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Développement d'une nouvelle technique de mesure de la résistance à l'insuline avec un traceur du transport du glucose, le [125I]-6-Déoxy-6-Iodo-D-glucose : Etude réalisée chez le rat

Abstract : Insulin resistance (IR) is a key defect in the development of many metabolic complications, such as Metabolic Syndrome and type 2 diabetes. Assessment of IR is of great clinical interest. There are no accurate and convenient procedure for insulin resistance measurement available in clinical practice. [123I]6-deoxy-6-iodo-D-glucose (6DIG) has been developed as a new tracer of glucose transport. An experimental protocol and a compartmental model were developed to study 6DIG transport in myocardium, and provide a cardiac IR index. The aim of this study was first to valide this cardiac IR index, second to develop a protocol for muscle IR index with 6DIG, and third to group this two protocols in one, transposable in humans. Results show that cardiac IR index is reproducible and sensitive. An empirical descriptor (ED), based on an analysis of tissue-activity curves has been develop. It is reproducible and sensitive. Mathematical modelisation permit to estimate 6DIG transport in skeletal muscle, and provide a muscle IR index. An ED, correlated with index values, has been developed. Skeletal muscle and myocardic IR index are significantly correlated with GIR, provided by the gold standard assessment of IR, the hyperinsulinaemic glucose clamp. ED are well correlated with GIR but no significantly. The two ED measured during the same experimental protocol, are reproducible and sensitive. Results are very encouraging for further use in Nuclear Medicine in humans, and for physiopathological studies in animals.
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https://tel.archives-ouvertes.fr/tel-00517348
Contributor : Julien Vollaire <>
Submitted on : Tuesday, September 14, 2010 - 12:31:17 PM
Last modification on : Friday, November 6, 2020 - 4:04:33 AM
Long-term archiving on: : Wednesday, December 15, 2010 - 2:43:12 AM

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  • HAL Id : tel-00517348, version 1

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Julien Vollaire. Développement d'une nouvelle technique de mesure de la résistance à l'insuline avec un traceur du transport du glucose, le [125I]-6-Déoxy-6-Iodo-D-glucose : Etude réalisée chez le rat. Sciences du Vivant [q-bio]. Université Joseph-Fourier - Grenoble I, 2010. Français. ⟨tel-00517348⟩

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