Epidemiology of drug-resistant malaria, The Lancet Infectious Diseases, vol.2, issue.4, pp.209-218, 2002. ,
DOI : 10.1016/S1473-3099(02)00239-6
Selection and reversal of Plasmodium berghei resistance in the mouse model following repeated high doses of artemether, Parasitology Research, vol.92, issue.3, pp.215-219, 2004. ,
DOI : 10.1007/s00436-003-1029-9
Recrudescence in artesunate-treated patients with falciparum malaria is dependent on parasite burden not on parasite factors, Am. J. Trop. Med. Hyg, vol.6820, pp.147-162, 2003. ,
Establishment of artemisinin combination therapy as first line treatment for combating malaria: Artemisia annua sustainable supply chain of artemisinin, Curr. Sci, vol.8922, pp.1097-1102, 2005. ,
Production of the antimalarial drug precursor artemisinic acid in engineered yeast, Nature, vol.272, issue.7086, pp.940-943, 2006. ,
DOI : 10.1038/nature04640
Activated oxygen mediates the antimalarial activity of qinghaosu, Prog. Clin. Biol. Res, vol.31324, pp.95-104, 1989. ,
Oxygen enhances the antimalarial activity of the imidazoles, Am. J. Trop. Med. Hyg, vol.3225, pp.660-665, 1983. ,
Mechanism-Based Design, Synthesis, and in vitro Antimalarial Testing of New 4-Methylated Trioxanes Structurally Related to Artemisinin: The Importance of a Carbon-Centered Radical for Antimalarial Activity, Journal of Medicinal Chemistry, vol.37, issue.9, pp.1256-1258, 1994. ,
DOI : 10.1021/jm00035a003
Characterization of the First Covalent Adduct between Artemisinin and a Heme Model, Journal of the American Chemical Society, vol.119, issue.25, pp.5968-5969, 1997. ,
DOI : 10.1021/ja970412g
Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin, Angewandte Chemie International Edition, vol.133, issue.10, pp.1954-1057, 2001. ,
DOI : 10.1002/1521-3773(20010518)40:10<1954::AID-ANIE1954>3.0.CO;2-9
Alkylation of heme by the antimalarial drug artemisinin, Chemical Communications, vol.29, issue.5, pp.414-416, 2002. ,
DOI : 10.1039/b110817b
NMR characterization of covalent adducts obtained by alkylation of heme with the antimalarial drug artemisinin, Inorganica Chimica Acta, vol.339, pp.488-496, 2002. ,
DOI : 10.1016/S0020-1693(02)00940-4
by the antimalarial drug artemisinin, FEBS Letters, vol.17, issue.1-3, pp.245-24831, 2004. ,
DOI : 10.1016/S0014-5793(03)01448-0
The antimalarial drug artemisinin alkylates heme in infected mice, Proc. Natl. Acad. Sci. USA 2005, pp.13676-13680 ,
DOI : 10.1073/pnas.0500972102
Heme Alkylation by Artesunic Acid and Trioxaquine DU1301, Two Antimalarial Trioxanes, ChemBioChem, vol.10, issue.4, pp.653-658, 2005. ,
DOI : 10.1002/cbic.200400249
C10-modified artemisinin derivatives: efficient heme-alkylating agents, Angew. Chem. Int. Ed, vol.4434, pp.2060-2063, 2005. ,
DOI : 10.1002/anie.200462556
Reaction of antimalarial endoperoxides with specific parasite proteins., Antimicrobial Agents and Chemotherapy, vol.38, issue.8, pp.1854-1858, 1994. ,
DOI : 10.1128/AAC.38.8.1854
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin Artemisinins target the SERCA of Plasmodium falciparum, J. Biol. Chem. Nature, vol.2733637, issue.424, pp.16192-16198, 1998. ,
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure, Biochem. Pharmacol, vol.4838, pp.569-573, 1994. ,
Bilharzioses invasives, La Presse M??dicale, vol.34, issue.21, pp.1641-1645, 2005. ,
DOI : 10.1016/S0755-4982(05)84241-1
Schistosomiasis and International Travel, Clinical Infectious Diseases, vol.35, issue.4, pp.446-450, 2002. ,
DOI : 10.1086/341895
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.542.5639
