Nature Nat Genet Nat Genet, vol.387, issue.20, pp.903-911, 1997. ,
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay, Nature Neuroscience, vol.127, issue.11, pp.1187-1196, 2004. ,
DOI : 10.1038/ng0896-485
A frameshift mutation in MC4R associated with dominantly inherited human obesity, Nature Genetics, vol.20, issue.2, pp.111-113, 1998. ,
DOI : 10.1038/2404
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms, Human Molecular Genetics, vol.12, issue.5, pp.561-74, 2003. ,
DOI : 10.1093/hmg/ddg057
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency, Journal of Clinical Investigation, vol.110, issue.8, pp.1093-103, 2002. ,
DOI : 10.1172/JCI0215693
Plasma leptin levels in male patients with idiopathic central diabetes insipidus, Journal of Endocrinological Investigation, vol.82, issue.part2, pp.451-455, 1999. ,
DOI : 10.1007/BF03343589
Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome, New England Journal of Medicine, vol.359, issue.9, pp.918-945, 2008. ,
DOI : 10.1056/NEJMoa0801119
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency, New England Journal of Medicine, vol.341, issue.12, pp.879-84, 1999. ,
DOI : 10.1056/NEJM199909163411204
Fat chance: genetic syndromes with obesity, Clinical Genetics, vol.8, issue.2, pp.83-93, 2004. ,
DOI : 10.1111/j.0009-9163.2004.00300.x
Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster, Nature Genetics, vol.40, issue.6, pp.719-740, 2008. ,
DOI : 10.1371/journal.pgen.0030235
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism, Human Molecular Genetics, vol.18, issue.17, pp.3257-65, 2009. ,
DOI : 10.1093/hmg/ddp263
Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader???Willi syndrome, European Journal of Human Genetics, vol.18, issue.11, 2010. ,
DOI : 10.1038/ejhg.2010.102
The snoRNA HBII-52 Regulates Alternative Splicing of the Serotonin Receptor 2C, Science, vol.311, issue.5758, pp.230-232, 2006. ,
DOI : 10.1126/science.1118265
Identification of 28 novel mutations in the Bardet???Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease, Human Genetics, vol.101, issue.1, pp.583-93, 2010. ,
DOI : 10.1007/s00439-010-0804-9
URL : https://hal.archives-ouvertes.fr/inserm-00462147
Establishing a connection between cilia and Bardet???Biedl Syndrome, Trends in Molecular Medicine, vol.10, issue.3, pp.106-115, 2004. ,
DOI : 10.1016/j.molmed.2004.01.003
Disruption of Intraflagellar Transport in Adult Mice Leads to Obesity and Slow-Onset Cystic Kidney Disease, Current Biology, vol.17, issue.18, pp.1586-94, 2007. ,
DOI : 10.1016/j.cub.2007.08.034
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling, Human Molecular Genetics, vol.18, issue.7, pp.1323-1354, 2009. ,
DOI : 10.1093/hmg/ddp031
New Alstr??m Syndrome Phenotypes Based on the Evaluation of 182 Cases, Archives of Internal Medicine, vol.165, issue.6, pp.675-83, 2005. ,
DOI : 10.1001/archinte.165.6.675
Mutational spectrum of COH1 and clinical heterogeneity in Cohen syndrome, Journal of Medical Genetics, vol.43, issue.5, p.22, 2006. ,
DOI : 10.1136/jmg.2005.039867
Albright's Hereditary Osteodystrophy and Defective G Proteins, New England Journal of Medicine, vol.322, issue.20, pp.1461-1463, 1990. ,
DOI : 10.1056/NEJM199005173222010
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis., Proceedings of the National Academy of Sciences, vol.87, issue.21, pp.8287-90, 1990. ,
DOI : 10.1073/pnas.87.21.8287
The role of GNAS and other imprinted genes in the development of obesity, International Journal of Obesity, vol.22, issue.1, pp.6-17, 2010. ,
DOI : 10.1038/ijo.2009.222
The Human Obesity Gene Map: The 2005 Update, Obesity, vol.33, issue.4, pp.529-644, 2006. ,
DOI : 10.1038/oby.2006.71
A major predisposition locus for severe obesity, Am J Hum Genet, vol.70, pp.4-15, 2002. ,
Genome-Wide Scan of Obesity in Finnish Sibpairs Reveals Linkage to Chromosome Xq24, Journal of Clinical Endocrinology & Metabolism, vol.85, issue.9, pp.3183-90, 2000. ,
DOI : 10.1210/jc.85.9.3183
TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition, Human Molecular Genetics, vol.15, issue.18, pp.2709-2729, 2006. ,
DOI : 10.1093/hmg/ddl204
