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Etude phytochimique et activité cytotoxique des métabolites secondaires de Ferula elaeochytris Korovin et Ferula lycia Boiss (Apiacées)

Abstract : Plants of the genus Ferula (Apiaceae) are perennial herbs distributed in Central Asia, the Mediterranean region and North Africa. Recent studies have shown the interest of some compounds isolated from Ferula species as chemopreventive agents and to overcome resistance to cancer. Thus, we have studied two Turkish plants of the genus Ferula: Ferula elaeochytris Korovin and Ferula lycia Boiss. Seven new sesquiterpene esters, along with thirteen known ones, two phenolic acids and a saponin were isolated. All structures were established by spectral methods, NMR, MS. All isolated compounds were tested for their cytotoxic activities against two tyrosine kinase inhibitor-resistant leukemic cell lines: K562R (imatinib-resistant) and DA1-3b/M2 (dasatinib-resistant). Elaeochytrin A (6-anthraniloyljaeschkeanadiol) proved to be the most active and selective to tumor cells with IC50 around 10 :M.
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Submitted on : Friday, September 24, 2010 - 2:45:02 PM
Last modification on : Thursday, February 21, 2019 - 9:56:03 AM
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  • HAL Id : tel-00520891, version 1

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Racha Alkhatib. Etude phytochimique et activité cytotoxique des métabolites secondaires de Ferula elaeochytris Korovin et Ferula lycia Boiss (Apiacées). Chimie. Université du Droit et de la Santé - Lille II, 2010. Français. ⟨tel-00520891⟩

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