Penetration of Host Skin by Cercariae of Schistosoma mansoni. I. Observed Entry into Skin of Mouse, Hamster, Rat, Monkey and Man, The Journal of Parasitology, vol.42, issue.6, pp.565-580, 1956. ,
DOI : 10.2307/3274873
Activity of the acetabular secretory apparatus of cercariae of Schistosoma mansoni under experimental conditions The role of ingested hemoglobin in the nutrition of Schistosoma mansoni, Exp. Parasitol. J. Parasitol, vol.111112, issue.56, pp.191-211, 1961. ,
Proteolytic degradation of host hemoglobin by schistosomes, Parasitology International, vol.47, pp.1-9, 1997. ,
DOI : 10.1016/S1383-5769(98)80112-8
The ingestion of red blood cells by Schistosoma mansoni Studies of a proteolytic enzyme from Schistosoma mansoni, J. Parasitol. Brit. J. Pharmacol, vol.591415, issue.14, pp.60-63, 1959. ,
Haematological Studies on the Gut Contents of Certain Nematode and Trematode Parasites, Journal of Helminthology, vol.XXXI, issue.01, pp.53-62, 1940. ,
DOI : 10.1098/rspb.1926.0039
Pigment formation in Schistosoma mansoni infections in the white mouse, Am. J. Trop. Med. Hyg, vol.1517, pp.28-31, 1966. ,
The pigment formed during haemoglobin digestion by malarial and schistosomal parasites, Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, vol.43, issue.3, pp.517-523, 1972. ,
DOI : 10.1016/0305-0491(72)90135-6
Haemozoin in Schistosoma mansoni, Molecular and Biochemical Parasitology, vol.111, issue.1, pp.217-221, 2000. ,
DOI : 10.1016/S0166-6851(00)00299-1
Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus, FEBS Lett, vol.57920, pp.6010-6016, 2005. ,
Inhibition of heme aggegation by chloroquine reduces Schistosoma mansoni infection The in vitro effects of various lysomotropic agents on the gut of Schistosoma mansoni schistosomula, J. Infect. Dis. J. Parasitol, vol.1902122, issue.77, pp.843-852, 1991. ,
Chemotherapy of Schistosomiasis: An Update, Parasitology Today, vol.14, issue.10, pp.418-422, 1998. ,
DOI : 10.1016/S0169-4758(98)01323-4
Drug resistance in schistosomes, Parasitology Today, vol.9, issue.5, pp.162-166, 1993. ,
DOI : 10.1016/0169-4758(93)90138-6
THE SUCCESSFUL USE OF ANTIMONY IN BILHARZIOSIS, The Lancet, vol.192, issue.4958, pp.325-327, 1918. ,
DOI : 10.1016/S0140-6736(01)02807-0
A New Group of Antischistosomal Compounds, Angewandte Chemie International Edition in English, vol.5, issue.10, pp.857-908, 1966. ,
DOI : 10.1002/anie.196608571
Schistosomiasis Drug Therapy and Treatment Considerations, Drugs, vol.42, issue.3, pp.379-405, 1991. ,
DOI : 10.2165/00003495-199142030-00004
THE ACTIONS OF ANTIMONIALS ON GLYCOLYTIC ENZYMES OF SCHISTOSOMA MANSONI, British Journal of Pharmacology and Chemotherapy, vol.160, issue.4, pp.459-462, 1954. ,
DOI : 10.1111/j.1476-5381.1954.tb00861.x
Biochemical and pharmacological effects in relation to the mode of action of antischistosomal drugs, Biochemical Pharmacology, vol.28, issue.16, pp.2413-2418, 1979. ,
DOI : 10.1016/0006-2952(79)90001-7
Antischistosomal drugs : past, present ? and future ? Pharmac. Ther [30] Harder S. Chemotherapeutic approaches to schistosomes : current knowledge and outlook [31] Bloom A. Studies of the mode of action of metrifonate and DDVP in schistosomes cholinesterase activity and the hepatic shift, Parasitol. Res. Acta Pharmacol. Toxicol, vol.6832, issue.49, pp.35-85, 1981. ,
DOI : 10.1016/0163-7258(95)00026-7
The effects of inhibitors on the hydrolysis of acetylcholine by four species of schistosoma, Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, vol.55, issue.1, pp.5-10, 1976. ,