The SLC6A14 gene shows evidence of association with obesity, Journal of Clinical Investigation, vol.112, issue.11, pp.1762-72, 2003. ,
DOI : 10.1172/JCI200317491
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population, Human Molecular Genetics, vol.17, issue.12, pp.1798-802, 2008. ,
DOI : 10.1093/hmg/ddn070
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity, Nature Genetics, vol.279, issue.11, pp.1354-1363, 2008. ,
DOI : 10.1038/ng.244
Cloning and Functional Expression of a Human Na+and Cl--dependent Neutral and Cationic Amino Acid Transporter B0+, Journal of Biological Chemistry, vol.274, issue.34, pp.23740-23745, 1999. ,
DOI : 10.1074/jbc.274.34.23740
Polymorphisms in the Amino Acid Transporter Solute Carrier Family 6 (Neurotransmitter Transporter) Member 14 Gene Contribute to Polygenic Obesity in French Caucasians, Diabetes, vol.53, issue.9, pp.2483-2489, 2004. ,
DOI : 10.2337/diabetes.53.9.2483
URL : https://hal.archives-ouvertes.fr/hal-00094121
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations, Human Molecular Genetics, vol.17, issue.13, pp.1916-1937, 2008. ,
DOI : 10.1093/hmg/ddn089
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes, Nature Genetics, vol.68, issue.8, pp.863-870, 2005. ,
DOI : 10.1038/ng1604
URL : https://hal.archives-ouvertes.fr/hal-00174474
Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population, International Journal of Obesity, vol.19, issue.6, pp.908-920, 2007. ,
DOI : 10.1038/sj.ijo.0803510
Cannabinoid Type-1 Receptor Gene Polymorphisms Are Associated with Central Obesity in a Southern Brazilian Population, Disease Markers, vol.25, issue.1, pp.67-74, 2008. ,
DOI : 10.1155/2008/841490
The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men, Endocrine, vol.49, issue.Suppl 4, pp.138-179, 2007. ,
DOI : 10.1007/s12020-007-0022-y
) Are Associated with Obesity Phenotypes in Men, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.6, pp.2382-2388, 2007. ,
DOI : 10.1210/jc.2006-2523
Variants and Haplotypes Predispose to Early Onset Obesity and Impaired Glucose and Insulin Metabolism in German Obese Children, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.12, pp.4948-52, 2006. ,
DOI : 10.1210/jc.2006-0540
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population, Diabetes & Metabolism, vol.35, issue.1, pp.37-42, 2009. ,
DOI : 10.1016/j.diabet.2008.06.005
With Obesity-related Phenotypes, Obesity, vol.28, issue.Suppl 1, pp.1708-1721, 2008. ,
DOI : 10.1038/oby.2008.262
Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants, Endocrine, vol.57, issue.Suppl 1, pp.103-112, 2009. ,
DOI : 10.1007/s12020-009-9194-y
in Obesity: Association With Morbid Obesity in Finns, Obesity, vol.20, issue.9, pp.2113-2122, 2008. ,
DOI : 10.1038/oby.2008.313
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene, Human Molecular Genetics, vol.16, issue.15, pp.1837-1881, 2007. ,
DOI : 10.1093/hmg/ddm132
URL : https://hal.archives-ouvertes.fr/hal-00172976
Common Variation in SIM1 Is Reproducibly Associated With BMI in Pi ma Indians, Diabetes, vol.58, issue.7, pp.1682-1691, 2009. ,
DOI : 10.2337/db09-0028
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants, PLoS ONE, vol.43, issue.3, p.1361, 2007. ,
DOI : 10.1371/journal.pone.0001361.s003
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations, Nature Genetics, vol.276, issue.2, pp.157-166, 2009. ,
DOI : 10.1016/S0006-291X(02)00379-0
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups, PLoS Genetics, vol.19, issue.4, p.1000916, 2010. ,
DOI : 10.1371/journal.pgen.1000916.s012
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation, Nature Genetics, vol.294, issue.1, pp.25-34, 2009. ,
DOI : 10.1086/521580
Origins and functional impact of copy number variation in the human genome, Nature, vol.36, issue.7289, pp.704-716, 2010. ,
DOI : 10.1038/nature08516
The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI, Obesity, vol.17, issue.12, pp.2254-2261, 2009. ,
DOI : 10.1086/519795
Large, rare chromosomal deletions associated with severe early-onset obesity, Nature, vol.40, issue.7281, pp.666-70, 2010. ,
DOI : 10.1038/nature08689
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2, Nature, vol.30, issue.7281, pp.671-676, 2010. ,
DOI : 10.1038/nature08727
