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Étude de l'altération de la réponse aux radiations ionisantes par deux inhibiteurs de tyrosine kinase : le STI571 (Glivec®) et le BIBW 2992

Abstract : Concurrent chemoradiation is one of the main weapon in the treatment of cancer. The targeted therapies may act on the mechanisms of tumor resistance to radiation and are therefore very promising in combination with radiotherapy. The STI571 (imatinib or Gleevec ®) inhibits specifically the Bcr-Abl tyrosine kinase. It leads to radiosensitization in K562 chronic myeloid leukemia cell line by alterations of the cell cycle. The BIBW2992 is a selective inhibitor of EGFR and HER2. The BIBW 2992 shows cytotoxic and radiosensitizing effects on pancreatic adenocarcinoma cells BxPC3 and Capan-2, regardless of KRAS status. The mechanism underlying this radiosensitization is not unequivocal, involving both changes in the cell cycle and induction of mitotic death. Our results show that the combination of an inhibitor of tyrosine kinase with ionizing radiation may lead to a radiosensitization in vitro with mechanisms depending on the type of cell line.
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https://tel.archives-ouvertes.fr/tel-00574782
Contributor : Florence Huguet <>
Submitted on : Tuesday, March 8, 2011 - 7:11:19 PM
Last modification on : Tuesday, July 21, 2020 - 3:59:15 AM
Long-term archiving on: : Thursday, June 9, 2011 - 2:39:54 AM

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  • HAL Id : tel-00574782, version 1

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Florence Huguet. Étude de l'altération de la réponse aux radiations ionisantes par deux inhibiteurs de tyrosine kinase : le STI571 (Glivec®) et le BIBW 2992. Sciences du Vivant [q-bio]. Université Paris Sud - Paris XI, 2010. Français. ⟨tel-00574782⟩

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