DOI : 10.1016/0306-4492(76)90003-4
In vitro selection of drug resistant Schistosoma mansoni Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Int. J. Parasitol. Kenya. Emerg. Infect. Dis, vol.1735, issue.6, pp.767-771, 1987. ,
Hycanthone, a new active metabolite of lucanthone Pica-Mattoccia L., Cioli D. Studies of the mode of action of oxamniquine and related schistosomicidal drugs, J. Med. Chem. Am. J. Trop. Med. Hyg, vol.103637, issue.34, pp.867-876, 1967. ,
New Medications-1981, Annual Review of Pharmacology and Toxicology, vol.21, issue.1, pp.597-604, 1981. ,
DOI : 10.1146/annurev.pa.21.040181.003121
Evidence for the mode of antischistosomal action of hycanthone, Life Sciences, vol.37, issue.2, pp.161-167, 1985. ,
DOI : 10.1016/0024-3205(85)90419-9
The Chemotherapy of Schistosomiasis, Annual Review of Pharmacology and Toxicology, vol.25, issue.1, pp.485-508, 1985. ,
DOI : 10.1146/annurev.pa.25.040185.002413
Hycanthone Resistance: Development in Schistosoma mansoni, Science, vol.172, issue.3987, pp.1057-1058, 1971. ,
DOI : 10.1126/science.172.3987.1057
Drug resistance to schistosomicides and other anthelmintics of medical significance, Acta Tropica, vol.56, issue.2-3, pp.213-231, 1994. ,
DOI : 10.1016/0001-706X(94)90064-7
Schistosoma mansoni: Hycanthone/oxamniquine resistance is controlled by a single autosomal recessive gene, Experimental Parasitology, vol.75, issue.4, pp.425-432, 1992. ,
DOI : 10.1016/0014-4894(92)90255-9
Antibacterial activities of nitrothiazole derivatives, Journal of Antimicrobial Chemotherapy, vol.14, issue.1, pp.31-39, 1984. ,
DOI : 10.1093/jac/14.1.31
A comparison of the susceptibility to niridazole of Schistosoma mansoni and S. intercalatum in mice, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.67, issue.2, pp.245-249, 1973. ,
DOI : 10.1016/0035-9203(73)90151-X
Relationship between structure, conformation and antischistosomal activity of nitroheterocyclic compounds, Mol. Pharmacol, vol.646, pp.604-616, 1970. ,
Jr Reductive metabolisme of niridazole by adult Schistosoma mansoni. Correlation with covalent binding to parasite macromolecules, Mol. Pharmacol, vol.2447, pp.291-299, 1983. ,
Field trials of ambilhar in the treatment of urinary bilharziosis in schoolchildren, pp.827-835, 1966. ,
Antischistosomal and some toxicological properties of a nitrodiphenylaminoisothiocyanate (C9333-Go/CGP4540), Experientia, vol.1549, pp.604-606, 1976. ,
4-isothiocyanato-4'-nitrodiphenylamine (C9333-Go/CGP4540), an anthelminthic with an unusual spectrum of activity against intestinal nematodes, filariae and schistosomes, Experientia, vol.3250, pp.457-458, 1976. ,
Glutathione redox state, lipid peroxide levels, and activities of glutathione enzymes in oltipraz-treated adult Schistosoma mansoni, Biochemical Pharmacology, vol.38, issue.23, pp.4307-4313, 1989. ,
DOI : 10.1016/0006-2952(89)90530-3
Differential effects of oltipraz and its oxy-analogue on the viability of schistosoma mansoni and the activity of glutathione S-transferase, Biochemical Pharmacology, vol.42, issue.6, pp.1287-1292, 1991. ,
DOI : 10.1016/0006-2952(91)90267-9
Chemoprotective effects of two dithiolethiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity, pp.932-935, 1983. ,
Coordinate induction of glutathion-S-transferase ?, µ and ? expression in murine liver after a single administration of oltipraz, Mol. Pharmacol, vol.4554, pp.469-474, 1994. ,
Antischistosomal affects of cyclosporin A, Agents Actions, vol.1155, pp.380-383, 1981. ,