Insulin Biosynthesis: Evidence for a Precursor, Science, vol.157, issue.3789, pp.697-700, 1967. ,
DOI : 10.1126/science.157.3789.697
ISOLATION, PURIFICATION, AND CHARACTERIZATION OF ??-LIPOTROPIC HORMONE FROM SHEEP PITUITARY GLANDS, Canadian Journal of Biochemistry, vol.45, issue.7, pp.1163-74, 1967. ,
DOI : 10.1139/o67-133
Precursor convertases in the secretory pathway, cytosol and extracellular milieu, Essays In Biochemistry, vol.38, pp.79-94, 2002. ,
DOI : 10.1042/bse0380079
Knock-out mouse models of proprotein convertases: unique functions or redundancy?, Frontiers in Bioscience, vol.Volume, issue.13, pp.4960-71, 2008. ,
DOI : 10.2741/3055
Furin at the cutting edge: From protein traffic to embryogenesis and disease, Nature Reviews Molecular Cell Biology, vol.2, issue.10, pp.753-66, 2002. ,
DOI : 10.1038/nrm934
NARC-1/PCSK9 and Its Natural Mutants: ZYMOGEN CLEAVAGE AND EFFECTS ON THE LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR AND LDL CHOLESTEROL, Journal of Biological Chemistry, vol.279, issue.47, pp.48865-75, 2004. ,
DOI : 10.1074/jbc.M409699200
Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases, Journal of Biological Chemistry, vol.273, issue.18, pp.11107-11121, 1998. ,
DOI : 10.1074/jbc.273.18.11107
Endoproteolytic Cleavage of Its Propeptide Is a Prerequisite for Efficient Transport of Furin Out of the Endoplasmic Reticulum, Journal of Biological Chemistry, vol.270, issue.6, pp.2695-702, 1995. ,
DOI : 10.1074/jbc.270.6.2695
Structural Elements That Direct Specific Processing of Different Mammalian Subtilisin-like Prohormone Convertases, Journal of Biological Chemistry, vol.270, issue.37, pp.21509-21525, 1995. ,
DOI : 10.1074/jbc.270.37.21509
Curbing activation: proprotein convertases in homeostasis and pathology, The FASEB Journal, vol.17, issue.10, pp.1215-1242, 2003. ,
DOI : 10.1096/fj.02-0831rev
Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications, Journal of Molecular Endocrinology, vol.24, issue.1, pp.1-22, 2000. ,
DOI : 10.1677/jme.0.0240001
On the Processing of Proghrelin to Ghrelin, Journal of Biological Chemistry, vol.281, issue.50, pp.38867-70, 2006. ,
DOI : 10.1074/jbc.M607955200
Impaired Intestinal Proglucagon Processing in Mice Lacking Prohormone Convertase 1, Endocrinology, vol.145, issue.3, pp.1349-55, 2004. ,
DOI : 10.1210/en.2003-0801
and Melanocortin Receptors Cannot Be Influenced by Syndecan-3, Endocrinology, vol.147, issue.4, pp.1621-1652, 2006. ,
DOI : 10.1210/en.2005-1373
Prohormone convertase 1 is necessary for the formation of cholecystokinin 8 in Rin5F and STC-1 cells, J Biol Chem, vol.272, pp.9450-9456, 1997. ,
Prohormone Convertase 1/3 Is Essential for Processing of the Glucose-dependent Insulinotropic Polypeptide Precursor, Journal of Biological Chemistry, vol.281, issue.16, pp.11050-11057, 2006. ,
DOI : 10.1074/jbc.M601203200
Biological Processing of the Cocaine and Amphetamine-regulated Transcript Precursors by Prohormone Convertases, PC2 and PC1/3, Journal of Biological Chemistry, vol.278, issue.17, pp.15007-15021, 2003. ,
DOI : 10.1074/jbc.M212128200
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, ??-MSH, and ??-endorphin, Endocrine, vol.89, issue.3, pp.429-466, 2009. ,
DOI : 10.1007/s12020-009-9163-5
Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics, Journal of Neurochemistry, vol.99, pp.215-240, 2010. ,
DOI : 10.1111/j.1471-4159.2010.06760.x
Identification of Inhibitors of Prohormone Convertases 1 and 2 Using a Peptide Combinatorial Library, Journal of Biological Chemistry, vol.273, issue.41, pp.26589-95, 1998. ,
DOI : 10.1074/jbc.273.41.26589
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing, J Neurosci, vol.20, pp.639-687, 2000. ,
The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation, Journal of Neurochemistry, vol.99, pp.1275-84, 2010. ,
DOI : 10.1111/j.1471-4159.2010.06706.x
Nescient Helix-Loop-Helix 2 Interacts with Signal Transducer and Activator of Transcription 3 to Regulate Transcription of Prohormone Convertase 1/3, Molecular Endocrinology, vol.22, issue.6, pp.1438-1486, 2008. ,
DOI : 10.1210/me.2008-0010
Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3), Diabetologia, vol.89, issue.Suppl 1, pp.504-517, 2009. ,
