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Recalage de flux de données cinématiques pour l'application à l'imagerie optique

Abstract : Optical imaging techniques, have taken, since many years, a great part in the preclinicalstudies. The luminescence signal could be now recorded with a short time resolution whichenables studies with freely moving animals. This is an improvement because several studieshighlighted the impact of anesthetics agent and animal handling to perform studies inphysiological conditions. In this thesis, we define the tools, based on computer visionmethods, which offer the possibility to express the potential of this modality.In some cases, animal movement and low signal produce weak localization of the signal.Therefore we propose to improve localization of the optical data for a freely moving animal byusing motion field obtained from the multi-channel data. First, we introduce silhouetteconstraints and landmarks on the mouse skin within a variation framework. To take intoaccount all data in the registration framework, we combine the previously defined criteria,with global ones which measure compactness of signal distribution. Fusion is formulated as adiscrete population framework which produces strong experimental results in comparison topairwise method.In the last part, we propose an original approach to enable 3D optical imaging in case offreely moving animal. Therefore, we present a novel model-based method to animal trackingfrom monocular video which allows the 3D measurement of the signal. The 3D animal poseand the illumination are dynamically estimated through minimization of an objective functionwith constraints on the signal position. Experimental results demonstrate the potential of ourapproach for 3D accurate measurement with freely moving animal.
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Submitted on : Monday, November 29, 2021 - 11:24:09 AM
Last modification on : Monday, November 29, 2021 - 11:24:10 AM
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  • HAL Id : tel-00545424, version 1



Mickaël Savinaud. Recalage de flux de données cinématiques pour l'application à l'imagerie optique. Autre. Ecole Centrale Paris, 2010. Français. ⟨NNT : 2010ECAP0028⟩. ⟨tel-00545424⟩



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