Efficacy of mirazid in comparison with praziquantel in egyptian Schistosoma mansoniinfected school children and households, Am. J. Trop. Med. Hyg, vol.7256, pp.119-123, 2005. ,
Lack of evidence for an antischistosomal activity of myrrh in experimental animals, Am. J. Trop. Med. Hyg, vol.7157, pp.206-210, 2004. ,
Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance, Expert Review of Anti-infective Therapy, vol.4, issue.2, pp.199-210, 2006. ,
DOI : 10.1586/14787210.4.2.199
Comparative in vitro and in vivo activity of racemic praziquantel and its levorated isomer on Schistosoma mansoni, J. Infect. Dis, vol.159, pp.589-59261, 1989. ,
Comparison of the therapeutic afficacy and side effects of a single dose of levo-praziquantel with mixed isomer praziquantel in 278 cases of schistosomiasis japonica, Am. J. Trop. Med. Hyg, vol.4562, pp.345-349, 1991. ,
High-performance liquid chromatographic determination of the stereoselective biotransformation of the chiral drug praziquantel, Journal of Chromatography B: Biomedical Sciences and Applications, vol.578, issue.2, pp.265-271, 1992. ,
DOI : 10.1016/0378-4347(92)80425-P
Light and scanning electron microscopy studies on the effects of the enantiomers of praziquantel and its main metabolite on Schistosoma mansoni in vitro, Parasitol. Res, vol.7865, pp.392-397, 1992. ,
Praziquantel: mechanisms of anti-schistosomal activity, Pharmacology & Therapeutics, vol.29, issue.1, pp.129-156 ,
DOI : 10.1016/0163-7258(85)90020-8
Praziquantel: mode of action, Biochemical Society Transactions, vol.15, issue.1, pp.68-70, 1987. ,
DOI : 10.1042/bst0150068
Bioavailability of Praziquantel Increases with Concomitant Administration of Food, Antimicrobial Agents and Chemotherapy, vol.44, issue.10, pp.2903-2904, 2000. ,
DOI : 10.1128/AAC.44.10.2903-2904.2000
Results of toxicological studies of praziquantel, Arzneim.-Forsch, vol.3469, pp.1137-1144, 1984. ,
Toxicological profile of praziquantel, a new drug against cestode and schistosome infections, as compared to some other schistosomicides, Arzneim.-Forsch, vol.3170, pp.555-565, 1981. ,
[71] Pica-Mattoccia L., Cioli D. Sex-and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment Schistosoma mansoni : chemotherapy of infections of different ages, Arzneim.-Forsch. Int. J. Parasitol. Exp. Parasitol, vol.317273, issue.61, pp.538-541, 1981. ,
Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance, Expert Review of Anti-infective Therapy, vol.4, issue.2, pp.199-210, 2006. ,
DOI : 10.1586/14787210.4.2.199
Effect of praziquantel on the immature stages of Schistosoma haematobium, International Journal for Parasitology, vol.35, issue.13, pp.1453-1457, 2005. ,
DOI : 10.1016/j.ijpara.2005.05.002
Schistosoma mansoni: Myogenic Characteristics of Phorbol Ester-Induced Muscle Contraction, Experimental Parasitology, vol.78, issue.3, pp.302-316, 1994. ,
DOI : 10.1006/expr.1994.1032
A benzodiazepine derivative and praziquantel: Effects on musculature of Schistosoma mansoni and Schistosoma japonicum, Naunyn-Schmiedeberg's Archives of Pharmacology, vol.190, issue.3, pp.309-315, 1978. ,
DOI : 10.1007/BF00507974
Are Ca 2+ channels targets of praziquantel action?, Int. J. Parasitol, vol.3578, pp.1-9, 2005. ,
Praziquantel: an urgent and exciting challenge Influence of praziquantel and Ca 2+ on the bilayer-isotropichexagonal transition of model membranes, Parasitol. Today Mol. Biochem. Parasitol, vol.1280, issue.25, pp.14-20, 1988. ,
Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro, Parasitology, vol.31, issue.02, pp.401-405, 1986. ,