DOI : 10.1007/s00125-008-1210-x
Impaired Prohormone Convertases inCpe fat/Cpe fat Mice, Journal of Biological Chemistry, vol.276, issue.2, pp.1466-73, 2001. ,
DOI : 10.1074/jbc.M008499200
Proprotein convertases as therapeutic targets, Expert Opinion on Therapeutic Targets, vol.48, issue.10, pp.1289-300, 2008. ,
DOI : 10.1128/IAI.72.1.602-605.2004
Deletion of the Gene Encoding Proprotein Convertase 5/6 Causes Early Embryonic Lethality in the Mouse, Molecular and Cellular Biology, vol.26, issue.1, pp.354-61, 2006. ,
DOI : 10.1128/MCB.26.1.354-361.2006
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: Divergent or shared functions, Biochimie, vol.76, issue.3-4, pp.197-209, 1994. ,
DOI : 10.1016/0300-9084(94)90147-3
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization, Proceedings of the National Academy of Sciences, vol.96, issue.4, pp.1321-1327, 1999. ,
DOI : 10.1073/pnas.96.4.1321
URL : https://hal.archives-ouvertes.fr/hal-00126413
Pro-protein convertases (PCs) other than PC6 are not tightly regulated for implantation in the human endometrium, Reproduction, vol.133, issue.6, pp.1189-97, 2007. ,
DOI : 10.1530/REP-06-0285
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine, PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine, pp.54-60, 2009. ,
DOI : 10.1016/j.regpep.2008.07.006
VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5, Genes & Development, vol.22, issue.11, pp.1465-77, 2008. ,
DOI : 10.1101/gad.479408
The Furin Inhibitor Hexa-D-Arginine Blocks the Activation of Pseudomonas aeruginosa Exotoxin A In Vivo, Infection and Immunity, vol.70, issue.12, pp.7136-7145, 2002. ,
DOI : 10.1128/IAI.70.12.7136-7139.2002
Polyarginine Inhibits gp160 Processing by Furin and Suppresses Productive Human Immunodeficiency Virus Type 1 Infection, Journal of Biological Chemistry, vol.279, issue.47, pp.49055-63, 2004. ,
DOI : 10.1074/jbc.M403394200
The Role of Subtilisin-like Proprotein Convertases for Cleavage of the Measles Virus Fusion Glycoprotein in Different Cell Types, Virology, vol.252, issue.2, pp.387-98, 1998. ,
DOI : 10.1006/viro.1998.9464
A novel protein expression strategy using recombinant bovine respiratory syncytial virus (BRSV): modifications of the peptide sequence between the two furin cleavage sites of the BRSV fusion protein yield secreted proteins, but affect processing and function of the BRSV fusion protein, Journal of General Virology, vol.85, issue.7, pp.1815-1839, 2004. ,
DOI : 10.1099/vir.0.80010-0
Reverse Genetics Demonstrates that Proteolytic Processing of the Ebola Virus Glycoprotein Is Not Essential for Replication in Cell Culture, Journal of Virology, vol.76, issue.1, pp.406-416, 2002. ,
DOI : 10.1128/JVI.76.1.406-410.2002
Processing of the Ebola virus glycoprotein by the proprotein convertase furin, Proceedings of the National Academy of Sciences, vol.95, issue.10, pp.5762-5769, 1998. ,
DOI : 10.1073/pnas.95.10.5762
PACE4 Expression in Mouse Basal Keratinocytes Results in Basement Membrane Disruption and Acceleration of Tumor Progression, Cancer Research, vol.65, issue.16, pp.7310-7319, 2005. ,
DOI : 10.1158/0008-5472.CAN-05-1213
Proprotein Convertases in Tumor Progression and Malignancy, The American Journal of Pathology, vol.160, issue.6, 2002. ,
DOI : 10.1016/S0002-9440(10)61140-6
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis, Journal of Clinical Investigation, vol.111, issue.11, pp.1723-1755, 2003. ,
DOI : 10.1172/JCI200317220
The Proprotein Convertases Furin and PACE4 Play a Significant Role in Tumor Progression, Molecular Carcinogenesis, vol.28, issue.2, pp.63-72, 2000. ,
DOI : 10.1002/1098-2744(200006)28:2<63::AID-MC1>3.3.CO;2-3
Pro-protein convertase gene expression in human breast cancer, International Journal of Cancer, vol.267, issue.6, pp.966-71, 1997. ,
DOI : 10.1002/(SICI)1097-0215(19970611)71:6<966::AID-IJC10>3.0.CO;2-4
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability, Cancer Res, vol.57, pp.5226-5257, 1997. ,
MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice, Int J Oncol, vol.32, pp.1073-83, 2008. ,
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model, Molecular Cancer, vol.8, issue.1, p.73, 2009. ,
