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Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires

Abstract : Hemorphins are cryptic bioactive peptides derived from ß chain of haemoglobin proteolysis. Their biological presence has often been associated with physiological or pathological conditions, like cancers. Thus, it was already suggested that hemorphins could be used as marker of pathology. Previous studies achieved in our laboratory demonstrated that hemorphin-7 was decreased in serum of diabetic patients. We worked on a population of 120 patients with type 1 and type 2 diabetes and we studied different hypothesis: hemorphins metabolism, impact of glycated haemoglobin. Moreover, we researched the role of LVVH7 in insulin signalisation. The results suggested that hemorphin-7 concentrations in serum of diabetic patients are specific of this pathology but glycation of haemoglobin have no impact on liberation of hemorphins. In parallel, we characterized hemorphin-7 in tumor progression of lung cancers. Cathepsin D, previously demonstrated as a key enzyme in hemorphins generation and also in tumor progression, has been studied in vitro in lung cancers, cultured in acidified conditions, favourable to metastasis. In addition, we also identified hemorphin-7 liberation in acidified media culture.
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Delphine Féron. Significations physiopathologiques des hémorphines de type 7 dans le diabète et les cancers broncho-pulmonaires. Sciences agricoles. Université de La Rochelle, 2010. Français. ⟨NNT : 2010LAROS293⟩. ⟨tel-00537556⟩

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