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Traitement de l'information sensorielle et nociceptive par le réseau de la corne dorsale de la moelle épinière

Abstract : First relay of peripheral sensory and nociceptive information, the dorsal horn network of the spinal cord is a dynamic integrator, rather than a simple relay. The aim of this work is to caracterize input/output transformation and to assess the effect of network parameters as cellular, synaptic and connectivity properties. We used a combined theoretical and experimental approach through the development of a new experimental hybrid platform, based on the NEURON simulator. We developped a realistic network model of the dorsal horn and theoretical quantification tools from signal processing algorithm and information theory. We demonstrated the importance of intrinsic neuronal properties as well as inhibitory control for the information transfer. This work can lead to a novel approach of virtual pharmacology for the exploration of new pain treatment.
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https://tel.archives-ouvertes.fr/tel-00548761
Contributor : Yann Le Franc <>
Submitted on : Monday, December 20, 2010 - 1:23:16 PM
Last modification on : Monday, October 19, 2020 - 11:05:40 AM
Long-term archiving on: : Friday, December 2, 2016 - 6:17:23 PM

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  • HAL Id : tel-00548761, version 1

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Yann Le Franc. Traitement de l'information sensorielle et nociceptive par le réseau de la corne dorsale de la moelle épinière. Neurosciences [q-bio.NC]. Université Victor Segalen - Bordeaux II, 2004. Français. ⟨tel-00548761⟩

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