DOI : 10.1186/1476-4598-8-73
Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3 Cloning and primary sequence of a 5 kb cDNA, FEBS Letters, vol.81, issue.1, pp.82-90, 1992. ,
DOI : 10.1016/0014-5793(92)80169-H
fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas., Journal of Clinical Investigation, vol.80, issue.6, pp.1545-1554, 1987. ,
DOI : 10.1172/JCI113240
SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer, Clinical Cancer Research, vol.15, issue.1, pp.274-83, 2009. ,
DOI : 10.1158/1078-0432.CCR-08-1163
Gene expression profiling of alveolar soft-part sarcoma (ASPS), BMC Cancer, vol.25, issue.9, 2009. ,
DOI : 10.1097/00000478-200109000-00005
Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic miceThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba., Canadian Journal of Physiology and Pharmacology, vol.87, issue.10, pp.831-839, 2009. ,
DOI : 10.1139/Y09-073
Significance of absent prohormone convertase 1/3 in inducing clinically silent corticotroph pituitary adenoma of subtype I--immunohistochemical study, Pituitary, vol.5, issue.4, pp.221-224, 2002. ,
DOI : 10.1023/A:1025321731790
Defective Expression of Prohormone Convertase 1/3 in Silent Corticotroph Adenoma, Endocrine Journal, vol.54, issue.5, pp.777-82, 2007. ,
DOI : 10.1507/endocrj.K07-059
Frequent Appearance of Autoantibodies Against Prohormone Convertase 1/3 and Neuroendocrine Protein 7B2 in Patients with Nonfunctioning Pituitary Macroadenoma, Endocrine, vol.22, issue.3, pp.335-375, 2003. ,
DOI : 10.1385/ENDO:22:3:335
A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's beta -Secretase, Journal of Biological Chemistry, vol.275, issue.48, pp.37712-37719, 2000. ,
DOI : 10.1074/jbc.M005339200
Convertases other than furin cleave beta-secretase to its mature form, Faseb J, vol.15, pp.1810-1812, 2001. ,
Proprotein convertase activity contributes to the processing of the Alzheimer's beta-amyloid precursor protein in human cells: evidence for a role of the prohormone convertase PC7 in the constitutive alphasecretase pathway, J Neurochem, vol.73, pp.2056-62, 1999. ,
Proteolytic Processing of Familial British Dementia-associated BRI Variants, Journal of Biological Chemistry, vol.277, issue.3, pp.1872-1879, 2002. ,
DOI : 10.1074/jbc.M108739200
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia, Nat Neurosci, vol.2, pp.984-992, 1999. ,
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment, Proceedings of the National Academy of Sciences, vol.102, issue.6, pp.2069-74, 2005. ,
DOI : 10.1073/pnas.0409736102
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia, Nature Genetics, vol.34, issue.2, pp.154-160, 2003. ,
DOI : 10.1038/ng1161
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9, Nature Genetics, vol.41, issue.2, pp.161-166, 2005. ,
DOI : 10.1086/344207
A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of Low-Density Lipoprotein Cholesterol, The American Journal of Human Genetics, vol.78, issue.3, pp.410-432, 2006. ,
DOI : 10.1086/500615
Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia, Clinical Genetics, vol.277, issue.5, pp.419-441, 2004. ,
DOI : 10.1111/j.0009-9163.2004.0238.x
A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree, Human Genetics, vol.114, issue.4, pp.349-53, 2004. ,
DOI : 10.1007/s00439-003-1071-9
Genetic and Metabolic Determinants of Plasma PCSK9 Levels, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.7, pp.2537-2580, 2009. ,
DOI : 10.1210/jc.2009-0141
Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis, BMJ, vol.326, issue.7404, p.1423, 2003. ,
DOI : 10.1136/bmj.326.7404.1423
Relationship of Baseline Serum Cholesterol Levels in 3 Large Cohorts of Younger Men to Long-term Coronary, Cardiovascular, and All-Cause Mortality and to Longevity, JAMA, vol.284, issue.3, pp.311-319, 2000. ,
DOI : 10.1001/jama.284.3.311
Low LDL, and Protection against Coronary Heart Disease, New England Journal of Medicine, vol.354, issue.12, pp.1264-72, 2006. ,
DOI : 10.1056/NEJMoa054013
Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells, Molecular Cell, vol.2, issue.4, pp.505-519, 1998. ,
DOI : 10.1016/S1097-2765(00)80150-1
Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase, Journal of Biological Chemistry, vol.280, issue.44, pp.36551-36560, 2005. ,
DOI : 10.1074/jbc.M502264200
Proprotein convertases: lessons from knockouts, The FASEB Journal, vol.20, issue.12, pp.1954-63, 2006. ,
DOI : 10.1096/fj.05-5491rev
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin, Development, vol.125, pp.4863-76, 1998. ,
Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2, Proceedings of the National Academy of Sciences, vol.94, issue.13, pp.6646-51, 1997. ,
DOI : 10.1073/pnas.94.13.6646
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects, Proceedings of the National Academy of Sciences, vol.99, issue.16, pp.10293-10301, 2002. ,
DOI : 10.1073/pnas.162352599
Impaired fertility in mice deficient for the testicular germ-cell protease PC4, Proceedings of the National Academy of Sciences, vol.94, issue.13, pp.6842-6848, 1997. ,
DOI : 10.1073/pnas.94.13.6842
SPC4/PACE4 regulates a TGFbeta signaling network during axis formation, Genes Dev, vol.14, pp.1146-55, 2000. ,
The Mutant Growth Hormone-Releasing Hormone (GHRH) Receptor of the Little Mouse Does Not Bind GHRH, Endocrinology, vol.140, issue.11, pp.5066-74, 1999. ,
DOI : 10.1210/en.140.11.5066
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice, Human Molecular Genetics, vol.15, issue.11, pp.1884-93, 2006. ,
DOI : 10.1093/hmg/ddl111
A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat, Developmental Biology, vol.306, issue.2, pp.584-98, 2007. ,
DOI : 10.1016/j.ydbio.2007.03.523
Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function, New England Journal of Medicine, vol.333, issue.21, pp.1386-90, 1995. ,
DOI : 10.1056/NEJM199511233332104
Genetics of obesity, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.372, issue.6505, pp.1095-105, 2006. ,
DOI : 10.1038/372425a0
Variation in FTO contributes to childhood obesity and severe adult obesity, Nature Genetics, vol.165, issue.6, pp.724-730, 2007. ,
DOI : 10.1073/pnas.0400782101
URL : https://hal.archives-ouvertes.fr/hal-00173651
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity, Science, vol.316, issue.5826, pp.889-94, 2007. ,
DOI : 10.1126/science.1141634
Genome-wide Linkage Analysis for Severe Obesity in French Caucasians Finds Significant Susceptibility Locus on Chromosome 19q, Diabetes, vol.53, issue.7, pp.1857-65, 2004. ,
DOI : 10.2337/diabetes.53.7.1857
URL : https://hal.archives-ouvertes.fr/hal-00174527
Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE, J Appl Physiol, vol.90, pp.1777-87, 2001. ,
A genome-wide scan for quantitative trait loci linked to obesity phenotypes among West Africans, International Journal of Obesity, vol.55, issue.3, pp.255-264, 2005. ,
DOI : 10.1038/sj.ijo.0802873
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10, Nat Genet, vol.20, pp.304-312, 1998. ,
Common nonsynonymous variants in PCSK1 confer risk of obesity, Nature Genetics, vol.269, issue.8, pp.943-948, 2008. ,
DOI : 10.1093/hmg/ddl111
Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study, Human Molecular Genetics, vol.18, issue.18, pp.3496-501, 2009. ,
DOI : 10.1093/hmg/ddp280
Combined Analyses of 20 Common Obesity Susceptibility Variants, Diabetes, vol.59, issue.7, pp.1667-73, 2010. ,
DOI : 10.2337/db09-1042
Association of PCSK1 rs6234 with Obesity and Related Traits in a Chinese Han Population, PLoS ONE, vol.41, issue.5, p.10590, 2010. ,
DOI : 10.1371/journal.pone.0010590.t003
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden, Human Molecular Genetics, vol.18, issue.8, pp.1489-96, 2009. ,
DOI : 10.1093/hmg/ddp041
Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion, BMC Medical Genetics, vol.46, issue.1, p.86, 2010. ,
DOI : 10.2337/diab.46.12.1990
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study, International Journal of Obesity, vol.17, issue.6, pp.669-79, 2009. ,
DOI : 10.1017/BJN20061901
Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study, Obesity, vol.9, issue.7, pp.1369-77, 2010. ,
DOI : 10.1017/BJN20061901
URL : https://hal.archives-ouvertes.fr/inserm-00505128
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism, Human Molecular Genetics, vol.11, issue.17, 1997. ,
