Abstract : Bone remodeling is mediated by the osteoclasts and osteoblasts coupling. Xenoestrogens are endocrines disruptors that could interfere with bone remodeling. We have investigated the effect of tetradifon on bone remodeling. We have shown that disturbance of bone remodeling and metabolism were accompanied with a secondary genotoxic effect via oxidative damages. Bone is the main site of metastases for many cancer diseases such as the breast cancer. We have used Walker 256/B to induce bone metastases in rats. In vitro, ATA effects on these cells have provided acceptable results by inducing apoptosis and reducing ROS releasing. In vivo effects of ATA, have been investigated in a designed several model of breast cancer skeletal metastases. ATA did not prevent the bone loss but reduced the oxidative stress damage in the bone microenvironment. Microtomography and histology were used to detect and differentiate bone alterations due to osteolytic with or without ATA treatment. We have also shown that newly metaplastic, osteosclerotic, apposed bone was observed in the periosteal envelope of cancerous and ATA treated group. A hepatorenal bilan of this animal model of bone metastases was investigated. In this study, it seems that in situ inoculation of Walker 256 cells is not associated with renal and hepatic complications.