Intelligent multielectrode arrays: improving spatiotemporal performances in hybrid (living-artificial), real-time, closed-loop systems

Abstract : This thesis presents a promising new bioelectronics system, the Hynet. The Hynet is a Hybrid (living-artificial) Network, developed to study the long-term behavior of electrogenic cells (such as Neurons or Beta-cells), both individually and in a network. It is based on real-time closed-loop communication between a cell culture (bioware) and an artificial processing unit (hardware and software). In the first version of our Hynet, we use commercial Multielectrode Arrays (MEA) that limits its spatiotemporal performances. A new Intelligent Multielectrode Array (iMEA) is therefore developed. This new analog/mixed integrated circuit provides a large-scale, high-density, and adaptive interface with the Bioware, which improves the real-time data processing and the low-noise acquisition of the extracellular signal.
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Guilherme Bontorin. Intelligent multielectrode arrays: improving spatiotemporal performances in hybrid (living-artificial), real-time, closed-loop systems. Micro and nanotechnologies/Microelectronics. Université Sciences et Technologies - Bordeaux I, 2010. English. ⟨tel-00561026⟩

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