DOI : 10.1093/hmg/11.17.1997
URL : https://hal.archives-ouvertes.fr/hal-00174706
Genomewide Association Studies ??? Illuminating Biologic Pathways, New England Journal of Medicine, vol.360, issue.17, pp.1699-701, 2009. ,
DOI : 10.1056/NEJMp0808934
Association Between Common Polymorphisms of the Proopiomelanocortin Gene and Body Fat Distribution: A Family Study, Diabetes, vol.54, issue.8, pp.2492-2498, 2005. ,
DOI : 10.2337/diabetes.54.8.2492
Association of Proopiomelanocortin Gene Polymorphisms with Obesity in the IRAS Family Study, Obesity Research, vol.25, issue.9, pp.1491-1499, 2005. ,
DOI : 10.1038/oby.2005.180
Uncovering the roles of rare variants in common disease through whole-genome sequencing, Nature Reviews Genetics, vol.39, issue.6, pp.415-440, 2010. ,
DOI : 10.1038/nrg2779
Rare Variants Create Synthetic Genome-Wide Associations, PLoS Biology, vol.81, issue.1, p.1000294, 2010. ,
DOI : 10.1371/journal.pbio.1000294.t001
Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees, Diabetes, vol.57, issue.9, pp.2511-2519, 2008. ,
DOI : 10.2337/db08-0153
Global variation in copy number in the human genome, Nature, vol.38, issue.7118, pp.444-54, 2006. ,
DOI : 10.1126/science.1117196
cnvHap: an integrative population and haplotype???based multiplatform model of SNPs and CNVs, Nature Methods, vol.8, issue.7, pp.541-547, 2010. ,
DOI : 10.1038/nmeth.1466
Melanocortin 4 Receptor Gene Variation Is Associated With Severe Obesity in Pima Indians, Diabetes, vol.53, issue.10, pp.2696-2705, 2004. ,
DOI : 10.2337/diabetes.53.10.2696
Common PCSK1 Haplotypes Are Associated With Obesity in the Chinese Population, Obesity, vol.79, issue.7, pp.1404-1413, 2010. ,
DOI : 10.1038/ng.156
FTOgene variation and measures of body mass in an African population, BMC Medical Genetics, vol.73, issue.1, p.21, 2009. ,
DOI : 10.1136/adc.73.1.25
Identification of positional candidate genes for body weight and adiposity in subcongenic mice, Physiological Genomics, vol.31, issue.1, pp.75-85, 2007. ,
DOI : 10.1152/physiolgenomics.00267.2006
Genetic deficiency for proprotein convertase subtilisin/kexin type 2 in mice is associated with decreased adiposity and protection from dietary fat-induced body weight gain, International Journal of Obesity, vol.275, issue.11, 2010. ,
DOI : 10.1210/en.2003-0829
Molecular basis of human CD36 gene mutations, Mol Med, vol.13, pp.288-96, 2007. ,
A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes, Human Mutation, vol.24, issue.1, p.104, 2004. ,
DOI : 10.1002/humu.9256
URL : https://hal.archives-ouvertes.fr/hal-00174525
CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions, Journal of Clinical Investigation, vol.115, issue.11, pp.3177-84, 2005. ,
DOI : 10.1172/JCI25299
Single-nucleotide Polymorphism of CD36 Locus and Obesity in European Adolescents, Obesity, vol.2008, issue.7, pp.1398-403, 2010. ,
DOI : 10.1016/0959-437X(95)80025-5
Lack of Association of CD36 SNPs With Early Onset Obesity: A Meta-Analysis in 9,973 European Subjects, Obesity, vol.315, issue.4, 2010. ,
DOI : 10.1038/ng.301
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120, Nature Medicine, vol.52, issue.1, pp.90-94, 2005. ,
DOI : 10.1074/jbc.M201624200
Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells, Diabetologia, vol.447, issue.Suppl 1, pp.289-98, 2009. ,
DOI : 10.1007/s00125-008-1202-x
The regulation of adipogenesis through GPR120, Biochemical and Biophysical Research Communications, vol.354, issue.2, pp.591-598, 2007. ,
DOI : 10.1016/j.bbrc.2007.01.028
New mutations in BBS genes in small consanguineous families with Bardet-Biedl syndrome: detection of candidate regions by homozygosity mapping, Mol Vis, vol.16, pp.137-180, 2010. ,
Genomics approach to the analysis of bacterial communities dynamics in Hirschsprung???s disease-associated enterocolitis: a pilot study, Pediatric Surgery International, vol.44, issue.1, pp.465-71, 2010. ,
DOI : 10.1007/s00383-010-2586-5
Genomic insights into early-onset obesity, Genome Medicine, vol.2, issue.6, p.36, 2010. ,
DOI : 10.1186/gm157
URL : http://doi.org/10.1186/gm157
From Disease Association to Risk Assessment: An Optimistic View from Genome-Wide Association Studies on Type 1 Diabetes, PLoS Genetics, vol.38, issue.10, p.1000678, 2009. ,