DOI : 10.1016/0014-4894(86)90146-3
The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response, J. Immunol, vol.13982, pp.215-220, 1987. ,
Role of host antibody in the chemotherapeutic action of praziquantel against Schistosoma mansoni: identification of target antigens, Molecular and Biochemical Parasitology, vol.34, issue.2, pp.99-108, 1989. ,
DOI : 10.1016/0166-6851(89)90001-7
Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection, Revista do Instituto de Medicina Tropical de S??o Paulo, vol.46, issue.4, pp.231-233, 2004. ,
DOI : 10.1590/S0036-46652004000400010
Determination of ED 50 values for praziquantel-resistant and ?susceptible Schistosoma mansoni isolates, Int. J. Parasitol, vol.3485, pp.979-987, 2004. ,
Drug-resistant schistosomiasis: resistance to praziquantel and oxamniquine induced with Schistosoma mansoni in mice is drug specific, Am. J. Trop. Med. Hyg, vol.5186, pp.83-88, 1994. ,
Characterization of isolates of Schistosoma mansoni from egyptians villagers that tolerate high doses of praziquantel, Am. J. Trop. Med. Hyg, vol.5587, pp.214-218, 1996. ,
Current status of sensitivity to praziquantel in a focus of potentiel drug resistance in Egypt, Int. J. Parasitol, vol.3588, pp.787-791, 2005. ,
Low efficacy and tolerance of praziquantel in a new, intense focus of Schistosoma mansoni infection, Am. J. Trop. Med. Hyg, vol.5389, pp.167-170, 1995. ,
Short report: failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection, Am. J. Trop. Med. Hyg, vol.74, pp.342-344, 2006. ,
Current Progress in the Development and Use of Artemether for Chemoprophylaxis of Major Human Schistosome Parasites, Current Medicinal Chemistry, vol.8, issue.15, pp.1841-1859, 2001. ,
DOI : 10.2174/0929867013371581
Preventive effect of artemether in experimental animals infected with Schistosoma mansoni, Parasitol. Int, vol.4992, pp.19-24, 2000. ,
Effect of artemether against Schistosoma haematobium in experimentally infected hamster, Int. J. Parasitol, vol.3093, pp.1001-1006, 2000. ,
Comparative stydy of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice, Trans. R. Soc. Trop. Med. Hyg, vol.9694, pp.318-323, 2002. ,
A double-blind field trial on the effects of artemether on Schistosoma japonicum infection in a highly endemic focus in southern China, Acta Tropica, vol.96, issue.2-3, pp.184-190, 2005. ,
DOI : 10.1016/j.actatropica.2005.07.013
Oral artemether for prevention of Schistosoma mansoni infection: randomised controlled trial, The Lancet, vol.355, issue.9212, pp.1320-1325, 2000. ,
DOI : 10.1016/S0140-6736(00)02114-0
Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia, Acta Trop, vol.8297, pp.175-181, 2002. ,
Effect of praziquantel together with artemether on Schistosoma japonicum parasites of different ages in rabbits, Parasitol. Int, vol.4998, pp.25-30, 2000. ,
Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animals, Acta Tropica, vol.80, issue.1, pp.9-18, 2001. ,
DOI : 10.1016/S0001-706X(01)00138-3
ARTEMETHER AS ADJUVANT THERAPY TO PRAZIQUANTEL IN MURINE EGYPTIAN SCHISTOSOMIASIS MANSONI, Journal of Parasitology, vol.91, issue.1, pp.175-178, 2005. ,
DOI : 10.1645/GE-322R
Schistosomiasis Vaccine:Research to Development, Parasitology Today, vol.14, issue.3, pp.99-104, 1998. ,
DOI : 10.1016/S0169-4758(97)01207-6
Development of a vaccine against Schistosoma japonicum in China: a review, Acta Tropica, vol.96, issue.2-3, pp.106-116, 2005. ,
DOI : 10.1016/j.actatropica.2005.08.005
Prospects for A Schistosome Vaccine, Current Drug Targets-Immune, Endocrine & Metabolic Disorders, vol.2, issue.3, pp.281-290, 2002. ,
