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étude théorique de la transduction mécano-chimique dans l'adhérence cellulaire

Abstract : Complex systems observed in molecular biology are subject of major interest for statistical physic out of equilibrium. This is the case in particular of the focal adhesions which has been the center of theoretical investigation. The descriptions of this system have been limited to the understanding of mature focal adhesions that have a life-span superior to ten minutes. However, the understanding of what happen at the early stage remains fully open. The goal of this PhD is to propose a model of bidirectional mecano-chemical transduction process, from the Inside to the outside and reciprocally, based on the allosteric character of the interaction between integrins (sensing the extracellular matrix) and an activable cytoplasmic Partner, talin. This work is divided in three parts : i) a modelisation of the cell border based on the calculation of the chemical potential of the activable Partner and on its cycle of activation, ii) the numerical and analytical resolution of the equations proposed before and iii) an update of the previous model where the integrins have been allowed to diffuse and present in this case the ability to cluster in high constraints regions.
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Contributor : Olivier Ali <>
Submitted on : Tuesday, January 11, 2011 - 12:58:09 PM
Last modification on : Friday, October 16, 2020 - 1:47:03 PM
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  • HAL Id : tel-00554766, version 1


CNRS | U823 | UJF


Olivier Ali. étude théorique de la transduction mécano-chimique dans l'adhérence cellulaire. Biophysique []. Université Joseph-Fourier - Grenoble I, 2010. Français. ⟨tel-00554766⟩



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