DOI : 10.1371/journal.pgen.1000678.s006
Human obesity as a heritable disorder of the central control of energy balance, International Journal of Obesity, vol.14, issue.7, pp.55-61, 2008. ,
DOI : 10.1016/j.cmet.2007.06.004
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity, American Journal of Clinical Nutrition, vol.90, issue.5, pp.1418-1443, 2009. ,
DOI : 10.3945/ajcn.2009.27958
APOA2, Dietary Fat, and Body Mass Index, Archives of Internal Medicine, vol.169, issue.20, pp.1897-906, 2009. ,
DOI : 10.1001/archinternmed.2009.343
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations, Journal of Molecular Medicine, vol.25, issue.5, pp.537-583, 2009. ,
DOI : 10.1007/s00109-009-0451-6
The common FTOvariant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924, BMC Medical Genetics, vol.458, issue.Suppl 3, p.131, 2009. ,
DOI : 10.1038/nature07848
Association of the Common Fat Mass and Obesity Associated (FTO) Gene Polymorphism with Obesity in a Japanese Population, Endocrine Journal, vol.57, issue.4, 2010. ,
DOI : 10.1507/endocrj.K09E-305
FTO Genotype and the Weight Loss Benefits of Moderate Intensity Exercise, Obesity, vol.276, issue.3, pp.641-644, 2010. ,
DOI : 10.1371/journal.pone.0004428
Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity, Archives of Internal Medicine, vol.168, issue.16, pp.1791-1798, 2008. ,
DOI : 10.1001/archinte.168.16.1791
Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents, Archives of Pediatrics & Adolescent Medicine, vol.164, issue.4, pp.328-361, 2010. ,
DOI : 10.1001/archpediatrics.2010.29
Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene, American Journal of Clinical Nutrition, vol.90, issue.2, pp.425-433, 2009. ,
DOI : 10.3945/ajcn.2009.27652
Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein ??3 subunit gene (GNB3) C825T polymorphism, Pharmacogenetics, vol.13, issue.8, pp.453-462, 2003. ,
DOI : 10.1097/00008571-200308000-00003
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene, Pharmacogenetics and Genomics, vol.19, issue.9, pp.730-733, 2009. ,
DOI : 10.1097/FPC.0b013e3283307cf1
Effect of the Common -866G/A Polymorphism of the Uncoupling Protein 2 Gene on Weight Loss and Body Composition under Sibutramine Therapy in an Obese Taiwanese Population, Molecular Diagnosis & Therapy, vol.7, issue.1, pp.101-107, 2010. ,
DOI : 10.1007/BF03256359
Ala55Val Polymorphism on UCP2 Gene Predicts Greater Weight Loss in Morbidly Obese Patients Undergoing Gastric Banding, Obesity Surgery, vol.55, issue.6B, pp.926-959, 2007. ,
DOI : 10.1007/s11695-007-9171-6
Influence of the A???G (-3826) uncoupling protein-1 gene (UCP1) variant on the dynamics of body weight before and after gastroplasty in morbidly obese subjects, International Journal of Obesity, vol.22, issue.12, pp.1244-1249, 1998. ,
DOI : 10.1038/sj.ijo.0800775
Mini-Gastric Bypass in a Patient Homozygous for Factor V Leiden, Obesity Surgery, vol.38, issue.1, pp.104-111, 2007. ,
DOI : 10.1007/s11695-007-9014-5
Re-operations Following Laparoscopic Adjustable Gastric Banding, Obesity Surgery, vol.12, issue.6, pp.851-857, 2002. ,
DOI : 10.1381/096089202320995691
Relationship between Single Nucleotide Polymorphisms in Leptin, IL6 and Adiponectin Genes and their Circulating Product in Morbidly Obese Subjects before and after Gastric Banding Surgery, Obesity Surgery, vol.15, issue.1, pp.11-23, 2005. ,
DOI : 10.1381/0960892052993431
Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity on Weight Loss of Morbidly Obese Subjects after Laparoscopic Adjustable Gastric Banding and Hypocaloric Diet, The Journal of Clinical Endocrinology & Metabolism, vol.90, issue.9, pp.5064-5073, 2005. ,
DOI : 10.1210/jc.2005-0404
Natriuretic Peptides, Journal of the American College of Cardiology, vol.50, issue.25, pp.2357-68, 2007. ,
DOI : 10.1016/j.jacc.2007.09.021
Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations, Human Molecular Genetics, vol.16, issue.11, pp.1343-50, 2007. ,
DOI : 10.1093/hmg/ddm084
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects, Human Molecular Genetics, vol.18, issue.13, pp.2495-501, 2009. ,
DOI : 10.1093/hmg/ddp169