DOI : 10.2174/1568008023340587
Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice, Parasite Immunology, vol.162, issue.3, pp.77-84, 2006. ,
DOI : 10.1038/nri843
Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae, Experimental Parasitology, vol.13, issue.2, pp.134-142, 1963. ,
DOI : 10.1016/0014-4894(63)90063-8
The irradiated cercariae vaccine model: Looking on the bright side of radiation, Parasitology Today, vol.11, issue.8, pp.288-293, 1995. ,
DOI : 10.1016/0169-4758(95)80041-7
Design and synthesis of novel artemisinin-like ozonides with antischistosomal activity, Helv. Chim. Acta, vol.88, pp.2865-2872, 2005. ,
Synthesis and Antimalarial Activity of Trioxaquine Derivatives, Chemistry - A European Journal, vol.10, issue.7, pp.1625-1636, 2004. ,
DOI : 10.1002/chem.200305576
The antimalarial drug artemisinin alkylates heme in infected mice, Proc. Natl. Acad. Sci. USA 2005, pp.13676-13680 ,
DOI : 10.1073/pnas.0500972102
Preparation and antimalarial activities of trioxaquines, new modular molecules with a trioxane skeleton linked to a 4-aminoquinoline, ChemBiochem, vol.4, pp.281-283, 2000. ,
'scher K??rper aus Isochinolin), Helvetica Chimica Acta, vol.20, issue.1, p.673, 1939. ,
DOI : 10.1002/hlca.19390220184
New synthesis of praziquantel: 2-(cyclohexylcarbonyl-1,2,3,6,7,11b- hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, Heterocycles, vol.204, pp.1731-1735, 1983. ,
A short synthesis of praziquantel, Journal of Heterocyclic Chemistry, vol.21, issue.1, pp.189-190, 1986. ,
DOI : 10.1002/jhet.5570230139
An internal imino-Diels-Alder route to a tetrahydroisoquinoline, The Journal of Organic Chemistry, vol.49, issue.26, pp.5269-5271, 1984. ,
DOI : 10.1021/jo00200a057
ChemInform Abstract: Synthesis of Praziquantel via N-Acyliminium Ion Cyclization of Amido Acetals Through Several Synthetic Routes., ChemInform, vol.48, issue.9, pp.2279-2285, 1998. ,
DOI : 10.1002/chin.199909184
Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel, Tetrahedron, vol.54, issue.26, pp.7395-7400, 1998. ,
DOI : 10.1016/S0040-4020(98)00401-3
Amino Acid Derived Heterocycles:?? Lewis Acid Catalyzed and Radical Cyclizations from Peptide Acetals, The Journal of Organic Chemistry, vol.67, issue.12, pp.3985-3988, 2002. ,
DOI : 10.1021/jo010990m
Synthesis and Antimalarial Activity of Trioxaquine Derivatives, Chemistry - A European Journal, vol.10, issue.7, pp.1625-1636, 2004. ,
DOI : 10.1002/chem.200305576
Tetraalkylammonium trihydridocyanoborates. Versatile, selective reagents for reductive aminations in nonpolar media, The Journal of Organic Chemistry, vol.46, issue.17, pp.3571-3574, 1981. ,
DOI : 10.1021/jo00330a048
A reductive amination/lactamisation procedure using borohydrure reagents A convenient synthesis of substituted 1,2,4-trioxanes via Co(II) catalysed oxygenation of cinnamyl alcohol Regioselective Mukaiyama hydroperoxysilylation of 2-alkyl-or 2-aryl-prop-2-en-1-ols: application to a new synthesis of 1, Synlett Tetrahedron Lett. Tetrahedron Lett, vol.39214, issue.42, pp.81-83, 1994. ,
Novel method for the preparation of triethylsilyl peroxides from olefins by the reaction with molecular oxygen and triethylsilane catalysed by bis-(1,3-diketonato)cobalt (II) ,
Enantioselective total synthesis of all four stereoisomers of Yingzahaosu C, Tetrahedron Lett, vol.3516, pp.9429-9432, 1994. ,
Co(III)-alkyl complex-and Co(III)-alkylperoxo complexcatalyzed triethylsilylperoxidation of alkenes with molecular oxygen and triethylsilane, Org. Lett, vol.417, pp.3595-3598, 2002. ,
Synthesis of Tetrasubstituted Ozonides by the Griesbaum Coozonolysis Reaction:?? Diastereoselectivity and Functional Group Transformations by Post-Ozonolysis Reactions, The Journal of Organic Chemistry, vol.69, issue.19, pp.6470-6473, 2004. ,
DOI : 10.1021/jo040171c
Electrophilic amination of carbanions by N-carboxamido oxaziridines, Tetrahedron Letters, vol.41, issue.13, pp.2247-2251, 2000. ,
DOI : 10.1016/S0040-4039(00)00140-4
Phosphorylation of Centrin during the Cell Cycle and Its Role in Centriole Separation Preceding Centrosome Duplication, Journal of Biological Chemistry, vol.276, issue.23, pp.20774-20780, 2001. ,
DOI : 10.1074/jbc.M101324200
Deuterium isotope effects for migrating and nonmigrating groups in the solvolysis of neopentyl-type esters, Journal of the American Chemical Society, vol.103, issue.2, pp.436-442, 1981. ,
DOI : 10.1021/ja00392a031
Structural correlations for nucleophilic addition to the C=O group. The solvatation angle, Helv. Chim. Acta, vol.8623, pp.1222-1233, 2003. ,
N-fluorobis-[(trifluoromethyl)sulfonyl]imide: an efficient reagent for the ?-fluorination of functionalized carbonyl compounds Elemental fluorine. Part 9 1 catalysis of the direct fluorination of 2- substituted carbonyl coumpounds 2, J. Org. Chem. J. Fluorine Chem, vol.5625, issue.92, pp.4925-4929, 1991. ,
Synthesis of ??-Fluorocarboxylates from the Corresponding Acids Using Acetyl Hypofluorite, The Journal of Organic Chemistry, vol.66, issue.22, pp.7464-7468, 2001. ,
DOI : 10.1021/jo010677k
Stannyl radical-mediated cleavage of ?-deficient heterocyclic sulfones. Synthesis of ?-fluoroesters, J. Org. Chem, vol.6527, pp.4169-4174, 2000. ,
Site-selective fluorination of organic compounds using 1-alkyl-4-fluoro-1,4-diazabicyclo[2.2.2]octane salts (selectfluor reagents), The Journal of Organic Chemistry, vol.58, issue.10, pp.2791-2796, 1993. ,
DOI : 10.1021/jo00062a023
400 MHz, DMSO-d 6 , 333 K) ? (ref : trifluoroéthanol, ppm) ,
400 MHz, DMSO-d 6 , 333 K) ? (ref : trifluoroéthanol, ppm) ,
400 MHz, DMSO-d 6 , 333 K) ? (ref : trifluoroéthanol, ppm) ,
400 MH, DMSO-d 6 , 333 K) ? (ref : trifluoroéthanol, ppm) ,
(s, 3H, H 3 C12, pp.170974-170976 ,
attestent les corrélations 1 H-1 H de la COSY, les atomes de carbone, dont les déplacements chimiques sont à 31,1 et 32,3 ppm, sont en ? position. D'une manière similaire, les atomes de carbone ,
(s, 3H, H 3 C12, pp.201070-201072 ,
attestent les corrélations 1 H-1 H de la COSY, les atomes de carbone, dont les déplacements chimiques sont à 24,9 et 31,2 ppm, sont en ? position. D'une manière similaire, les atomes de carbone ,
(s, 3H, H 3 C13, Hz et 3 J =3,7 Hz, 1H, HC9), pp.42-44 ,
attestent les corrélations 1 H-1 H de la COSY, les atomes de carbone, dont les déplacements chimiques sont à 24,9 et 26,9 ppm, sont en ? position. D'une manière similaire, les atomes de carbone ,
Total synthesis of (-)-praziquantel: an anthelmintic drug, J. Chem. Res, pp.186-187, 2004. ,
Synthesis of stable-isotope labeled [M+7] and [M+6] 2-(methylamino)imidazole, J. Label. Compd. Radiopharm, vol.453, pp.1055-1064, 2002. ,
The Pictet-Spengler condensation: a new direction for an old reaction, Chemical Reviews, vol.95, issue.6, pp.1797-1842, 1995. ,
DOI : 10.1021/cr00038a004
Liquid chromatographic separation of praziquantel enantiomers in serum using a cellulose-based chiral stationary phase, Journal of Pharmaceutical and Biomedical Analysis, vol.11, issue.11-12, pp.1141-1144, 1993. ,
DOI : 10.1016/0731-7085(93)80095-I
Enantioselective analysis of praziquantel in plasma samples, J. Chromatography B, vol.6966, pp.307-311, 1997. ,
Non-conventional hydrolase chemistry: amid and carbamate bond formation catalysed by lipases [7] Djeghaba Z. Les enzymes en synthèse organique IX: acylation enzymatique des amines secondaires cycliques, Bioorg. Med. Chem. Bull. Soc. Chim. Belg, vol.7, issue.104, pp.2189-2197, 1995. ,
Optisch aktive Amine durch Lipase-katalysierte Methoxyacetylierung, Journal f??r Praktische Chemie/Chemiker-Zeitung, vol.118, issue.1, pp.381-384, 1997. ,
DOI : 10.1002/prac.19973390166
Engineering lipase B from Candida antarctica, Tetrahedron Asymmetry, vol.1510, pp.2743-2748, 2004. ,
DOI : 10.1016/j.tetasy.2004.06.031
Enzymatic amidification for the synthesis of biodegradable surfactants: Synthesis of N-acylated hydroxylated amines, Journal of Molecular Catalysis B: Enzymatic, vol.5, issue.1-4, pp.13-17, 1998. ,
DOI : 10.1016/S1381-1177(98)00016-2
Candida antarctica B lipase catalyzed resolution of (±)-1-(heteroaryl)ethylamines, Tetrahedron Asymmetry, vol.812, pp.2675-2677, 1997. ,
Kinetic resolution of propanolol by a lipase-catalyzed N-acetylation, Bioorg. Med. Chem, vol.713, pp.433-436, 1997. ,
Enzyme-mediated enantioselective acylation of secondary amines in organic solvents Addition of enantiopure ?-sulfinyl carbanions to (S)-N-sulfinimines: asymmetric synthesis of ?-amino sulfoxides and ?-amino alcohols Asymmetric synthesis of 1,4-dideoxy-1,4-imino-D-ribitol via stereoselective addition of allylphenylsulfone to an aryl N-sulfinylimine, Tetrahedron Lett. J. Org. Chem. Tetrahedron Asymmetry, vol.321516, issue.12, pp.4197-4198, 1991. ,
A Convenient Method for the Determination of the Absolute Configuration of Chiral Amines, The Journal of Organic Chemistry, vol.68, issue.8, pp.3287-3290, 2003. ,
DOI : 10.1021/jo026732m
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines, The Journal of Organic Chemistry, vol.34, issue.9, pp.2543-2549, 1969. ,
DOI : 10.1021/jo01261a013
Applications of MTPA (Mosher) Amides of Secondary Amines:?? Assignment of Absolute Configuration in Chiral Cyclic Amines, The Journal of Organic Chemistry, vol.61, issue.24, pp.8469-8495, 1996. ,
DOI : 10.1021/jo960373b
Asymmetric synthesis of novel C 2 -symmetric bismorpholines Synthetic studies on Mannostatin A and its derivatives: a new family of glycoprotein processing inhibitors, Tetrahedron Asymmetry J. Am. Chem. Soc, vol.132021, issue.116, pp.857-865, 1994. ,
The use of N-formylamino acids in peptide synthesis, J. Am. Chem. Soc, vol.802204965923, issue.2009, pp.1154-1158, 1955. ,
The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitol Pica-Mattoccia L., Cioli D. Sex-and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment, Int. J. Parasitol, vol.5523, issue.34, pp.695-700, 1965. ,
An improved perfusion technique for recovering adult schistosomes from laboratory animals, Am. J. Trop. Med. Hyg, vol.164, pp.483-486, 1967. ,
Praziquantel: mechanisms of anti-schistosomal activity, Pharmacology & Therapeutics, vol.29, issue.1, pp.129-156 ,
DOI : 10.1016/0163-7258(85)90020-8
Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.96, issue.3, pp.318-323, 2002. ,
DOI : 10.1016/S0035-9203(02)90110-0
Artemether administered together with haemin damages schistosomes in vitro, Trans. R. Soc. Trop. Med. Hyg, vol.957, pp.67-71, 2001. ,
The potential of artemether for the control of schistosomiasis, International Journal for Parasitology, vol.31, issue.14, pp.1549-1562, 2001. ,
DOI : 10.1016/S0020-7519(01)00297-1